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1 esource costs of defence may be difficult to afford.
2 brains of Homo sapiens can be energetically afforded.
3 d robust humoral and cellular responses, and afforded 100% protection against a lethal intracerebral
4 oallylamine undergo aza-Prins cyclization to afford (1R,5S,7S)-7-[(benzyloxy)methyl]-2-tosyl-6-oxa-2-
5 ylamino-3-aryl/alkyl-4-(2-R-vinyl)isoxazoles afford 2-aryl/alkyl-5-aryl/alkyl/methoxycarbonyl-1H-pyrr
6 alimides onto isolated or conjugated alkenes affords 2,3-disubstituted benzopyrans and benzoxepins.
7 on of the amidine-tethered anthranilate then affords 2,3-disubstituted-3H-quinazolin-4-ones in good t
10 of 3 with 2 equiv of elemental sulfur in THF affords 4(*) via unexpected C-H bond activation, which r
11 ith a diene in the presence of triethylamine afforded (4+3) cycloadducts in good to excellent yields.
12 y means of Et2Zn/CuCN.2LiCl or CuCN.2LiCl to afford 5-alkyl or 4-alkyl cyclopentenone regioisomers: t
13 entenone regioisomers: the former conditions afford 5-alkyl substituted cyclopentenones via beta-carb
15 The RV144 ALVAC-HIV prime, AIDSVAX B/E boost afforded 60% efficacy against human immunodeficiency vir
16 -4] sulfurane that reductively eliminates to afford a 3,6-dihydrothiazine, which is selectively conve
17 e group on each of its two terminal aryls to afford a bidentate chelating ligand (CN(tBu)Ar3NC) that
19 ld conditions (often at room temperature) to afford a broad range of electronically diverse and funct
20 ement of the N-activated boronate complex to afford a dearomatized intermediate, which undergoes a Le
21 uggest that an RARalpha specific agonist may afford a new strategy for lipid-lowering and CVD risk re
23 many rounds of mutagenesis and screening to afford a proficient biocatalyst for enantioselective cle
25 ylation, triggering a 1,2-alkyl migration to afford a range of nonracemic spirocyclic ketones with hi
26 o atom donors (PhIO, IBX-ester, and H2O2) to afford a rare example of a singly oxygenated sulfenate,
28 hole mobility from optimized BHJ morphology afford a very high power conversion efficiency (PCE) (19
29 alyzed and acid-catalyzed transformations to afford a wide variety of 1,2-diamide functionalized prod
30 g ethynyl-1,2-benziodoxol-3(1H)-one (EBX) to afford a wide variety of 3-alkynyl-3-alkyl/aryl 2-oxindo
32 y ligand (initially (S)-MonoPhos, 58:42 er), afforded a hemilabile bidentate (S)-MonoPhos-alkene-Rh(I
33 methyl-2,2'-bipyridine (Me2Bipy) and Fe(CO)5 afforded a heterobimetallic [(Me2Bipy)AgFe(CO)5][B{3,5-(
34 ith CoCl2 followed by treatment with NaBEt3H afforded a highly active and reusable solid Zr12-TPDC-Co
35 tripyrrane, followed by oxidation with DDQ, afforded a polycyclic aromatic hydrocarbon (PAH)-porphyr
36 5 CH2 K and [U(Tren(TIPS) )(THF)][BPh4 ] (2) afforded a rare diuranium parent phosphinidiide complex
38 hene dialcohol in 2% ethanol-dichloromethane afforded a tetraphenylthiapyreniporphyrin in 31% yield.
