ライフサイエンスコーパス: agenesis

1 ovement is possible despite total cerebellar agenesis'.

2 ng of the genetic etiology of familial tooth agenesis.

3 nd Slit2 upregulation, resulting in callosal agenesis.

4 the most common cause of isolated pancreatic agenesis.

5 n factor 1a) in ten families with pancreatic agenesis.

6 with blind hemivagina and ipsilateral renal agenesis.

7 nopus foregut resulted in liver and pancreas agenesis.

8 lopmental defects associated with pancreatic agenesis.

9 of both ligands in mice, resulted in kidney agenesis.

10 box transcription factor, both lead to cecal agenesis.

11 o be the most common cause of human pancreas agenesis.

12 ental disorders are associated with callosal agenesis.

13 a loss of foregut gene expression and organ agenesis.

14 ified as likely pathogenic in isolated tooth agenesis.

15 and intestine development and caused spleen agenesis.

16 6 in 15/27 (56%) individuals with pancreatic agenesis.

17 tion, as their loss of function causes liver agenesis.

18 2-O-sulfotransferase (Hs2st) leads to kidney agenesis.

19 ne gliosis, increased Slit2, and complete CC agenesis.

20 piratory system, such as lung hypoplasia and agenesis.

21 %) and 2 of 10 fetuses (20%) with unilateral agenesis.

22 phenotype correlation between PAX9 and tooth agenesis.

23 d in Fgf10 knockout mice, which exhibit lung agenesis.

24 mesenchyme is inhibited, resulting in renal agenesis.

25 piratory tract abnormalities, including lung agenesis.

26 function of the PAX9 protein underlies tooth agenesis.

27 68%, while survival was 54% in patients with agenesis.

28 duals with both orofacial clefting and tooth agenesis.

29 tations are also causal for hereditary tooth agenesis.

30 y shaped, or ectopic, otoconia, or otoconial agenesis.

31 n permanent diabetes mellitus and cerebellar agenesis.

32 AX9, and TGFA play a role in isolated dental agenesis.

33 a of the basement membrane and also in renal agenesis.

34 is may be the best models for isolated tooth agenesis.

35 d in more severe cases, exhibited unilateral agenesis.

36 ing a significant number of patients with LG agenesis.

37 f the 219InsG mutation and its role in tooth agenesis.

38 th defects that resemble human sacral/caudal agenesis.

39 ra mater, consequently resulting in calvaria agenesis.

40 ses, including apoptosis and dopamine neuron agenesis.

41 le for a specific pattern of inherited tooth agenesis.

42 a large family with autosomal-dominant tooth agenesis.

43 three families with autosomal-dominant tooth agenesis.

44 tations are associated with human pancreatic agenesis.

45 have been identified in patients with tooth agenesis.

46 hinese families with nonsyndromic (NS) tooth agenesis.

47 l coccygeal segments to complete lumbosacral agenesis.

48 re a rare cause of pancreatic and cerebellar agenesis.

49 4 additionally revealed homolateral vaginal agenesis.

50 obstructed hemivagina and ipsilateral renal agenesis.

51 ongitudinal vaginal septum and lower vaginal agenesis.

52 ntrols, especially in patients with complete agenesis.

53 assification 1.2) with associated left renal agenesis.

54 in 2 families with suspected syndromic tooth agenesis.

55 cortical abnormalities, and partial callosal agenesis.

56 isability and frequently displaying callosal agenesis.

57 xhibited partial or complete corpus callosum agenesis.

58 intellectual disability, and corpus callosum agenesis.

59 es from individuals with isolated pancreatic agenesis.

60 tear production and LG volume reduction and agenesis.

61 ectasias, capillary anomalies, and capillary agenesis.

62 ngle gene mutations associated with callosal agenesis.

63 of PAX9 that is responsible for human tooth agenesis (1) affects its functions.

64 tuses that had bilateral or unilateral renal agenesis (29 subjects) or severe congenital renal dyspla

65 ized by a high prevalence of corpus callosum agenesis (32/80; 40%), and mild to severe cerebellar hyp

66 ound in 7 of 19 fetuses with bilateral renal agenesis (37%) and 2 of 10 fetuses (20%) with unilateral

67 t PTF1A mutations in humans cause cerebellar agenesis, a birth defect of the human cerebellum.

