ライフサイエンスコーパス: adversity

1 ilience (defined as the ability to cope with adversity).

2 ons are intervening to address family social adversity.

3 This result was mainly due to childhood adversity.

4 er circumstances of structural and political adversity.

5 f resilience, a crucial adaptive response to adversity.

6 vidual to maintain health despite stress and adversity.

7 rights-related trauma also led to continuing adversity.

8 ove the lives of those exposed to stress and adversity.

9 aternal smoking during pregnancy, and family adversity.

10 effects were specific to different types of adversity.

11 depressive symptoms as well as to continuing adversity.

12 es associated with well-being in contexts of adversity.

13 es associated with the effects of early life adversity.

14 ng in ways that increase persistence through adversity.

15 depression in response to severe or chronic adversity.

16 rs at the cost of atom economy and synthetic adversity.

17 ct neural mechanisms for persistence through adversity.

18 sm, higher hostility, and greater early life adversity.

19 ciated with relative resilience to childhood adversity.

20 don their projects lies in their response to adversity.

21 ontogenetic adaptation in response to early adversity.

22 whether they reported childhood or adulthood adversity.

23 ic status or those with greater psychosocial adversity.

24 ppear to be independent of earlier childhood adversity.

25 f life, the most recent 2 years, and overall adversity.

26 roups, such as patients exposed to childhood adversity.

27 e, and psychopathology), as well as economic adversity.

28 tudies of domestic violence, abuse and early adversity.

29 vironmental stress in the form of early life adversity.

30 n sitters that experienced early nutritional adversity.

31 y, impulsivity and aggression, and childhood adversity.

32 s not apparent in subjects without childhood adversity.

33 ive disorder in the context of environmental adversity.

34 ristic enabling one to thrive in the face of adversity.

35 continue after the period of exposure to the adversity.

36 literature linking telomere length and early adversity.

37 ities and is more common following childhood adversity.

38 daptation of young people faced with extreme adversity.

39 cial risks, such as poverty and psychosocial adversity.

40 x, intrauterine complications, and postnatal adversity.

41 Early life adversity.

42 iorate the broad and costly effects of early adversity.

43 as the conserved transcriptional response to adversity.

44 range of poor outcomes associated with early adversity.

45 g disease by mitigating the effects of early adversity.

46 y to psychological consequences of childhood adversity.

47 tionalization is a significant form of early adversity.

48 erson-dependent variables such as early-life adversity.

49 responses to an imminent threat brace us for adversities.

50 ic manipulations or additional environmental adversities.

51 nd exposures to other childhood psychosocial adversities.

52 rs, whereas others adapt well in the face of adversity?

53 p between cumulative childhood and adulthood adversity, adding up a range of severe financial, trauma

54 about the consequences of stress and extreme adversities, advances in theory and methods for studying

55 Given that childhood adversities affect cardiometabolic health and multiple h

56 ittle is known about how early socioeconomic adversity affects auditory brain function.

57 ne the conserved transcriptional response to adversity alongside other proposed measurements of biolo

58 Childhood adversities, particularly recent adversities, already show an impact on health outcomes b

59 nonhuman animal research suggests that early adversity alters aversive learning and associated neuroc

60 r humans as well as for other species, early adversity alters the neurobiology of aversive learning b

61 g on existing data, we argue that early-life adversity amplifies crosstalk between peripheral inflamm

62 ponded to a survey on childhood psychosocial adversities and adult CVD risk behaviors in 2008 to 2009

63 We investigated the role of childhood adversities and adulthood stressors in liability for bip

64 10 to 17 years who were asked about lifetime adversities and current distress symptoms.

65 disorder are more likely to report childhood adversities and recent stressors than individuals withou

66 jectively qualifies as exposure to childhood adversity and a dearth of prospective studies, substanti

67 completed interview assessment of cumulative adversity and a structural magnetic resonance imaging pr

68 individuals with both childhood psychosocial adversity and adult neighborhood disadvantage are at an

69 ses partially explain the link between early adversity and adult survival.

70 e documents an association between childhood adversity and cardiometabolic outcomes across the life c

71 est a causal relationship between early-life adversity and changes in DNA methylation in several "can

72 nse that mediates the effects of both social adversity and dominance on decreases in health.

