ライフサイエンスコーパス: age-related change

1 hat incentive processing should also undergo age-related change.

2 ell, CD8 and CD4 subpopulations demonstrated age-related changes.

3 k throughout adulthood prevent most of these age-related changes.

4 f the murine biomarkers in DMD, with similar age-related changes.

5 tum, with the latter being more sensitive to age-related changes.

6 rmation is accumulating about infections and age-related changes.

7 pan, chimpanzees did not display significant age-related changes.

8 t, dorsal medial prefrontal cortex showed no age-related changes.

9 ing of rewards and costs undergo substantial age-related changes.

10 ous system and displays neurodevelopment and age-related changes.

11 ral stem cells being especially sensitive to age-related changes.

12 ntal conditions may accelerate or potentiate age-related changes.

13 lly-curated and readily accessible source of age-related changes.

14 y properties, appears ideal for easing these age-related changes.

15 Before accounting for age-related change, 50.0% (75 eyes) showed progression b

16 Are these age-related changes amenable to genetic manipulations th

17 xically, DNA repair can itself be subject to age-related changes and deterioration.

18 rieval and to understand the neural basis of age-related changes and individual differences in the ca

19 rinsic and extrinsic factors impact observed age-related changes and sex-related differences in skele

20 We found that these age-related changes are associated with the repression o

21 ntralized resource in which data on multiple age-related changes are collated.

22 However, age-related changes are likely multifactorial, and the r

23 ome-wide patterns of DNA methylation so that age-related changes are profoundly delayed, while change

24 It is unclear whether these age-related changes are secondary to decreases in region

25 process, and demonstrate that most of these age-related changes are, by their fundamental nature, re

26 Age-related changes associated with metabolic disturbanc

27 These differences were independent of age-related changes at the choroid-retina interface.

28 set the stage for integrated analyses of how age-related changes at the molecular, cellular and popul

29 in the SVZ declines through aging; however, age-related changes attributable specifically to the SVZ

30 to aging processes in joint tissues, but the age-related changes being discovered certainly could pla

31 is age reset requires novel methods to mimic age-related changes but also offers opportunities for st

32 Age-related changes can also be linked to each other in

33 integrity during adulthood and show that its age-related changes can be rescued by a TIE2 agonistic a

34 However, underlying health status and age-related changes can have an impact on tolerance of h

35 This study examined age-related changes, gender differences, and the interac

36 t study was twofold: (1) to test patterns of age-related change (i.e., linear, quadratic, and cubic)

37 These age-related changes impact older transplant candidates a

38 determine the mechanism responsible for the age related change in B-1a cell IgM, we established a mi

39 These data shed light on the nature of age related changes in reaching-to-grasp movements and e

40 of decline of lung function is greater than age-related change in a substantial proportion of patien

41 inguish between biological and chronological age-related change in arterial health in humans.

42 Age-related change in asymmetry in non-right-handed typi

43 eft heart morphology over time suggests less age-related change in H2RA users.

44 ion in the elderly, much less is known about age-related change in pulmonary artery systolic pressure

45 However, there was no evidence of age-related change in Ricco's area for either achromatic

46 his study was to longitudinally characterize age-related change in sympathetic innervation of the spl

47 There is no age-related change in the cross-sectional area of the fo

48 ations in the reward system, and identify an age-related change in the direction of the relationship

49 mously and others of which are imposed by an age-related change in the local milieu or systemic envir

50 Here, we identify an age-related change in the temperature preference of adul

51 We tested the hypothesis that age-related change in waist circumference (to reflect ce

52 ultiplexed Raman spectroscopy to analyze the age-related changes in 7 proteins, 3 lipids, and 8 advan

53 Raman spectroscopy can identify and quantify age-related changes in a single nondestructive measureme

54 Moreover, age-related changes in Abeta oligomers and tau phosphory

55 n adapt to blur and disparity stimuli and to age-related changes in accommodative amplitude.

56 Age-related changes in amygdala functional connectivity

57 analysis was used to evaluate positional and age-related changes in angle morphology.

58 ATP in the 1A arteriole, and to investigate age-related changes in ATP overflow.

59 Secondary analyses suggested age-related changes in attention bias to happy faces.

60 The age-related changes in behaviour and dendritic spine den

61 leus (SCN), relatively little is known about age-related changes in Bmal1 expression in other tissues

62 Furthermore, age-related changes in body composition are still unclea

63 ases significantly with age, coinciding with age-related changes in body composition that are common

64 lated to chronological age or are related to age-related changes in body composition.

