ライフサイエンスコーパス: age of onset

1 use was identified inversely correlated with age of onset.

2 or PLCE1, specific mutations correlated with age of onset.

3 neuron (FS-->SP) synapses, depending on the age of onset.

4 marijuana users was associated with earlier age of onset.

5 both of anticipation and of heritability of age of onset.

6 ume, (11)C-Pittsburgh Compound B binding, or age of onset.

7 d 10 and 5 y, respectively, before estimated age of onset.

8 f the population, the foods involved and the age of onset.

9 ry cortical region 15 y before the estimated age of onset.

10 um (11)C-PBR28 binding correlated with lower age of onset.

11 disease (AD) and is associated with earlier age of onset.

12 and variation in downstream methylation and age of onset.

13 nitor allele length is the major modifier of age of onset.

14 S170F mutation causing the earliest reported age of onset.

15 ther Parkinsonian syndromes, VP had an older age of onset.

16 d prion diseases although it does not modify age of onset.

17 ociated with conduct disorder, regardless of age of onset.

18 lial amyloid cardiomyopathy, with an earlier age of onset.

19 inct tumor spectra with varying severity and age of onset.

20 erity of HD and is inversely correlated with age of onset.

21 with risk of sporadic ALS, site of onset, or age of onset.

22 ssociated with sCJD but conferred an earlier age of onset.

23 cade to chorioretinal dystrophy with a later age of onset.

24 ease that determine disease presentation and age of onset.

25 ral mechanism of AD that is independent from age of onset.

26 ual age of subjects rather than with disease age of onset.

27 ons remained significant after adjusting for age of onset.

28 complex cognitive-emotional with increasing age of onset.

29 ants associated with a significantly younger age of onset.

30 T promoter are bidirectional modifiers of HD age of onset.

31 ther a selected variant is fixed or not) and age of onset.

32 t amyloid deposition in human brain and LOAD age-of-onset.

33 isease severity accompanied by a decrease in age-of-onset.

34 tatives of these categories across different ages of onset.

35 e, with longer expansions leading to earlier ages of onset.

36 ioration in SARA was associated with younger age of onset (-0.02 points per year [0.01] per year of a

37 Ten subjects had confirmed diabetes (mean age of onset 15 years [range 5-28]), and 13 had metaboli

38 Age of onset 21 was associated with a smaller hippocampu

39 was exacerbated by Trp53 co-deletion (median age of onset 275 days, penetrance 82% at 1 year), with c

40 PPs facilitated melanoma development (median age of onset 308 days, penetrance 40% at 1 year).

41 impairment (mean visual acuity, 20/40; mean age of onset, 42 years), even in the sporadic case of fa

42 nary artery disease was common (33%; average age of onset, 49.4 years), and untreated LDL-C concentra

43 oimaging evaluations 2.4 years apart [median age of onset = 67 years (range: 49-76), seven females].

44 in the study (367 girls and 408 boys; median age of onset, 7.5 months [interquartile range, 4.2-16.5

45 ADAD (odds ratio 1.09 per 1 year increase in age of onset, 95% CI 1.04-1.14, p=0.0003); and motor sym

46 arly autonomic failure, female gender, older age of onset, a short interval from disease onset to rea

47 pe correlation between podocin mutations and age of onset, a worldwide cohort of 430 patients from 40

48 Alzheimer's disease (AD) age of onset (ADAOO) varies greatly between individuals,

49 Although the age of onset, affected muscles, and severity vary consid

50 clinical manifestations of JMML in terms of age of onset, aggressiveness, and organ infiltration wit

51 h differentiated the clusters in two models: age of onset, allergic sensitization, severity, and rece

52 Patients with early age-of-onset Alzheimer's disease show more rapid progres

53 We found (1) a younger age of onset among blacks; (2) better survival in blacks

54 The older age of onset among female cases in general, and among fe

55 8%) occurred, but with a large left shift in age of onset among residual deaths.