68 understanding how this mutation caused renal agenesis, a failure of fetal kidney development.

69 l anomalies including callosal hypoplasia or agenesis, abnormal basal ganglia and cerebellar hypoplas

70 tions as the most common cause of pancreatic agenesis, accounting for 15 of 27 (56%) patients with in

71 R) syndrome and Six1(-/-) mice exhibit renal agenesis, although the ureter is present.

72 Eighty-two individuals with tooth agenesis and 328 individuals with no birth defect were r

73 in protein, result in nonsyndromic otoconial agenesis and a severe balance disorder in mice.

74 It has been proposed that tooth agenesis and cancer development share common molecular p

75 the developing ureteric bud developed kidney agenesis and collecting duct cells had severe cytoskelet

76 Nfib-deficient animals also exhibit callosal agenesis and delayed lung maturation, indicating haploin

77 Frem1(eyes2) mice have eye defects, renal agenesis and develop retrosternal diaphragmatic hernias

78 t to determine the association between tooth agenesis and DNA sequence variation in the genes MSX1 an

79 ing Wnt2/2b expression exhibit complete lung agenesis and do not express Nkx2.1, the earliest marker

80 This is consistent with widespread agenesis and dysgenesis of organs observed in Fgf10-/- m

81 umans, PDX-1 gene mutation causes pancreatic agenesis and early- and late-onset type 2 diabetes.

82 These mutants display ventral pancreas agenesis and ectopic masses of hepatocytes.

83 b) in the ventral endoderm leads to tracheal agenesis and ectopic primary bronchi.

84 ne the most common cause of human pancreatic agenesis and establish a key role for the transcription

85 ects in lung maturation and exhibit callosal agenesis and forebrain defects that are similar to, but

86 ATA6 haploinsufficiency can cause pancreatic agenesis and heart defects.

87 In the distal limb, there were agenesis and hyperpigmentation of claws, interdigital we

88 Renal agenesis and hypodysplasia (RHD) are major causes of ped

89 this reduction is sufficient to explain the agenesis and hypoplasia observed in both mutants.

90 and environmental) determining both callosal agenesis and its autistic features, and what are the pro

91 individuals with isolated central pair (CP) agenesis and normal body laterality, from two unrelated

92 face and neck, sclerocornea, corpus callosum agenesis and other brain anomalies.

93 ctural abnormalities, in particular callosal agenesis and pontine hypoplasia, delayed myelination and

94 fects range from mild hypoplasia to complete agenesis and Probst's bundle formation.

95 ical and molecular association between tooth agenesis and self-reported family history of cancer.

96 h increases the spectrum of congenital tooth agenesis and suggests attenuated Wnt signaling in endoth

97 etic contributions to kidney development and agenesis and the factors influencing susceptibility to r

98 ip/palate is also associated with both tooth agenesis and the gene TGFA, we included TGFA in the anal

99 Agenesis and tooth displacements were the most common de

100 ullerian ducts characterized by uterovaginal agenesis and underdeveloped female genital organs.

101 otal of 218 patients (14%) had diaphragmatic agenesis and underwent repair.

102 fects, including epidermis and prostate buds agenesis and urothelial abnormalities.

103 out mice leads to high bone mass, lymph node agenesis, and altered lymphocyte differentiation.

104 ve complete cleft secondary palate, calvaria agenesis, and other skull defects with complete phenotyp

105 atures of syndromes associated with callosal agenesis, and provides a genetic and developmental frame

106 incidence of unilateral and bilateral renal agenesis, and smaller kidneys with fewer nephrons.

107 A small proportion of RetDN/+ mice had renal agenesis, and the remainder had hypoplastic kidneys and

108 Genetic defects responsible for tooth agenesis are only now beginning to be uncovered.

109 ructed Seminal Vesicle and Ipsilateral Renal Agenesis) as an acronym for Zinner syndrome analogous to

110 ion in the entire epiblast leads to pancreas agenesis associated with abnormal gut regionalization.

111 Tracheal agenesis/atresia (TA) is a rare but fatal congenital dis

112 ion can be identified in families with tooth agenesis, but heterogenous or multiple genes may be resp

113 ctive studies are needed to confirm if tooth agenesis can be used as a risk marker for cancer.

