ライフサイエンスコーパス: afferent

1 c target recognition by incoming presynaptic afferents.

2 llover of glutamate from prefrontal cortical afferents.

3 from entorhinal but not Schaffer-collateral afferents.

4 iable times to spike threshold in converging afferents.

5 fibers, namely slowly adapting type 1 (SA1) afferents.

6 nduction of action potentials within primary afferents.

7 ng theta-burst stimulation (TBS) of cortical afferents.

8 ptive pathways in the CNS compared with skin afferents.

9 only observed at the level of striatonigral afferents.

10 t interaction between DEP and airway C-fiber afferents.

11 ry impairment in AD using DBS of hippocampal afferents.

12 ent neurons excites calyx and dimorphic (CD) afferents.

13 ires CB1 receptors on cortical glutamatergic afferents.

14 temporally precise activation of vestibular afferents.

15 ed by functional rapidly adapting trigeminal afferents.

16 receive direct sensory input from peripheral afferents.

17 synapses with presynaptic entorhinal cortex afferents.

18 laboratory to selectively label only spinal afferents.

19 tions include substantial heterogeneities in afferent activation levels and excitatory synaptic weigh

20 tics of bladder mechanosensitive single-unit afferent activities (SAAs) in rats with a bladder outlet

21 Using our new preparations, we found that afferent activity evoked by noxious pinch in these prepa

22 erable interest given its ability to elevate afferent activity over an extended time course.

23 onally classified based on their response to afferent and efferent cardiovascular stimuli, with neuro

24 PFC), M2 can be defined by a distinct set of afferent and efferent connections, microstimulation resp

25 When functional effects of afferent and efferent fibre activation were balanced, a

26 ts-fish whose hair-cell organs are devoid of afferent and efferent innervation-to KA or NMDA.

27 l and clinical investigations, activate both afferent and efferent pathways.

28 In this work, we describe the pattern of afferent and efferent projections of the ACo by using fl

29 stochemistry for markers of various visceral afferent and efferent systems with c-Fos-based activity

30 cerebral reorganization occurs for both the afferented and deafferented early visual cortex (EVC).

31 appa-opioid receptors (KORs) on dopaminergic afferents and can negatively regulate dopamine release.

32 that has the capacity to stimulate visceral afferents and facilitate neuronal TRPV1 signaling.

33 of GABApre neuron axo-axonic contacts on Ia afferents and of the recurrent inhibitory circuit betwee

34 - and polysynaptic connections between these afferents and the ascending propriospinal interneurons o

35 videnced by the activation of murine colonic afferents, and sensitization responses to capsaicin in d

36 ive to drugs of abuse, such as cocaine, when afferents are collectively stimulated electrically.

37 Despite these many contacts, type II afferents are insensitive to sound and only weakly depol

38 mp experiments demonstrate that serotonergic afferents are largely excitatory for mitral cells (MCs)

39 Serotonergic afferents are predominately inhibitory for MCs in the AO

40 Merkel-cell associated afferents are thought to play a major role in form perce

41 e periventricular nucleus with many synaptic afferents arising from neuromedin S(+) neurons of the su

42 timulation of mossy fiber and climbing fiber afferents as CS and US, while alternating between short

43 apes maturation of the developing ascending (afferent) auditory system before hearing begins.

44 both postsynaptic membrane polarization and afferent axon fibre polarization, which boosts cooperati

45 DCS polarizes afferent axons and postsynaptic neurons, boosting cooper

46 Single spinal afferent axons bifurcated many times upon entering the b

47 9a can regulate the mature phenotype whereby afferent axons predominantly innervate neural-side tall

48 n myelinated reticulospinal and lateral line afferent axons.

49 Through this procedure, afferent BP-related neural profiles (BPnPs) were derived

50 As it is known that the LVN conducts afferent BP-related signals, this study aimed to investi

51 f neuromodulation from the nominal target to afferent brain regions.

52 Our results demonstrate that: (i) afferent, but not efferent, cVNS synchronously activates

53 vated potassium depolarizes the postsynaptic afferent by altering ion permeation through hyperpolariz

54 he transmitter phenotype of major IP and MnR afferents by combining retrograde tract tracing with imm

55 sms involved in activation of airway sensory afferents by DEPs.