56 nts with biallelic MAK mutations had a later age of onset and a milder retinal phenotype compared wit

57 etected variable expressivity in relation to age of onset and a possible case of incomplete penetranc

58 s presented a common phenotype with an early age of onset and a prompt macular degeneration, whereas

59 In PSP an RS phenotype, male gender, older age of onset and a short interval from disease onset to

60 The median age of onset and age at examination of 40 patients with

61 ts as a potent genetic modifier for AD risk, age of onset and conversion.

62 ed greatly among the mouse models concerning age of onset and cortical brain region.

63 17 individuals with the mutation) to analyze age of onset and death in affected and censored individu

64 ich is second only to congenital NCL for its age of onset and devastating progression.

65 Mean age of onset and disease duration were 70.6 (SD+/- 6.42)

66 chanism for the observed correlation between age of onset and disease severity with respect to the le

67 atrophy enlargement and BCVA, adjusting for age of onset and duration of disease.

68 logy underlying wheezing phenotypes based on age of onset and duration of disease.

69 ized or complex partial), seizure frequency, age of onset and duration of epilepsy with Braak stage a

70 ociations between asthma phenotypes based on age of onset and duration of symptoms, and (i) spirometr

71 According to multivariate analysis, young age of onset and elevated ESR appeared to be predictive

72 What effect does the role of age of onset and etiology of MD have on cortical respons

73 ther synucleinopathies, resulting in a lower age of onset and exacerbating disease progression.

74 iation with the acute phase response and its age of onset and female preponderance appear to have evo

75 campal volumes in MDD patients, moderated by age of onset and first episode versus recurrent episode

76 ffects of rs13102260 on HTT expression to HD age of onset and have implications for HTT silencing tre

77 er hippocampal volumes after controlling for age of onset and hyperglycemia exposure (main effect of

78 ound heterozygotes had significantly earlier age of onset and increased diabetes mellitus, compared t

79 t of patients with a variety of CHD: (1) the age of onset and initial treatment of AF, coexistence of

80 which may explain the marked differences in age of onset and manifestations.

81 ce slow inactivation suggests that a delayed age of onset and milder symptoms in association with a l

82 onian phenotypes but tend to have an earlier age of onset and more associated cognitive changes than

83 n of family members presenting with an early age of onset and multiple primary tumors.

84 reported in multiple families with variable age of onset and N98S that has been described as an earl

85 The similar age of onset and neurological decline in the two unrelat

86 shown that the severity of disease symptoms, age of onset and progression are related to the length o

87 partially functional mutant frataxin delays age of onset and reduces diabetes mellitus, compared to

88 e to overnutrition profoundly influences the age of onset and severity of diet-induced type 2 diabete

89 ominant blinding retinopathies with variable age of onset and severity.

90 urological symptoms and the contributions of age of onset and specific mutation type on symptoms.

91 e of cataracts based on the lens appearance, age of onset and systemic findings.

92 were separable into specific groups based on age of onset and the degree of slowing of motor nerve co

93 Mean age of onset and the presence of cardiomyopathy and diab

94 d 'in the last 12 months', doctor diagnosis, age of onset and treatments of asthma, rhinitis and ecze

95 h riluzole-treated ALS cases with an earlier age of onset and with a shorter diagnostic delay display

96 or neurodevelopmental disorders with diverse ages of onset and socioemotional symptoms.

97 terms of prevalence in males versus females, age of onset, and histologic features.

98 d in vitiligo susceptibility versus vitiligo age of onset, and illustrate that genome-wide analyses c

99 eatures of multiple sclerosis that differ by age of onset, and made recommendations regarding the tre

100 ADRS scores, controlling for age, education, age of onset, and race.

101 exhibit a sex bias in rates of presentation, age of onset, and symptom severity.

102 effect of FA on AD severity, chronicity, and age of onset, and the temporal relationship between the

103 the CAG repeat is inversely correlated with age of onset (AO) in HD patients, while environmental an

104 peat diseases in which both disease risk and age of onset are strongly dependent on the repeat length

105 cannabis use parameters, including a younger age of onset, are frequently reported.

106 Atypical clinical traits included an earlier age of onset (around 30 years), aggressiveness (three ha

107 ear female preponderance (76.5%) with a mean age of onset at 54 years.