65 genic mouse strain that exhibits accelerated age-related changes in body composition.

66 We discovered distinct age-related changes in both model organisms.

67 by nestin gene regulatory elements to define age-related changes in both numbers of satellite cells t

68 trajectory of brain development, reflecting age-related changes in brain excitability.

69 Age-related changes in brain function include those affe

70 esonance spectroscopy (MRS) has demonstrated age-related changes in brain metabolites that may underl

71 Here we report age-related changes in brain size in autistic and typica

72 Understanding the relationships between age-related changes in brain structure and cognitive fun

73 Preliminary data showed no substantial age-related changes in brentuximab vedotin pharmacokinet

74 d plasticity, and this could in part reflect age-related changes in Ca2+ homeostasis.

75 The molecular factors that regulate age-related changes in cardiac physiology and contribute

76 d cardiovascular mortality but its effect on age-related changes in cardiac structure and function is

77 nes the effect of daily physical activity on age-related changes in cardiac structure, function, meta

78 mes of ageing can now be delayed or reduced, age-related changes in cellular, molecular and physiolog

79 eral auditory system that reduce audibility, age-related changes in central auditory and attention-re

80 Thus, age-related changes in central progestogen formation in

81 that APOE epsilon4 carriers showed stronger age-related changes in cerebrospinal fluid phosphorylate

82 Together, our data reveal multiple age-related changes in chromosome architecture that coul

83 Age-related changes in circadian rhythms may contribute

84 These data support age-related changes in CNI metabolism.

85 resent a pilot study illustrating how normal age-related changes in cognition and the linguistic cont

86 These findings suggest that even very subtle age-related changes in cognition have detrimental effect

87 function, and up to half of the variance in age-related changes in cognition, brain volume, and neur

88 l and longitudinal study in order to address age-related changes in community-dwelling individuals.

89 apacity with aging but has limited effect on age-related changes in concentric remodeling, diastolic

90 Developmental and adult age-related changes in cortical thickness followed close

91 Age-related changes in crowding may in part explain slow

92 literature, our tentative conclusion is that age-related changes in CSF circulatory physiology and th

93 KEY POINTS: Age-related changes in cutaneous microvascular and cardi

94 these responses are maximally restrained by age-related changes in cutaneous microvascular and cardi

95 e examination of one potential substrate for age-related changes in decision-making, namely age-relat

96 on melanoma progression, we examined whether age-related changes in dermal fibroblasts could drive me

97 Previous studies have demonstrated age-related changes in detrusor function and urothelial

98 extent of, and interindividual variation in, age-related changes in DNA methylation at specific CpG i

99 ion patterns, leading to the hypothesis that age-related changes in DNA methylation may partially und

100 DR is generally strongly protective against age-related changes in DNA methylation.

101 NF- and GABA-related genes exhibited similar age-related changes in DNAm and correlation with gene ex

102 Age-related changes in dynamics occur in accommodative a

103 However, Shc proteins did not influence age-related changes in energy expenditure or RQ.

104 Studies examining the age-related changes in expression of these proteins have

105 g have identified subsets of genes that show age-related changes in expression.

106 erations in colonic 5-HT signalling underlie age-related changes in faecal output in mice and whether

107 A simulation model was developed to predict age-related changes in foraging energetics of individual

108 development of posterior alpha power whereas age-related changes in frontal theta power deviated from

109 ging studies have associated such decline to age-related changes in general cognitive-control network

110 For this purpose, age-related changes in globin phenotypes of circulating

111 These data are the first to show age-related changes in gray:white matter ratio and corpu

112 These results are consistent in pattern with age-related changes in gray:white matter ratio and regio

113 Age-related changes in HC, height, and weight between bi

114 not a statistically significant predictor of age-related changes in HDL-cholesterol, triglyceride, in

115 ot well understood, several studies describe age-related changes in hematopoietic stem cells (HSCs) w

116 Here, we systematically investigated age-related changes in homotopic RSFC in 214 healthy ind

117 We observed marked age-related changes in homotopic RSFC with regionally sp

118 We argue that age-related changes in HSCs and in the hematopoietic sys

119 In this study, we explored age-related changes in human immunity during a primary v

120 There are limited data regarding age-related changes in immune function and metabolism of

121 Age-related changes in immune regulation are likely to a

122 and discuss a conceptual framework in which age-related changes in immunity might also affect the ba

123 These age-related changes in JNK phosphorylation correlated wi

124 We present longitudinal data on age-related changes in leg composition, strength, and mu

125 Age-related changes in lens elasticity and ciliary muscl

126 mporal dynamics and structural correlates of age-related changes in lexical-semantic processing.