73 Early-life adversity and epigenetic mechanisms might explain some o

74 biological mechanism through which childhood adversity and functional genetic variation in HPA axis r

75 Combined exposure to high childhood adversity and high adult disadvantage was associated wit

76 To assess the roles of early adversity and individual psychological resilience in imm

77 ve focused on risk factors such as childhood adversity and life events; information on the nature and

78 Childhood adversity and lifetime psychopathology were each associa

79 f incident CVD compared with a low childhood adversity and low adult disadvantage.

80 nfluence brain function before any childhood adversity and may be a diathesis for the interaction bet

81 h new neuroscientific evidence linking early adversity and nurturing care with brain development and

82 posing factors (moderators such as childhood adversity and obesity), stressors and pathogens can lead

83 The relationship between early adversity and outcomes across the lifespan is apparent i

84 of vulnerability, linking exposure to early adversity and psychiatric risk.

85 he main and interactive effects of childhood adversity and rs16969968 genotype on diagnosis of ND and

86 Significant interactive effects of childhood adversity and rs16969968 genotype were observed in men (

87 Cumulative adversity and stress are associated with risk of psychia

88 stress and reward networks after early-life adversity and suggest mechanistic roles for Crh-expressi

89 e and indicate that close ties between early adversity and survival arise even in the absence of heal

90 e first study to find an association between adversity and telomere length in children, and contribut

91 Early adversity and telomere length were significantly associa

92 ed to clarify the relationship between early adversity and telomere length while exploring factors af

93 ave evaluated the relationship between early adversity and telomere length, a marker of cellular sene

94 l implications for research on resilience to adversity and the early origins of disease.

95 tency among studies investigating early-life adversity and the effect of parental stress, even if the

96 ed upon the presence or absence of childhood adversity and the presence or absence of lifetime psycho

97 treatment for children exposed to a range of adversity and types of mental disorders.

98 Telomere length is associated with early adversity and with chronic stressors in adulthood in man

99 tute care and an index of multiple childhood adversities, and the effects remained significant after

100 lts (n=30) with a history of early childhood adversity, and a control group (n=30) without trauma exp

101 de both incidental influences, such as early adversity, and intentional influences that can be produc

102 Recent adversity appeared to uniquely predict poor health, soma

103 Childhood adversities are common, highly co-occurring, and strongl

104 ilarly, in registry-based studies, childhood adversities are more common among individuals who later

105 Females who experience the most adversity are also socially isolated in adulthood, sugge

106 Genetic factors and early-life adversity are critical in the etiology of mood disorders

107 ividual differences in impulsivity and early adversity are known to be strong predictors of adolescen

108 ts suggest that CTRA responses to early life adversity are not restricted to WEIRD cultural contexts

109 e anticipatory reactions to potential future adversity are observed across a range of anxiety disorde

110 nd their relation to antisocial behavior and adversity are poorly understood.

111 or the conserved transcriptional response to adversity as a marker of biological embedding of social

112 ptions of threat on campus by framing social adversity as common and transient.

113 movement and how they override scarcity and adversity as dense packs.

114 Social adversity biases the cognitive schema that the individua

115 en they did not experience early nutritional adversity but had no effect in sitters that experienced

116 e (5-HTTLPR) and exposure to early childhood adversities (CA) are independently associated with indiv

117 Cumulative adversity (CA) increases stress sensitivity and risk of

118 hat raises four basic issues: whether social adversities can be considered homogeneous, whether the c

119 Our data highlight that physiological adversity can exist when clinical disruptions are minor,

120 rain imaging in children suggests that early adversity can interfere with white matter development in

121 Although childhood adversities (CAs) are known to be highly co-occurring, m

122 r settings and is critical in recovery after adversity, challenging understanding of the circuitry in

123 specific biological mechanism through which adversity contributes to altered brain function, which i

124 eta-analysis to establish whether early-life adversity contributes to potentially pathogenic pro-infl

125 fferential gene methylation as a function of adversity contributes to the emergence of individual ris

126 d to a conserved transcriptional response to adversity (CTRA) in circulating leukocytes that may cont

127 elated conserved transcriptional response to adversity (CTRA) involving increased expression of proin

128 show a conserved transcriptional response to adversity (CTRA) involving increased expression of proin

129 ls-the conserved transcriptional response to adversity (CTRA).

130 kocyte conserved transcriptional response to adversity (CTRA).

