ライフサイエンスコーパス: affinity

1 ible in the intrinsically encoded nucleosome affinity.

2 activity but was a KOR agonist with moderate affinity.

3 to decrease both HbA and HbS oxygen binding affinity.

4 contributions of contact residues to binding affinity.

5 ity of rigid nucleosides while reducing A3AR affinity.

6 nt in thermostability and a reduction in CD4 affinity.

7 hat binds to the Kv1.3 ion channel with high affinity.

8 nd the shared receptor IL-12Rbeta1 with high affinity.

9 ional to FcRn expression and albumin-binding affinity.

10 razines with high dopamine D2 receptor (D2R) affinity.

11 rganic semiconductors with very low electron affinity.

12 ibute to transporter substrate and inhibitor affinities.

13 diated by only slight differences in binding affinities.

14 -chains fine-tunes sequence specific binding affinities.

15 hGal-3 (hGal-3C) and hGal-7), with known HMO affinities.

16 ists to determine their kinetic profiles and affinities.

17 d a significant reduction in Galphaq binding affinity (10-fold increase in Ki compared with WT RGS2 i

18 the DNA consensus with a 30-fold increase in affinity (100 nm).

19 shown to bind and inhibit SULT1A3 with high affinity, 23 (+/-2) nM, and to bind weakly, if at all, t

20 omain (ABD) of beta-III-spectrin causes high-affinity actin binding and decreased thermal stability i

21 naling with timing coherent with rapid LFA-1 affinity activation.

22 identification of a previously unknown high-affinity AICE2 motif at a human single-nucleotide polymo

23 imately 14-17 m(2)/g), had similar intrinsic affinities and capacities for fluoride, and did not leac

24 he clinical course of disease, with stronger affinities and longer half-lives in indolent cases, and

25 eometries without compromising their binding affinities and specificities.

26 difficult owing to competition with the high affinity and abundance of its endogenous nucleotide subs

27 the non-linear relationship between binding affinity and binding probability and the fact that indep

28 with the newly identified site having higher affinity and both sites required for WRC activation.

29 ght on the crucial interactions for both the affinity and dissociation kinetics of this family of lig

30 Several analogues showed subnanomolar affinity and excellent KOP receptor selectivity acting a

31 that lead to a decreased nucleotide binding affinity and incorporation rate.

32 ng by purified MpPR-1 occurs with micromolar affinity and is saturable in vitro Sterol binding by MpP

33 ivalent contacts with DNA, leading to robust affinity and moderate specificity for AT-rich elements.

34 resulting inhibitor combines high inhibitory affinity and selectivity with a good stability in plasma

35 m by which Cmpd-15 modulates agonist binding affinity and signalling.

36 ated the selection of DNA aptamers with high affinity and specificity against S.

37 The CIPs had high affinity and specificity for bacterial detection and pro

38 ationalized the molecular basis for enhanced affinity and specificity for USP7.

39 amers, BLG14 aptamer sequence has shown high affinity and specificity to both beta-LG A and B with di

40 Thus, binding site affinity and transcription factor levels are finely tune

41 crimination, to determine the stoichiometry, affinity, and shape of macromolecular complexes with dis

42 ectly correlated with target tubulin binding affinity, and the reduction in differential functional a

43 This intricate modulation of binding affinity, and thus cooperativity, renders our new cuboct

44 d IgE of the allergic effector cells via low-affinity anti-human IgE Abs with dissociation constants

45 We demonstrated that these low-affinity anti-IgE mAbs bind to the cell surface-bound Ig

46 on is contained to ensure generation of high-affinity antibody is unknown.

47 Protective high-affinity antibody responses depend on competitive select

48 target guanylate cyclase with submicromolar affinity (apparent KD-values of 663 +/- 121 nM and 231 +

49 alled "second shell" residues, that increase affinity are typically identified by directed evolution

50 High-affinity arrestin binding requires receptor phosphorylat

51 ly palmitate with a similar order of binding affinity as tablysin-15, a known palmitate-binding prote

52 ignificantly modulates DENV protease binding affinity, as revealed by engineering the binding loop of

53 owed gating alterations, a reduced glutamate affinity associated with a strong decrease of NMDA-evoke

54 m826 binds to H7N9 HA with subnanomolar affinity at acidic pH and 10-fold lower affinity at neut

55 ibody (DX-2507) that binds to FcRn with high affinity at both neutral and acidic pH, prevents the sim

56 nearly eightfold enhancement in dimerization affinity at low pH.