127 Studies examining age-related changes in LTCCs have focused primarily on m

128 molecular and cellular changes of aging with age-related changes in lung physiology and disease susce

129 There are indications that at least some age-related changes in lymphopoiesis may be reversible.

130 We examined whether age-related changes in mammographic density were differe

131 Age-related changes in maternal reproductive allocation

132 Opposing age-related changes in mechanical and neural components

133 ations of mitochondria from mouse liver show age-related changes in membrane morphology.

134 ions in the hippocampal network that predict age-related changes in memory function and present poten

135 However, it is unclear if these age-related changes in microvascular and cardiac functio

136 In addition, we present evidence of age-related changes in mitochondrial Ang receptor expres

137 S generation), and whether exercise reverses age-related changes in mitochondrial function.

138 escribe the effect of light level on normal, age-related changes in monocular and binocular functiona

139 Taken together, these data suggest that age-related changes in MSC population dynamics result in

140 dial temporal lobe (MTL) in episodic memory, age-related changes in MTL structure and function may pa

141 for this group is that they are experiencing age-related changes in multiple organ systems, including

142 thritis occurs in older adults who also have age-related changes in muscle, bone, fat, and the nervou

143 ated tau 181/beta-amyloid 42 levels modulate age-related changes in myelin water fraction.

144 f >/= 30 kg/m(2), enhanced the expression of age-related changes in N glom in African Americans with

145 ry accuracy and reduce the commonly observed age-related changes in neural activity associated with s

146 this way, the model was modified to reflect age-related changes in neuromuscular function.

147 Nonetheless, age-related changes in neuron number do occur in focal r

148 e conclude that the general distribution and age-related changes in neuropeptides indicate a modulato

149 Here we aimed to (1) characterize the age-related changes in nigral dopaminergic neurons in th

150 d (2) What are the predicted consequences of age-related changes in norepinephrine signaling for cogn

151 Although muscle functional decline precedes age-related changes in other tissues, its contribution t

152 regions of the mouse brain exhibit different age-related changes in oxidative stress, as indicated by

153 acrophage TLR2 or FcgammaRIII expression, or age-related changes in phagocytic potential and bacteric

154 Concentrations changed with age, suggesting age-related changes in phthalate exposure and perhaps me

155 These data suggest that the accumulation of age-related changes in promoter-associated CpG islands m

156 We hypothesize that age-related changes in protein structural stability, oxi

157 Age-related changes in rabbit O-CALT are similar to thos

158 igated whether crowding also plays a role in age-related changes in reading speed.

159 Little is known about age-related changes in red blood cell (RBC) membrane tra

160 nificant alterations in linear and nonlinear age-related changes in resting oscillatory power and net

161 Moreover, this typical age-related changes in rich-club organisation were chara

162 ung and aged memory-impaired rats to examine age-related changes in ripple architecture, ripple-trigg

163 n rPPC grey matter volume better account for age-related changes in risk preferences than does age pe

164 We also measured age-related changes in ROS production and mitochondria m

165 mm Hg [SE, 0.037 mm Hg]); associations with age-related changes in SBP between 6 and 17 years of age

166 marker of individual difficulties as well as age-related changes in sensation, perception, and compre

167 Moreover, age-related changes in skeletal muscle metabolism are af

168 Here we identified age-related changes in skin properties and CCBAs from st

169 ing in the Study of Physical Performance and Age-Related Changes in Sonomans (SPPARCS) to predict dea

170 lopment of cancer by accumulating mutations, age-related changes in stem cells likely contribute to a

171 To analyze age-related changes in susceptibility to experimental St

172 n older subjects, critically contributing to age-related changes in SW oscillations.

173 ess, apoE2-TR mice showed similar or greater age-related changes in synaptic loss, neuroinflammation,

174 Although age-related changes in synaptic plasticity are an import

175 This review centers on age-related changes in T cells, which are dramatically a

176 ith a long postoperative life expectancy, as age-related changes in the anatomy of the anterior segme

177 The development and patterns of spontaneous age-related changes in the anterior cruciate ligament (A

178 peripheral choroid during accommodation, and age-related changes in the anterior sclera.

179 we present here a comprehensive study of the age-related changes in the Arabidopsis thaliana glycated

180 There were no age-related changes in the area of V1.

181 or connectivity in the ASD group and examine age-related changes in the ASD and control groups.

