ライフサイエンスコーパス: aggravate

1 age-related memory loss will be dramatically aggravated.

2 aploid A. arenosa and diploid A. lyrata were aggravated.

3 To determine whether PAK dysfunction aggravates AD phenotype, 3xTg-AD mice were crossed with

4 horylation by SRPK2 plays a critical role in aggravating AD pathogenesis.

5 cy already existed before transplant and was aggravated after transplant.

6 hanced release of proinflammatory cytokines, aggravated airway inflammation, and increased mucus prod

7 activation of each PGD2 receptor resulted in aggravated airway neutrophilia, tissue myeloperoxidase a

8 Global inactivation of CES1 aggravated alcohol- or MCD diet-induced liver inflammati

9 , whereas DNase1(-/-)/Trap1(m/m) mice had an aggravated ALI, suggesting that NETs directly influence

10 eption protected WT progeny from allergy, it aggravated allergic airway inflammation in B cell-defici

11 -Blockers and ACE inhibitors synergistically aggravate anaphylaxis at least partly by decreasing the

12 Importantly, bestatin does not aggravate anaphylaxis in CD13-deficient mice.

13 reg cells toward a pathogenic phenotype that aggravates and perpetuates disease.

14 both organisms allows the identification of aggravating and alleviating genetic interactions between

15 Infiltrating monocyte-derived macrophages aggravate APAP hepatotoxicity, and the pharmacological i

16 IL-1R2 deficiency aggravated arthritis severity and increased mRNA levels

17 Aggravated assault rates have decreased from a peak of 4

18 Moreover, GAP43 knockdown aggravated astrogliosis-induced microglial activation an

19 with KLF2-deficient DCs into Ldlr(-/-) mice aggravated atherosclerosis compared with control mice, m

20 tains disruption of monocyte homeostasis and aggravates atherosclerosis.

21 e toward a T helper-1-associated milieu that aggravates atherosclerosis.

22 suspected mechanism by which sIgM deficiency aggravates atherosclerosis.

23 to efflux cholesterol without significantly aggravating autophagy defects.

24 ed eosinophil-directed migration in vivo and aggravated both AHR and eosinophil influx into the airwa

25 owth hormone (GH) are elevated in T1D, which aggravates both hyperglycemia and dyslipidemia.

26 This evolved into type III by aggravating both mechanical substrates.

27 netic (beclin siRNA) inhibition of autophagy aggravated BPA neurotoxicity.

28 r cortical spreading depression (CSD), which aggravates brain damage.

29 n injury or cerebral ischemia, significantly aggravates brain damage.

30 The NCCM phenotype may be aggravated by a common CSRP3 variant in one of the famil

31 The progression of diabetes in males is aggravated by a selective loss of beta-cell mass, while

32 These effects are aggravated by D9 deficiency and dependent upon a virus t

33 y removal of negative supercoils and further aggravated by expression of mutant Top1.

34 nsport in China, and accident injury risk is aggravated by inadequate emergency response systems and

35 spread of antibiotic-resistant bacteria are aggravated by incorrect prescription and use of antibiot

36 ain in the right hip and right leg which was aggravated by limb movement.

37 ur during critical illness and are allegedly aggravated by parenteral nutrition (PN).

38 ortality in patients with CKD and is further aggravated by peritoneal dialysis (PD).

39 also estimated the fraction of these deaths aggravated by pregnancy on the basis of a systematic rev

40 These degenerative changes are further aggravated by proinflammatory cytokines including IL-1be

41 The hyperexcitability is aggravated by reactive oxygen species (ROS).

42 tional defect of NK cells in MPN was further aggravated by ruxolitinib treatment.

43 holestatic potential of certain drugs may be aggravated by simultaneous inhibition of BSEP and MDR3.

44 mild muscle hyperalgesia, which was markedly aggravated by sound stress (peaking 15 days after exposu

45 progressive degeneration of striated muscles aggravated by sterile inflammation.

46 aused by the initial cascade of inflammation aggravated by subsequent sepsis to which the body has be

47 er, whether these behaviors are mitigated or aggravated by surgery.

48 bioactivity, effects that were in some cases aggravated by surgical menopause.