39 min benchtop C-N cross-coupling methodology, affording a broad range of arylated diazaspiro precursor
41 ficantly alter the lithium plating behavior, affording a promising route to suppress lithium dendrite
43 function of substrate type and concentration affords a kinetic model in which the two S = 1/2 interme
44 binding abilities, with sumanene (C21 H12 ) affords a novel type of organometallic sandwich [Cs(C21
45 VDZ with linear scaling and correction terms affords a powerful and efficient tool for structure eluc
46 via topological nanomechanical architecture affords a promising route towards the realization of top
48 erions allows their in situ modification and affords a route to chemically trigger deaggregation and
50 clophane bisradical dication (DAPQT(2(*+))), affords a symmetric [2]catenane (SC.7PF6) and an asymmet
53 wide variety of chemical contexts because it affords a very detailed, visual and intuitive analysis t
54 fur host, the quinonoid imine-doped graphene affords a very tiny shuttle current of 2.60 x 10(-4) mA
55 ation of isoconversional activation energies affords accurate kinetic modeling of both isothermal and
58 dihydro-2,3,4-benzothiadiazepine 2,2-dioxide afforded, after loss of dinitrogen and subsequent ring c
60 nyl boronates add to glycolaldehyde imine to afford allylic hydroxyl allenes, and allyl boronates add
61 sion, in order to avoid a side reaction that afforded an alternative cyclization product, are discuss
63 quivalents of benzo-15-crown-5 ether (B15C5) afforded an unprecedented example (outside of matrix iso
64 zed C(sp3)X-C(sp3)ZnX Negishi cross-coupling affording an omega-hydroxy hemiacetal which was macrocyc
65 ime, whether exploring novel taxonomic space affords an advantage in terms of novel compound discover
68 Ar)L)Fe(NAd) (5) with chlorotriphenylmethane afforded ((Ar)L)FeCl((*)NAd) (6) with concomitant expuls
69 ed by column chromatographic purification to afford azaBODIPYs appended with one and two dipyrrometha
72 pective study, circumferential trabeculotomy afforded better long-term success and visual outcomes th
73 usive to GABA and homocarnosine, and CPP-115 afforded brain GABA+ concentration changes comparable to
74 merization of CP 3 in dry 1,2-dichloroethane affords bright green diamagnetic Co(III)(TPP)(N-py-DTDA(
79 eve a level of protection equivalent to that afforded by either single agent at its full dose.IMPORTA
81 antage of the high spatiotemporal resolution afforded by genetically encoded Forster resonance energy
83 ince the demonstration of sterile protection afforded by injection of irradiated sporozoites, CD8(+)
84 Combined with the long interrogation times afforded by ion traps, a broad range of molecular ions c
85 cost efficiency and ease of data production afforded by next-generation sequencing have created new
89 e that the association with non-specific DNA afforded by polymerization may enable regulatory behavio
97 gely overlooked the distinct role of viruses afforded by their unique ability to rapidly mutate and a
99 capitalize on the precise and rapid control afforded by this optogenetic tool, together with quantit
101 ufficient for processing the large data sets afforded by this technological advancement, and are unsu
102 ance, and the other functional opportunities afforded by usage of a heteroaromatic system, we believe
103 s also revealed that the protective immunity afforded by vaccination with the batA mutant strain is p
105 th lithium-magnesium and lithium-zinc amides affords C-2 or C-8 functionalized derivatives in a regio
108 n, oxygen, sulfur, and fluorine nucleophiles afforded chiral 3,4-disubstituted 2-(trifluoromethyl)pyr
109 stimulation to a particular phase of tremor afforded clinically significant tremor relief (up to 87%
110 nges in the ratios of the two photocatalysts afford complementary chemical control over these reactio
111 fied hit VA240 in synthesized analogues 6-41 afforded compound 11 (N-[(1-benzyl-1H-indol-3-yl)methyl]
112 are wet-exfoliated under mild conditions and afford countless features that are single and double lay
113 reaction of TEMPO with Lewis acid and Cp*2Fe afforded [Cp*2Fe][(C5H6Me4NOE(C6F5)3] (E = B 10, Al 11).
114 4 with isobutene while with benzoyl peroxide afforded [Cp*2Fe][PhC(O)OE(C6F5)3] (E = B 5, Al 6).
120 With SnCl4, the cyclopropane dicarboxylates afforded cyclopentene derivatives through ring opening f
122 high spatial and temporal resolution of fMRI affords detailed mapping of regional pharmacodynamics th
124 des functionalized dichloronaphthalenes that afford diazatetracenes using Buchwald-Hartwig aminations
126 ing of beta-vinyl and ortho-methyl C-H bonds affords dimethylindene, demonstrating that the dehydroge
128 unsymmetrical dienophiles, these dendralenes afforded diversity-oriented quick access to many polycyc
130 f ring-fused cyclopentanones was achieved to afford efficient access to a range of spiroindanones.
135 approximately 5,000-7,000 cells/mm(2) ) that affords enhanced resolution in the frontal visual field.
137 .e. solvent, temperature and catalyst study) affords excellent yields (61-98 %) and mostly >90 % opti
138 atment of (Z)-1 with a minimum amount of THF afforded exclusively (E)-1 as the other diastereomeric p
141 on while reactions with C6Cl4O2 or (tht)AuCl afford formal oxidation of the phosphindene center and t
142 led the re-programming of SdCPS2 activity to afford four distinct products, thus advancing our unders
144 ng restrictions to nonprofit academic users, affording freely available high-quality, low-cost molecu
145 hesis polymerization (CM-ROMP) strategy that affords functionalized Grubbs-II initiators that subsequ
146 multiple homologs or homeologs in polyploids affords greater tolerance to mutations that can impact g
147 nt of mass spectrometers with detectors that afford high mass accuracy and resolution, such as time-o
149 in biomedical imaging, due to its ability to afford high-resolution images at depths in the cm range.
