ライフサイエンスコーパス: afferent neuron

1 encode acoustic signals for the postsynaptic afferent neuron.

2 ly compared MC4R-expressing vagal and spinal afferent neurons.

3 f injured and neighboring noninjured primary afferent neurons.

4 , cholinergic neurons, and intrinsic primary afferent neurons.

5 fluorescent protein in all Nav1.8-expressing afferent neurons.

6 ic and tonic discharge rates of postsynaptic afferent neurons.

7 K(ATP) channel current (IK(ATP)) in primary afferent neurons.

8 s have been identified on trigeminal primary afferent neurons.

9 We investigated the role of CARTp in vagal afferent neurons.

10 ignaling might also affect extrinsic primary afferent neurons.

11 into the proximal urethra to label urethral afferent neurons.

12 or potential A1 (TRPA1) expressed in sensory afferent neurons.

13 ased in dorsal root ganglia-containing colon afferent neurons.

14 ic regulatory peptides at the level of vagal afferent neurons.

15 e cannabinoid 1 (CB(1)) receptor on group IV afferent neurons.

16 hypertrophy and hyperexcitability of bladder afferent neurons.

17 d by an indirect mechanism of stimulation of afferent neurons.

18 ed by neuromodulators acting directly on the afferent neurons.

19 B, NR2C, and NR2D) immunoreactivity in vagal afferent neurons.

20 tion by direct action on dissociated primary afferent neurons.

21 processes of intrinsic and extrinsic primary afferent neurons.

22 in the long-term survival of target-deprived afferent neurons.

23 adder activity and the properties of bladder afferent neurons.

24 me-dependent inward I(h) currents in bladder afferent neurons.

25 ize than capsaicin-sensitive C-fiber bladder afferent neurons.

26 a maneuver that selectively excites group IV afferent neurons.

27 -1 receptors, expressed by enteric and vagal afferent neurons.

28 expressed in the intestine and by some vagal afferent neurons.

29 rons, indicating heterogeneity among type II afferent neurons.

30 the immunohistochemical phenotype of primary afferent neurons.

31 SCI; however, changes were modest in bladder afferent neurons.

32 s suggested activation of similar subsets of afferent neurons.

33 nt neurons but is rarely observed in bladder afferent neurons.

34 using transganglionic labeling of vestibular afferent neurons.

35 beled from muscle were larger than cutaneous afferent neurons.

36 x differences in trigeminal ganglion primary afferent neurons.

37 in the expression of Na(v)1.8 in non-bladder afferent neurons.

38 take via CCK(A) receptors expressed on vagal afferent neurons.

39 oximately 30% of calbindin/intrinsic primary afferent neurons.

40 tion of the TTX-R sodium currents in bladder afferent neurons.

41 un expression is not associated with bladder afferent neurons.

42 trigeminal masticatory muscle and cutaneous afferent neurons.

43 nsmission of substance P and CGRP by primary afferent neurons.

44 on terminals of trigeminal (TG) nociceptive afferent neurons.

45 ceptors are expressed by human and rat vagal afferent neurons.

46 ain sensitivity by depletion of unmyelinated afferent neurons.

47 hen transmitted with remarkable precision to afferent neurons.

48 associated prions entered the simian CNS via afferent neurons.

49 ctrical activity of TRPM8-expressing corneal afferent neurons.

50 and transmitted to the hindbrain via sensory afferent neurons.

51 t is expressed almost exclusively in primary afferent neurons.

52 ally distinct populations of spiral ganglion afferent neurons.

53 nd messenger RNA were expressed by cutaneous afferent neurons.

54 igeminal ganglion neurons and 30% of corneal afferent neurons.

55 enterochromaffin cells and intrinsic primary afferent neurons.

56 LPS which suppresses leptin effects on vagal afferent neurons.

57 essential nociceptive integrators in primary afferent neurons.

58 ation via activation of corneal cool primary afferent neurons.

59 in-insensitive, mechanically sensitive vagal afferent neurones.

60 tion of TRPV1 may sensitize small intestinal afferent neurones.

61 diator that can excite and sensitize primary afferent neurones.

62 on between CCK and 5-HT in the vagal primary afferent neurones.

63 function of 5-HT3 receptors on gastric vagal afferent neurones.