108 se chi(2) meta-analysis across ten pediatric-age-of-onset autoimmune diseases (pAIDs) in a case-contr

109 atypical form of gastric NET has an earlier age of onset, behaves more aggressively and has atypical

110 here were no significant differences in mean age of onset between homozygotes and the minimal and mod

111 Secondary outcomes included age of onset, body mass index, and effect on protein fun

112 We assessed Parkinson's disease age of onset both as a categorical variable (dichotomise

113 opsychiatric disorders vary substantially in age of onset but are best understood within the context

114 y, apolipoprotein E4 carriers have a delayed age of onset by 10 years (P = 0.02).

115 ost common anxiety disorder; it has an early age of onset--by age 11 years in about 50% and by age 20

116 ing antisense oligonucleotides (ASOs) at the age of onset can extend survival and rescue the neurolog

117 Because the age of onset can vary by several years among those with

118 ldren with normal intelligence show an early age of onset, chronicity, and high prevalence of comorbi

119 categories, which differ in cell of origin, age of onset, clinical and histologic presentation, patt

120 d poorer tumor-specific survival and earlier age of onset compared with patients homozygous for the m

121 We evaluate how age of onset could indicate the need for germline mutati

122 in CD is associated with osteoporosis and an age of onset dependent influence towards underweight, hi

123 ssed genotypic influences on susceptibility, age of onset, disease severity, as well as brain lesion

124 s of AD that take into consideration varying age of onset (early versus late) and the influence of ag

125 Despite the observed age of onset effects, longitudinal studies are needed to

126 ed with the estimated presbyopia prevalence, age of onset, employment rate, gross domestic product (G

127 and AIS, smoking is a risk factor for early age of onset, even among those with few vascular risk fa

128 The mean age of onset for individuals with AA was significantly y

129 Genetic variability in DNM3 modifies age of onset for LRRK2 Gly2019Ser parkinsonism and infor

130 before age 6 (P = .0008 compared to expected age of onset for psoriatic arthritis in childhood).

131 ith ND individuals in psychosis symptoms and age of onset for psychosis proneness; this continues to

132 We used data for age of onset (from first report of cognitive decline), d

133 ar subgroups that reflect differences in the age of onset, gender predominance and response to therap

134 -generational kindreds, and by analysing the age of onset, gender ratio and survival in a large cohor

135 multiple system atrophy-cerebellar ataxia), age of onset, gender, and early autonomic symptoms, on t

136 r duration among essential tremor cases with age of onset >40 years.

137 oungest generation had significantly earlier age of onset (>10 years) compared with the next oldest g

138 The reported age of onset has important implications for the diagnosi

139 ed progression of ataxia symptoms related to age of onset have implications for the design of clinica

140 et (hazard ratio 1.28, P < 0.014); (v) older age of onset (hazard ratio 1.02, P = 0.001); and (vi) de

141 FEV(1) was also dependent on exacerbations, age of onset, height, age, sex, and log10 sputum eosinop

142 m C-peptide were lower hemoglobin A1C, older age of onset, higher frequency of HLA DR3 genotype, and

143 ly mirror the human disease in regard to the age of onset, histological appearance, invasiveness and

144 a genome-wide association study of vitiligo age of onset in 1,339 generalized vitiligo patients, wit

145 to well-established findings implicating the age of onset in alcohol use in the development of alcoho

146 enesis in general and modifies breast cancer age of onset in BRCA1/2 mutations carriers.

147 VEGFA seems to be associated with a younger age of onset in combination with poor response rates to

148 es the natural history of AD typified by the age of onset in E280A mutation carriers.

149 nia is a complex mental disorder with a peak age of onset in early adulthood.

150 D disease allele was associated with delayed age of onset in familial cases, whereas the presence of

151 Anticipation is the phenomenon whereby age of onset in genetic disease decreases in successive

152 -type HTT allele was associated with earlier age of onset in HD patients in an extreme case-based coh

153 gating contribute significantly to an early age of onset in SCA13.

