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1 h spatial and temporal resolution that light affords.
2 se bicycles formed W(CO)(5) complexes (3) or afforded 1,2-dihydrophosphetes with P-bound alkenyl grou
3 and deals with greener oxidants like oxygen, affording 1,4-ketocarbonyls as a value-added end product
4 phosphitylation/oxidation, then deprotection afforded 10, which was a full agonist in Ca(2+)-release
6 ormed MF-NB1, was radiolabeled with (18)F to afford (18)F-OF-NB1 in more than 95% radiochemical purit
7 ing pharmacological therapy was estimated to afford 2.7 additional years (for an 80-year-old) to 8.3
8 yl elimination via O-S or C-S bond cleavage, affording 2-pyridinyl acetates, Ph(3)P-catalyzed [4 + 2]
10 h was optimized at the 2- and 7-positions to afford 26 and 29 as potent allosteric inhibitors of HIV-
11 ns of indolines with alkenes or aldehydes to afford 3-alkylindoles and bisindolylmethanes with turnov
12 n of the synthesized 9H-fluorene derivatives afforded 9H-hydroxy-functionalized quaternary fluorene d
15 l hypothesis that NOP partial agonists would afford a dual pharmacological action of attenuating Park
16 n (N(2)) was observed at room temperature to afford a ligand functionalized product via a [3 + 2] ann
17 ArOH + HO(2)(*) -> ArO(*) + H(2)O(2) neither afford a linear correlation nor agree with the experimen
19 /all of a participants' medication: couldn't afford a prescribed medication; skipped medication doses
21 s with selenium dioxide and malononitrile to afford a series of alpha-carbonyl selenocyanates in mode
22 t active cellular processes by P. aeruginosa afford a significant benefit to S. maltophilia during po
23 er and a Hantzsch ester, which decomposes to afford a tertiary radical that is readily trapped by the
24 cycloaddition with the cyclopropane diester afford a trouble-free formulation of the valued hexahydr
25 alkyne, have been utilized as dienophiles to afford a wide range of different THP derivatives up to 7
26 ion and a challenging Pauson-Khand reaction, afforded a 17-step synthesis of the molecule in enantioe
27 found to be robust on a multigram scale and afforded a central spirocyclobutanone scaffold for carbo
29 ne-tuning of pore size, shape, and chemistry afforded a series of distinct host-guest binding sites w
31 sing a titanium-reductive amination reaction affording a 50/50 mixture of cis and trans isomers and (
32 unctionalize benzylic and allylic C-H bonds, affording a broad scope of enantioenriched primary amine
33 able strategy to induce cellular senescence, affording a distinct way to control joint inflammation a
35 ariant of this transformation was developed, affording a set of alpha-chiral amides with unprecedente
36 bonds in doubly stereoconvergent processes, affording a single stereoisomer of the product from two
37 ntate phosphoramidite-Ni complex in ethanol, affording a variety of enantioenriched products in up to
38 he nonchiral ligands around the metal center affords a chiral structure with two geometrically differ
41 Electrocyclization of an advanced precursor affords a dihydrobenzimidazole, which is expected to ser
42 that proceeds in the presence of azides and affords a glycosyl acceptor for the installation of a mo
43 uid chromatography-mass spectrometry (LC-MS) affords a highly promising solution for absolute quantif
44 was that synthesis of SLs (host-like lipids) affords a mechanism that allows P. gingivalis to persist
46 5-di[3',5'-diformyl(1,1'-biphenyl)]porphyrin affords a porphyrin tubular organic cage, PTC-1(2H).