64 an act at P2X receptors expressed on primary afferent neurones.

65 iological roles for P2X receptors on primary afferent neurones.

66 llowing distribution was found for cutaneous afferent neurons: 26% CGRP, 7% SP, 1% SOM, 26% ChTB, 44%

67 tic studies, ablation of capsaicin-sensitive afferent neurons abolishes bombesin-induced gastroprotec

68 reduced injury-induced activation of primary afferent neurons, activation of spinal neurons, and the

69 In spinal cord dorsal horn and in sensory afferent neurons, adenosine acts as a neuromodulator wit

70 and peripheral terminals of transduced vagal afferent neurons allowing for bright imaging of the nerv

71 and pharmacological responsiveness of vagal afferent neurones and fibres, although the effects of DI

72 otease-activated receptor 2 (PAR2) on spinal afferent neurons and cause persistent inflammation and h

73 on of retrograde tracing to identify corneal afferent neurons and double label in situ hybridization

74 However, the molecular identity of the afferent neurons and fibres mediating this reflex respon

75 Sensory signal transduction of the inner ear afferent neurons and hair cells (HCs) requires numerous

76 ease by keratinocytes activates both primary afferent neurons and immune cells to promote inflammator

77 stimulating CART and Y2R expression in vagal afferent neurons and in inhibiting food intake are augme

78 ive ion channel that is expressed on primary afferent neurons and is upregulated following inflammati

79 fewer stimulus-evoked action potentials from afferent neurons and loss of presynaptic Ca(V)1.3a calci

80 Our studies focused on primary afferent neurons and on their central targets in the spi

81 out the organization of their connections to afferent neurons and targets in the hindbrain.

82 detected between IB4- or ChTB-binding muscle afferent neurons and the total muscle afferent populatio

83 tion of nascent protein synthesis in primary afferent neurons and their axons.

84 s with functional sensitivity differences in afferent neurons and, in the case of inner hair cells of

85 d Adelta fiber DRG neurons including bladder afferent neurons, and might modulate activity of bladder

86 different cochlear elements (organ of Corti, afferent neurons, and stria vascularis) can degenerate i

87 ence for peripheral sensitization of primary afferent neurons, and there are no reports of persistent

88 ifferent classes of vagal and spinal primary afferent neurons, and underscore the role of the melanoc

89 the presynapse and stabilizing contacts with afferent neurons--and suggest that Ribeye plays an organ

90 These afferent neurones are activated by punctate mechanical s

91 Given that group IV afferent neurons are activated via chemically sensitive

92 also noted that TRPM8-IR or CGRP-IR corneal afferent neurons are almost entirely small and lack NF20

93 Piezo2 corneal afferent neurons are almost exclusively non-calcitonin g

94 Distinct clusters of IGL-afferent neurons are also located in the medial vestibul

95 heterogeneous population of ON- and OFF-type afferent neurons are combined to give rise to response s

96 Other IGL-afferent neurons are evident in Barrington's nucleus, th

97 Primary afferent neurons are functionally heterogeneous.

98 III) and metabolically (group IV) sensitive afferent neurons are important to this reflex in normal

99 CGRP(+) SP(-) afferent neurons are likely to be non-nociceptive.

100 Because human primary afferent neurons are not readily obtained, we sought to

101 with NeuN established that intrinsic primary afferent neurons are OTR-expressing.

102 Spinal afferent neurons are responsible for the transduction an

103 Vagal afferent neurons are therefore early integrators of peri

104 led that the majority of capsaicin-sensitive afferent neurones (both Adelta- and C-fibres) innervatin

105 , while Na(v)1.9 is expressed in non-bladder afferent neurons but is rarely observed in bladder affer

106 We performed RNA-seq on purified peripheral afferent neurons, but found no striking differences in g

107 ermines the neurochemical phenotype of vagal afferent neurons by regulating a switch between states t

108 oup of neuromasts, suggesting that different afferent neurons can convey information about receptive

109 e and intensity begins in the cochlea, where afferent neurons can fire action potentials at constant

110 Discovery of these afferent neurons capable of triggering hunger advances u

111 Because these afferent neurons carry sound information from the cochle

112 the expression of TTX-R channels in bladder afferent neurons changes after spinal cord transection,