56 se preference and excitatory strength of the afferent CA3 and entorhinal inputs effectively timed the

57 Compared to normally sighted, afferented central and peripheral EVC enhance their func

58 the level of the periphery but rather at the afferent-central neuron synapse.

59 eurons to uncover an RVM-spinal cord-primary afferent circuit controlling pain thresholds.

60 While some information is known about the afferent circuitry that endogenously drives this neural

61 A dedicated cerebellar nuclear afferent comprised of feedback collaterals from premotor

62 fect neural computation, we examined primary afferent connections in the Drosophila olfactory system.

63 By increasing the excitability of afferent connections to the hippocampus, we control the

64 s expressing the Gpr151 gene, by tracing the afferent connectivity of this diencephalic cell populati

65 sed mechanism showing differential gating of afferent control of D1 and D2 MSN activity by KORs in a

66 Solitary tract (ST) afferents converged onto NTS-CeA second-order sensory ne

67 ABSTRACT: The major afferent cortical pathway in the visual system passes th

68 Depolarization of the postsynaptic afferent could also elevate potassium in the synaptic cl

69 In contrast, afferent cVN activation amplifies systemic inflammatory

70 ndicated that the total number of functional afferents decreased with age.

71 Muscle afferents displayed a higher probability of glutamate re

72 is conferred at the level of three glutamate afferents: dorsal raphe nucleus (DR), pedunculopontine n

73 t have been chronically de-efferented and de-afferented due to amputation.

74 However, activity of Merkel afferents during active touch has not been directly meas

75 ourse of transient IFRs in muscle spindle Ia afferents during stretch (i.e., lengthening) of passive

76 In addition to a laminar framework, LCIC afferent-efferent patterns suggest a multimodal mosaic,

77 B4 (IB4)-binding, but not TRPV1(+), sensory afferents eliminated movement-induced BTP, suggesting th

78 Four distinct morphological types of spinal afferent ending in the bladder were identified.

79 The connectivity pattern of afferented EVC suggests adaptive changes that might enha

80 b slices to measure the synaptic dynamics of afferent-evoked input at physiological stimulus frequenc

81 rt the hypothesis that ACh/NE modulation and afferent excitation define thalamic oscillatory states a

82 -current candidates suggested that turtle CD afferents express KCNQ3, KCNQ4, and ERG1-3 potassium cha

83 em for the long-term manipulation of bladder afferent expressed opsins.

84 hanisms to maximize the dynamic range of its afferent fibers, which operate at the physiological limi

85 ular type I and type II hair cells and their afferent fibres send information to the brain regarding

86 of weapons during systole, when baroreceptor afferent firing is maximal, relative to diastole.

87 pend on sensory feedback from mechanosensory afferents for the dynamic control of movement.

88 ervated from the LHbL, whereas pVTA receives afferents from LHbM and LHbL.

89 It receives afferents from neurons in L10a of the optic tectum, whic

90 ry tract reflexes are mediated by peripheral afferents from the bladder (primarily in the pelvic nerv

91 t of weakly activated populations of sensory afferents from the nose, thus demonstrating a change in

92 he ascending connections of the nTTD and the afferents from the syrinx to the trigeminal sensory colu

93 ke immunoreactivity, and the organization of afferents from the three branches of the trigeminal nerv

94 There was also dramatic loss of markers of afferent GABAergic cartridge synapses, resembling the co

95 receptors (nAChRs) in regulating vestibular afferent gain and activation timing.

96 angle may be a useful experimental probe of afferent gains and/or the integrity of automatic fusimot

97 rtex and other brain regions beyond the core afferents identified previously.

98 nges in sensory behavior concordant with the afferent imbalance, which is present at birth and nonpro

99 To study of the role of nociceptive sensory afferents in freely behaving mice, we developed a fully

100 nd a comparison with the organization of VMH afferents in lizards suggests a homologous similarity of

101 We demonstrate that muscle spindle primary afferents in passive muscle fire in direct relationship

102 ming noxious stimuli at the primary synaptic afferents in the dorsal horn of the spinal cord.

