ライフサイエンスコーパス: adverse effect

1 Sedation was the most common adverse effect.

2 induced alopecia is a common and distressing adverse effect.

3 hich clozapine may act to cause this serious adverse effect.

4 O cooperative anticancer effect with minimal adverse effect.

5 nificant reductions of CAA pathology lacking adverse effects.

6 urotoxin B's therapeutic efficacy and reduce adverse effects.

7 ivate betaAR signalling of the heart without adverse effects.

8 Impression Improvement scale), relapse, and adverse effects.

9 clude increased artefact production and more adverse effects.

10 ociated with decreased hip fracture risk and adverse effects.

11 ure study of 19 forestry workers reported no adverse effects.

12 tical constraints whilst minimizing risks of adverse effects.

13 ts, but their chronic use causes paradoxical adverse effects.

14 er, but not in tumor tissue, without humoral adverse effects.

15 stable angina without clinically significant adverse effects.

16 resulted in treatment discontinuation due to adverse effects.

17 , without any clear signal of any unexpected adverse effects.

18 g(II)] or as methylmercury (CH3Hg), can have adverse effects.

19 e rates but were associated with significant adverse effects.

20 This approach leads to profound dose-related adverse effects.

21 nging behaviour, although not always without adverse effects.

22 to assess clinical outcomes and longer-term adverse effects.

23 mes and contrast its apparent beneficial and adverse effects.

24 ) is limited by concerns about its cognitive adverse effects.

25 ritin level and total iron-binding capacity, adverse effects.

26 rch is needed to assess generalizability and adverse effects.

27 elagolix were associated with hypoestrogenic adverse effects.

28 thenic acids), would ameliorate any observed adverse effects.

29 between episodes, patient satisfaction, and adverse effects.

30 s will limit exposure and have a low risk of adverse effects.

31 ccessfully completed in all patients without adverse effects.

32 egies that may differ in their likelihood of adverse effects.

33 rotransmitters, and may therefore have fewer adverse effects.

34 ding key information to limit immune-related adverse effects.

35 ng in surgical settings, protamine, exhibits adverse effects.

36 igh-dose prednisolone with potentially fewer adverse effects.

37 o toxicants and stressors that could lead to adverse effects.

38 of BMP2 while simultaneously suppressing its adverse effects.

39 ing enzymes, this approach can cause various adverse effects.

40 f life in young patients and cause life-long adverse effects.

41 children withdrew from the study because of adverse effects.

42 re no treatment-related mortality or serious adverse effects.

43 ntral component, which also causes important adverse effects.

44 imens, longer-term measures of alopecia, and adverse effects.

45 lls, and provide a strategy to prevent these adverse effects.

46 tumor immunity were observed, still without adverse effects.

47 No participant withdrew due to adverse effects.

48 ta on quality of life and little evidence of adverse effects.

49 % to 29% of patients reported opioid-induced adverse effects.

50 ectiveness, as well as clinical outcomes and adverse effects.

51 ng mortality rates, neurologic outcomes, and adverse effects.

52 ric modulation, could be responsible for the adverse effects.

53 ective analgesics with reduced liability for adverse effects.

54 is needed to assess longer-term efficacy and adverse effects.

55 5 MBq; <0.10 mug) was well tolerated with no adverse effects.

56 equently to induce catch-up growth, with few adverse effects.

57 No patients were withdrawn for adverse effects.

58 irical antibiotic treatment without apparent adverse effects.

59 hort-term pharmacokinetics and extra-cardiac adverse effects.

60 r dystrophy but are accompanied by prominent adverse effects.

61 inconsistent outcomes and potentially severe adverse effects.

62 ifferences were observed in the incidence of adverse effects.

63 ive agents, laboratory values, and potential adverse effects.

64 one was designed to be effective without the adverse effects.