113 atter, which more closely resemble cutaneous afferent neurons, consist of a smaller number of C-fiber

114 odies are arrangements of intrinsic neurons, afferent neurons containing dense core vesicles, and sys

115 These results show that activity in primary afferent neurons contributes to ongoing SCI pain.

116 Inhibition of primary afferent neurons contributes to the antihyperalgesic eff

117 temporal progression of wave I amplitude of afferent neurons correlate with susceptibility and resis

118 development of wild-type fish, we found that afferent neurons could form specific synapses in the abs

119 elapsed before it became clear that visceral afferent neurons could themselves also be targets for gu

120 significantly larger in medium-sized bladder afferent neurons (diameter: 37.8 +/- 0.3 microm), a smal

121 Many auditory, vestibular, and lateral-line afferent neurons display spontaneous action potentials.

122 We investigated whether afferent neurons distinguish hair-cell polarities by ana

123 These results indicate that lateral-line afferent neurons do not require synaptic activity to dis

124 grade fluorescent labeling of dental primary afferent neurons (DPANs) has been described in rats thro

125 Both bladder and non-bladder afferent neurons exhibit limited increases in Na(v)1.9 e

126 Muscle afferent neurons exhibited positive staining as follows:

127 patch-clamp recordings, dissociated bladder afferent neurons exhibiting tetrodotoxin (TTX)-resistant

128 It is not clear whether primary afferent neurons express functional cell-surface opioid

129 y, these data indicate that group IV primary afferent neurons express multiple receptor defects in ca

130 Our results indicate that most vagal afferent neurons express NMDA receptor ion channels comp

131 of the study was to determine whether vagal afferent neurons express OX-R1 and OX-R2 and whether ore

132 We hypothesized that a proportion of corneal afferent neurons express Piezo2, and that these neurons

133 Depending on the nutritional status, vagal afferent neurons express two different neurochemical phe

134 The percentage of bladder afferent neurons expressing nNOS-IR was increased in L6

135 chlear potentials and changes in hair cells, afferent neurons, fibrocytes in spiral limbus and ligame

136 A subset of afferent neurons fired an action potential in response t

137 ulation to regenerate more axons than muscle afferent neurons following injury.

138 Neuromasts, and afferent neurons for both neuromasts and ampullary organ

139 erior lateral line of larval zebrafish, each afferent neuron forms synaptic contacts with hair cells

140 evoked currents in isolated, labelled muscle afferent neurons from control and heart failure (induced

141 hannels in the L6-S1 spinal cord and bladder afferent neurons from L6-S1 DRG in rats.

142 The urinary bladder is innervated by small afferent neurons from L6/S1 DRG, of which approximately

143 member 8 (TRPM8) transcripts in any corneal afferent neurons, further suggesting that Piezo2 is not

144 the NMDA receptor subunit phenotype of vagal afferent neurons has not been determined.

145 mechanisms responsible for activating these afferent neurons have yet to be identified.

146 In dye-labeled bladder afferent neurons, HCN-2-positive cells were found in app

147 acting at type 1 receptors (CCK1Rs) on vagal afferent neurons; however, CCK agonists have failed clin

148 ditory and vestibular sense organs and their afferent neurons; however, how auditory and vestibular f

149 The activity of individual afferent neurones in the mammalian cochlea can be driven

150 ance P-containing capsaicin-sensitive spinal afferent neurones in the upper thoracic (T1-T4) dorsal r

151 induced obesity locks the phenotype of vagal afferent neurons in a state similar to that normally occ

152 EA results in abnormal responses of group IV afferent neurons in cardiomyopathic rats.

153 lar recordings were made in vivo from A-type afferent neurons in cat L(6-7) DRGs.

154 r the mu-opioid receptor (muOR) into primary afferent neurons in dorsal root ganglia (DRGs) of rats,

155 form was also observed within muscle spindle afferent neurons in dorsal root ganglia with a higher pr

156 of the CB(1) and TRPv1 receptors on group IV afferent neurons in heart failure, we performed terminal

157 ay contribute to hypersensitivity of primary afferent neurons in irritable bowel syndrome patients.