151 ling to produce (18)F-SO3F(-) was simple and afforded high radiochemical purity suitable for biologic
152 on in PD follows a distinct spatial pattern, affords high diagnostic accuracy, and is associated with
154 region between 1500-1700 nm (NIR-IIb window) affords high spatial resolution, deep-tissue penetration
155 nd the photolysis of 2,5-diphenyltetrazoles, affording highly reactive nitrile imines, is probed via
156 ric (MS) characterization of these molecules affords highly accurate molecular weight (MW) and drug-t
158 pheric pressures of trifluoroethylene (TrFE) affords hydrofluoronickelacyclopentanes L2Ni(C4F6H2) 2a-
159 h cleaves the C1-C2 bond of its substrate to afford hydroxymethylphosphonate on the biosynthetic path
160 mation of a silicon(I) radical intermediate, afforded [(IMe )2 SiH](+) I(-) (2) comprising the first
163 aryl-substituted benzylic stereocenters are afforded in excellent yields and enantiomeric ratios of
165 ether at ca. 150-250 degrees C for 5-25 min affords in most cases the 1,3-diaryl-1,4-dihydrobenzo[e]
166 doxime-based sorbent materials, but may also afford insight to understanding the extensive accumulati
167 f a Pfizer fragment library was optimized to afford IRAK4 inhibitors with nanomolar potency in cellul
169 id-point redox potential of the redox switch affords it sensitivity to cellular redox homeostasis.
172 d yields of dA, whereas less reactive thiols afford lower yields presumably due to a polarity mismatc
173 as rapidly grown in the last two decades and afforded many examples of bioinspired materials that are
174 unprecedented in vivo reduction process that affords Meisenheimer complexes of the clinical candidate
175 side-chain chlorination of 3-methylbenzoate affording methyl 3-(chloromethyl)benzoate, which is an i
176 gamma-C(sp(2))-H and gamma-C(sp(3))-H bonds afforded moderate yields of the gamma-C(sp(2))-H and gam
180 (CO)-C(CO) bond cleavage of 1,2-diketones to afford N,N'-diaroyl-N-arylbenzamidine intermediates.
181 l dinuclear complex under mild conditions to afford N-alkylated indole derivatives in good yield (up
182 wth factor to genome-free MS2 viral capsids, affording nanoscale delivery vectors that can target a v
183 es had a decrease in reports of inability to afford needed follow-up care (difference-in-differences
184 of ln kaddn vs 1/T were unimodal and linear, affording negative activation energies and entropies.
186 ng between pi-pi*and charge-transfer states, affording new insight into reverse intersystem crossing.
188 mphocyte depletion, continuous combo therapy afforded no greater T1D protection than did BAFFR-Fc alo
190 cross-talk between these two pathways could afford novel therapeutic opportunities for treating or h
191 o carry azides through the reaction sequence affords O-(omega-azidoalkyl-N,N-dialkylhydroxylamines th
192 ace mapping, we presented visual or auditory affording objects both within and outside subjects' reac
193 lar, the use of tandem mass spectrometry has afforded one of the most versatile methods to acquire st
196 -dichloroethane at 100 degrees C for 24 h to afford ortho-benzoxylated tertiary benzamides is describ
197 act with boronic esters and a N-activator to afford ortho-substituted benzylic boronic esters with fo
201 ectures can be well stabilized in liquids to afford permanent porosity, and thus opens up a new appro
203 known to enhance the absorption of light and afford photocatalysis with MOFs under visible-light irra
205 oute employs readily available reagents that afford polylactide in good yields with narrow polydisper
206 e processes are likely to be linked, thereby affording possibilities to improve vaccine design and to
207 Coupled to local translation, this process affords precise spatial and temporal control of protein
208 tive metal-free C-O and C-N bond-cleaving to afford prevalent heterocyclic structures of N-substitute
210 lybdenum monoaryloxide pyrrolide complex and affords products at a yield of up to 73 per cent and an
211 otherapy and PBT to treat unresectable NSCLC afford promising clinical outcomes and rates of toxic ef
213 equence, HVEM-deficient recipients failed to afford protection against respiratory reinfection with i
216 in mice leads to reduced atherosclerosis and affords protection against ischemia/reperfusion injury o
221 ating an external trigger for reactivity and affording residue specificity, GECX enables the capture
223 ive field effect transistor (ISFET) with the afforded SAM resulted in the production of a KI-sensitiv
224 Surrogate biomarkers for clinical outcomes afford scientific and economic efficiencies when investi
225 s for the hydrosilylation of CO2 by R3SiH to afford sequentially the bis(silyl)acetal, H2C(OSiR3)2, a
230 oxygenated or thiol-containing nucleophiles affording stable precursors of alpha-hydrazinoimines in
231 ation of the alt-lactam proceeds smoothly to afford stereoregular polymers with narrow dispersities.