182 Depression may also accentuate age-related changes in the biophysical properties of cor

183 ute to HSC aging, little is known on whether age-related changes in the bone marrow niche regulate HS

184 Here, we provide an overview of age-related changes in the brain's chromatin structures,

185 that underlie interindividual variability in age-related changes in the brain.

186 degeneration in both fiber tracts, only the age-related changes in the cingulate bundle correlate wi

187 is study was designed to elucidate potential age-related changes in the concentration, structure, and

188 studies in the macaque monkey have revealed age-related changes in the density of nicotinamide adeni

189 age of effect, they do not account for these age-related changes in the distribution of de novo mutat

190 The relationship between age-related changes in the expression of the astrocytic

191 There were also no age-related changes in the extent of the coverage of end

192 ses in chondrocytes thought to contribute to age-related changes in the extracellular matrix are infl

193 Age-related changes in the hematopoietic compartment are

194 Many age-related changes in the hematopoietic system, in part

195 Our study suggests that age-related changes in the HSP mechanisms are sufficient

196 The authors examined age-related changes in the influence of this general fac

197 gnetic stimulation paradigm, we examined the age-related changes in the interhemispheric effects from

198 unger subjects, but there was no evidence of age-related changes in the magnitude or direction of pha

199 iod in delayed matching to sample tasks, and age-related changes in the microcolumnar organization of

200 Age-related changes in the microstructure of these tract

201 Overall, age-related changes in the mouse show similar structural

202 To examine age-related changes in the neural systems for reading in

203 magnetic resonance imaging was used to study age-related changes in the neural systems for reading in

204 mmon correlational methods are confounded by age-related changes in the neurovascular signaling.

205 Age-related changes in the niche have long been postulat

206 perception remains largely unaffected by the age-related changes in the optical media (yellowing of t

207 ings provide important new insights into the age-related changes in the peripheral blood pool of olde

208 There are well-characterized age-related changes in the peripheral repertoire of CD8

209 Our studies demonstrated several deleterious age-related changes in the pool of Ag-specific CD8 T cel

210 Age-related changes in the protein and mRNA expression o

211 vestigated novel molecular markers and their age-related changes in the rat IVD.

212 To test the hypothesis that age-related changes in the response to simulated jet lag

213 emporal order memory declines as a result of age-related changes in the rodent brain.

214 To explore age-related changes in the SCN, we have performed in viv

215 y reflect stem cell intrinsic alterations or age-related changes in the stem cell supportive microenv

216 The current study aimed to determine whether age-related changes in the superior longitudinal fascicu

217 icularly CMV, which has been associated with age-related changes in the T cell pool.

218 evalence of AMD was associated with distinct age-related changes in the T-cell compartment.

219 Age-related changes in the thymic cytokine milieu parall

220 lysis reveals that individuals with ASD show age-related changes in the trajectory of microglial and

221 ells and antigen-presenting cells (APC), and age-related changes in the tumor microenvironment.

222 To define age-related changes in the visual field by comparing 'st

223 We believe that age-related changes in the ways salient stimuli are proc

224 proteins is necessary for understanding the age-related changes in their density throughout the maca

225 ammatory conditions is dependent on specific age-related changes in their molecular repertoire that e

226 posure to factors in young blood counteracts age-related changes in these central nervous system para

227 In addition, the potential for age-related changes in these measures to affect the sex

228 d is seen throughout the cochlea long before age-related changes in thresholds or hair cell counts.

229 mice reversed these changes, suggesting that age-related changes in TNFalpha expression are an import

230 We find that (1) age-related changes in tradeoffs partition the life cycl

231 so be considered as potential mechanisms for age-related changes in transcript levels.

232 Rapid reduction in threshold coupled with age-related changes in transduction protein levels and t

233 ts aged 8-19 years, we aimed to characterize age-related changes in trial-to-trial intraindividual va

234 ular senescence processes, may contribute to age-related changes in vascular function and health.

235 al cortex and their association with certain age-related changes in visual perception.

236 ctive measurement, with potential to measure age-related changes in vivo.

237 icity in the nucleus accumbens is central to age-related changes in voluntary running.

238 racts except the brain stem, indicating that age-related changes in white matter microstructure diffe

239 adolescents and adults with ASD and whether age-related changes in white matter microstructure diffe

240 ued progress is being made on characterizing aging-related changes in cartilage.