154 ncrease in risk for CRC incidence and death; age of onset in the FDR was not significantly associated

155 fied a quantitative trait locus for vitiligo age of onset in the major histocompatibility complex (MH

156 fespan calendar predicted the characteristic age of onset in young adults and sex differences in schi

157 d with measures of striatal degeneration and age-of-onset in a cohort of 25 HD brains (r = 0.56, P =

158 ed phenotype to major psychosis with younger age of onset indicate congruence between the linkage and

159 activation shifts have been linked to early age of onset inherited erythromelalgia, while mutations

160 ct above 35 repeats causes disease, with the age of onset inversely related to the degree of expansio

161 Average age of onset is 7 months, with delay to diagnosis of 9.1

162 The typical age of onset is approximately 5-7 years, and the majorit

163 Median age of onset is in the late teens to early 20s for both

164 olyQ) repeat (>37Q) in huntingtin (htt), and age of onset is inversely correlated with the length of

165 28-year difference between parent and child age of onset is observed (p = 0.002), but including indi

166 Age of onset is often between 6 months and 7 years.We as

167 ies, since symptom onset is near certain and age of onset is predictable.

168 th African Arab-Berber populations, although age of onset is variable.

169 tients, PD patients with pain had an earlier age of onset, longer disease duration, and higher depres

170 as greatest over time in T1DGC subjects with age of onset </=5 years (P = 0.004) and onset between ag

171 ABCA4 mutations as well as age of onset <20 years were significantly associated wit

172 survival ranged from 1 to 17 years, with the age of onset <40 years in six (10%) and >60 in 19 (30%).

173 0(-5)) (unstratified p < 0.0001, stratified [age of onset <50 years and unaffected age >50 years] p <

174 AF (unstratified p = 1 x 10(-8), stratified [age of onset <50 years and unaffected age >50 years] p =

175 or persistent PTSD, 69.6% for pre-late life (age of onset <55 years and age at last diagnosis <55 yea

176 a, 1.8% had persistent PTSD into later life (age of onset <55 years as well as a recent diagnosis).

177 We hypothesized that BPD cases with an early age of onset (</=21 years old) would be particularly lik

178 urvival rate is negatively impacted by older age of onset, male sex, scleroderma renal crisis, pulmon

179 Early age of onset might be a sign of hereditary RCC.

180 e hypothesized that stratification of IBD by age of onset might identify additional genes associated

181 gested genetic variability within DNM3 as an age-of-onset modifier of disease (n=232; rs2421947; hapl

182 eristics than typical TTS, including younger age of onset, more frequent ST-segment depression, highe

183 because of differences, such as the younger age of onset, multi-focality of P-NETs, and concomitant

184 d motor symptoms were more common at younger age of onset (myoclonus 0.93, 0.90-0.97, p=0.0007; seizu

185 had a more severe phenotype with an average age of onset of 10 months, an average corrected QT inter

186 (232 eyes; 102 male [77.3%]) evaluated with age of onset of 36.9 +/- 11.4 years.

187 nifestations and personal/family history, an age of onset of 46 years or younger should trigger consi

188 e 20 in all but one patient, with an average age of onset of 7.9 years.

189 ed eight females and four males, with a mean age of onset of 73 years (range: 49-82).

190 significantly associated as modifiers of the age of onset of AD (CD44, rs187116, P=1.29 x 10(-)(1)(2)

191 le negative (G-) AD subjects exhibit delayed age of onset of AD (P=0.017) and significantly reduced r

192 es, unstratified and stratified according to age of onset of AF and unaffected age >50 years, there w

193 lated with differences in the prevalence and age of onset of age-associated diseases (e.g., dementia,

194 being female, older, and married; an earlier age of onset of alcohol dependence; and self-reported de

195 It increases the occurrence and lowers the age of onset of Alzheimer's disease.

196 family, is the major genetic modifier of the age of onset of Alzheimer's disease.

197 We determined the age of onset of amenorrhea after breast cancer for women

198 lationship between the log incidence and log age of onset of amyotrophic lateral sclerosis is consist

199 SNP did not associate significantly with the age of onset of angiographically verified coronary arter

200 been no genome-wide association study of the age of onset of asthma in children.