114 ltisystem disorder characterized by callosal agenesis, cataracts, cardiomyopathy, combined immunodefi

115 ion to the five principal features (callosal agenesis, cataracts, hypopigmentation, cardiomyopathy, a

116 Can kindreds with tooth agenesis caused by MSX1 or PAX9 mutations be distinguish

117 y, we investigated whether the 5 known tooth-agenesis-causing MSX1 missense mutations disrupt this Pa

118 Bmp4 promoter construct, and that most tooth-agenesis-causing PAX9 mutations impair DNA binding and B

119 st-derived dental mesenchyme and cause tooth agenesis disorder when mutated in mouse and/or human.

120 ptors (NgR123-null mice) display complete CC agenesis due to axon misdirection evidenced by ectopic a

121 ta6 in the pancreas caused severe pancreatic agenesis due to disruption of pancreatic progenitor cell

122 han sall1-null mice including complete renal agenesis, exencephaly, limb and anal deformities.

123 ng bilateral cleft lip and palate and tongue agenesis, following the loss of the primary cilia in the

124 all available data on worldwide third molar agenesis frequencies, with a particular emphasis on expl

125 Finally, we found large differences among agenesis frequency depending on geographic region.

126 nd toward improved survival in patients with agenesis from 47% in the first 2 years to 59% in the las

127 autistic behaviour associated with callosal agenesis from autism more generally.

128 When patients with diaphragmatic agenesis from the first 2 years were compared with simil

129 Individuals with tooth agenesis had an increased risk of having a family histor

130 The survivors with diaphragmatic agenesis had prolonged hospital stays compared with pati

131 ranslocation associated with bilateral renal agenesis has implicated the gene encoding the nuclear st

132 ith orofacial clefting with or without tooth agenesis have MSX1 coding mutations by screening 33 indi

133 tions in PDX1 and PTF1A can cause pancreatic agenesis, however, most instances of this disorder are o

134 either factor are associated with pancreatic agenesis; however, homozygous deletion of both Gata4 and

135 eous stock-derived model of unilateral renal agenesis (HSRA) rat, which demonstrates 50%-75% spontane

136 included duplex and multiplex kidneys, renal agenesis, hydronephrosis and cystic kidney disease.

137 ompanied by hypogonadism and seminal vesicle agenesis/hypodysplasia.

138 mperature indicators were observed for renal agenesis/hypoplasia (positive) and anophthalmia/micropht

139 een AXIN2, FGF3, FGF10, and FGFR2 with tooth agenesis [i.e., individuals who carried the polymorphic

140 ariants in candidate disease genes for tooth agenesis in 10 multiplex Turkish families.

141 gene were identified segregating with tooth agenesis in 2 families, suggesting oligogenic inheritanc

142 us associated with pancreatic and cerebellar agenesis in a genome-wide linkage search of a consanguin

143 hrogenesis, the demonstrated rescue of renal agenesis in a model of a human genetic disease raises th

144 oduct associated with a severe form of molar agenesis in a single family.

145 agenesis was 36% more likely than mandibular agenesis in both sexes.

146 Here, we show that lung agenesis in Fgf10 knockout mice can be rescued by ubiqui

147 This prevented renal agenesis in Fras1(bl/bl) mice, permitting kidney develop

148 y the ureteric bud, leads to bilateral renal agenesis in humans with Fraser syndrome and blebbed (Fra

149 y a few genes have been linked to pancreatic agenesis in humans, with mutations in pancreatic and duo

150 factors PAX9 and MSX1 cause selective tooth agenesis in humans.

151 n mice, and GATA6 mutations cause pancreatic agenesis in humans.

152 r the development of specific types of teeth agenesis in humans.

153 ed with non-syndromic cleft palate and tooth agenesis in humans.

154 SX1 and PAX9 have been associated with tooth agenesis in mice and humans, but interestingly for human

155 tein kinase A and by the adrenal and gonadal agenesis in mice with null mutations in SF-1.

156 cent brainstem or die, leading to cerebellar agenesis in Ptf1a mutants.

157 ransgenes are capable of rescuing the kidney agenesis in RET-deficient mice or causing kidney hypodys

158 CAKUT that are markedly different than renal agenesis in Ret-null or RetY1062F mutant mice.

159 We analyzed patterns of partial tooth agenesis in seven kindreds with defined MSX1 mutations a

160 n contrast to complete deafness and cochlear agenesis in the C3HeB/FeJ strain, F2 Eya1(bor/bor) mutan

161 of orofacial clefting with or without tooth agenesis in this study population.