49 inhibited by intracellular Ca(2+) chelation, aggravated by thapsigargin, and unaffected by removal of

50 the health care system, a condition that is aggravated by the development of secondary conditions su

51 Concerns posed by arenavirus infections are aggravated by the lack of U.S. Food and Drug Administrat

52 This situation has been aggravated by the recent emergence of multidrug-resistan

53 e extent to which inflammatory responses are aggravated by Treg depletion was significantly greater d

54 sive and high-grade ovarian cancer, probably aggravating cancer progression and increasing mortality.

55 e through cardiac ryanodine receptors (RyR2) aggravate cardiac remodeling in mice carrying a human Ry

56 xycycline-regulatable transgenic mouse model aggravated cardiac hypertrophy, fibrosis, and contractil

57 ompartment before MI induction, resulting in aggravated cardiac inflammation and deteriorated clinica

58 of chronic myocardial edema and inflammation-aggravating cardiac fibrosis and dysfunction.

59 factor (erythroid-derived-2)-like 2 (Nrf2), aggravates cardiotoxin (CTX)-induced tibialis anterior (

60 stress and a high-fat, high-cholesterol diet aggravate cardiovascular disease, whereas regular physic

61 Macrophage and/or neutrophil depletion aggravated CCl4 -induced liver injury and impeded liver

62 , constitutive dephosphorylation of Ser-2808 aggravated CCM as manifested by shortened survival, dete

63 nfkb1(-/-) fibroblasts exhibit aggravated cell senescence because of an enhanced autocr

64 bers, which did not suffice to significantly aggravate cGN.

65 reas IND-treated MDSCs differentiated in TME aggravated clinical symptoms and delayed resolution of t

66 e reveal that IEC-specific depletion of Tyk2 aggravates colitis.

67 , IL-4(0/0), or STAT6(0/0) was significantly aggravated compared with that of wild-type control mice.

68 an overwhelming TH1 immune response, with an aggravated course of the nephritis that was reversible o

69 us, exogenous stress can benefit rather than aggravate cutaneous inflammatory dermatoses through the

70 in endogenous GC could benefit, rather than aggravate, cutaneous function and reduce inflammation in

71 S100A8 and S100A9 aggravate CVB3-induced myocarditis and might serve as th

72 ximately 92 in cystic kidneys, which in turn aggravates cyst growth by inhibiting oxidative phosphory

73 Moreover, SC depletion aggravated deficits in reinnervation and post-synaptic m

74 In contrast, the TAAR1 agonist RO5166017 aggravated degeneration induced by intrastriatal 6-OHDA

75 ent cell death, reduced hexokinase activity, aggravated depletion of intracellular ATP, decreased lac

76 cy could contribute to development of IBD or aggravate disease activity.

77 ncidence of spontaneous CNS autoimmunity and aggravated disease course, especially in the later stage

78 fts in the microbiota have a pivotal role in aggravating disease.

79 XBP1 or inducible expression of ATF6 in mice aggravates DN.

80 tions, the Li-dendrite growth can be further aggravated due to bending-induced local plastic deformat

81 Pharmacotherapy with mTOR inhibitors aggravates dyslipidemia, thus necessitating lipid-loweri

82 ed that several traits exhibited a gradually aggravating effect as plants were exposed to combined st

83 esynaptic in vivo knockout of beta-neurexins aggravated endocannabinoid-mediated inhibition of synapt

84 t of persistent asthma requires avoidance of aggravating environmental factors, use of short-acting b

85 mong the mediators of these effects, miR-217 aggravates ethanol-induced steatosis in hepatocytes.

86 sing CO2 concentrations has the potential to aggravate eutrophication in Taihu Lake where high nutrie

87 We hypothesized that B2 cells aggravate experimental aneurysm formation.

88 ion, disruption of the circadian clock is an aggravating factor associated with a range of human infl

89 cancer cell-intrinsic RUNX3 inactivation as aggravating factors for genomic instability.Significance

90 and hyperhomocysteinemia were established as aggravating factors for the aortic calcification in asso

91 rs and 2 weeks, non-eye pain intensity, QoL, aggravating factors, and associated factors) confirming

92 and interference with quality of life (QoL), aggravating factors, associated factors, associated non-

93 and the signaling pathways that initiate and aggravate fibrosis in CTS remain unknown.