65 d no hepatocellular carcinoma or other major adverse effects 11 months after vector injection, demons

66 he remaining women, primarily because of its adverse effects (34%).In women with HG, early enteral tu

67 ntinue sorafenib because of gastrointestinal adverse effects (8.7% v 10.8%; P = .047).

68 ir therapeutic effects (analgesia) and their adverse effects (addiction and overdose).

69 Significant adverse effects (AEs) have been associated with continuo

70 t, and clinical assessments recorded similar adverse effects after reduced-dose or partial-breast rad

71 ketamine with ECT might alleviate cognitive adverse effects and accelerate symptomatic improvement;

72 gically inhibited, were protected from these adverse effects and consequently survived.

73 iarrhythmic drugs are limited by ventricular adverse effects and efficacy loss as AF progresses.

74 response and are associated with substantial adverse effects and long-term risks.

75 This may pose problems with managing adverse effects and the design of efficient clinical tri

76 lief of the movement disorders is limited by adverse effects and the scarcity of evidence that the dr

77 nagement, but their use is highly limited by adverse effects and their variable efficacy in chronic p

78 s) versus undesirable consequences (burdens, adverse effects, and costs), the certainty in the eviden

79 among medications after discussing benefits, adverse effects, and costs.

80 d/or relapse rate, AChR autoantibody levels, adverse effects, and inflammatory markers.

81 t reduce overtreatment, decrease unnecessary adverse effects, and reduce risk of CR in the subset of

82 ement in erythema, and alleviation of pain), adverse effects, and subjective quality of life were mon

83 omplete responsiveness, potentially limiting adverse effects, and the occurrence of treatment resista

84 mainly due to an excess of gastrointestinal adverse effects, and there was no increase in hypoglycae

85 rength, motor function, quality of life, and adverse effect assessments.

86 Given the small effect size and adverse effects associated with aripiprazole, further an

87 in Europe, and emerging evidence suggesting adverse effects associated with iron supplementation of

88 To compare functional outcomes and adverse effects associated with radical prostatectomy, e

89 In addition to the adverse effects caused by pulmonary fibrosis, most patie

90 achieving statistically significantly lower adverse effects (change in breast appearance [p=0.007 fo

91 ill improve the balance of beneficial versus adverse effects compared with whole-breast radiotherapy.

92 for surveillance and management of potential adverse effects could improve cancer survivors' health a

93 , communication capacity, delirium severity, adverse effects, discharge outcomes, and overall surviva

94 broad TGF-beta blockers, while avoiding the adverse effects due to inhibition of multiple family mem

95 tics component, has been described to impart adverse effects during gestational and lactational expos

96 The viral oncogene blocks p53-mediated adverse effects during viral infection and transformatio

97 iding iron in a form that causes fewer or no adverse effects even when subjects are iron replete.

98 There were no significant adverse effects following 21 days exposure to concentrat

99 proctitis (RIP) is the most common clinical adverse effect for patients receiving radiotherapy as pa

100 s will be cured but bear the consequences of adverse effects for decades.

101 The severe adverse effect from chemotherapy drug is a leading cause

102 ng ICD-9 codes for poisoning from opioids or adverse effects from opioids.

103 factors and to what extent it is mediated by adverse effects from recent clozapine exposure or deteri

104 There were no adverse effects from the timolol during follow-up.

105 requiring hospitalization) and 2 hematologic adverse effects (grade 4 neutropenia and thrombocytopeni

106 scular dystrophy (DMD) patients, but various adverse effects have limited this treatment.

107 l-tolerated class of drugs with rare serious adverse effects, help preserve the phagocytic function o

108 were adapted from a DDI corpus, including i) adverse effect; ii) effect at molecular level; iii) effe

109 the dose separation between therapeutic and adverse effects in animals.

110 ion, school attendance, quality of life, and adverse effects in children in endemic helminth areas.

111 ross-reactivity leading to potential serious adverse effects in clinical application.

112 els should be regarded with caution, because adverse effects in copper homeostasis may occur.

