ライフサイエンスコーパス: ageing

1 +) release from the SR was maintained during ageing.

2 lity is that this was due to acceleration of ageing.

3 of chromosomes that play roles in cancer and ageing.

4 ronounced lineage skewing, a hallmark of HSC ageing.

5 quantity and becoming more disorganised with ageing.

6 6K1 target that contributes to adiposity and ageing.

7 s, such as obesity, liver steatosis, and for ageing.

8 between Alzheimer's disease and pathological ageing.

9 emained relatively low but stable throughout ageing.

10 unction contributes to pathological vascular ageing.

11 al with immunosuppression, ART exposure, and ageing.

12 cell-secreted exosomes led to the slowing of ageing.

13 .5 y) from the English Longitudinal Study of Ageing.

14 the possibility that Pol III is involved in ageing.

15 function and disuse is often associated with ageing.

16 in the heat-shock response, proteostasis and ageing.

17 be a novel therapeutic approach to vascular ageing.

18 could be of therapeutic benefit in vascular ageing.

19 nd atrophy, processes associated with muscle ageing.

20 ibutes to a dampened circadian rhythm during ageing.

21 ) endothelium but gradually decreases during ageing.

22 es and ethyl esters of branched acids during ageing.

23 tophagy through exercise may promote healthy ageing.

24 l of this potentially devastating disease of ageing.

25 the various cellular processes that control ageing.

26 ons between these entities in the context of ageing.

27 ng the risk of oocyte aneuploidy in maternal ageing.

28 mice provide a useful model of reproductive ageing.

29 changing patterns of physical activity with ageing.

30 hanges seen with age and in animal models of ageing.

31 discover the genetic causes of human cardiac ageing.

32 eviously been observed in an animal model of ageing.

33 one of the most important pathways linked to ageing.

34 diaphragm during adaptation to exercise and ageing.

35 ng experiments show greatly reduced rates of ageing.

36 hat vitamin D may act to control the rate of ageing.

37 0 years in the English Longitudinal Study of Ageing.

38 been increasingly linked both to disease and ageing.

39 c spliceosome components may prolong healthy ageing.

40 on of the liquid phase, called stress-driven ageing.

41 elopment of interventions to promote healthy ageing.

42 in human neurodegenerative disease and brain ageing.

43 g that can compromise procedural learning in ageing.

44 ype CD31(hi)Emcn(hi) vessels decrease during ageing.

45 healthy, active and independent lives whilst ageing.

46 at acetate levels increased gradually during ageing.

47 ganglia circuits that are affected by normal ageing.

48 cological interventions that promote healthy ageing across diverse genetic backgrounds may engage con

49 and uncover the variegated effects of human ageing across hippocampal regions.

50 use of population growth (38.4%), population ageing after accounting for population growth (34.6%), a

51 While ageing altered mouse CS, chronic S 38093 treatment signi

52 ffort in the nestling period affect cellular ageing and adult inflammation in the starling.

53 Japan has entered the era of super-ageing and advanced health transition, which is increasi

54 s an early and sometimes initiating event in ageing and age-related disorders involving tissues with

55 l blood flow in brain regions susceptible to ageing and Alzheimer's disease.

56 ts XPB, XPD, and p8 lead to severe premature ageing and cancer propensity in the genetic diseases xer

57 or structural change which is common to both ageing and crystallization.

58 ges in cell and matrix composition with both ageing and degeneration.

59 ated with cognitive deficits associated with ageing and dementia, it was hypothesised that DBN protei

60 e proteome - appears highly relevant to both ageing and disease.

61 of off-odours in the raw meat increased with ageing and display time and oxidative groups.

62 t lower rates resulting in a reduced rate of ageing and enhanced protection against these age-related

63 oncentration effect as a consequence of long ageing and for the use of plastic pipelines no more oper

64 sh the relationship between the processes of ageing and HIV infection in neurocognitive impairment.

65 proteinopathy has recently been described in ageing and in association with cognitive impairment, esp

66 The world population is ageing and increasing in size.

67 that CAA has on cognition in the context of ageing and intracerebral haemorrhage, as well as in Alzh

68 Uterine ageing and labour dysfunction should be investigated fur

69 critical for development, and implicated in ageing and many complex diseases, such as cancer.

70 ed DM deactivation, characterizes successful ageing and may explain differential ageing trajectories

71 oporosis, which are strongly associated with ageing and morbidity in the general population.