103 Quantitative assessment of TRPV1-lineage afferents in the epidermis of the hind paws of the repor

104 to target expression of ChR2 to glycinergic afferents in the ICC and made whole-cell recordings in v

105 f-stimulation sustained by activation of PFC afferents in the NAc.

106 pha-synuclein present in dopaminergic nigral afferents in the regulation of adult neural stem cell ma

107 descending motor circuits and large diameter afferents in the spinal cord.

108 descending motor pathways and large diameter afferents in the spinal cord.

109 that Merkel and unidentified slowly adapting afferents in the whisker system of behaving mice respond

110 and enhances the motor output during lumbar afferent-induced locomotor rhythms.

111 Such segregation means that visceral afferent information followed separate lines to reach th

112 he somatosensory cortex is that it processes afferent information from the contralateral side of the

113 , is considered to rely on embedded visceral afferent information, although few details are known.

114 within a neuron can impact the processing of afferent inhibitory input and associated behavior.

115 It is well established that sensory afferents innervating muscle are more effective at induc

116 ediated slow excitation, we recorded from CD afferents innervating the turtle posterior crista during

117 Analysis of gene expression and afferent innervation on E6 suggests that ectopic Wnt9a e

118 deficits and noted no reduction in cutaneous afferent innervation or upregulation of the injury marke

119 TS-CeA neurons received at least one primary afferent input (classed 'second order') indicating that

120 Afferent input attenuated PA, but not AP, MEPs during vo

121 Preventing movement-induced afferent input by saphenous nerve block before, but not

122 he extent that HVC activity is influenced by afferent input during the learning, perception, or produ

123 f motor neurons, with a large convergence of afferent input for feedback control.

124 , suggesting that mAChR activation increases afferent input impedance by closing calyceal potassium c

125 dings demonstrate the importance of aberrant afferent input in the maintenance of neuropathic pain an

126 ol and provide new insights into the role of afferent input on motor neuron activity.SIGNIFICANCE STA

127 show that the development of proprioceptive afferent input to motoneurons (MNs) and Renshaw cells (R

128 es suggest that during naturalistic stimuli, afferent input to the olfactory bulb is subject to stron

129 ing the cytoarchitecture and organization of afferent input to the sensory trigeminal complex, which

130 cells produces robust amplification of brief afferent input, and thus the relative strength of axoden

131 lel and in some cases topographic pattern of afferent input.

132 period of Myk/+ behavior, highlighting that afferent inputs are critical upstream mediators.

133 oing synaptic dynamics and how modulation of afferent inputs by diffuse stimulation changes synaptic

134 lia disorder that can be induced by aberrant afferent inputs from the cerebellum.

135 Afferent inputs to the remaining regions of the Ov prope

136 Afferent inputs to the ventral tegmental area (VTA) cont

137 1) expressing C-fibres] or only non-TRPV1 ST afferent inputs, and never a combination of both.

138 synapses by increasing the gain on remaining afferent inputs, thereby restoring firing rate codes for

139 reinnervation of muscle by motor and sensory afferents is completed in the periphery.

140 hat alpha-SYN present in dopaminergic nigral afferents is essential for the normal cycling and mainte

141 erent-mediated slow excitation of vestibular afferents is mediated by muscarinic acetylcholine recept

142 erent-mediated slow excitation of vestibular afferents is of considerable interest given its ability

143 location of the nerve cell bodies of spinal afferents is well known to reside in dorsal root ganglia

144 cleft between type I hair cells and calyceal afferents, K(+) ions accumulate as a function of activit

145 nner; (ii) efferent cVNS enabled by complete afferent KES nerve block enhances the anti-inflammatory

146 atory benefits of cVNS; and (iii) incomplete afferent KES nerve block exacerbates systemic inflammati

147 Afferent light signaling drives behavioral changes and r

148 ) involves a bilateral brain circuit whereby afferent light signals in the optic nerve ultimately dri

149 Recent studies suggest that type II afferents may be cochlear nociceptors, and can be excite

150 The selective impairment in D2 afferents may promote the influence of D1 inputs to driv

151 sed as a simple, non-invasive measure of the afferent mechanisms underlying healthy motor function, a

152 (VNS) reflects a dynamic interaction between afferent mediated decreases in central parasympathetic d

153 voked activation of mechanosensitive primary afferent meningeal nociceptors that innervate the crania

154 ions of granule layer anatomical features to afferent mixing.SIGNIFICANCE STATEMENT Cerebellar granul

155 creased during the VNS active phase owing to afferent modulation of parasympathetic central drive.