113 show that HPbetaCD addition mitigates these adverse effects in human fibroblasts by significantly re

114 ass burning were sufficient to induce severe adverse effects in human lung cells.

115 nister radiopharmaceutical unlikely to cause adverse effects in humans.

116 outcomes, but little is known about possible adverse effects in offspring of A(H1N1)-vaccinated mothe

117 AES may exert context-specific beneficial or adverse effects in patients with critical illness.

118 No adverse effects in relation to safety of the radiopharma

119 We observe similar adverse effects in sanitation, shelter, and health care

120 The frequencies of adverse effects in the Sb(v) and fluconazole groups were

121 Treatment-related adverse effects included 2 infectious complications (pne

122 ts; however, some GBCAs have a small risk of adverse effects, including nephrogenic systemic fibrosis

123 All patients experienced multiple adverse effects, including thyroid toxicity, thrombocyto

124 d NK cells after haploidentical HSCT without adverse effects, increased GVHD, or higher mortality, an

125 inexor shows promising efficacy, its primary adverse effect is high-grade thrombocytopenia.

126 An approach to attenuate this adverse effect is to develop selective VDR modulators (V

127 hyponatremia (TIH), a clinically significant adverse effect, is poorly understood.

128 In both mice and dogs, no-observed-adverse effect level (NOAEL) was observed at a 12 mg/kg/

129 mum tolerated dose (MTD) and the no observed adverse effect level (NOAEL) were estimated to exceed 40

130 effect level (NOAEL) and the lowest-observed-adverse-effect level (LOAEL) of supplemented, oral, free

131 atherosclerosis.We estimated the no-observed-adverse-effect level (NOAEL) and the lowest-observed-adv

132 As a result, the no-observed-adverse-effect-level (NOAEL) of GS-AuNPs was >1000 mg kg

133 OUTCOME MEASURES: lowest observed adverse effect levels (LOAEL), postinterventional occurr

134 However, significant systemic adverse effects limited its use in this small series, an

135 ost comprehensive study to date of potential adverse effects manifesting after the perinatal period.

136 Here, we hypothesized that these adverse effects may be mediated by neurosteroids, given

137 the same population, safety was assessed by adverse effect monitoring.

138 Adverse effects more frequent in the augment-aripiprazol

139 with an increased risk of cumulative severe adverse effects, musculoskeletal effects, or stroke.

140 ed until progressive disease or unacceptable adverse effects occurred.

141 ted with cannabis use is mediated through an adverse effect of cannabis on medication adherence is un

142 Hand-foot syndrome (HFS) is a common adverse effect of capecitabine treatment.

143 Purpose Cardiac dysfunction is a serious adverse effect of certain cancer-directed therapies that

144 (4-PBA), an ER stress inhibitor lowered the adverse effect of diabetes on SCI, reduced EB dye extrav

145 We found no evidence for an adverse effect of early-life PFAS exposure on metabolic

146 RATIONALE: A potential adverse effect of high folate intake during pregnancy on

147 Hypoglycemia is a major adverse effect of insulin therapy for people with type 1

148 The most common adverse effect of LARC is nuisance bleeding, which can b

149 The main adverse effect of primaquine is erythrocyte age and dose

150 duced ocular hypertension (OHT) is a serious adverse effect of prolonged GC therapy that can lead to

151 By contrast, the adverse effect of RAS pathway mutations on the risk of r

152 Our research confirms an adverse effect of sugar intake from sweet food/beverage

153 r HO-CDI rates; this highlights an important adverse effect of the PIP/TAZO shortage and the importan

154 A1 ubiquitin-deficient mutants inhibited the adverse effects of Abeta on the surface expression of AM

155 vides an innovative platform for identifying adverse effects of abused psychostimulants and pharmaceu

156 signalling mechanisms promote resilience to adverse effects of acute traumatic stress and facilitate

157 lume, and no other subfield volume, mediates adverse effects of aging on memory.