72 Loss of proteostasis underlies ageing and neurodegeneration characterized by the accumu

73 have been widely observed in tumorigenesis, ageing and neurodegenerative diseases, highlighting the

74 PSD95 levels are diminished in ageing and neurodegenerative disorders, including Alzhei

75 ined expression patterns of snoRNAs in joint ageing and OA and examined them as potential biomarkers.

76 monstrate snoRNA expression levels in murine ageing and OA joints and serum for the first time.

77 s of small nucleolar RNAs (snoRNAs) in joint ageing and OA may provide diagnostic biomarkers and ther

78 determining their functional significance in ageing and osteoarthritis, and provides potential diagno

79 snoRNAs as novel markers of musculoskeletal ageing and osteoarthritis.

80 ely to be due to a complex interplay between ageing and other phenomena such as disuse and diseases.

81 ing atrial contraction are remodelled during ageing and provides a basis for future work aiming to un

82 croscopic state in a metallic glass, such as ageing and rejuvenation, through a set of simple equatio

83 accelerated growth may also mean more rapid ageing and shortened lifetime.

84 damage accumulate in skeletal muscle during ageing and the ability of muscle cells to respond to inc

85 Accumulation of CD45(-) PCs during ageing and the presence of rotavirus-specific clones ent

86 ates to advanced physiological and cognitive ageing and the risk of mortality.

87 ucation and qualifications of its workforce, ageing and turnover of village doctors, fragmented healt

88 The risk of RVO increased with ageing and was more among males.

89 a fifth of the world's population, which is ageing and which has a growing prevalence of chronic non

90 nstrumental for understanding the biology of ageing and will allow modulation of its ticking rate and

91 to promote synaptic and cognitive health in ageing, and to enhance compensatory capacity for synapti

92 ic pathways that contribute to adiposity and ageing are activated by the mammalian target of rapamyci

93 aggregates that form under stress or during ageing are preferentially retained by the mother cell, i

94 In the ageing arm (70-84 years), genetically predicted triglyce

95 xample, obesity, cardiovascular disease, and ageing as well as neurodevelopmental disorders like auti

96 itochondrial proteostasis in skeletal muscle ageing, as well as its broader implications for systemic

97 ty for synaptic connectivity in pathological ageing associated with Abeta deposition.

98 Ageing associates with significant alterations in somati

99 were measured following periods of calendar ageing at low voltages, at and well below the manufactur

100 , is sensitive to the detrimental effects of ageing at morphological and molecular levels.

101 at levels below the set point will result in ageing being contaminated by the unpredictable and patho

102 ntroduces a clinically-relevant neuroimaging ageing biomarker and demonstrates that combining distinc

103 Structurally, the ageing brain atrophies as white and grey matter volumes

104 en, many of which were similar to effects of ageing, but also with a few key differences.

105 Not only will this increase the rate of ageing, but it will also increase the probability of dev

106 Physical activity is key for successful ageing, but questions remain regarding the optimal physi

107 posed that the hypothalamus helps to control ageing, but the mechanisms responsible remain unclear.

108 vity of Pol III mediates the acceleration of ageing by TORC1.

109 demonstrate a novel approach whereby protein ageing can be greatly accelerated: the constant unfoldin

110 hat several key functional attributes of HSC ageing can be reversed.

111 the brain regulate immune responses, but in ageing can negatively affect brain function.

112 Ageing can occur at different rates, but what controls t

113 hat neuroimaging and epigenetics measures of ageing can provide complementary data regarding health o

114 Dysfunctional telomeres activate DDR in ageing, cancer and an increasing number of identified pa

115 erious variation, morphological development, ageing, cancer and behaviour.

116 ed over the past 25 years, due to population ageing, changes in non-communicable disease rates, and i

117 Fewer AIDS-related deaths and an ageing cohort have resulted in an increase in the propor

118 These findings show that maternal ageing compromises the oocyte SAC-APC/C axis leading to

119 icochemical properties under three different ageing conditions (i.e. 25 degrees C, 45 degrees C and 6

120 rine was detected, but was not influenced by ageing conditions, and tyramine was only detected in som

121 However, ageing does not affect people uniformly.

122 Ageing drives changes in neuronal and cognitive function

123 sity is associated with accelerated cellular ageing during development and increased inflammation dur

124 Innovation Partnership on Active and Healthy Ageing (EIP on AHA) are to enable European citizens to l

125 dents from the English Longitudinal Study of Ageing (ELSA), at baseline and follow-up.

126 e of FS in the English Longitudinal Study of Ageing (ELSA).

127 they develop from a combination of genetic, ageing, environmental and lifestyle risk factors.