162 in more common cases of incisor or premolar agenesis, indicating that these have a different etiolog

163 Tooth agenesis is a common craniofacial abnormality in humans

164 Pancreatic agenesis is a human disorder caused by defects in pancre

165 Internal carotid artery agenesis is a rare anomaly that can be clinically asympt

166 the 1994 paper was to show that 'cerebellar agenesis is always associated with profound motor defici

167 Results showed that tooth agenesis is associated with markers of the genes MSX1 an

168 Since tooth agenesis is commonly found in individuals with cleft lip

169 Tooth agenesis is complex, and variations in about a dozen gen

170 tering a patient with lacrimal dysgenesis or agenesis is not an uncommon occurrence in an oculoplasti

171 Tooth agenesis is one of the most common developmental anomali

172 Tooth agenesis is one of the most common developmental anomali

173 Oligodontia, a severe form of tooth agenesis, is genetically and phenotypically a heterogene

174 nactivated in human patients with cerebellar agenesis, is required to segregate the cerebellum from m

175 s autism spectrum disorders, corpus callosum agenesis, Joubert syndrome, Kallmann syndrome, and horiz

176 fralpha1(TM/TM) mice display bilateral renal agenesis, lack enteric neurons in the intestines, and ha

177 Despite molar agenesis, Lhx6/7-deficient animals have normal incisors

178 ignificant progress in the genetics of tooth agenesis, many gaps in knowledge exist in refining the g

179 specific CAKUT phenotype of unilateral renal agenesis may also be mutated in humans with isolated CAK

180 Oral clefts and syndromic forms of tooth agenesis may be the best models for isolated tooth agene

181 e missing teeth in syndromes involving tooth agenesis may be useful.

182 nitive impairments in subjects with callosal agenesis may overlap with the profile of autism spectrum

183 tood, but congenital venous valve aplasia or agenesis may play a role in some cases.

184 ospital stays compared with patients without agenesis (median, 68 vs. 30 days).

185 malformations, which include isolated tooth agenesis, microdontia, short tooth roots, taurodontism,

186 ice results in cardiac malformation, adrenal agenesis, neural tube, placental defects and partially p

187 otient and autism symptomatology in callosal agenesis, nor evidence that the presence of any residual

188 branching ureteric bud (UB), and that renal agenesis occurs in homozygous Fras1 null mutant blebbed

189 t women are 14% more likely than men to have agenesis of >/=1 third molars and that maxillary agenesi

190 Furthermore, we found that having agenesis of 1 or 2 molars was most common, while agenesi

191 esis of 1 or 2 molars was most common, while agenesis of 3 or 4 molars was least common.

192 s Odd 1(-/-) mutant embryos exhibit complete agenesis of adrenal glands, metanephric kidneys, gonads,

193 smorphism, brain malformation (microcephaly, agenesis of corpus callosum, and simplified gyration), a

194 mations including hippocampus hypoplasia and agenesis of corpus callosum, as well as neuromuscular an

195 ation family with affected males showing ID, agenesis of corpus callosum, cerebellar hypoplasia, micr

196 oss of Lmx1a and Ngn2 expression, as well as agenesis of DA neurons in the midbrain floor plate.

197 clear receptor superfamily, causes selective agenesis of dopaminergic neurons in midbrain.

198 in defects, whereas Nfic-deficient mice have agenesis of molar tooth roots and severe incisor defects

199 The phenotype is characterized by severe agenesis of multiple laminated cerebral structures affec

200 It is typically attributed to agenesis of the abducens and facial cranial nerves.

201 ants had shortened limbs and almost complete agenesis of the autopod because of reduced cell prolifer

202 is an autosomal recessive disorder marked by agenesis of the cerebellar vermis, ataxia, hypotonia, oc

203 this defect could arise from instability or agenesis of the ciliary central microtubules due to loss

204 anual motor coordination in individuals with agenesis of the corpus callosum (ACC) was studied using

205 and five sporadic individuals with isolated agenesis of the corpus callosum (ACC) without intellectu

206 Disruption of the Nfia gene causes agenesis of the corpus callosum (ACC), hydrocephalus, an

207 the brain, including microcephaly (MIC) and agenesis of the corpus callosum (ACC).