158 Medication use might reduce the adverse effects of air pollution in individuals with isc

159 Furthermore, the adverse effects of ATB2 cells on glucose homeostasis wer

160 This cost is probably due to the adverse effects of autoimmunity and curtailment of horiz

161 None of the studies reported adverse effects of C. asiatica.

162 To determine the efficacy and adverse effects of cerebral embolic protection devices i

163 ling the existence of synergistic as well as adverse effects of chromatin modifiers on removal of res

164 cal and microbiologic responses and possible adverse effects of clarithromycin (CLM) combined with pe

165 Understanding the adverse effects of contemporary approaches to localized

166 INTERPRETATION: Between 20% and 36% of the adverse effects of continued cannabis use on outcome in

167 Common adverse effects of CPAP and MADs included oral or nasal

168 c dysregulation because of poor efficacy and adverse effects of current agents.

169 ese findings substantiate concerns about the adverse effects of developmental Mn exposure in humans.

170 No major adverse effects of donepezil were observed, but it had a

171 ction, but effective methods to mitigate the adverse effects of drought are not available.

172 gy to generate human cells for screening for adverse effects of drugs in humans.

173 This may be important in the prevention of adverse effects of early repetitive pain on brain develo

174 Recent studies have indicated potential adverse effects of FA overdoses, and FA protection durin

175 risk of ID and the potential mechanisms for adverse effects of high iron status during pregnancy.

176 overall fractures.Current evidence shows no adverse effects of higher protein intakes.

177 geneic cells to be effective in ameliorating adverse effects of hormone deficiency, including bone he

178 ence highlighting the evolutionary conserved adverse effects of hyperglycemia on neurogenesis and bra

179 Targeting of endophilin B2 alleviates adverse effects of IAV infection on respiratory and immu

180 specifically target CX3CR1 could reduce the adverse effects of inflammation and augment activity-dep

181 unliganded transcription factors to dial out adverse effects of insulin sensitizers.

182 MNPs is a promising approach to mitigate the adverse effects of iron on the infant gut.

183 This review summarizes studies on the adverse effects of iron on various outcomes; suggests po

184 n increasing number of studies have reported adverse effects of iron that was given to infants and yo

185 -40 T-cell agonist antibodies can rescue the adverse effects of MEK inhibition on T cells in both mou

186 rotect human health and the environment from adverse effects of mercury.

187 oderator of plant and ecosystem responses to adverse effects of more variable precipitation, manageme

188 ctively whether social capital mitigates the adverse effects of natural disaster on cognitive decline

189 neonicotinoids (neonics) in the environment, adverse effects of neonics in many species, including ma

190 Early detection of adverse effects of novel therapies and understanding of

191 y a compensatory role that may mitigate some adverse effects of oil-exposure in vivo.

192 macology underlying the therapeutic and main adverse effects of opioids and its implications for clin

193 forebrain (cBF) is selectively vulnerable to adverse effects of perinatal stressors, and impaired cBF

194 ontrol group that reported PTSD symptoms and adverse effects of plant-based cannabis use in adults wi

195 should be interpreted in light of potential adverse effects of postponing surgery.

196 be one of the underlying mechanisms for the adverse effects of prenatal lead on the offspring, but e

197 sons for initiating anti-TNF were failure or adverse effects of previous therapy in 42 patients (93%)

198 A1-exosomes is efficient for minimizing the adverse effects of SE in the hippocampus and preventing

199 identify studies that addressed efficacy and adverse effects of single or combination pharmacotherapy

200 rrelation between epigenetic aberrations and adverse effects of space relevant irradiation on cogniti

201 In addition, adverse effects of statins may limit their tolerability

202 ubstantial number of patients are spared the adverse effects of systemic chemotherapy.