131 Comprehensive evaluations of adversity demonstrated more extensive telomere length ch

132 Females who experience >/=3 sources of early adversity die a median of 10 years earlier than females

133 ould be mediators between the experiences of adversities during childhood and the development of emot

134 Chronic nutritional adversity during adulthood did not affect rover or sitte

135 Children exposed to various forms of adversity early in life are at increased risk for a broa

136 Adversity early in life was associated with higher level

137 Early life adversity (ELA) has been associated with an increased ri

138 hy young adults for the impact of early-life adversity (ELA) in relation to the G-to-A single nucleot

139 is, recent treatment history, and early life adversity (ELA) were determined by psychological autopsy

140 l mechanisms through which the experience of adversity emerges as individual risk for mental illness

141 n children, children with a history of early adversity evidenced mature connectivity (negative amygda

142 Adversity experienced during gestation is a predictor of

143 that enlistment may serve as an escape from adversity for some individuals, at least among men.

144 The adversities from the original ACE scale items were assoc

145 ion of conserved transcriptional response to adversity genes and distinct patterns of proinflammatory

146 How does adversity get under the skin of the developing child?

147 The early adversity group showed altered hypothalamus-pituitary-ad

148 inflammatory upstream signaling in the early adversity group.

149 Animal models also suggest that early adversity has a negative impact on the development of pr

150 Medium-term climatic adversity has frequently caused similar health, social,

151 exposure to severe psychological or physical adversity has ignited interest in the mechanisms that pr

152 Early life adversity has known impacts on adult health and behavior

153 In animal models, similar variants of early adversity have been shown to modify amygdala-hippocampal

154 s of interventions for young children facing adversity have demonstrated multiple, positive effects b

155 nal, such that among subjects with childhood adversity, high IL-6 forecasted depression 6 months late

156 ernal genotype, and indices of socioeconomic adversity (housing, employment, education, electricity,

157 e studies with data collection pre- and post-adversity; however, prestressor assessments are not alwa

158 it is not possible to remove the stress and adversities in people's lives, it may be possible to mod

159 to depression might be associated with early adversity in addition to the effect of depression.

160 ent stress depends on the specific timing of adversity in adolescence.

161 sociated with psychological stress and early adversity in adults; however, no studies have examined w

162 than single events, it is also possible that adversity in childhood has larger effects on later life

163 ospective study of the relation of financial adversity in childhood to lung function in midlife.

164 Adversity in early childhood exerts an enduring impact o

165 are elucidating principles of adaptation to adversity in early childhood with molecular, cellular, a

166 oratory behavior; however, early nutritional adversity in the larval period increased sitter but not

167 imate partner violence (IPV), and continuing adversity in women in Timor-Leste.

168 Early adversity, in the form of abuse, neglect, socioeconomic

169 isorders that are associated with early-life adversity, including depression, schizophrenia, bipolar

170 Childhood adversity increases the methylation level of the CHRNA5

171 Early-life adversity increases the risk for psychopathology in late

172 Evidence shows that similar early life adversities induce sex-dependent epigenetic reprogrammin

173 ent-related (for which there was no recorded adversity) injury.

174 ine the association between a specific early adversity, institutional care and telomere length.

175 ntal factors, sex hormones, and psychosocial adversity interact to increase risk through hormonal fac

176 aster to show that chronic early nutritional adversity interacts with rover and sitter allelic varian

177 understanding of the most harmful childhood adversities is still incomplete because of complex inter

178 al processing of reward following early life adversity is a highly promising depressive intermediate

179 Because early-life adversity is a powerful determinant of subsequent vulner

180 Early adversity is an important risk factor that relates to in

181 Early-life adversity is associated with a broad scope of life-long

182 Early-life adversity is associated with accelerated cellular ageing

183 Socioeconomic adversity is associated with accelerated epigenetic agin

184 Early financial adversity is associated with adult lung function partly

185 Thus, we assessed whether cumulative adversity is associated with differences in gray matter

186 Early-life adversity is associated with increased vulnerability to

187 We provide evidence that early life adversity is associated with significant reductions in E

188 Childhood adversity is associated with telomere shortening, and se

189 e hypothesis that the response to early-life adversity is system-wide and genome-wide and persists to

190 ns, which are disproportionately affected by adversity, is needed to determine cross-cultural validit

191 We suggest that childhood adversity leads to persistent alterations in transcripti

192 Paths from continuing adversity led to depressive symptoms, and PTSD symptoms,

193 levels but lower depression scores at higher adversity levels (p=2.3E-05).