57 olar affinity at acidic pH and 10-fold lower affinity at neutral pH.

58 tracellular pH sensor perturbs the potassium affinity at the extracellular selectivity filter by more

59 ions undergo somatic hypermutation (SHM) and affinity-based selection toward antigen in activated ger

60 y during cyclic re-entry to ensure efficient affinity-based selection.

61 t of an age-related subunit switch from high affinity beta2-containing nAChRs to low affinity beta4-c

62 high affinity beta2-containing nAChRs to low affinity beta4-containing nAChRs, in addition to the los

63 However, the strong picomolar binding affinity between GAS6 and AXL and the promiscuity of sma

64 Binding affinity between proteins and NPs and the occurrence of

65 Of interest, the binding affinity between Sesn2 and AMPK upstream LKB1 is impaire

66 lding and binding, and identified 2,618 high-affinity binders.

67 nctional homodimer (or "lysibody") with high-affinity binding and specificity for carbohydrate determ

68 tween a QD and a molecular probe to even low-affinity binding events at the QD/solvent interface.

69 egg white lysozyme demonstrate how nanomolar affinity binding of asymmetrical antigen is enabled thro

70 eight of the nine candidates exhibited high-affinity binding to human chemokines.

71 Domain 4 exhibited low-affinity binding to LRP6 in in vitro binding assays, and

72 nd fast procedure to purify trypsin based on affinity binding with ferromagnetic particles of azocase

73 e RNA-binding surface allow for high- or low-affinity binding with functional implications.

74 channel electrophysiology to measure resting affinities (binding free energies) of these and other ag

75 rmational entropy would render the resulting affinity biologically meaningless.

76 DMSP demethylases (DmdAs) have low substrate affinities, but AcuIs have very high substrate affinitie

77 at it enhanced thermostability and increased affinity by 60-fold.

78 rdomain linker modulates the histone-binding affinity by interacting with the PHD domain.

79 retation is the determination of the binding affinity by isotherms of weight-average sedimentation co

80 ed novel genetically encoded ER-targeted low-affinity Ca(2+) indicators optimized for examining axona

81 s made by the model correlated well with the affinity changes observed in vitro of TnT mutants for Tm

82 The presynaptic, high-affinity choline transporter is a critical determinant o

83 rs, secreted into culture media, purified by affinity chromatography and characterized by biolayer in

84 Using RNA-affinity chromatography and mass spectrometry, we furthe

85 Affinity chromatography experiments identified the prima

86 ruct was further pursued for optimisation of affinity chromatography purification.

87 ia integrin VLA-3 (CD49c/CD29) with a higher affinity compared with other Arg-Gly-Asp binding integri

88 ergy state displayed improved ligand binding affinity, compared with the wild-type enzyme, demonstrat

89 In physiological high-affinity conditions using a multivalent immunogen, rare

90 Moreover, the monomer-dimer equilibrium affinity constant was determined using native MS, reveal

91 discharge of siRNA from its carrier, higher affinity continually led to stronger silencing.

92 expression of OsCOPT1, which encodes a high-affinity copper transport protein, as well as other copp

93 Ctr2, has been proposed to function as a low-affinity Cu transporter, a lysosomal Cu exporter, or a r

94 c screen around E. coli that identified high-affinity cytochrome bd oxidase as an essential bacterial

95 trostatics are validated against drug-target affinity data, yielding superior computational accuracy

96 e strong B cell pulling forces and stringent affinity discrimination.

97 The ability of antibodies to accumulate affinity-enhancing mutations in their complementarity-de

98 Affinity enrichment mass spectrometry revealed that the

99 o excess nitrogen involve only low substrate affinity enzymes.

100 Computed fluoride-ion affinities (FIAs) of the hydroalane adducts as well as D

101 our antigens in mouse models; and (d) use in affinity fluorescence and super-resolution microscopy.

102 of ALA, and variants of PEPT2 have different affinities for ALA.

103 two Ca(2+)-saturated C2 domains have similar affinities for membranes lacking PIP2, but the C2B domai

104 ferences, which can illustrate co-TF binding affinities for motif analysis.

105 hey display different binding mechanisms and affinities for their interaction with the PRR of Itch.

106 newly characterized 2-aminopyrimidines with affinity for AChBP showed only two to be agonists on the

107 mic sequence type 258 (ST258), have shown an affinity for acquiring and disseminating resistance plas

108 DNA binding assays suggest that Zta has high affinity for all four sequences examined, whereas AP-1 h

109 carboxamide, a pan antagonist with nanomolar affinity for all four subtypes.