94 4a) (Trp53(-/-)Cdkn2a(-/-) mice) resulted in aggravated fibrosis after transverse aortic constriction

95 deletion or pharmacologic inhibition of MIF aggravated fibrosis and inflammation, whereas treatment

96 ation and inflammatory T cell responses were aggravated following Treg depletion, regardless of the t

97 d glucose intolerance, however, this was not aggravated further by IUGR.

98 eased susceptibility to severe CP, which was aggravated further when combined with smoking.

99 lts of a functional study indicated that the aggravating GA genotype of IL17F rs6913472 was associate

100 The aggravating genotypes were associated with high IL22RA2

101 ARALAR deficiency did not aggravate glutamate-induced neuronal death in vitro, alt

102 mic control, whose reduction during diabetes aggravates glycemic volatility and contributes to the pa

103 it occurs in several parts of the world, may aggravate harmful effects of ROS-inducing stressors such

104 ert's Syndrome (GS; UGT1A1*28 polymorphism), aggravated health effects have been determined.

105 at compromises left ventricular function and aggravate heart failure.

106 ion of TREM2 was found to be responsible for aggravated hepatitis, indicating a novel role for TREM2

107 Our results indicate that T2DM aggravates HF after MI through defective mitophagy, asso

108 Both mild and moderate HHcy aggravated HG-impaired endothelium-dependent vascular re

109 HHcy aggravated HG-increased phosphorylation of eNOS at threo

110 responsiveness compromises tissue perfusion, aggravates hypertension, and sets the stage for later pe

111 pression and anxiety was identified with (1) aggravated hypo-function of the right-lateralized dorsal

112 to the depletion of the oxygen pool, further aggravating hypoxia in the Baltic Sea.

113 t NF-kappaB inactivation in oligodendrocytes aggravated IFN-gamma-induced remyelinating oligodendrocy

114 chronic viral infections may precipitate or aggravate immune dysregulation in RAG-deficient hosts.

115 The severity of C5a-ALI was aggravated in C5-deficient mice.

116 itic spine phenotype of Fmr1(-/y) cortex was aggravated in Fmr1(-/y); Cyfip2(+/-) double-mutant mice.

117 Staphylococcus aureus infection was aggravated in humanized mice, compared with wild-type or

118 Finally, NTN was aggravated in mice with macrophage-specific impairment o

119 TNF-induced albuminuria was aggravated in mice with podocyte-specific ABCA1 deficien

120 Deposition of amyloid appears aggravated in patients with cerebral small-vessel diseas

121 ne (TMPD)-mediated peritonitis was similarly aggravated in STING-deficient mice.

122 begin during puberty and are generally more aggravated in the knockout females.

123 here that Ang II-mediated calcium influx is aggravated in the podocytes under the conditions of type

124 NMJ deficits are aggravated in these mice when compared to single FE65- a

125 hylaxis, and collagen-induced arthritis were aggravated, in contrast to experimental autoimmune encep

126 Scale formation and acanthosis were aggravated, in correlation with increased IL-17A and IL-

127 erresponsiveness and Ndrg1-deficient T cells aggravate inducible autoimmune inflammation.

128 tion-restricted) stress reduced, rather than aggravated inflammation and improved epidermal function

129 in-angiotensin system, which correlates with aggravated inflammation and more lung injury.

130 , we report that the mechanism by which this aggravated inflammation arises is through the inhibition

131 Anti-CD3 aggravated inflammation in the small intestines of Slamf

132 the first time, these data show that TREM-1 aggravates inflammation in ALI by activating NLRP3 infla

133 nce for a novel mechanism that localizes and aggravates inflammation via phospholipase A2-dependent d

134 influx or by enhancing cytokine production, aggravating inflammation and tissue injury.

135 e during coinfection was not associated with aggravated inflammatory cytokine response or cell infilt

136 ice, compared with wild-type mice, exhibited aggravated injury and an impaired transition of renal ma

137 tion in epididymal adipose tissue (EAT), and aggravated insulin resistance in response to DIO.