49 cking pattern and linker conformation, which affords a strong interlayer trapping of molecules along
51 Here we discuss how developmental psychology affords a unique and critical opportunity to employ this
52 t on glycoproteins, measured simultaneously, affords a unique opportunity to quantitatively study how
54 such a coupling are overcome, in situ FCLSM affords a unique way to explore reactivity at the electr
55 dimensionality, morphology, and phase) will afford access to a broader range of breakthrough propert
57 stituted alpha-phthalimido ester enolates to afford alpha-tetrasubstituted, beta-trisubstituted alpha
59 roscopy strategy based on (13)C detection to afford an essentially complete set of (13)Calpha, (13)Cb
60 dundant copies of tRNA(fMet) from the genome afforded an E. coli strain in which the efficiency of no
62 or more O-glycans under negative-mode MS(2) affords an easy way to discover additional O-glycosylati
63 centers with significant LDLT experience and affords an opportunity to expand LDLT in cases of ABO in
65 nding how to decipher textural details would afford another method of extracting knowledge of the phy
66 sign of biomaterial-based vaccines that will afford antitumor immune protection at mucosal surfaces,
67 ts of metal atoms in high-index metal facets afford appealing physical and chemical properties, which
68 The alkene-isocyanate cycloaddition method affords beta-lactams from glycals with high regio- and s
70 of postoperative pulmonary complications and afforded better short-term postoperative outcomes compar
71 ibe a plasmid-based library methodology that affords bidirectional, graded modulation of gene express
72 idic borane-functionalized phenylnorbornenes afforded both a soluble linear copolymer and a cross-lin
75 s in the retinal fovea, where the resolution afforded by a dense array of cone photoreceptors is pres
77 arrangement of Mes*P=C=C(H)R' (R' = tBu, Ad) afforded by C-H activation, isobutene elimination, and C
79 methods that provide the tissue specificity afforded by cis-regulatory elements and the conditionali
81 The significantly greater passive protection afforded by DeltagD-2 persisted after controlling for th
82 on as the relative precision of predictions, afforded by each learning system, using hierarchical Bay
84 in vitro system to examine the capabilities afforded by functional redundancy in fatty acid synthesi
87 , this study highlights potential protection afforded by IgA arising from either direct IgM-to-IgA or
89 emonstrates that the enhanced predictability afforded by KAF holds over potentially much longer leads
90 and will also leverage the statistical power afforded by longitudinal imaging studies in patient samp
91 itically important for their survival and is afforded by low levels of Histone 2A (H2A) ubiquitinatio
94 tion of protection against CDI later in life afforded by natural C. difficile immunization events req
95 lly relevant time resolutions, such as those afforded by single-molecule fluorescence measurements.
96 rying degrees of spatiotemporal manipulation afforded by such techniques allow microglial ablation be
99 ded additional site-specific information not afforded by the conventional quality control (QC) method
105 nally mild conditions (14 degrees C, 1 h) to afford C-H-vinylated products, 1-azadienes of E configur
106 3-hydrotriboranes, while hydride abstraction affords cationic triboranes, which represent the first d
107 nctionalization of C-H bonds will ultimately afford chemists transformative tools for editing and con
112 ition substituents of the core pyridine ring afforded compounds M4K2009, M4K2117, and M4K2163, each w
115 acy in rats is improved when the environment affords cues that animals can incorporate into motor rou
116 oved performance in complex mixture analysis affording detailed characterization of low abundant CLs
118 tion of a seven-membered transition state to afford di-, tetra-, and pentapeptides in 78-95% yields.
120 ents and nonprofits design aid programs that afford dignity and facilitate beneficial outcomes for re
121 rized with respect to oxidative addition (to afford dihydrides, M(H)(2) ) and as acids, heterolytical
122 ent radical coupling of [1.1.1]propellane to afford diverse functionalized bicyclopentanes using vari
124 different alpha-functionalized nitroalkenes affords diversely substituted sulfonylfurans and dihydro
125 lations (oscillation-based FC) is thought to afford dynamic information exchange across task-relevant
126 arylhydrazones toward 2-oxo-3-butenoates to afford (E)-diazoaryl-benzo[b]azepine derivatives in exce
127 tibody-drug conjugate by trans-cyclooctenes, affording efficient drug liberation in plasma and cell c
128 fer catalysts to couple two ionic reactants, affords enantioenriched gamma-fluoroamines in high yield
130 ture that is free of institutional barriers, affording equal opportunities for each individual to suc
131 ification of metal organic frameworks (MOFs) affords exceedingly high surface area materials with pre
133 trary, N-(4-chlorophenyl)-2-ethynylbenzamide afforded exclusively polyfunctionalized isoindolinones w
134 ther enhanced by introducing a Lewis base X, affording faster kinetic rate constants and the ability
135 ized parameters carried out on a large scale afforded feruloylated lysophosphatidylcholine (FLPC) in
136 Bulk electrolyses of 1 at -1.60 V vs SHE afford flavanone, 2'-hydroxychalcone, 2'-hydroxy-3-pheny
137 of porous ionic molecules of opposite charge affords framework-like materials where the ratio between
138 fers turnover frequencies of up to 60 h(-1), affording full conversion at 5 mol% catalyst loading in
139 ines (sulfamidate imines/sulfonyl imines) to afford functionalized 2-pyridinyl acetates (alpha-pyridy
141 red azaindole heterocycles that collectively afford fused cyclobutane containing scaffolds that offer
142 anes under mild acid-catalyzed conditions to afford fused meso-aryl sapphyrins in 15-18% yields.
143 f Cs(2)CO(3) in dioxane at 100 degrees C and affords fused heterocycles in high yields up to 99%.