128 and fragmented, and decreases in amount with ageing, especially in energy storing tendons.

129 hat, unfortunately, appears to manifest with ageing, especially in the last third of the lifespan.

130 influence of pre-fermentative maceration and ageing factors on the ester profiles of Pedro Ximenez sp

131 a first-order kinetic model, with FP samples ageing faster than TFs.

132 d of forensic entomology for identifying and ageing forensically important blowfly species, primarily

133 ombining distinct measurements of biological ageing further helps to determine risk of age-related de

134 Ageing generates senescent pathologies, some of which ca

135 Healthy ageing has disparate effects on different cognitive doma

136 Innovation Partnership on Active and Healthy Ageing, has initiated an allergy sentinel network (the M

137 r making individualised predictions of brain ageing have been developed.

138 th men in the USA, we examined the effect of ageing, HIV infection (by disease stage), and their inte

139 udes that a sedentary lifestyle, obesity and ageing impair the vasodilator response of the muscle mic

140 Therefore, ageing impairs AJ activity, which appears to reflect Src

141 Ageing impairs the activity of adherens junctions, which

142 mming and early life functional decline with ageing in an IUGR non-human primate model.

143 s enrolled in the Environmental Influence on Ageing in Early Life (ENVIRONAGE) Study, a Belgian birth

144 hort (ENVIRONAGE [Environmental Influence on Ageing in Early Life]), a total of 730 mother-newborn pa

145 ssion of neurocognitive impairment caused by ageing in individuals with HIV.

146 the oocyte pool is formed, with reproductive ageing in later life.

147 x2 and Bmi1 are ablated, as we observed that ageing in mice started with a substantial loss of these

148 rders, all of which are also associated with ageing in the general population.

149 d by a mechanical force, undergo accelerated ageing in times scales of minutes to days.

150 Ageing increased internalization and degradation of VE-c

151 bution of single muscle fibre adaptations to ageing-induced atrophy and functional impairment is stil

152 KEY POINTS: Ageing-induced endothelial dysfunction contributes to or

153 oviding a potential mechanism to explain how ageing influences their amplitude and function.

154 cal variation in the search for reproducible ageing interventions.

155 Limiting the debilitating consequences of ageing is a major medical challenge of our time.

156 Ageing is a progressive decline of intrinsic physiologic

157 Ageing is associated with a number of changes in the bra

158 Ageing is associated with an accumulation of damage to m

159 KEY POINTS: Ageing is associated with an increased risk of cardiovas

160 ABSTRACT: Ageing is associated with marked large artery stiffening

161 We hypothesised that maternal ageing is associated with utero-placental dysfunction, p

162 Skeletal muscle ageing is characterised by atrophy, a deficit in specifi

163 Ageing is driven by a loss of transcriptional and protei

164 In the blood, haematopoietic stem cell (HSC) ageing is linked to several functional shortcomings.

165 A hallmark of tissue ageing is the irreversible oxidative modification of its

166 Telomere shortening, a marker of cellular ageing, is linked with arterial stiffening.

167 Once considered an inevitable consequence of ageing, it is now eminently preventable and treatable.

168 model consistently displayed acceleration of ageing-like physiological changes or a shortened lifespa

169 FN-I receptor on their microglia, induces an ageing-like transcriptional microglial signature, and im

170 challenge, have therapeutic implications for ageing LQTS patients.

171 Ageing maintained the integrated Ca(2+) influx via ICa-L

172 ABSTRACT: Primary ageing markedly attenuates cutaneous vasodilatation and

173 loss of elastin and its disorganisation with ageing may aid in the development of treatments to preve

174 ests that epigenetic changes associated with ageing may be involved in the differential exhibition of

175 uccessful maintenance of the proteome during ageing may be linked to the increased lifespan and healt

176 These results demonstrate that ageing may result in decreased GABAergic inhibition in t

177 us formation of GSG in non-stressed p53R172H ageing mice.

178 During ageing, microglia acquire a phenotype that may negativel

179 Here we show that ageing microglial phenotype is largely imposed by interf

180 We developed and validated the IMPACT-Better Ageing Model-a probabilistic model that tracks the popul

181 ly without amyloid-beta accumulation (normal ageing, n = 13), and neurologically normal elderly with

182 ical amyloid-beta accumulation (pathological ageing, n = 15).

183 resent study, we report a novel finding that ageing negatively impacts nAChR efficacy in auditory tha

184 cell manipulations in mice, we explored how ageing of cortico-basal ganglia networks alters the micr

185 ith age in littermates, suggesting premature ageing of dopamine synapses in GKI mice.