156 Stretch-sensitive Ia afferent monosynaptic connections with motoneurons form

157 a published closed-loop simulation model of afferented muscle to explore the mechanisms responsible

158 In vitro, the afferent nerve calyx surrounding type I hair cells cause

159 first morphological identification of spinal afferent nerve endings in the mammalian urinary bladder.

160 The majority of spinal afferent nerve endings were CGRP-immunoreactive.

161 le, and modulate serotonin-sensitive primary afferent nerve fibers via synaptic connections, enabling

162 s caused by the activation of small diameter afferent nerve fibres and therapeutic effects on the ass

163 the mechanism responsible for the underlying afferent nerve pathology, we examined the sensory nervou

164 l membrane being enveloped in a single large afferent nerve terminal, named the calyx, and by the exp

165 ne (CQ)- and histamine-induced activation of afferent nerves in the dorsal thoracic skin of the mouse

166 xplained by the increased proximity of their afferent nerves to the esophageal lumen, and therefore g

167 cing action potential discharge from colonic afferent nerves.

168 profoundly affected by the states of primary afferent neuron mechanics.

169 Single afferent neuron recordings from the lateral line reveale

170 Afferent neuron recordings revealed that hair cells with

171 grade fluorescent labeling of dental primary afferent neurons (DPANs) has been described in rats thro

172 s with functional sensitivity differences in afferent neurons and, in the case of inner hair cells of

173 Spinal afferent neurons are responsible for the transduction an

174 Polarization of afferent neurons in upstream brain regions may modulate

175 results we hypothesized the polarization of afferent neurons in upstream brain regions may modulate

176 These findings were recapitulated in primary afferent neurons isolated from dorsal root ganglia (DRG)

177 ining membrane mechanics of cultured primary afferent neurons of the dorsal root ganglia (DRG).

178 oked action potentials (spikes) in hair-cell afferent neurons of the lateral line.

179 Canal afferent neurons provide essential inputs to neural circ

180 Afferent neurons target only one rostral or caudal locat

181 from turtle vestibular hair cells and their afferent neurons to show that potassium ions accumulatin

182 Primary afferent neurons transduce sensory information about tem

183 We performed RNA-seq on purified peripheral afferent neurons, but found no striking differences in g

184 For small-diameter primary afferent neurons, it is unclear to what extent different

185 iosis may affect the excitability of primary afferent neurons, many of which are nociceptive.

186 te membrane mechanical properties of primary afferent neurons, which provide, to our knowledge, a new

187 in the long-term survival of target-deprived afferent neurons.

188 nd the precise encoding of stimulus onset in afferent neurons.SIGNIFICANCE STATEMENT Numerous studies

189 acting at type 1 receptors (CCK1Rs) on vagal afferent neurons; however, CCK agonists have failed clin

190 SAR by epicardial application of a selective afferent neurotoxin, resiniferatoxin, selectively lowere

191 of the CSAR by epicardial application of the afferent neurotoxin, RTX, selectively lowered diastolic

192 an essential step in transforming transient afferent nociceptive signals into a stable pain percepti

193 opioid receptors (MORs) expressed by primary afferent nociceptors initiate tolerance and OIH developm

194 s driven and/or modulated by a group of five afferent nuclei (the Medial Magnocellular nucleus of the

195 functional distribution among excitatory SNc afferent nuclei in response to cocaine, and suggest a co

196 ively modulate signal reception processed by afferent nuclei.

197 location receives convergent input from each afferent nucleus in parallel.

198 avior and systemic metabolism in response to afferent nutrient and hormonal signals.

199 estrogen receptor alpha (ERalpha)-expressing afferents of GnRH neurons, including kisspeptin neurons

200 ansgenic Gpr151-Cre mouse line, monosynaptic afferents of habenular and thalamic Gpr151-expressing ne

201 Mechanosensory afferents of the massive array of chordotonal organs (Jo

202 e expression patterns among cochlear type II afferents of two genes found in C-fibers: calcitonin-rel

203 In the olfactory bulb, afferent olfactory receptor neurons respond to increasin

204 However, afferents onto SNc dopamine neurons themselves appear in

205 Our results suggest that although the afferent ORN synapse shows strong synaptic depression, d

206 critical developmental insult is key to the afferent pathology.