158 Bladder afferent neurons in L1, L2, L6 and S1 dorsal root gangli

159 Primary afferent neurons in mammalian dorsal root ganglia (DRGs)

160 inergic (P2X) receptors are found in cranial afferent neurons in nodose ganglia and their central ter

161 Most vagal afferent neurons in rat nodose ganglia express mRNA codi

162 efective acidification of synaptic vesicles, afferent neurons in rbc3alpha mutants had reduced firing

163 of receptors and neuropeptides in rat vagal afferent neurons in response to CARTp was studied using

164 Chemogenetic stimulation of these afferent neurons in sated mice markedly activates AgRP n

165 robust spontaneous spiking from lateral-line afferent neurons in the absence of external stimuli.

166 NOS-IR was subsequently evaluated in bladder afferent neurons in the DRG and in the associated spinal

167 close apposition to the perikarya of primary afferent neurons in the MTN with a marked rostrocaudal g

168 cause MC4R is known to be expressed in vagal afferent neurons in the nodose ganglion (NG), we also sy

169 nnel that serves as a marker of the group IV afferent neurons in the periphery.

170 We examined the role of primary afferent neurons in the somatosensory cortical "reactiva

171 dentified discrete subpopulations of corneal afferent neurons in the trigeminal ganglion.

172 locity sensitivity of muscle spindle primary afferent neurons in the trigeminal mesencephalic nucleus

173 Additionally, activation of VTA afferent neurons in the ventral BNST and the infralimbic

174 eveal that birth order diversifies lateralis afferent neurons in the zebrafish.

175 s, indicating that AEA is acting on group IV afferent neurons in this preparation.

176 Polarization of afferent neurons in upstream brain regions may modulate

177 results we hypothesized the polarization of afferent neurons in upstream brain regions may modulate

178 iferate over the body surface, the number of afferent neurons increases linearly.

179 sed in apical and Cgrpalpha in basal type II afferent neurons, indicating heterogeneity among type II

180 ring RNA knockdown of TRPV4 in mouse primary afferent neurons inhibited the hypersensitivity caused b

181 Single neuronal discharges of vagal primary afferent neurones innervating the duodenum were recorded

182 In summary, afferent neurons innervating bladder or proximal urethra

183 We investigated whether primary afferent neurons innervating different regions of the lo

184 g an increase in excitability of the primary afferent neurons innervating the area.

185 dominantly expressed in medium-sized bladder afferent neurons innervating the bladder and that inhibi

186 exus neurons thought to be intrinsic primary afferent neurons (IPANs).

187 t the reduced responsiveness in the group IV afferent neuron is an initiating factor in the developme

188 the characteristic frequency) of individual afferent neurones is invariant with intensity.

189 esponsiveness of CB(1) receptors on group IV afferent neurons is blunted in cardiomyopathy.

190 ween the membranes of the hair cells and the afferent neurons is conspicuously irregular and often in

191 Injury involving afferent neurons is discussed because of the relevance o

192 The release of SP from primary afferent neurons is increased during nociception, and SP

193 However, membrane mechanics of primary afferent neurons is largely unknown.

194 The action of gut hormones on vagal afferent neurons is now recognised to be an early step i

195 One distinguishing feature of primary afferent neurons is their ability to bind the lectin IB(

196 These findings were recapitulated in primary afferent neurons isolated from dorsal root ganglia (DRG)

197 Co-expression of TGR5 and TRPA1 in cutaneous afferent neurons isolated from mice was analyzed by immu

198 Whole-cell patch-clamp recordings in vagal afferent neurons isolated from rat nodose ganglia demons

199 For small-diameter primary afferent neurons, it is unclear to what extent different

200 h is likely due to loss of PIEZO2 protein in afferent neurons leading to disturbed proprioception cau

201 in the inter-digestive period, inhibit vagal afferent neurons leading to increased food intake.

202 iosis may affect the excitability of primary afferent neurons, many of which are nociceptive.

203 s, unlike bladder afferent neurons, urethral afferent neurons may be hyperexcitable well into DM prog

204 Loss of GABA(B) receptors on primary afferent neurons may contribute to the development of me

205 electrophysiological properties of urethral afferent neurons may therefore contribute to voiding dys

206 profoundly affected by the states of primary afferent neuron mechanics.