110 erfacial hot-spot that dominates the binding affinity for an anti-interleukin-23 (anti-IL-23) antibod

111 te that MV-associated VEGF90K has a weakened affinity for Bevacizumab, causing Bevacizumab to be inef

112 ts to insulin to create insulin analogs with affinity for both the insulin receptor (IR) and mannose

113 Although SbCCR1 displayed higher affinity for caffeoyl-CoA or p-coumaroyl-CoA than for fe

114 B anchor, Ppc89, while also enhancing Sid4's affinity for casein kinase 1delta (CK1delta).

115 mational changes was associated with a lower affinity for CD4.

116 loop of aprotinin, a small protein with high affinity for DENV protease.

117 strogen receptors (ERs) including beneficial affinity for ERbeta.

118 Isoflavones have an affinity for estrogen receptors (ERs) including benefici

119 fucose of this glycan greatly increases the affinity for FcgammaRIII, resulting in enhanced FcgammaR

120 We measured binding affinity for four synbodies against VLPs from multiple G

121 Compounds with relatively high affinity for HSA (</=2 muM) showed high and sustained bl

122 hat variants of activated PC have a stronger affinity for integrin VLA-3, which reveals novel therape

123 orylation of Sid4 by NIMA(Fin1) reduces Sid4 affinity for its SPB anchor, Ppc89, while also enhancing

124 use the cells lacked this inhibitor, and its affinity for legumain is 100-fold higher than that of cy

125 (beta-CD)-based polymer network with higher affinity for PFOA compared to powdered activated carbon,

126 ls bearing T cell receptors (TCRs) with high affinity for self-antigen are eliminated.

127 asingly important with increasing adsorption affinity for solid surfaces.

128 hains were cloned as IgG1, and those of high affinity for specific SAEs, assayed by means of ELISA an

129 edly, we show that a full reduction in eIF3j affinity for the 43S PIC requires an ATP-dependent, but

130 mined, whereas AP-1 has considerably reduced affinity for the asymmetric sequence (meZRE2).

131 have been prepared and used to study binding affinity for the BCL2 i-motif DNA.

132 In contrast, CaMKII peptide increases Ca(2+) affinity for the C-domain of CaM by stabilizing the two

133 elective DNA-binding protein exhibiting high affinity for the Holliday junction and promoting DNA bri

134 Despite exhibiting higher affinity for the MR than either eplerenone or spironolac

135 In addition, (123)I-FP-CIT has modest affinity for the serotonin transporter (SERT), predomina

136 om green mamba venom that exhibits nanomolar affinity for the V2R without any activity on 155 other G

137 ructural analog of suramin, has an increased affinity for TIMP-3 and increased ability to inhibit TIM

138 he target DNA or prebending it increases its affinity for transpososomes by over an order of magnitud

139 negatively charged hyaluronan shows enhanced affinity for YKL-40 over neutral chitohexaose.

140 y inhibitor peptide, revealing its increased affinity for, and retention in, cholesterol-rich membran

141 subpopulation based on addiction to the high-affinity glucose transporter, Glut3.

142 h the advantages of small size, high binding affinity, good stability, lack of immunogenicity, and ea

143 the conformation of the A1 domain to a high-affinity GPIbalpha binding competent state.

144 ESI-MS assay identified 100% of ligands with affinities >500 M(-1) and >/=93% of all HMO ligands (hGa

145 hat NDD-713 and -825 have nanomolar beta1-AR affinity >500-fold beta1-AR vs beta2-AR selectivity and

146 ardiovascular system, varied from the lowest-affinity H782A/K786A peptide (0.011 s, 747 mum) to the h

147 6A peptide (0.011 s, 747 mum) to the highest-affinity H782Q/K786N peptide (0.192 s, 15.7 mum).

148 and (nat)Lu-NeoBOMB1 bound to GRPR with high affinity (half maximal inhibitory concentration, 1-2 nM)

149 preparation of conjugates with fluorophore, affinity handle, and pharmacological agents.

150 formations are amenable to cooperative, high-affinity histone binding.