201 activation are dependent upon the cause and age of onset of blindness.

202 Finally, an effect of genotype on the age of onset of CAD was detected but only in men carryin

203 ently been reported, which may influence the age of onset of CAD.

204 ver-expression, and also correlated with the age of onset of cancer, aggressiveness of the disease an

205 lower 40 Hz power correlated with an earlier age of onset of cannabis use (p<0.04).

206 77, p < .001) and positively associated with age of onset of cannabis use (r = .51, p = .027) but was

207 cular risk) underlies the relatively earlier age of onset of cardiovascular diseases among African Am

208 nicities had a higher prevalence and earlier age of onset of cataract than Europeans.

209 e first genome-wide association study of the age of onset of childhood asthma among participants in t

210 These brain changes are associated with age of onset of depression, as well as cumulative life-t

211 The increasing prevalence and younger age of onset of diabetes foreshadow greater diabetes-att

212 There was no correlation between age of onset of disease and prevalence of these mtDNA SN

213 so consistently identified the importance of age of onset of disease and the presence of eosinophils

214 f the mip1 mutant strain correlates with the age of onset of disease associated with the human orthol

215 The age of onset of disease is inversely correlated with the

216 A in adults with CVS and correlate this with age of onset of disease.

217 Age of onset of dystonia, duration of disease prior to s

218 Age of onset of generalized vitiligo also involves a sub

219 The disease risk and age of onset of Huntington disease (HD) and nine other r

220 The age of onset of Huntington's disease (HD) is determined

221 tion has recently been suggested between the age of onset of inherited erythromelalgia and the extent

222 esence of human leukocyte antigen (HLA-)B27, age of onset of JIA, and sex were analyzed for their pre

223 1383 in BPIFB1 were also associated with the age of onset of lung cancer (p = 0.001 and 0.006, respec

224 Age of onset of major symptoms (syncope or cardiac arres

225 particular, we focus on the effects that the age of onset of male puberty and rates of spermatogenesi

226 Age of onset of multiple sclerosis (MS) peaks in the 3rd

227 Median age of onset of neurological symptoms was 14 years (rang

228 ior cortical regions but also with the young age of onset of PCA.

229 Pathways associated with age of onset of persistent P. aeruginosa infection were

230 phenotypes, including lung disease severity, age of onset of persistent Pseudomonas aeruginosa (P. ae

231 In short-term users, a younger age of onset of regular cannabis use and greater frequen

232 ndophenotype, which normalize by the typical age of onset of schizophrenia unless there has been more

233 ulthood, which temporally coincides with the age of onset of schizophrenia.

234 cal presentation is variable, and depends on age of onset of seizures and the location and size of le

235 cipants with sodium mutations had an earlier age of onset of stiffness (5 years versus 10 years), fre

236 Preliminary data suggests that age of onset of symptoms (pediatric vs. adult) may be a

237 The age of onset of symptoms and the clinical presentation o

238 mean [SD] age, 29.9 [14.7] years; mean [SD] age of onset of symptoms, 21.9 [13.3] years) showed atro

239 125Ser and p.Arg127Cys mutations in terms of age of onset of symptoms, extent of nail involvement, an

240 The age of onset of the affected family members was the seco

241 wever, the inclusion of individuals past the age of onset of the defining behaviors complicates inter

242 variables (lung function, reversibility and age of onset of the disease) or by biomarkers (eosinophi

243 cteristics and whether these SNPs affect the age of onset of the disease, recurrence, and survival.

244 iation of the two SNPs in 4q22/SNCA with the age of onset of the disease.