145 od, rubber tyres and mixed plastic waste-can afford gram-scale quantities of graphene in less than on
149 he cobalt-corrole CoBr(8) as electrocatalyst affords H(2)O(2) as the main product in homogeneous solu
150 icient benzylic oxidation of heteroarenes to afford heterocyclic styrenes by the action of nickel cat
151 tags of minimal size (ca. 15-20 amino acids) affording high-affinity lanthanide ion binding, and X-ra
154 mechanochemical approach is demonstrated to afford highly crystalline graphite nanosheets at ambient
155 uorene/arylideneindolin-2-one derivatives to afford highly substituted bisperoxides with high selecti
157 drolysis of the resulting benzophenone azine affords hydrazine and benzophenone, with the latter amen
158 s identification of an impending seizure may afford improved treatments, such as antiepileptic drug c
159 4-dialkylideneisochroman-1-one skeletons are afforded in a solvent-dependent manner whereas difluorom
160 iles such as amines, hydrazines, and TMSN(3) afforded, in a one-pot two-step procedure, valuable scaf
161 able side chains, e.g., poly(valerolactone), affording independent control of melting temperature and
162 s, curve shape, and time-dependence, and may afford insights that clarify the hormetic dose-response
164 etallic intermediate thermally decomposes to afford large amounts of elimination products together wi
165 and the shape of the peripheral pockets, to afford large changes in the global pore geometry that ca
166 odivergent biocatalyst was also obtained for affording mirror-image forms of the desired bicyclic pro
168 le derivatives and a concise synthesis route affording more than a gram of a major fragment of anti-H
170 e methylene group containing substrates that affords multifunctional naphthalenes, phenanthrenes, qui
172 ductive intramolecular C-H bond amination to afford N-heterocyclic products using aliphatic azide sub
173 ally depends on finely tuned interactions to afford neuronal activity propagation over long distances
174 ical targeting of OCT2 could be exploited to afford neuroprotection in cancer patients requiring trea
177 enhancement via halogen substitutions, which afforded new anti-C. difficile agents with ultrapotent a
178 alumina column chromatographic purification afforded new dithia-bis(calix)-sapphyrins with two meso-
183 mbined with REs, the sulfone-modified linker affords novel MOFs, RE-hpt-MOF-1 (RE: Y(3+), Ho(3+), Er(
185 ment of enolizable partners was developed to afford over 80 novel ring-fused, N-substituted 4-quinoli
187 y crown ethers to modulate perovskite films, affording passivation of undercoordinated surface defect
188 ulfur molecules via a single-collision event affords persuasive evidence for a likely source of organ
191 ses that measurements of waist circumference afford practitioners with an important opportunity to im
192 a metal-organic framework can be designed to afford precise control over the size, structure and spat
193 nzymatic methods or a combination thereof to afford precise modification of specific amino acid or su
195 ice infected with Salmonella typhimurium and affording preliminary promising results in terms of tole
196 ipants with glaucoma reported they could not afford prescribed medication more frequently than partic
197 hyl fumarate and electron-deficient styrenes afford primarily beta-hydride elimination side reactivit
199 ating versus suppressive immune responses in affording protection from HIV.IMPORTANCE CD40-CD40 ligan
201 ant, photoinduced CRP approach which readily affords quantitative yields of protein-polymer conjugate
202 nitiated using 365 nm light-emitting diodes, affords radicals at room temperature as observed by elec
203 Culture-independent mNGS of blood products afforded rapid and precise assessment of pathogen identi
205 sively activated by designer drugs (DREADDs) afford remotely reversible control of cellular signaling
206 red and electronic absorption spectroscopies affords resolution of the electronic structure of the ox
209 ory decrease in synaptic drive to the muscle affording robust and stable muscle activity, and was ind
210 uently catalyze covalent bond rearrangement, affording selective assembly of the oligomeric sequences
214 tensive concentration of dilute samples, and affords similar sensitivity to comparable liquid chromat
216 ropanation using alpha-cyanodiazoacetates to afford stable norcaradienes bearing three stereogenic ce
217 aspartic acid containing peptide catalyst to afford stable, helically chiral products in up to >99:1
219 proanthocyanidins and hydroxycinnamic acids, affording strong antioxidant activity, as detected by th
220 ly triflated with trimethylsilyl triflate to afford strongly Lewis acidic sites for dehydroalkoxylati
221 onfirms that the templated electro-synthesis affords structural defects in the metal-organic framewor
223 hydrogen peroxide, and hydroxyl radicals, to afford superb antitumor efficacy on mouse models of brea
224 retinitis pigmentosa, a lead compound, Q525, afforded sustained RET activation and prevented photorec
226 cal, which subsequently reacts with mCPBA to afford the alcohol product and regenerate the aroyloxy r
228 ophenyl)borane (10-20 mol %) are employed to afford the C=C coupled products (31 examples) in good to
229 as well as 2-carbonyl-3-propargyl indoles to afford the corresponding carbazoles in decent yields.
230 enyl ring have been employed successfully to afford the corresponding nitrene insertion product in go
231 erature in the presence of inorganic base to afford the coupling product in good-to-excellent yields.