138 nflammation and treatment with oral iron may aggravate intestinal inflammation.

139 uate A20 expression in A20 heterozygote mice aggravated intimal hyperplasia following partial carotid

140 activation further decreased cell viability, aggravated intracellular LDH release, intracellular Ca(2

141 ss nearby vascular structures, which further aggravates ischemia by reducing local microcirculatory f

142 When Ager was deleted, hyperglycemia did not aggravate ischemic brain damage any longer.

143 energy substrate of the brain, hyperglycemia aggravates ischemic brain damage in acute stroke.

144 On the one hand, innate immunity both aggravates ischemic injury and impedes remodeling after

145 yeast cells to identify genes whose deletion aggravated its fitness.

146 aises concern that ustekinumab may unmask or aggravate joint disease in selected patients.

147 ed the expression of UCP2 and sirtuin 3, and aggravated kidney injury but did not affect STC1 express

148 20 haploinsufficiency in vascular allografts aggravates lesions of TA by exacerbating inflammation, S

149 -) mice exhibited increased inflammation and aggravated liver damage upon viral infection, which was

150 Inhibition of KCa3.1 aggravated liver fibrosis during carbon tetrachloride ch

151 , whereas adoptive transfer of hepatic ILC2s aggravated liver inflammation and tissue damage.

152 ence that IL-22 protects against and IL-22BP aggravates liver fibrosis and cirrhosis in humans with c

153 lammatory functions early post-APAP, thereby aggravating liver injury.

154 ivation of the innate immune system, further aggravating liver injury.

155 disruption of iron homeostasis and possibly, aggravated loss of liver functions.

156 e suffer increased mortality associated with aggravated lung injury.

157 s, and conversely, down-regulation of miR-21 aggravated metformin's action and revealed significant p

158 ther no significant (ramipril) or a modestly aggravating (metoprolol) effect, their combined administ

159 Such increases were concomitant with aggravated microglial activation and neuroinflammatory s

160 n anaphase, and increasing chromosome length aggravates missegregation in topo II mutant cells.

161 Beclin-1/LC-3 and downregulation of p62, and aggravated mitochondrial dysfunctions and ER stress as s

162 Thus, mutated YARS2 aggravates mitochondrial dysfunctions associated with th

163 n risks for comorbidities, but also to avoid aggravating MS-related disability.

164 to prolonged deterioration of lung function, aggravated mucus production, peri-vascular, peri-bronchi

165 , including eosinophils and lymphocytes, and aggravated mucus production.

166 Suppression of miR-132 aggravates multiple layers of pathology at the molecular

167 en seen in humans with chronic inflammation, aggravates murine atherosclerosis through programming mo

168 mmunization of myositis-prone mice with FHL1 aggravated muscle weakness and increased mortality, sugg

169 IL-1beta receptor blockade abrogated aggravated NCGN in gp91(phox)-deficient mice.

170 s themselves, resulting in either minimal or aggravated neointima formation.

171 Intrauterine infection (chorioamnionitis) aggravates neonatal hypoxic-ischemic (HI) brain injury,

172 triggers pro-inflammatory processes that can aggravate neuronal degeneration and functional impairmen

173 ive nephritogenic immunity was sufficient to aggravate NTN within 2.5 days, a period when macrophages

174 thermore, absence of Treg1 cells resulted in aggravated NTN with selectively dysregulated renal and s

175 7.1 and B7.2 (double knockout; DKO) revealed aggravated obesity-related metabolic dysregulation, redu

176 level necessary for genome-editing, thereby aggravating off-target effects.

177 Silencing of Malat1 also significantly aggravated OGD-induced expression of the proapoptotic fa

178 Both cardiac phenotypes were aggravated on pressure overload.

179 ans of many diseases but also can strikingly aggravate or start systemic pathophysiological processes

180 ion of variations in wound care, wounds were aggravated or minimally handled postinjury.

181 ministered on a delayed basis and should not aggravate outcomes associated with hemorrhagic stroke.

182 toms from the primary injury that can become aggravated over time because of secondary cell death.

183 dothelial cells, we here show that TGF-beta1 aggravates oxidative stress-mediated inflammatory activa

184 forest communities and ozone, which further aggravates ozone pollution.