151 rements, we find that SdrC is engaged in low-affinity homophilic bonds that promote cell-cell adhesio

152 PSMA affinities (IC50) and internalization kinetics of (99m)T

153 By identifying the cellular origin of high affinity IgE and the clonal selection of high affinity m

154 y as well as allergic reaction, but how high affinity IgE antibodies are produced in memory responses

155 tor-like 1[EMR1](+)MPs), mast cell MPs (high-affinity IgE receptor [FcepsilonRI](+)c-kit(+)MPs), and

156 Neutralisation of the high-affinity IL-15 receptor binding subunit, IL-15ralpha in

157 eir slow biodegradation and limited sorption affinities, IL cations have a high potential to reach aq

158 igated by performing an antigen and antibody affinity immunoassay.

159 Cellular studies determined the affinity, immunoreactivity, and specificity of [(89)Zr]Z

160 D of 170 nM, which corresponds to a 120-fold affinity improvement compared to the parent molecule.

161 her genotypes, JFH-1 NS3 binds RNA with high affinity in a functionally active form that is capable o

162 mins with either decreased or increased FcRn affinity in combination with a low or high FcRn-expressi

163 f the allosteric basis for the decreased DNA affinity in RcnR's metal-bound states.

164 erminal region of RING1B (C-RING1B), with an affinity in the low micromolar range ( approximately 10

165 This correlates with picomolar affinities, increased residence times and an absence of

166 show that targeting FimH with M4284, a high-affinity inhibitory mannoside, reduces intestinal coloni

167 ufficient to induce deletion of high- or low-affinity InsB9-23-reactive CD4(+) T cells; however, we o

168 t was further supported by modeling the high-affinity interaction between the optimized sequence on h

169 en)Cl2 (en, ethylenediamine) promotes a high-affinity interaction with exquisite selectivity for this

170 the advantages that it is applicable to low-affinity interactions because the complexes are not obse

171 Binding affinity is greatly enhanced by residues flanking the cr

172 ptor (IL-6R) for two adnectins with distinct affinities (Kd, Adnectin1 approximately 6.2 pM vs Kd, Ad

173 rescently labeled substrate) and the binding affinity (KD ) indicate that, in both mutants, Cpd-5 sho

174 ntified and optimized a novel series of high affinity KMO inhibitors with favorable physicochemical p

175 d binding input molecules in water with high affinity leading to displacement of CB7 from included ph

176 nduced alterations decrease RcnR-DNA binding affinity, leading to rcnAB expression.

177 n-inducing ligand" (APRIL) is a natural high-affinity ligand for BCMA and transmembrane activator and

178 pyrrolidinyl analogues were found to be high affinity ligands for the CB1 and CB2 cannabinoid recepto

179 s and nanoparticles using peptides and other affinity ligands may represent a general strategy to inc

180 s functional interaction interface with high-affinity ligands.

181 We report on the online coupling of FcRn affinity liquid chromatography (LC) with electrospray io

182 Affinity maturation is a Darwinian process in which B ly

183 n (HHIP) and subjected to multiple rounds of affinity maturation through the screening of macrocyclic

184 ns are required to maintain stability during affinity maturation.

185 Here we cloned and characterized rare affinity-matured human NANP-reactive memory B cell antib

186 In addition to affinity measurements with purified components, Kd value

187 lity of a reliable application of the immuno-affinity membrane developed for biosensors and bioassays

188 ffinity IgE and the clonal selection of high affinity memory B cells into the plasma cell fate, our f

189 with iron-rich sedimentary rocks, but their affinities, metabolism, and, hence, their contributions

190 itching, allows FIN219 to switch to its high-affinity mode and thereby enhances JA signaling under co

191 the anti-HER2 trastuzumab moiety paired with affinity-modulated VH and VL regions of the anti-EGFR GA

192 However, it is unclear if affinity mutations in the hypervariable CDRs generally i

193 ective washing and elution allows the higher affinity nanoparticles to be isolated.

194 70 to His (Y370H) resulted in saturable high-affinity nitrate transport activity and nitrate selectiv

195 m-NPF6.6 was a pH-dependent nonbiphasic high-affinity nitrate-specific transport protein.

196 Expression of genes encoding high substrate affinity nitrogen assimilation enzymes (GS-GOGAT system)

197 f 6 mum, which was moderately lower than the affinity observed for the TIGIT/necl-5 interaction (3.2

198 We calculated and compared the binding affinities of 20 carefully selected genes with their dru

199 In the second case, the affinities of a broad-spectrum inhibitor for 22 bromodom

200 hology and previously suggested phylogenetic affinities of Parvancorina are also re-evaluated.

