ライフサイエンスコーパス: aerobactin

1 ead) and the chromosomal locus iuc (encoding aerobactin).

2 lly similar Fe-siderophore complexes like Fe-aerobactin.

3 tem but lacked the ability to produce or use aerobactin.

4 amiliar traditional counterparts, e.g., iut (aerobactin; 57%) and sfaS (S fimbriae; 14%), thus possib

5 We have also determined that aerobactin, a common bacterial siderophore involved in v

6 enes encoding the synthesis and transport of aerobactin, a hydroxamate siderophore associated with in

7 ent (DeltaiucA) derivatives established that aerobactin accounted for the overwhelming majority of in

8 These data strongly support that aerobactin accounts for increased siderophore production

9 he cytotoxic necrotizing factor 1 (cnf1) and aerobactin (aer) gene sequences to characterize the 15 O

10 Three are linked to genes for enterobactin, aerobactin, and yersiniabactin.

11 and transport of the hydroxamate siderophore aerobactin are located within a 21-kb iron transport isl

12 er, these data confirm and extend a role for aerobactin as a critical virulence factor for hvKP.

13 with significant sequence similarity to the aerobactin biosynthesis enzymes IucB and IucC, respectiv

14 In addition, one clone contained the aerobactin biosynthesis gene iucA.

15 e absence of iuc (which encode hemolysin and aerobactin biosynthesis), nonagglutination of digalactos

16 e, whose predicted product is similar to the aerobactin biosynthetic enzymes IucA and IucC.

17 la dysenteriae type 1 strains do not produce aerobactin but do contain sequences downstream of selC t

18 sulting in the generation of hvKP1DeltaiucA (aerobactin deficient), hvKP1DeltairoB (salmochelin defic

19 s hvKP1, A1142, and A1365 and their isogenic aerobactin-deficient (DeltaiucA) derivatives established

20 ion sequences upstream and downstream of the aerobactin genes and an integrase gene that was nearly i

21 he same location in Shigella sonnei, but the aerobactin genes are not located within SHI-2 in Shigell

22 ression of the Shigella flexneri chromosomal aerobactin genes during growth of the bacterium within t

23 I and V, suggesting a common origin for the aerobactin genes in both S. flexneri and E. coli pColV.

24 The presence of the aerobactin genes on plasmids in E. coli pColV and Salmon

25 The map locations of the aerobactin genes vary among closely related species.

26 h the relative activity being enterobactin > aerobactin > yersiniabactin > salmochelin, suggesting th

27 to utilize the siderophores enterobactin and aerobactin, indicating that transport of these compounds

28 ream of selC and contains genes encoding the aerobactin iron acquisition siderophore system, colicin

29 The siderophore aerobactin is the dominant siderophore produced by hyper

30 for Shigella island 3, revealed a conserved aerobactin operon associated with a P4 prophage-like int

31 The association of the aerobactin operon with phage genes and mobile elements a

32 These included sitABCD, genes of the aerobactin operon, hlyF, iss, genes of the salmochelin o

33 ts in siderophore receptors for salmochelin, aerobactin, or yersiniabactin displayed reduced fitness

34 of the proteins encoded by this operon, the aerobactin outer membrane receptor, Iut, was reduced in

35 Since it appears that aerobactin production is a defining trait of hvKP strain

36 on of digalactoside-coated beads, absence of aerobactin production, membership in serogroups O6 and O

37 During intracellular growth, aerobactin promoter activity was repressed relative to t

38 re receptor mutants, including the DeltaiutA aerobactin receptor mutant and the DeltafyuA yersiniabac

39 ha (putative adhesin siderophore), and iutA (aerobactin receptor).

40 Specific deletion of the aerobactin siderophore system and E. coli iro locus, whi

41 An S. boydii aerobactin synthesis mutant, 0-1392 iucB, was constructe

42 he 63-kDa FrgA protein has homology with the aerobactin synthetases IucA and IucC of Escherichia coli

43 tases (NIS synthetases) characterized by the aerobactin synthetases IucA and IucC.

44 These studies indicate that the aerobactin system is not highly expressed by bacteria wi

45 Interestingly, in contrast to aerobactin, the inability to produce enterobactin, salmo

46 ochelin, suggesting that the contribution of aerobactin to virulence is dependent on both innate biol

47 Further, aerobactin was the primary factor in conditioned medium

48 he ferric siderophores desferrioxamine B and aerobactin were not readily bioavailable to Trichodesmiu