207 Vagal afferent neurons mediate the effects of some gut signals

208 ulmonary mechanoreceptors indicates that the afferent neurones mediating cough are quite distinct fro

209 Here we show that each afferent neuron of the posterior lateral line establishe

210 Elevating dopamine levels in beta'-afferent neurons of aged flies restores cold sensitivity

211 or subunit is present in a majority of vagal afferent neurons of nodose ganglia (NG), immunoreactivit

212 undergo proliferation and differentiate into afferent neurons of the auditory and vestibular ganglia.

213 apoptosis of neuroepithelial hair cells and afferent neurons of the cochlea.

214 ining membrane mechanics of cultured primary afferent neurons of the dorsal root ganglia (DRG).

215 mMOR-1B4-LI was present in afferent neurons of the dorsal root ganglia and their pr

216 We show that the primary afferent neurons of the haltere's mechanoreceptors respo

217 oked action potentials (spikes) in hair-cell afferent neurons of the lateral line.

218 thermal and chemical sensitivity of primary afferent neurons of the pain pathway, but many aspects o

219 3 functions primarily in skeletal muscle, Ia-afferent neurons, or in Schwann cells that myelinate Ia-

220 etermined that abnormalities in the group IV afferent neuron population (associated with the metaboli

221 The percentage of cutaneous afferent neurons positive for SOM and IB4 exceeds that f

222 Cutaneous afferent neurons positive for SP were smaller, while ChT

223 Group IV afferent neurons, primarily stimulated by the metabolic

224 troreceptive ampullary organs, innervated by afferent neurons projecting respectively to the medial a

225 Canal afferent neurons provide essential inputs to neural circ

226 PM8-mediated cold sensitivity on nociceptive afferent neurons provides a mechanism of cold allodynia.

227 Moreover, afferent neurons reassume their biased innervation patte

228 Single afferent neuron recordings from the lateral line reveale

229 Afferent neuron recordings revealed that hair cells with

230 ata indicate that the tracheal and laryngeal afferent neurones regulating cough are polymodal Adelta-

231 CK, GLP-1, PYY and ghrelin that act on vagal afferent neurons regulating food intake and autonomic re

232 nvestigate phenotypic differences in primary afferent neurons relaying sensory information from deep

233 Auditory information transfer to afferent neurons relies on precise triggering of neurotr

234 We propose that these airway afferent neurones represent a distinct subtype and that

235 Although information in tactile afferent neurons represented by firing rates has been st

236 ation by acting directly on TNFR1 in primary afferent neurons, resulting in p38-dependent modulation

237 A single afferent neuron routinely contacts a group of neuromasts

238 c inhibition of transmitter release from the afferent neurons (S-cells) mediating the startle respons

239 The extrinsic primary afferent neurons send distress and other signals to the

240 body of evidence has demonstrated that vagal afferent neurones show non-uniform properties and that d

241 from directional or oriented motion, the T2 afferent neurons show clear motion orientation selectivi

242 arrageenan (Carg) injected cats, some A-type afferent neurons showed to have two distinct receptive f

243 nd the precise encoding of stimulus onset in afferent neurons.SIGNIFICANCE STATEMENT Numerous studies

244 hile squid exhibit peripheral alterations in afferent neurons similar to those that drive persistent

245 found in a subset of small-diameter, primary afferent neurones, some of which are also sensitive to c

246 e-related peptide (CGRP), and MOR in primary afferent neurons suggested an interaction of these pepti

247 eurotrophin3 (NT3), which is required for Ia-afferent neuron survival.

248 Afferent neurons target only one rostral or caudal locat

249 n and is more abundant on trigeminal primary afferent neurons than analogous extracranial neurons, ma

250 chemically distinct subpopulation of corneal afferent neurons that are not polymodal nociceptors or c

251 1 is expressed in a subpopulation of primary afferent neurons that express several different neurotra

252 neural tube, eventually differentiating into afferent neurons that form synaptic contacts with both e

253 regulation of efferent properties of primary afferent neurons that initiate neurogenic inflammation a

254 ctivation of CCK1 receptors (CCK1R) on vagal afferent neurons that innervate the gastrointestinal tra

255 gy to compare central projections of primary afferent neurons that innervate the masseter muscle and