208 and speech execution in 25 participants with agenesis of the corpus callosum (AgCC) and 21 matched ne

209 t for hemispheric dominance in patients with agenesis of the corpus callosum (AgCC) and found reduced

210 ate fMRI in eight adult humans with complete agenesis of the corpus callosum (AgCC) and normal intell

211 specifically, we investigated the effect of agenesis of the corpus callosum (AgCC), one of the most

212 Agenesis of the corpus callosum (CC) is a rare birth def

213 motor and sensory neuropathy associated with agenesis of the corpus callosum (HMSN/ACC), a neurodevel

214 ene of peripheral neuropathy with or without agenesis of the corpus callosum (SLC12A6).

215 h is a model with polycystic kidney disease, agenesis of the corpus callosum and hydrocephalus.

216 previously that Nfia-deficient mice exhibit agenesis of the corpus callosum and other forebrain defe

217 ound sensorineural hearing loss, and partial agenesis of the corpus callosum are hallmarks of the cli

218 Agenesis of the corpus callosum is a common brain malfor

219 Agenesis of the corpus callosum is a congenital conditio

220 ficiency: Nova2-/- but not Nova1-/- mice had agenesis of the corpus callosum, and axonal outgrowth de

221 , spastic quadriplegia, developmental delay, agenesis of the corpus callosum, and enlargement of the

222 s severe brain malformations (lissencephaly, agenesis of the corpus callosum, and midbrain malformati

223 cluding enlarged ventricles, thinned cortex, agenesis of the corpus callosum, and significantly reduc

224 ventricles, reduced cerebral cortex, partial agenesis of the corpus callosum, and thinning of layers

225 Donnai-Barrow syndrome is associated with agenesis of the corpus callosum, congenital diaphragmati

226 titutional DNA-mismatch repair deficiency is agenesis of the corpus callosum, the cause of which has

227 ntonasal dysplasia, interhemispheric lipoma, agenesis of the corpus callosum, tibial hemimelia, preax

228 aracterized by severe mental retardation and agenesis of the corpus callosum.

229 Those children with large defects or agenesis of the diaphragm have the highest mortality and

230 nital diaphragmatic hernia (CDH), those with agenesis of the diaphragm.

231 Fgf9 null (Fgf9(-/-)) mouse embryos have agenesis of the embryonic cecum, lacking both mesenchyma

232 beta-catenin in Isl1-expressing cells caused agenesis of the hindlimb skeleton and absence of the low

233 Agenesis of the lateral incisor on the non-cleft side wa

234 Hypoplasia and agenesis of the liver lobe is a rare abnormality.

235 chondrial function, embryonic lethality, and agenesis of the liver.

236 of both Osr1 and Osr2 (Osr1/Osr2) results in agenesis of the lungs, trachea and esophagus.

237 Agenesis of the mutant germ cells was accompanied by inc

238 (Dnmt1) in pancreatic progenitors results in agenesis of the pancreas due to apoptosis of progenitor

239 left-dominant liver and short pancreas with agenesis of the pancreatic tail and lateral part of the

240 vival and proliferation, and consequently in agenesis of the perineum and severe hypoplasia of the ge

241 of Esrrg on both alleles (Esrrg(-/-)) showed agenesis of the renal papilla but normal development of

242 In addition, lack of both ligands causes agenesis of the swim bladder, the structural homolog of

243 This appears to be attributable to agenesis or dysgenesis of the majority of RHT-projecting

244 Imbalance of these cues results in CC agenesis or dysgenesis.

245 Isolated or nonsyndromic tooth agenesis or hypodontia is the most common human malforma

246 e most severe renal anomaly, bilateral renal agenesis or hypoplasia (RA/H), has limited the ability t

247 Among them, renal agenesis or hypoplasia, decreased innervation of the gut

248 nephronectin gene frequently display kidney agenesis or hypoplasia, which can be traced to a delay i

249 diated AKT/MAPK activation resulted in renal agenesis or kidney rudiments, whereas mutation of this r

250 PTF1A mutations in patients with pancreatic agenesis or neonatal diabetes but no cerebellar phenotyp

251 potential avenues for therapies for callosal agenesis or related neurodevelopmental disorders.

252 Complete loss of function in mice results in agenesis or severe disruption of periocular mesenchyme s

253 ion of the mouse Sall1 gene results in renal agenesis or severe dysgenesis.