203 Several studies investigating potential adverse effects of the pandemic A(H1N1) vaccine have sup

204 sly operating microfluidic setup revealed no adverse effects of the residual DMSO after the solvent r

205 pain and joint swelling and tenderness; and adverse effects of the tests.

206 atorial strategy to treat as well as prevent adverse effects of therapy in patients with wet AMD and

207 These adverse effects of tPA were ameliorated in PPK (Klkb1)-d

208 Adverse effects of troublesome major elements (Fe(3+), T

209 Adverse effects of vaccines have been recognized for man

210 ss quality of care and the effectiveness and adverse effects of various therapies.

211 There is limited knowledge regarding the adverse effects of wastewater-derived microplastics, par

212 o all chromatin states, suggesting the least adverse effect on adjacent genes.

213 to be carefully studied due to the observed adverse effect on drug loading.

214 that core fucosylation exerted a significant adverse effect on FcgammaRIIIA binding, in vitro ADCC, a

215 egeneration of furcation defects without any adverse effect on healing process.

216 h heparanase inhibitors, since the potential adverse effect on NK cell infiltration might limit the a

217 use of the drug and should help counter the adverse effect on public health of exaggerated claims ab

218 n turnover in ATM-depleted cells also has an adverse effect on the DNA base excision repair pathway,

219 9 weeks of gestational age has no short-term adverse effect on the mother or infant among nulliparous

220 An adverse effect on this relationship, rather than disrupt

221 Steroid hormones produce adverse effects on biota as well as bioaccumulation in f

222 h high iron status during pregnancy may have adverse effects on birth outcomes, including oxidative s

223 the evidence that early schistosomiasis has adverse effects on birth, growth, and development.

224 c acids exhibit both nonspecific binding and adverse effects on blood clotting that limit their use.

225 ther CR can be implemented in humans without adverse effects on body composition.We evaluated the eff

226 es and because their use is limited by their adverse effects on bone and cardiac tissues, we hypothes

227 ons include abnormal growth and development, adverse effects on bone and the cardiovascular system, a

228 led trials (RCTs) suggest calcium could have adverse effects on cardiovascular disease, although thes

229 Obesity has adverse effects on cardiovascular hemodynamics and cardi

230 other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.

231 age associated with synovitis but might have adverse effects on cartilage and periarticular bone.

232 s, extracted from human dental pulp, with no adverse effects on cell viability, or on their subsequen

233 and maintenance resulted in initially small adverse effects on consumers, but ultimately led to popu

234 lts suggested HF-FPW could cause significant adverse effects on fish, and the organic contents might

235 the Latin American population, with no major adverse effects on health or reproduction.

236 cohol and tobacco, cannabis can have serious adverse effects on health, and some people have difficul

237 armful algal blooms (CyanoHABs) have serious adverse effects on human and environmental health.

238 or marine organisms has been associated with adverse effects on humans.

239 beta-cell failure is not expected to produce adverse effects on insulin secretion.

240 r with aerodynamic diameter <2.5 (PM2.5) had adverse effects on longitudinal measures of insulin sens

241 ments with mammals reveal that this can have adverse effects on memories formed prior to hibernation.

242 for the effects of sildenafil that, through adverse effects on mitochondrial function and endoplasmi

243 ipulation of neural circuits in vivo without adverse effects on neuronal physiology and circuit funct

244 depletion of conventional eIF2 complexes has adverse effects on normal but not oncogenic growth.

245 trative tasks to mitigate or eliminate their adverse effects on physicians, their patients, and the h

246 premature development of complications, with adverse effects on quality of life and unfavourable effe

247 vioral tests showed no significant long-term adverse effects on sciatic nerve functions.

248 Chloride load is associated with significant adverse effects on survival out to 1 year even after con

249 ociated with potentially treatable long-term adverse effects on the brain that lead to accelerated fu

250 iological mechanisms, cocaine exerts various adverse effects on the cardiovascular system, many times

251 The 6 week long stimulation had no residual adverse effects on the electrophysiologic characteristic

252 njection did not cause significant long-term adverse effects on the functions of the injected nerve.