256 ticipate in control of food intake via vagal afferent neurons that innervate the upper gastrointestin

257 To determine whether vagal afferent neurons that project to the stomach or duodenum

258 imately 70% of bladder and proximal urethral afferent neurons that send axons through the pelvic nerv

259 By retrograde labeling afferent neurons that target hindlimb skin, we showed th

260 he percentage of retrogradely labeled muscle afferent neurons that were CGRP-positive was greater in

261 ved to depend on activation of vagal sensory afferent neurones, the mechanisms involved in exciting t

262 to exist in both the dorsal horn and sensory afferent neurons, the expression profile of specific nuc

263 chanism at the first central synapse of lung afferent neurons, the nucleus tractus solitarius.

264 lucagon-like peptide-1 (GLP-1)) excite vagal afferent neurons to activate an ascending pathway leadin

265 tease-activated receptor 2 (PAR2) on primary afferent neurons to cause neurogenic inflammation and hy

266 fferential contributions of vagal and spinal afferent neurons to chemosensation and chemonociception.

267 st that TNFalpha may act directly on primary afferent neurons to induce pain hypersensitivity.

268 Cholecystokinin (CCK) acts on vagal afferent neurons to inhibit food intake and gastric empt

269 ich then acts at opioid receptors on primary afferent neurons to inhibit nociception.

270 The ratio of afferent neurons to neuromasts differs between the anter

271 orie-rich diets reduces sensitivity of vagal afferent neurons to peripheral signals and their constit

272 of sympathetic, parasympathetic, and spinal afferent neurons to quantify their relative contribution

273 from turtle vestibular hair cells and their afferent neurons to show that potassium ions accumulatin

274 duced obesity alter the sensitivity of vagal afferent neurons to stimulation as well as their pattern

275 pamine neurons, because removing NMDARs from afferent neurons to the ventral tegmental area (VTA) als

276 in activates intrinsic and extrinsic primary afferent neurons to, respectively, initiate peristaltic

277 reated (NNCAP) rats (rats that lack group IV afferent neurons) to determine whether administration of

278 ination of presynaptic inhibition of startle afferent neurons together with distributed postsynaptic

279 Primary afferent neurons transduce sensory information about tem

280 filter properties among the three classes of afferent neurons: transmedullary cells, T2 neurons, and

281 Thus, unlike bladder afferent neurons, urethral afferent neurons may be hyper

282 Excitatory, pain transmitting primary afferent neurons utilizing glutamate as an excitatory ne

283 To test the hypothesis that vagal afferent neuron (VAN) GLP-1 receptors (GLP-1Rs) are nece

284 with remarkable precision and efficiency to afferent neurons via specialized ribbon synapses.

285 etic and parasympathetic efferent and spinal afferent neurons, via axons in colonic nerve trunks.

286 of CART peptide (CARTp) from cultured vagal afferent neurons was determined by enzyme-linked immunos

287 Bladder afferent neurons were labeled with axonal transport of F

288 The somata of CGRP- and SP-positive muscle afferent neurons were smaller than that of the overall m

289 led by IB4, a marker of unmyelinated primary afferent neurons, were largely absent.

290 ility of mechanoceptive Adelta-fiber bladder afferent neurons, which are usually capsaicin-insensitiv

291 te membrane mechanical properties of primary afferent neurons, which provide, to our knowledge, a new

292 uli evoked smaller postsynaptic responses in afferent neurons, which rapidly fatigued.

293 erves as the sole input for 10-30 individual afferent neurons, which requires extraordinary precision

294 is expressed in both bladder and non-bladder afferent neurons, while Na(v)1.9 is expressed in non-bla

295 as innocuous stimuli are detected by spinal afferent neurons, whose cell bodies lie in dorsal root g

296 Capsaicin-insensitive afferent neurones with cell bodies in the nodose ganglia

297 K+ currents was decreased by 52% in bladder afferent neurons with TTX-resistant spikes after 2 week

298 ffective and long-term transduction of vagal afferent neurons with viral vectors.

299 e medial organ of Corti and eventual loss of afferent neurons, with possible implications for human n

300 o organ of Corti), "primary" neural (loss of afferent neurons without loss of their hair cell targets