254 that stillborn fetuses with congenital renal agenesis or severe dysplasia would possess mutations in

255 lleles and one Etv5 allele show either renal agenesis or severe hypodysplasia, whereas kidney develop

256 frameshift mutation (Pax21Neu), show either agenesis or severe malformation of the cochlea, respecti

257 tic transcription factor HLXB9 causes sacral agenesis, our results implicate pancreatic transcription

258 e often in subjects with both CL/P and tooth agenesis (p = 0.0008), while the *6C-T variant was found

259 8) presented higher risk for having premolar agenesis (p = 0.02; OR = 1.8; 95% C.I., 1.1-3.0)].

260 y, hospital length of stay, and morbidity in agenesis patients remain significant.

261 ed quite well with the severity of the tooth agenesis pattern seen in vivo.

262 t the mutations co-segregated with the tooth agenesis phenotype (with exception of families in which

263 e GAG chain is key as evidenced by the renal agenesis phenotype in mice deficient in the HS biosynthe

264 ng view that the defect underlying the renal agenesis phenotype is due to a primary role for 2-O sulf

265 nusual and interesting account of cerebellar agenesis published in Brain in 1994 by Glickstein, in wh

266 ve been made, the genetic etiology of dental agenesis remains largely unknown.

267 ggin overexpression caused colobomas, pecten agenesis, replacement of the ventral RPE by neuroepithel

268 Further, we propose that cerebellar agenesis represents a new, dorsal-to-ventral, cell fate

269 Agenesis requires an extensive work-up as a number of as

270 syndrome CRASH (acronym for corpus callosum agenesis, retardation, aphasia, spastic paraplegia, hydr

271 The siblings have a pattern of severe tooth agenesis similar that in to previous reports, suggesting

272 Previous evidence from tooth agenesis studies suggested IRF6 and TGFA interact.

273 ology, we found that 8/26 (about a third) of agenesis subjects presented with autism.

274 of subepidermal hemorrhagic blisters, renal agenesis, syndactyly or polydactyly and permanent fusion

275 that a loss of Eya 1 function leads to renal agenesis that is a likely result of failure of metanephr

276 ted with unique phenotypes of familial tooth agenesis that mainly involve posterior teeth.

277 th dominantly inherited forms of human tooth agenesis that mainly involve posterior teeth.

278 PAX9 are associated with non-syndromic tooth agenesis that preferentially affects posterior dentition

279 identified in only one fetus with unilateral agenesis; this subject also had two RET mutations.

280 compared a group of 26 adults with callosal agenesis to a group of 28 adults with a diagnosis of aut

281 etes manifestations, ranging from pancreatic agenesis to adult-onset diabetes with subclinical or no

282 ng from severe manifestations, such as renal agenesis, to potentially milder conditions, such as vesi

283 esis of >/=1 third molars and that maxillary agenesis was 36% more likely than mandibular agenesis in

284 Tooth agenesis was assessed in permanent teeth and was defined

285 A significant reduction of LG size or agenesis was associated with mutations affecting protein

286 In conclusion, tooth agenesis was associated with positive self-reported fami

287 The worldwide rate of agenesis was found to be 22.63% (95% confidence interval

288 plete concordance of the mutation with tooth agenesis was observed in the extended family.

289 was hyperactive in these foreguts when lung agenesis was observed.

290 Pancreatic agenesis was present in 21 case subjects (six new); two

291 tions are a common cause of congenital tooth agenesis, we screened 92 affected individuals, represent

292 years of the study, 36% of the patients with agenesis were discharged on tube feedings and 22% on oxy

293 childhood behaviour indicated children with agenesis were less likely to meet diagnostic criteria fo

294 anscription factor PDX-1 leads to pancreatic agenesis, whereas heterozygosity for PDX-1 mutations has

295 ciency in mice results in metanephric kidney agenesis, whereas knockdown or mutation studies in zebra

296 Caudal regression syndrome (sacral agenesis), which impairs development of the caudal regio

297 r characterized by pancreatic and cerebellar agenesis, which indicates that the association of P48 an

298 WNT pathways genes in the etiology of tooth agenesis while revealing new candidate genes.

299 USG and MRI showed left renal agenesis with compensatory hypertrophy of the right kidn

300 nockdown of zebrafish Otop1 leads to otolith agenesis without affecting the sensory epithelium or oth