186 Its prevalence is increasing because of ageing of the population and improved treatment of acute

187 associated (P=2.2 x 10(-8)) with epigenetic ageing of the prefrontal cortex, independent of the prop

188 ss and visual impairment, yet the growth and ageing of the world's population is causing a substantia

189 Hence, with the ageing of Western societies, we still need to anticipate

190 PRETATION: A greater than expected effect of ageing on episodic memory and motor function with advanc

191 Despite numerous studies on the impact of ageing on individual muscle fibres, the contribution of

192 amples were monitored at 3, 6 and 9months of ageing on lees.

193 results have been reported on the impact of ageing on structure and functions of skeletal muscle fib

194 temperature (6, 15 and 30 degrees C) during ageing on the colour, phytochemical composition and bioa

195 We examined the impact of ageing on the ultrastructure and function of mitochondri

196 ting chronic diseases for active and healthy ageing]), one of the reference sites of the European Inn

197 In maternal ageing, oocytes show increased inter-sister kinetochore

198 regation of eye lens proteins as a result of ageing or congenital mutations.

199 expression of these markers is influenced by ageing or degeneration.

200 ee-energy minima which are either amorphous (ageing) or crystalline (devitrification).

201 ns of high translational value for targeting ageing- or disease-associated hippocampal dysfunction.

202 l processes contributing to the reproductive ageing patterns in three albatross species (two biennial

203 and evolutionary forces shaping variation in ageing patterns.

204 structure and function is a major feature of ageing per se and that qualitative adaptations of muscle

205 (YO) and elderly (EL) men in order to study ageing per se without the confounding effects of impaire

206 adults in order to understand the effects of ageing per se without the confounding impact of impaired

207 ne and spermidine were observed with chilled ageing period and were greater in chilled export (43d at

208 For the ageing periods considered in the present study, malondia

209 and results in the emergence of a premature ageing phenotype in the heart.

210 would show impaired function and a premature ageing phenotype.

211 genetically predicted triglycerides with two ageing phenotypes - longevity ( >/=95 years) and frailty

212 terventions to address complex care needs of ageing PLHIV are crucial to address shorter life expecta

213 universal health coverage, especially for an ageing population living with multiple comorbidities in

214 tive cancer therapy in a clinically assessed ageing population of long-term survivors of childhood ca

215 uring impact on health outcomes for a global ageing population.

216 lation (AF) is increasing, due partly to the ageing population.

217 continue to increase in prevalence with the ageing population.

218 hronic neurological disorders increases with ageing populations, access to neurologist care is likely

219 unding required for the care of their future ageing populations.

220 Hence, markers of the underlying biological ageing process are needed to help identify people at inc

221 pecies (ROS) in vivo plays a key role in the ageing process has been extensively studied, but remains

222 sent the hypothesis that one hallmark of the ageing process is a significant decline in adaptive home

223 The ageing process is separate from, and independent of, exe

224 ht some of the shared mechanisms between the ageing process itself and emerging pathogenic mechanisms

225 lso help uncover mechanisms underpinning the ageing process itself is open to question.

226 mmune systems change dramatically during the ageing process, often accompanied by major increases in

227 ap with those known to directly modulate the ageing process.

228 fy the fundamental mechanisms underlying the ageing process.

229 he trajectory of the physiology of the human ageing process.

230 causative or a consequence of an underlying ageing process.

231 ty will not adequately describe the inherent ageing process.

232 derstand individual differences in the brain ageing process; hence, techniques for making individuali

233 omen) from the English Longitudinal Study of Ageing provided serum levels of IGF-1 in 2008 and again

234 icantly associated (P=4.5 x 10(-9)) with the ageing rate across five brain regions and harbours a cis

235 ased biomarkers of brain age: the epigenetic ageing rate and estimated proportion of neurons.

236 and tropical biomes, demonstrating that the ageing rate of photosynthetic capacity is positively cor

237 ecause of uncertainty across species in the 'ageing rate:' the rate at which leaf photosynthetic capa

238 Ageing rates vary among different proteins, but in all c

239 by 25% by 2025, mainly reflecting population ageing rather than an increase in prevalence of disabili

240 The links between cellular and vascular ageing reflect a complex interaction between genetic and

241 that the links between cellular and vascular ageing reflect a complex interaction between genetic and

242 To examine ageing-related changes in the earliest stages of auditor

243 me enabling the extraction of knowledge from ageing-related data using quantitative influence informa

244 Here the authors show that maternal ageing-related embryonic abnormalities in mouse are caus

245 een genetically engineered to survive in the ageing-related hypothalamic inflammatory microenvironmen

246 dividual with normal vitamin D levels, these ageing-related processes will occur at lower rates resul

247 -)) mice develop normally but show premature ageing-related traits and when challenged by certain str

248 the role of splicing homeostasis in healthy ageing remains unclear.