201 In the first one, the affinities of two similar ligands for seven bromodomains

202 tight binding competitive inhibitor with an affinity of 545 pM for thrombin and is 4 orders of magni

203 hat is most distal from the membrane with an affinity of 6 mum, which was moderately lower than the a

204 Wettability is the affinity of a liquid for a solid surface.

205 ctions are isoform-specific, because the HSA affinity of Abeta monomers is lower for Abeta(1-42) than

206 analysis allows us to quantify the increased affinity of Au-catalysts to the Bergman cyclization tran

207 vered the molecular underpinnings of lowered affinity of Ca(2+) for CaM in the presence of Ng13-49 by

208 f eEF-2K, and Ca(2+) is shown to enhance the affinity of CaM toward eEF-2K.

209 CNBD of HCN2 channels decreases the apparent affinity of cAMP for the CNBD.

210 ion kinetic and intrahepatic albumin binding affinity of CyG can further be used to differentiate bet

211 horylation of KaiC, and how the differential affinity of KaiA for the different KaiC phosphoforms gen

212 periments disclosed a marked decrease in the affinity of Na(+) to bind the channel when the conformat

213 Measurements of the affinity of nanoparticles obtained by flowing particles

214 The lower affinity of oxidized LPMO could support its desorption a

215 PAA-nano-ZVI attachment and hence reduce the affinity of PAA-nano-ZVI for the collector surfaces thro

216 tive to the T allele by reducing the binding affinity of PAX2.

217 of the sedimentation coefficient and binding affinity of proteins in the micromolar range, the implem

218 The high affinity of SA to BSA was demonstrated by a binding cons

219 This complexin interaction reduces the affinity of synaptobrevin-2 for the 1:1 complex, thereby

220 reactivity differences to scale the membrane affinity of the decapeptide Gramicidin S cyclo(d-Phe-Pro

221 5C protein partner and enhances the apparent affinity of the interaction.

222 ead onto DNA termini and thereby improve the affinity of the NHEJ enzymatic components consisting of

223 erenes was observed to increase the electron affinity of the overall cluster, providing a noncovalent

224 letion of P1 CTD, but not P2 CTD reduced the affinity of the pentamer for RTA.

225 luate zircon sensitivity to the metallogenic affinity of their host rock.

226 tive deuteration affected either the binding affinity or the activation by the selected ligands for t

227 acceptors and their calculated methyl anion affinities, particularly when solvation by dimethyl sulf

228 mblies, including those with challenging low-affinity partners, and may facilitate the design of nove

229 OP-BChE) and BChE and provided equal binding affinity, permitting detection of the total enzyme amoun

230 m Saccharomyces cerevisiae are the Trk1 high affinity potassium transporter and the functionally redu

231 hods as well as the state-of-the-art binding affinity prediction methods.

232 may interfere with accurate protein-protein affinity prediction.

233 Mutant analysis confirms that affinity proteomics is a viable strategy for revealing p

234 WAS using a highly multiplexed aptamer-based affinity proteomics platform.

235 gene lists generated by Translating Ribosome Affinity Purification (TRAP) and CREB-target gene reposi

236 Translating ribosome affinity purification (TRAP) and in vitro luciferase rep

237 We employed affinity purification and immunoblotting to validate the

238 Cre recombinase-dependent miRNA tagging and affinity purification in mice.

239 Here, we describe a CRISPR affinity purification in situ of regulatory elements (CA

240 rotein interactions, we establish a ribosome affinity purification method that unexpectedly identifie

241 urification with mass spectrometry), for the affinity purification of a sequence-specific single-copy

242 Here, we use ChAP-MS (chromatin affinity purification with mass spectrometry), for the a

243 Protein affinity reagents are widely used in basic research, dia

244 e binding scaffolds, represent complementary affinity reagents to antibodies for various molecular an

245 an member of the GFR-alpha family, is a high-affinity receptor for GDF15.

246 going significant conformational changes for affinity regulation.

247 , we herein report a comprehensive structure-affinity relationship study for novel ligands targeting

248 2 scavenging by mutants with impaired CXCL12 affinity required drastically reduced receptor expressio

249 the pH at which a mAb elutes from protein A affinity resin.

250 ivity and cost-effective binding capacity of affinity resins for capture of the Fc-tagged rE1E2, we a

251 or glycoscience, such as glycan microarrays, affinity resins, and reference standards.

252 , has evolved a changed preference for a low-affinity, secondary binding motif.

