ライフサイエンスコーパス: africanum

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1 berculosis complex, namely M. microti and M. africanum.

2 lineage, the Euro-American X lineage, and M. africanum.

3 . tuberculosis, 6 (1%) were identified as M. africanum, 8 (1%) were identified as M. bovis, and 13 (2

4 and CFP-10, comparing M. tuberculosis to M. africanum and a strain of M. africanum complemented with

5 IFN-alphabeta receptor knockout mice with M. africanum and monitored bacterial growth, lung disease,

6 complex (354 cases of M. tuberculosis, 20 M. africanum and one case of M. bovis) and 69 (15%) were du

7 apparatus member, Rv3879c, is mutated in M. africanum, and individuals infected with M. africanum le

8 mplex includes M. tuberculosis, M. bovis, M. africanum, and M. microti.

9 rculosis, Mycobacterium bovis, Mycobacterium africanum, and Mycobacterium microti and had a sensitivi

10 However, there is no simple definition of M. africanum, and some authors question the validity of thi

11 y identified as M. bovis were shown to be M. africanum because they had a wild-type pncA sequence wit

12 dentifications for all TBC members except M. africanum, but further characterization resulted in prof

13 isolates from Sierra Leone, identified as M. africanum by biochemical and growth characteristics.

14 strains, although these were enriched in M. africanum cell lysates, suggesting a modest ESX-1 secret

15 erculosis to M. africanum and a strain of M. africanum complemented with M. tuberculosis Rv3879c.

16 In mice, M. africanum demonstrated smaller bacterial population size

17 Genotypic analyses identified a cluster (M. africanum group A) which included M. africanumT and was

18 These results confirm impaired fitness of M. africanum in vivo and indicate that Rv3879c is not requi

19 FN-alphabeta is pathogenic during chronic M. africanum infection and that the pathogenic effects may

20 Fourteen Sierra Leone M. africanum isolates (designated group A) had katG codon 2

21 Three M. africanum isolates (group B) had katG codon 203 ACT Thr,

22 Drug-resistant M. africanum isolates had katG and rpoB mutations similar t

23 All M. africanum isolates had the ancestral CTG Leu at katG cod

24 etion, specific to the animal-adapted and M. africanum L6 lineages, that restores ESAT-6 secretion by

25 africanum, and individuals infected with M. africanum less frequently demonstrate T-cell responses t

26 ovis and in the closely linked Mycobacterium africanum lineage 6 (L6) that likely account for this di

27 berculosis complex (TBC; M. tuberculosis, M. africanum, M. canettii, M. microti, M. bovis, and M. bov

28 M. tuberculosis, M. bovis, M. bovis BCG, M. africanum, M. microti, and M. canettii was developed.

29 haracterized isolates of M. tuberculosis, M. africanum, M. microti, M. bovis, and M. bovis BCG.

30 ositive pulmonary tuberculosis exposed to M. africanum progress less frequently to active disease wit

31 Future studies of M. africanum should include both phenotypic and genotypic a

32 habeta during infection with a Mycobacterium africanum strain that induces low IFN-beta levels.

33 These two M. africanum strains contain multiple (three and six) copie

34 ngly, coincident polymorphisms linked one M. africanum subtype I genotype with the dassie bacillus an

35 the oryx bacillus, and the two Mycobacterium africanum subtype I variants.

36 uberculosis (or M. africanum subtype II), M. africanum subtype I, M. bovis, M. bovis BCG, M. caprae,

37 r as MtbC composed of M. tuberculosis (or M. africanum subtype II), M. africanum subtype I, M. bovis,

38 de Mycobacterium tuberculosis, Mycobacterium africanum (subtypes I and II), Mycobacterium bovis (alon

39 Phenotypic identification of M. africanum yielded a heterogeneous collection of strains.

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