232 rgo highly diastereoselective allylations to afford the desired 1,3-dienyl-6-oxy motif and enable com
233 proceeds efficiently in a continuous flow to afford the desired products in moderate to excellent yie
236 ng that regions of highest species diversity afford the highest potential to discover novel natural p
237 nclude that pharmacological CSF1R inhibitors afford the most extensive versatility in manipulating mi
238 A silver-catalyzed protocol was found to afford the N-formylation of amines in moderate-to-good y
239 um salt of 6-bromoindole with triphosgene to afford the new dibrominated bis-indole ketone, bis(6-bro
241 ll in water for the direct aldol reaction to afford the products in excellent yields with high diaste
243 he collection and analysis of saliva samples afforded the ability to detect HAV infections in beachgo
244 atures but with notable chemical distinction afforded the attainment of a highly efficient energy tra
246 nic acid anhydride 1 with LiAlH(4)/Me(3)SiCl afforded the corresponding 1,8-naphthalenediyl-supported
247 eta-ketoester-substituted BC dihydrodipyrrin afforded the enone (E, 70%; Z, 3%); subsequent double-ri
248 Reaction of LH with Y(N(SiMe(3))(2))(3) afforded the heteroleptic complex, [{L}Y(N(SiMe(3))(2))(
250 ne-derived aminophenol-based boryl catalyst, affording the desired products in up to 91 % yield, >98:
251 mbrane, and lipoproteins by at least 5-fold, affording the opportunity for structural investigation o
253 labeling via FnbY occurs on the beta-carbon, affording the shortest linkage to protein backbone which
256 ommercially available R-2-bromophenylalanine affords the chiral tetrahydroisoquinoline 1 in 54% overa
257 logous reaction with toluylsulfenyl chloride affords the cluster [Fe(5) (mu(5) -C)(SC(7) H(7) )(CO)(1
258 ' = aryl, silyl) and Ph-Li to [Cu(II)]-C=CAr affords the corresponding C(sp)-C(sp) and C(sp)-C(sp2) c
259 yclooctatetraene, with lithium metal readily affords the corresponding tetra-anion instead of the exp
260 lyst, does not require external ligands, and affords the desired products in > 99% NMR yield in most
261 on of the central methyl group of the ligand affords the diiron mu-carbyne complex (P(6)ArC)Fe(2)(mu-
262 oyl chlorides (5-R'C(6)H(3)-2,6-{C(O)Cl}(2)) affords the diphosphametacyclophanes m-{-C(O)-C(6)H(3)-5
264 1-Pr(Ph), with [N(C(6)H(4)Br)(3)][SbCl(6)], affords the Pr(IV) complex [Pr(OSiPh(3))(4)(MeCN)(2)], 2
265 n the high-temperature, rapid-exchange limit affords the solvation numbers consistent with DFT comput
266 ddition cascade of 1,3,4-oxadiazole 9, which affords the stereochemically rich and highly functionali
267 of [Ph(3) EMe][I] with [Na{N(SiMe(3) )(2) }] affords the ylides [Ph(3) E=CH(2) ] (E=As, 1As; P, 1P).
275 er flight range and carrying capacity cannot afford to be as selective and so accept a wider range of
278 es a mode of regulating NK cells that is not afforded to IL-2 and is distinct from activation by solu
280 putationally, we consider too much precision afforded to negative prior beliefs as the main candidate
281 nt questions about the degree of objectivity afforded to neuropsychological tests in clinical practic
282 ficient direct Mn-I exchange of aryliodides, affording transient (aryl)lithium manganate intermediate
283 ese ligands activate RET tyrosine kinase and afford trophic signals irrespective of GFRalpha1 coexpre
286 with 1 equiv of Cy(7)Si(7)O(9)(OH)(3) in THF affords [U(OSiMe(3))(3)(Cy(7)Si(7)O(12))] (1) as orange
289 py "heads" and thiolate "tails" scrambles to afford up to 10 ternary assemblies via two processes: (1
290 serum biomarkers (e.g., cardiac troponin I) afforded up to 130-fold enhancement of near-infrared flu
291 rary developments in the use of chemometrics afford us the ability to predict changes in different as
292 it in proteins or in coordination complexes affords us a better understanding of the assembly and fu
293 o Pai, followed by stereospecific reduction, affords useful P-chiral phosphines; introduction instead
294 ology-directed analyses of these data layers afford valuable insights to build a global understanding
296 or the design and synthesis of periodic MOFs affording very efficient and fast ET to mimic natural ph
297 these assemblies show nonclose packings that afford voids to accommodate solvent molecules as a resul
298 tin-specific RCA products in HaCaT cells can afford washing-free imaging of single beta-actin protein