245 The average age of onset of the monogenic forms of autoimmune endocr

246 neurons of C. elegans, demonstrate that the age of onset of these defects is regulated by specific g

247 Although the age of onset of these diseases range from juvenile [i.e.

248 nal anisotropy in this region was related to age of onset of training and sensorimotor synchronizatio

249 The age of onset of type 2 diabetes is decreasing.

250 In cannabis-dependent subjects, earlier age of onset of use correlated with lower [DeltaBP(ND)]

251 tivity; and (3) the severity rather than the age of onset of vestibular dysfunction differentiates wh

252 A to published linkage studies investigating age-of-onset of Alzheimer's disease and body mass index

253 Here, the age-of-onset of association between genetic variants at

254 ApoE4 isoform significantly reduces the mean age-of-onset of dementia through unknown mechanisms.

255 men with truncating MLH1 mutations had later ages of onset of endometrial cancer than those with nont

256 ischaemic stroke was more prevalent at older ages of onset of symptoms of ADAD (odds ratio 1.09 per 1

257 Age of onset or duration of epilepsy and lateralized ele

258 higher dosage, longer duration, and earlier age of onset) or with distinct cannabinoid compounds (i.

259 her obesity early in adulthood affects risk, age of onset, or outcomes of patients with HCC.

260 eases have a sex bias in their presentation, age of onset, or treatment response.

261 various characteristics, including age, sex, age of onset, oral symptoms, histologic features, plasmi

262 Patients with PSP had an older age of onset (P < 0.001), but similar disease duration t

263 o APOL1 risk alleles associated with earlier age of onset (P = 0.01) and faster progression to ESRD (

264 C9P cases had an earlier age of onset (p=0.047) and, in the subset of patients wh

265 Asthma is a heterogeneous disease in which age of onset plays an important role.

266 x, recurrent MDD, recurrent early-onset MDD, age of onset, pre-pubertal onset MDD or typical-like MDD

267 eek 4), lower baseline anxiety, and an older age of onset predict response at 12 weeks.

268 Young age of onset, presence of ANA, and elevated ESR appeared

269 e sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes

270 reased dosewise (Ptrend<0.0001) with earlier age of onset (Ptrend=0.0009), independently.

271 The number of cases and median age of onset (range) for specific features were: seven w

272 subjects from the 43 families (n = 63), the age of onset ranged from 33 to 72 years (median 52 years

273 t temporally primary (based on retrospective age-of-onset reports) fear/anger, distress, disruptive b

274 The GRPS also differentiates classic age of onset schizophrenia from early onset and late-ons

275 Later age of onset, specific complicating features, and the SP

276 % CI, 1.12-1.45), with significantly younger age of onset (survey linear regression; adjusted beta, -

277 Age of onset, survival, ALS Functional Rating Scale (ALS

278 rom one another; ALS cases exhibited earlier age of onset than FTD cases; and individuals with spinal

279 ividuals with spinal-onset exhibited earlier age of onset than those with bulbar-onset.

280 t one person had non-focal involvement at an age of onset that was younger than 22 years.

281 Intriguingly, both aggregation and age of onset trend with repeat length in similar ways, e

282 Age of onset was </=3 years in 25 cases.

283 The mean age of onset was 16 years (range 3 to 39).

284 The median age of onset was 2.45 years with a male-to-female ratio

285 ld remember, whereas for the others the mean age of onset was 21 +/- 9 years.

286 Non-CLIPPERS patients' median age of onset was 52 years (interquartile range, 39-59) a

287 CLIPPERS patients' median age of onset was 58 years (interquartile range, 24-72) a

288 of pancreatic cancer by 2 to 6 years (median age of onset was 64 years for patients with normal weigh

289 Older age of onset was associated with slower VA loss: Patient

290 Average age of onset was earlier in multiple system atrophy-cere

291 The age of onset was highly variable, from early adulthood,

292 rk conditions, self-reported ever asthma and age of onset was obtained by household interview.

293 The latest age of onset was recorded at 64 years, in a patient diag

294 ross-sectional survey data in which reported age of onset was recorded.

295 In this cohort, the age of onset was variable but included cases of young-on

296 Greater dose and earlier age of onset were associated with these alterations.

297 ntrast, there was no association of vitiligo age of onset with any other MHC or non-MHC loci that are

298 ount sibling relations, sex of siblings, and age of onset, with respect to ischemic stroke incidence.

299 ores from 1 year of age and according to the age of onset within or after the first year of life.

300 small activation shifts have been linked to age of onset within the second decade of life.