253 verage of organ donation cases-with possibly adverse effects on the incidence of organ donations.

254 often underrecognized, delirium has serious adverse effects on the individual's function and quality

255 an intensive CO2 flux over 112000 ppm causes adverse effects on the plant growth, physiological and b

256 er repeated cycles of photoinduction without adverse effects on viability and proliferation.

257 aine than placebo, without increased risk of adverse effects or disability and consistent with previo

258 in terms of effectiveness, quality of life, adverse effects, or any other outcome in the short term,

259 ions that reported pain, quality of life, or adverse effect outcomes.

260 egy was associated with distinct patterns of adverse effects over 2 years.

261 ly potent antitumor activity and a tolerable adverse effect profile in a cohort of patients with an o

262 ations for and contraindications to therapy, adverse effect profile, and ongoing thrombotic risk fact

263 topical timolol treatment, which has a lower adverse-effect profile than conventional topical steroid

264 because of an unanticipated life threatening adverse effect: progressive multifocal leukoencephalopat

265 opulation, there was significant evidence of adverse effects related to exposure to PM2.5 and ozone a

266 ecular targets responsible for AHR-dependent adverse effects remain largely unknown; however, in zebr

267 alysis of eight million reports from the FDA Adverse Effect Reporting System.

268 predispose patients to treatment failure and adverse effects, respectively; however, these events are

269 ng radiation injury while protecting against adverse effects reveals a viable radiation countermeasur

270 s and may contribute toward infusion-related adverse effects such as allergic responses.

271 it both domains nonselectively, resulting in adverse effects such as cough and angioedema.

272 lamed tissue can reduce pain without central adverse effects such as sedation, apnoea, or addiction.

273 ve treatments for localized disease but have adverse effects such as urinary symptoms and sexual dysf

274 iring the use of high doses that often cause adverse effects, such as convulsions.

275 Conclusion Apart from treatment-associated adverse effects, survivors after initially successful th

276 Fibers showed greater adverse effects than PE beads.

277 es recommendations to manage sexual function adverse effects that occur as a result of cancer diagnos

278 zumab (BEV, anti-VEGF), it could reverse the adverse effects that precipitate fibrotic changes, druse

279 worms, flies, and mice, but it can also have adverse effects (the "insulin paradox").

280 on, have limitations and are associated with adverse effects; therefore, the identification of additi

281 The Opiates produce analgesia and other adverse effects through activation of the mu opioid rece

282 to twenty times more light exposure without adverse effects, thus bypassing the optical constraints

283 Adverse effects to aspirin included urticaria (n=177, 53

284 one of the key players in diabetes-mediating adverse effects to the neuronal and vascular components

285 ose used for recombination induction, caused adverse effects to the testis and to the reproductive en

286 alone or the ultrasound alone caused little adverse effects to tumor tissue, while the combined trea

287 complex molecular mechanisms underlying the adverse effects UV radiation (UVR) on skin homeostasis,

288 The most common adverse effect was decreased blood calcium (68.9% vs 59.

289 The most common adverse effect was hypokinesia (3 patients in the loraze

290 ication use, although discontinuation due to adverse effects was usually less than 5%.

291 ystrophic muscle, and potentially reduce the adverse effects, we have studied the effect of prednisol

292 Adverse effects were experienced in both the build-up an

293 with mandatory dose escalation if no serious adverse effects were experienced.

294 Drug-related adverse effects were infrequent.

295 Adverse effects were mild and well-tolerated and the the

296 ife as reported by the patient, and recorded adverse effects were monitored throughout the treatment

297 be translated to the non-human primates: no adverse effects were observed within 90 days after intra

298 No adverse effects were recorded.

299 , and equivalent or fewer late normal-tissue adverse effects were seen.

300 These adverse effects were significantly greater in LC-exposed