194 ciating with higher depression scores at low adversity levels but lower depression scores at higher a

195 campal volume and a measure of environmental adversity (life events questionnaire) in a large sample

196 mpromise development, with higher amounts of adversity linked to behavioral problems.

197 ychopathology, most individuals experiencing adversity maintain normal psychological functioning, sug

198 ostnatal smoking, psychosocial and obstetric adversity, maternal prenatal stress, and lifetime substa

199 sting that a threshold of socioenvironmental adversity may be necessary to increase incidence.

200 ether, these results suggest that early life adversity may have a lasting impact on serotonergic circ

201 These results suggest that early adversity may have long-lasting physiological consequenc

202 t can be used to examine how additional life adversity may provoke disease risk or resilience.

203 study suggests that the shadow of childhood adversity may reach far into later adulthood in part thr

204 se life events, including Physical or Sexual Adversity (mugged, threatened with a weapon, experienced

205 on and global commonalities in the impact of adversities, multi-morbidities and their consequences ac

206 were admitted with injury related to neither adversity nor accidents.

207 ual and the odds of paid sickness absence (1 adversity: odds ratio (OR) = 1.26, 95% confidence interv

208 hology among individuals who experienced the adversity of chronic childhood poverty.

209 umulative effects of childhood and adulthood adversities on adult telomere length.

210 e interaction of MAOA genotype and childhood adversities on antisocial outcomes in predominantly nonc

211 construal: It prevented students from seeing adversity on campus as an indictment of their belonging.

212 fic literature on the influence of childhood adversity on cardiometabolic outcomes that constitute th

213 tcomes can be traced to the impacts of early adversity on multiple and integrated biological systems

214 e full range of reported effects of prenatal adversity on offspring growth, we propose an integrative

215 ggestive of a persisting effect of childhood adversity on serotonergic neurodevelopment and emotional

216 rature suggests latent effects of early life adversity on serotonin function may play a role in this

217 g the effects on specific forms of childhood adversity on smoking risk, have been understudied.

218 the mechanisms of the effects of early-life adversity on the brain and the body.

219 r mitigating the consequences of significant adversity on the developing brain.

220 probe the protean consequences of early-life adversity on the developing brain.

221 x environment effect of CHRNA5 and childhood adversity on the risk for ND.

222 ween the rs3027172 genotype and psychosocial adversity on this drinking measure.

223 We focus on two forms of adversity, one in which children are exposed to childhoo

224 pment, which propose that antenatal maternal adversity operates through the biological pathways assoc

225 Exposure to high childhood adversity or high adult neighborhood disadvantage alone

226 anxiety in people who experienced childhood adversity or recent negative life events in a European w

227 nce interval (CI): 1.09, 1.45 (P = 0.002); 2 adversities: OR = 1.28, 95% CI: 1.09, 1.51 (P = 0.002);

228 = 1.28, 95% CI: 1.09, 1.51 (P = 0.002); >/=3 adversities: OR = 1.58, 95% CI: 1.29, 1.94 (P < 0.001)).

229 family income (p=0.014 and p<0.0001), family adversity (p<0.0001 for both), maternal psychopathology

230 Childhood adversities, particularly recent adversities, already sh

231 Adversity, particularly in early life, can cause illness

232 Exposure to childhood adversity potentiated the effects of recent stressors on

233 essed conflict-related PTEs, IPV, continuing adversity (poverty and insecurity), PTSD symptoms (the H

234 In adjusted models, lifetime cumulative adversity predicted 6% greater odds of shorter telomere

235 Experience of adversity predicted smaller heart rate and cortisol resp

236 female baboons to show that cumulative early adversity predicts natural adult lifespan.

237 Across 20 male cohorts, early adversity presaged antisocial outcomes more strongly for

238 nset of PTSD) traumatic events and childhood adversities, prior histories of separation anxiety disor

239 Multilevel models indicated that childhood adversity promotes clustering of depression and inflamma

240 These findings suggest that childhood adversity promotes the formation of a neuroimmune pipeli

241 protective factor for children experiencing adversity, promoting better stress and emotion regulatio

242 cells in vivo, triggered by injury or other adversity, provides an essential route to recovery for m

243 Eight categories of adversity (psychological maltreatment, physical abuse, s

244 Mothers experiencing adversity reduce maternal investment leading to stunted

245 10 years after hospital discharge following adversity-related (self-inflicted, drug-related or alcoh

246 fter discharge, and to compare risks between adversity-related and accident-related index injury afte

247 relative risks of death and re-admission for adversity-related compared with accident-related injury.