249 in the elderly, how lipolysis is impaired in ageing remains unknown.

250 ying genes regulating the pace of epigenetic ageing represents a new frontier in genome-wide associat

251 markers in Alzheimer's disease and cognitive ageing research is based on grouping the markers into th

252 (T0), and after 1 (T1) and 3 (T3) months of ageing, respectively).

253 Such a response resembles the anti-ageing response induced by dietary restriction (also kno

254 Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downr

255 and autophagy may become dysregulated during ageing resulting in the reduced clearance and accumulati

256 Conversely, ageing retardation and lifespan extension were achieved

257 Hypoxia is a feature of the ageing retina as extracellular debris accumulates betwee

258 However, that these cells remain in the ageing retina suggests the potential for functional rest

259 Ageing societies and a rising prevalence of dementia are

260 and the burden of disability is crucial for ageing societies.

261 ce in the developed world associated with an ageing society, highlighting the need for effective trea

262 In conclusion, ageing speed is substantially controlled by hypothalamic

263 We found that in healthy ageing, structural and functional alterations of muscle

264 tudy, we compared two Cognitive Function and Ageing Studies (CFAS I and CFAS II) of older people (age

265 MRC Cognitive Function and Ageing Study (CFAS) undertook baseline interviews in pop

266 65 y and over in the Cognitive Function and Ageing Study Wales (CFAS-Wales) cohort collected in 2011

267 City Over-75s Cohort, Cognitive Function and Ageing Study) performed from January 1, 1985, through De

268 ort, and 456 from the Cognitive Function and Ageing Study) with neuropathologic data; mean (SD) age a

269 We used data from the Rugao Longevity and Ageing Study, a population-based cohort study performed

270 Moreover, a significant effect of the ageing system was found on the kinetics of the wood rela

271 was the only volatile clearly influenced by ageing temperature, with the most pronounced effect at 3

272 inate were the major compounds influenced by ageing temperature.

273 Patterns of microvascular ageing that develop among muscles of diverse fibre type

274 KEY POINTS: In a rat model of ageing that is free of atherosclerosis or hypertension,

275 Upon ageing the intestinal defects were deteriorative with ma

276 With ageing, the IFM becomes stiffer and less fatigue resista

277 kg(-1) and 307.7mgkg(-1)) and increased with ageing time (366.2mgkg(-1), 1711.8mgkg(-1) and 2959.2mgk

278 s related to pre-fermentative maceration and ageing time, reported for the first time in sparkling wi

279 fected by salt content, antioxidant type and ageing time.

280 tanoic and hexanoic acids in the two studied ageing times.

281 Mitochondria were affected by ageing to very different extents, depending on the organ

282 ccessful ageing and may explain differential ageing trajectories across cognitive domains.

283 The ageing trajectory is shaped by both within-individual pr

284 with different amount of Cu without and with ageing treatment at 473 K.

285 al prowess that occurs solely as a result of ageing, unaffected by the confounding effects of inactiv

286 nalyses of adipose macrophages revealed that ageing upregulates genes that control catecholamine degr

287 ion between physical activity and successful ageing using data on 3,749 participants (age range = 60-

288 in a blunted hormonal responsiveness of the ageing uterus.

289 muscle contraction and is attenuated during ageing via alpha-adrenoreceptor (alphaAR) stimulation, b

290 Successful ageing was defined as good cognitive, motor, and respira

291 s shown in the English Longitudinal Study of Ageing, we projected continuing declines in dementia inc

292 dults from the English Longitudinal Study of Ageing were followed-up every two years until they repor

293 ion, significant, direct negative effects of ageing were noted on all neurocognitive domains (p<0.000

294 d, and these exosomal miRNAs declined during ageing, whereas central treatment with healthy hypothala

295 Alzheimer's disease compared to pathological ageing, whereas cortical full-length amyloid-beta42 accu

296 the shrinking workforce and rapid population ageing will not be evident for two decades.

297 n constant in the future, further population ageing will require an extra 71 215 care home places by

298 At the end of ageing, wines stored at 6 degrees C had the highest colo

299 dividual phenolic compounds decreased during ageing, with reduction of monomeric anthocyanins contrib

300 Slowing is a common feature of ageing, yet a direct relationship between neural slowing