207 n profiles mean that these parallel visceral afferent pathways encode viscerosensory signals to the a

208 ly activate efferent pathways while blocking afferent pathways.

209 leads to impaired fungal control during the afferent phase of cryptococcal infection.

210 for capsid function at both the efferent and afferent phases of viral replication.

211 creasing intracellular Ca(2+) Viscerosensory afferent processing was also disrupted, dampening low-fr

212 area of the cortical amygdala that receives afferent projections from both the main and accessory ol

213 f the LC and its surrounding region receives afferent projections from several brain areas which prov

214 The afferent projections of the ACo indicate that this nucle

215 dm1-positive innervation of POMC neurons via afferent projections originating from beyond the arcuate

216 the pattern of AR immunoreactivity or of the afferent projections to the AR- nucleus were observed.

217 defect consistent with NAION, (3) a relative afferent pupillary defect, (4) observed optic disc swell

218 area (VTA) dopamine neurons, whose glutamate afferents react robustly to cocaine.

219 ptogenetic inhibition of nociceptive sensory afferents reduced both ongoing pain and evoked cutaneous

220 ABSTRACT: The enhanced 'cardiac sympathetic afferent reflex' (CSAR) critically contributes to the ex

221 z equations were used to estimate arteriolar afferent resistance, efferent resistance (RE), and glome

222 Loss, or blockade, of NaV 1.7 did not affect afferent responses to noxious mechanical and chemical st

223 iation hypothesis was not tested directly as afferent responses to the conflicting patterns were not

224 To fill this gap, we simulated afferent responses to the dot patterns used in these rou

225 In contrast, afferent responses to this same stimulation remained con

226 n channels (ASICs), expressed in thin muscle afferents, sense the decrease in pH and evoke a pressor

227 Afferent sensory nerve activity was recorded during fin

228 arises from collateral damage to peripheral afferent sensory neurons by anticancer pharmacotherapy,

229 ), the most abundant neuropeptide in primary afferent sensory neurons, is strongly implicated in the

230 In afferent sensory neurons, trains of action potentials (s

231 iew discusses the physiological roles of the afferent (sensory) and motor (efferent) vagus in regulat

232 onses not through direct potentiation of the afferent signal per se, but rather by reducing the intri

233 This induces an afferent signal, which reduces body weight.

234 microbiota-neuronal interactions to modulate afferent signaling suggests that therapies that induce o

235 the main targets for supraspinal and sensory afferent signals adjusting gait.

236 dination and learning by integrating diverse afferent signals to generate climbing fibre inputs to th

237 hat, through the integration of efferent and afferent signals, the safety boundary around the body is

238 on the dynamic integration of multisensory (afferent) signals.

239 role in mechanical pain signaling by primary afferent somatosensory neurons.

240 These afferent specific deficits potentially impact neurogliaf

241 these results provide the first evidence for afferent-specific properties of glutamatergic transmissi

242 -4 neurons, mimicking the effect of a single afferent spike from a single TC neuron.

243 als evoked in the OFC by excitatory thalamic afferent stimulation, and this was prevented by JAK2 inh

244 ably truncating the postsynaptic response to afferent stimuli.

245 he hypothesis that better preservation of Ia afferent synapses and a change in presynaptic inhibition

246 lase (GAD65) as markers of, respectively, Ia afferent synapses and presynaptic inhibition (P-boutons)

247 After nerve transection, Ia afferent synapses and stretch reflexes are permanently l

248 of Ca(2+)-permeable AMPA receptors at muscle afferent synapses drives greater LTP following repetitiv

249 Importantly, muscle afferent synapses exhibited greater relative expression

250 with a near-complete loss of auditory nerve afferent synapses in the contralateral ear.