233 cornerstone for the management of CVRDs, and afford substantial financial risk protection for vulnera
234 re uniformly anchored on carbon nanotubes to afford substantially increased current density, improved
235 ydes were condensed with oxalyl boronates to afford substituted boryl imidazoles in a regiocontrolled
237 dent memory T cells (TRM) have been shown to afford superior protection against infection, particular
238 ided in the bottom-up formation mechanism to afford synthesis of group 3-based metallic nitride clust
239 nctionalization by Sharpless dihydroxylation affords tertiary azides in excellent enantioselectivity
240 recombines either as a peroxide anion 7' to afford the aldehyde-to-carboxylic acid product or as a h
241 high degree of regio- and enantiocontrol to afford the aziridine products in good to excellent yield
242 level summary statistics made available here afford the best-available molecular genetic index of PTS
243 Lewis-acid catalyzed 1,3-borotropic shift to afford the boronic ester products in high yield and with
245 Me3)2, which could activate H2 reversibly to afford the first Si(II)-stabilized mononuclear dihydrido
246 lsilyl]methyl ligand, react with B(C6F5)3 to afford the ion pairs, {[Tism(Pr(i)Benz)]M}[HB(C6F5)3] (M
251 r can promote ring-opening polymerization to afford the resulting poly(3',5'-cyclic 3-(3-butenyl) thy
252 ondary kinetic resolution of the product (to afford the symmetrical dibromide) under the reaction con
253 zinones has been successfully established to afford the title compounds in good to excellent yield un
255 Its further reaction with fluorobenzene afforded the CAr -H bond activation product [1-F-2-IMe -
256 nd nitrogen-containing functional groups and afforded the corresponding ketones in up to 98% yield.
257 use of hydrochloric acid (12 N) in methanol afforded the desired free amino acids in 80-88% yields.
258 f an N-allyl-5-methylisoxazole-3-carboxamide afforded the E-cinnamylamines plausibly via a ligand-fre
259 mma-arylations of allylamines have generally afforded the E-cinnamylamines, the bidentate directing g
261 ith the fluorophore-conjugated DpTz reagents afforded the fluorescently labeled GCGR and GLP-1R ECL m
262 ing a toluene solution of 3a or 3b at reflux afforded the rearranged species ArSn(3-tricyclo[2.2.1.0(
263 tion and lipase-catalyzed kinetic resolution afforded the target compound in high yield and up to 99%
265 velopment of a new one-pot reaction sequence afforded the tricyclic core of several aspidospermatan-t
266 malononitrile derivatives 2 and enamines 1, affording the appealing and highly substituted 1,4-dihyd
267 de catalysis solves a synthetic challenge by affording the enantioselective reduction of allenes, the
269 thogonal tag into a complex natural scaffold affording the possibility of site-selective modification
272 of primary, secondary and tertiary alcohols affords the corresponding glycosides in excellent yield
274 Subsequent deprotonation with LiN(SiMe3 )2 affords the fluoroalkynyl complex [Ru(C identical withCF
277 component of anxious temperament, because it affords the moment-by-moment temporal resolution needed
278 cells maintain a mitochondrial reserve that affords the organelles distinct homeostatic sensing and
279 rm ion cyclotron resonance mass spectrometry affords the resolving power to determine an unprecedente
281 profile through the use of rhodol scaffolds affords the unique opportunity to image neuronal voltage
284 nd edge-specific postsynthetic modifications afforded three organic cages with alkynyl, alkenyl, and
287 e suggest that salience is something that is afforded to actions that realise epistemic affordance, w
288 stemic affordance, while attention per se is afforded to precise sensory evidence - or beliefs about
289 - and stereoselective fashion to exclusively afford trans-vinyldiboronates in good to excellent yield
290 energy regions of the computed phase diagram affords two materials with previously unreported crystal
293 agnetic films by varying growth temperature, affording unprecedented insights into the origin of the
294 ology, we studied Ccr7-deficient mice, which afforded us the capacity to study infection in mice with
295 ost elegant and geometrically complex forms, affords us with an exhaustive library of natural templat
296 Bio-TDS is a flexible retrieval system that affords users from multiple bioscience domains (e.g. gen
297 chieved in high levels of stereoselectivity, affording versatile tertiary propargylic alcohols contai
299 on of Et2O into CH3CN solutions of the salts afforded X-ray quality crystals of five compounds with h
300 intermolecular version of this approach also afforded (Z)-alpha,beta-unsaturated amino esters in mode
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