248 micides in our estimates of 10-year risks of adversity-related deaths, we did not explicitly present

249 mitation of the study was under-recording of adversity-related injuries and misclassification of thes

250 Emergency hospital admission with adversity-related injury (ie, self-inflicted, drug-relat

251 Hospitalisation for adversity-related injury (violent, drug/alcohol-related,

252 r 10-19 y olds with emergency admissions for adversity-related injury (violent, drug/alcohol-related,

253 e significantly increased after all types of adversity-related injury except for girls who had violen

254 Adolescents discharged after adversity-related injury had higher risks of suicide (ad

255 ficient evidence that girls discharged after adversity-related injury had increased risks of accident

256 -y risks of mortality and re-admission after adversity-related injury with risks after accident-relat

257 Among adolescents discharged after adversity-related injury, one in 137 girls and one in 64

258 ission should be considered for all types of adversity-related injury, particularly for older adolesc

259 years) who were admitted as an emergency for adversity-related or accident-related injury between Apr

260 We identified admissions for adversity-related or accident-related injury to the Nati

261 dies and 70% of animal studies of early-life adversity reported increased methylation at this exon va

262 akthrough outcomes for young children facing adversity requires supporting the adults who care for th

263 Although early-life adversity results in hyperreactivity of the sympathetic

264 Research focused on early-life adversity revealed that early-life experiences have a pe

265 s, early hazards to the brain, and childhood adversity sensitise the dopamine system, and result in e

266 d by a relative or nonrelative) or Emotional Adversity (separation from biological mother or father f

267 Although cumulative lifespan adversity should have bigger impacts than single events,

268 Childhood adversity significantly increased ND risk in both sexes,

269 ches alter multiple components of early-life adversity simultaneously.

270 acteristics, prior trauma history, childhood adversity, sociodemographic characteristics, psychiatric

271 It may be that in the face of adversity (stress), death mechanisms are turned on at a

272 ale rats that experienced chronic early-life adversity/stress (CES).

273 Depression, childhood adversity, stressors, and diet can all influence the gut

274 was significantly associated with childhood adversity (T = 2.3; P = .03).

275 Single adversities tended to have nonsignificant relations with

276 In adjusted models for cumulative childhood adversity, the occurrence of each additional childhood e

277 arly experience, the heterogeneity of social adversity, the possible mediators of the biological embe

278 Among subjects exposed to high childhood adversity, the transition to depression was accompanied

279 be possible to modify interpretation of such adversities through cognitive style.

280 also conceptually outlines pathways linking adversity to cardiometabolic health, identifies evidence

281 score the importance of timing of adolescent adversity to long-term outcomes.

282 Adversity type and timing significantly impacted the ass

283 factors affecting the association, including adversity type, timing and study design.

284 phenotype and measures of social environment adversity varied among studies.

285 tablished prospective birth cohort (Maternal Adversity, Vulnerability, and Neurodevelopment) were use

286 Early adversity was also associated with higher levels of inte

287 Cumulative adversity was associated with smaller volume in medial p

288 4 young men included in this analysis, early adversity was directly associated with lower GM volumes

289 promoter SNP rs3027172 and with psychosocial adversity was found.

290 Childhood adversity was indexed by parental separation, low socioe

291 Early adversity was related to variation in brain structure bo

292 of health problems associated with childhood adversity, we argue that the field needs a second genera

293 logistic regression models of developmental adversities were used to adjust for potential confounder

294 l to early modern Iceland stress compounding adversities, where climate, trade, political domination,

295 OA did not interact with combined early life adversities, whereas maltreatment alone predicted antiso

296 tial correlations with severity of childhood adversity while controlling for confounding 5-HT effects

297 eses about causal mechanisms that link early adversity with lifelong impairments in learning, behavio

298 significant interactions with environmental adversity with respect to hippocampal volume.

299 ective investigation of associations between adversity within the first 6 years of life, internalizin

300 Risk factors were adversity within the first 6 years of the child's life (