251 by structural preservation after crush of Ia afferent synapses on regenerating motoneurons and decrea

252 r activity-dependent strengthening at muscle afferent synapses onto developing spinal projection neur

253 ctional organization of muscle and cutaneous afferent synapses onto immature rat lamina I spino-parab

254 ntiation were significantly higher at muscle afferent synapses, where it required Ca(2+)-permeable AM

255 Our hypothesis is that increased random afferent synaptic activity (i.e. synaptic noise) within

256 The afferent synaptic activity in the hippocampus was modula

257 tylcholine (ACh) and norepinephrine (NE) and afferent synaptic excitation.

258 nificant convergence of muscle and cutaneous afferent synaptic input onto individual projection neuro

259 all, our results show that disruption of the afferent taste signal to sodium salts disrupts the norma

260 ll understood, inhibition of bladder sensory afferents temporarily relieves pain.

261 cess Ca(2+) entry via CP-AMPARs may underlie afferent terminal damage following excitotoxic challenge

262 gnificant reorganization of mature gustatory afferent terminal fields in the nucleus of the solitary

263 uggesting that limiting Ca(2+) levels in the afferent terminal may protect against cochlear synaptopa

264 Prolonged application of AMPA caused loss of afferent terminal responsiveness, whereas blocking CP-AM

265 volve sites of action other than the primary afferent terminals.

266 ructure in reward and addiction; however, LS afferents that drive addiction behaviors are unknown.

267 urons (SGNs) are small caliber, unmyelinated afferents that extend dendritic arbors hundreds of micro

268 ed, owing to burst firing in several olivary afferents that fire asynchronously.

269 The individual nerve endings of spinal afferents that innervate the urinary bladder have never

270 cation of peripheral nerve endings of spinal afferents that transduce sensory stimuli into action pot

271 Outside the volume targeted by TC afferents, the resulting postsynaptic LFP signals were f

272 he region that receives orofacial nociceptor afferents, the spinal trigeminal nucleus.

273 rge conductances that minimize hair cell and afferent time constants in the presence of significant m

274 ge conductances that minimized hair cell and afferent time constants in the presence of significant m

275 abconnectin-3alpha in neurons or glial cells afferent to GnRH neurons.

276 d, elevates [K(+) ]cleft and depolarizes the afferent to potentials at which smaller and smaller EPSP

277 hannels, and contributes to depolarizing the afferent to potentials where a single EPSP (quantum) can

278 This depolarization enabled the afferent to reliably generate action potentials evoked b

279 d by a specific pair of dopaminergic neurons afferent to the mushroom bodies, via the D5-like DAMB do

280 nterrelated and involve common brain regions afferent to the nucleus accumbens, within the mesolimbic

281 ons from the medial septum (MS) as the major afferents to dentate PV interneurons.

282 not known how DEP exposure activates airway afferents to elicit symptoms, such as cough and bronchos

283 e application enhanced the sensitivity of CD afferents to mechanical stimulation, suggesting that mAC

284 Thus, a decrease in inhibitory afferents to MNTB neurons should lead to greater inhibit

285 ity may arise from an oversynchronization of afferents to the motor cortex, and that these symptoms a

286 LHb afferents to the pVTA are distinct from those to the RMT

287 f abuse on synaptic mechanisms of identified afferents to the SNc.

288 e dopamine systems themselves; glutamatergic afferents to the striatum; and one of two dopamine-recep

289 forcement circuitry is emerging: it includes afferents to the ventral tegmental area and substantia n

290 tion for muscle length and activity (sensory afferent), to modify motoneuron output to achieve graded

291 brainstem, receives constant viscerosensory afferent traffic as well as input from central regions c

292 ceived inputs derived from only unmyelinated afferents [transient receptor potential cation channel s

293 ng endomorphins are also released by primary afferents under ischaemic conditions.

294 metries across the radial axis that underlie afferent versus efferent circuits between the inner ear

295 biomarker of type II versus type I cochlear afferents (Vyas et al., ).

296 ferent-mediated fast excitation arises in CD afferents when the predominant efferent neurotransmitter

297 thin spinal cord circuits compared with skin afferents, which likely contributes to the higher preval

298 The hypoglossal afferents, which terminate medially in the dorsal horn a

299 urons receiving direct input from vestibular afferents within minutes, as well as a decrease in the c

300 sistent with the preponderance of cerebellar afferents within the pons, we observed a significant pos