241 us, this study reveals a novel mechanism for aging-related changes in CD8 T cells.

242 In sum, we have identified aging-related changes in cTfh that correlated with reduc

243 These results support the concept that aging-related changes in the prostate microenvironment m

244 S1 (WRN and BLM homologue) undergo premature age-related changes, including reduced life span under s

245 ithout (kappa range, -0.046 to 0.173) taking age-related change into consideration.

246 transmodal network whose lifespan pattern of age-related change intrinsically supports this model of

247 Many of these central age-related changes involve altered mechanisms of inhibi

248 Each of the >3000 age-related changes is associated with a specific tissue

249 ) with control subjects without intermediate age-related changes (large drusen).

250 These data suggest that particular age-related changes localize to DAergic subregions relev

251 Such age-related changes might partly account for the increas

252 These results may be relevant to age-related changes observed in neurodegenerative diseas

253 Age-related changes observed in vehicle-treated mice at

254 tes from old than young animals, although no age-related changes occur in C/EBPbeta mRNA, which is up

255 Age-related change of macular and circumpapillary RNFL m

256 Moreover, behavioral implications of age-related changes of cortical excitability remain elus

257 thod has been developed to spatially map the age-related changes of human lens alpha-crystallin by MA

258 Therefore, age-related changes of iron homeostasis in the RPE could

259 bly, independent of diet, RYGB also reversed age-related changes of membrane properties and occurrenc

260 ondrial energy production are characteristic age-related changes of post-mitotic retinal pigment epit

261 study examines the effect of melatonin upon age-related changes of some key proteins relevant to the

262 circadian patterns of task performance, and age-related changes of task.

263 Primary differences can be attributed to the age-related changes of the crystalline lens and CRC.

264 rther that genetic factors contribute to the age-related changes of the HSC subsets.

265 o T cell unresponsiveness, caused by various age-related changes of the immune system.

266 the resultant micrographs and determine the age-related changes of the LLP volume fraction and diame

267 n about the neural mechanisms that drive the age-related changes of the retina and, more specifically

268 ere used to assess the effects of cohort and age-related changes on body composition.

269 , careful necropsy and tissue histology show age-related changes only.

270 An underestimated aspect is that because of age-related changes, organ function such as erythropoiet

271 cell progeny is reduced in old mice, but the age-related changes responsible for these declines have

272 sizes in diffusion values between sexes and age-related changes showed findings parallel to ROI anal

273 linating white matter is more susceptible to age-related change than early-myelinating white matter,

274 recent developments in the understanding of age-related changes that affect key components of immuni

275 Immunosenescence is a series of age-related changes that affect the immune system and, w

276 ction anterior to the gland orifice; similar age-related changes that are detected in human subjects.

277 nimals, including mice and rats, demonstrate age-related changes that can contribute to osteoarthriti

278 cle during accommodation, and identify their age-related changes that could impact the optical change

279 acts displayed deviant early development and age-related changes that could underlie impaired brain f

280 to aging and raise the possibility that the age-related changes that occur in the nLOT might contrib

281 at recur during each seasonal cycle with the age-related changes that occur over years of growth.

282 After accounting for age-related change, the proportions decreased to 14.7%,

283 Brain diffusivity as a whole demonstrated age-related changes through four distinct periods of lif

284 Western blotting and proteomic methodology, age-related changes to a major protein, gammaS-crystalli

285 Widespread age-related changes to myelin were observed across the b

286 Our previous work demonstrated that age-related changes to the cellular chaperone repertoire

287 Age-related changes to the neurovascular unit (NVU), and

288 ency virus (HIV) infection induces premature age-related changes to the phenotype and function of mon

289 bidities, reduced physiological reserves and age-related changes to the spinal cord.

290 Understanding age-related changes to the UPR(ER) will provide new aven

291 this paper, we review existing literature on age-related changes, transplant outcomes, and complicati

292 end analysis before and after accounting for age-related change using the lower 95% confidence interv

293 This age-related change was due to an accelerated decrease in

294 None of these age-related changes were altered with exercise.

295 Some age-related changes were in an upward direction (GFAP an

296 All of these age-related changes were significantly attenuated in mCA

297 al tracts in ASD toddlers displayed abnormal age-related changes with greater fractional anisotropy a

298 osition in AD is thought to be the result of age-related changes with unknown mechanisms.

299 Yet, the impact of amyloid-beta on age-related changes within the medial temporal lobe (MTL

300 To what extent and by what means age-related changes within the niche contribute to this