253 leasing peptide-6 (GHRP-6) exhibit promising affinity, selectivity, and modulator activity on the clu

254 umerates peripheral blood lymphoblasts using affinity separations.

255 ce exhibited comparable accumulation of high-affinity signaled CD4(+)CD8(+) double-positive thymocyte

256 pore, the sugar release rate (koff) from the affinity site increased with elevated voltage, regardles

257 e motion was confined by DNA binding to high-affinity spots, suggesting a two-step mechanism for SSB

258 ovel sensors based on the Systematic Protein Affinity Strength Modulation (SPASM) technique.

259 e the robustness of [(3)H]RO6957022 binding, affinity studies were carried out for a wide range of CB

260 ent study further characterizes this high Pu affinity subfraction using electrospray ionization Fouri

261 finities, but AcuIs have very high substrate affinities, suggesting that an effective detoxification

262 proteolytically remodeled GP with picomolar affinity, suggesting that engineered ebolavirus vaccines

263 iol-redox proteomic technique, isotope-coded affinity tag labeling, to quantify the extent of NO2(-)-

264 SNOxICAT (S-nitrosothiol redox isotope-coded affinity tag), we found that exposure to NO2(-) under no

265 ion provided excellent detection of nanogold affinity tags in the context of wall fibrillar organizat

266 d series of integrative vectors with various affinity tags, including single tags 3xFLAG, 3xHA, 3xStr

267 (+) T cell responses mediated by shared high-affinity TCRs.

268 at C152 has an approximately 10-fold greater affinity than C461 for lipid bilayers, despite both solu

269 Compound 6 binds cereblon with a higher affinity than lenalidomide or pomalidomide.

270 e synbodies were broadly cross-reactive with affinities that ranged from 0.5 to 8 nM.

271 n intrinsic property of Syt1 with reasonable affinity that can be triggered by the vesicle docking C2

272 d FZD cysteine-rich domains (CRDs) with high affinity through a palmitoylated N-terminal "thumb" and

273 specific T cells and prevents escape of high-affinity thymocytes.

274 pant residues resulting in different binding affinity to ABA.

275 and CisoDGRC), which have different binding affinity to alphavbeta3 integrin, are reported from isol

276 r infrared probe was fabricated to have high affinity to apoptotic cells.

277 ides a structural basis for its high binding affinity to BET proteins.

278 adiotracer for PET that binds with nanomolar affinity to CXCR4.

279 thermore, we find that GDF15 binds with high affinity to GDNF family receptor alpha-like (GFRAL), a d

280 canavalin A (Con A), an enzyme with specific affinity to glucose.

281 tracer for PET imaging that binds with high affinity to GPIIb/IIIa receptors and has suitable pharma

282 site and that miRNA binding increases hAgo's affinity to GW182.

283 EFL variants tested showed decreased binding affinity to human and cynomolgus FcgammaRs compared with

284 , the authors engineer BoNT/B to improve its affinity to human receptors and enhance its therapeutic

285 We show that the affinity to NAD+ and UDP-containing factors during initi

286 eport that CHD6 and CHD7 both bind with high affinity to short linker DNA, whereas CHD8 requires long

287 ylR variants (R121C and P363S) have a higher affinity to their DNA binding sites, leading to a xylose

288 ntially nonredundant roles for high- and low-affinity Tregs in controlling autoimmunity.

289 ent activation of the rho module of integrin affinity triggering mediates chemokine-induced leukocyte

290 (VWD) variants, we test a recently proposed affinity up-regulation hypothesis which states that coll

291 he new compounds stands out 12b for its high affinity value (Ki = 0.27 nM) and for its anxiolytic-lik

292 anism to retain substrate proteins with high affinity while also generating functional switches to dr

293 rane fusion and had higher levels of binding affinity with NHR peptide N46.

294 by the reduction of CO2 into CO, whose high affinity with platinum triggers the formation of a Pt-CO

295 while, its relatively larger size and weaker affinity with SnI2 than FA+ ions will facilitate the int

296 stability while maintaining receptor-binding affinities, with three candidate peptides retaining full

297 l culture media corresponded to FcRn-binding affinity, with a approximately 3.3-fold increase after 1

298 Functional diversity in thermal affinity within the piscivore guild may therefore buffer

299 e to its ability to bind PPARgamma with high affinity without stimulating adipocyte differentiation a

300 aracterized by a flexible loop near the high-affinity zinc-binding site.