185 degeneration, nerve injury was significantly aggravated (P = 0.032) after prolonged CI.

186 ain-derived neurotrophic factor ratio, which aggravates p75 neurotrophin receptor-mediated cell death

187 rison of the mutations linked to either cold-aggravated pain or pain insensitivity, we propose a mode

188 HAP which impaired hepatic microcirculation, aggravated parenchymal damage, decelerated recovery, and

189 RGS5 deficiency aggravates pathophysiological features of hypertension,

190 effects on bone tissue, and osteoporosis can aggravate periodontitis.

191 ge (p.V1184A) in NaV1.9, which leads to cold-aggravated peripheral pain in humans.

192 trimental anti-angiogenic effects leading to aggravated peritubular capillary loss.

193 n culture further enhances MFGE8 expression, aggravates phagocytosis, and leads to neuronal injury.

194 or specifically in cardiomyocytes develop an aggravated phenotype induced by pressure overload.

195 Additionally, MO depletion of PDE1A aggravated phenotypes in pkd2 morphants, causing more se

196 1 in PINK1 or parkin loss-of-function mutant aggravates phenotypes caused by loss of either gene alon

197 tatins enhanced the canonical Hh-pathway and aggravated PHT and angiogenesis.

198 ion of APOE and of Abeta in the brain and in aggravated plaque burden.

199 fic insulin receptor knockout mice exhibited aggravated post-ischemic ventricular remodeling and dysf

200 of mediators that can induce lung injury or aggravate pre-existing injury, potentially leading to mu

201 CKD aggravates pre-existent traditional risk factors such as

202 ebellar organotypic cultured slices markedly aggravated prion-induced neurotoxicity.

203 ement-binding protein 2 is a key molecule in aggravating proinflammatory responses in endothelial cel

204 important for cell fitness, and its absence aggravates proteasome defects.

205 or shortage can increase amyloidogenesis and aggravate protein aggregation disorders.

206 as potential trigger of drug-induced or drug-aggravated psoriasis, in which Th17 cells sustain a pers

207 release extracellular DNA traps, which could aggravate pulmonary dysfunction.

208 Adenosine aggravated ragweed-induced allergic lung inflammation.

209 2alpha at the beginning of CKD significantly aggravated renal fibrosis, whereas it did not lead to re

210 D11c(+) cells separated from diseased kidney aggravated renal injury in AN mice.

211 responsible for promoting these effects and aggravating renal injury in HIV-transgenic mice.

212 Exogenous replication inhibition aggravates replication-originated DNA lesions without in

213 ceptor proteins in retinal inflammation that aggravates retinal cell death.

214 ate whether female recipients still carry an aggravated risk of this malignancy after kidney transpla

215 nsatory role of tissue redundancy of DMD (or aggravating role of tissue paucity of FED) on mitral reg

216 Moreover, ACE2 deficiency aggravated RSV-associated disease pathogenesis, mainly b

217 While zero levels (ppGpp degrees ) greatly aggravated sensitivity, high levels promoted resistance.

218 and elevated soluble brain Abeta, leading to aggravated spatial learning and memory deficits, thus em

219 nd beta-oxidation, a high-fat diet challenge aggravated steatohepatitis in mice with hepatocyte-speci

220 e on their involvement in neuroinflammation, aggravating stroke, temporal lobe epilepsy, neuropathic

221 Co-transcriptional R-loops could aggravate such conflicts by creating an additional barri

222 nnel does not cause kidney barrier injury or aggravate such injury under pathologic conditions.

223 phritogenic immune responses in vivo, it may aggravate such responses in clinically relevant situatio

224 not oleic acid, implying a buildup of LA for aggravating such pro-fibrotic effects.

225 fter CD8(+) T-cell depletion did not further aggravate symptoms of EBV infection.

226 ith a monoclonal IL-10 neutralizing antibody aggravated symptoms and prolonged disease to a similar d

227 ty for increased liver steatosis and develop aggravated systemic insulin resistance in response to hi

228 Individuals carrying the aggravating T allele of rs2227473 produced significantly

229 Aggravated TA in HET versus WT allografts correlated wit

230 asia in HET versus WT allografts, indicating aggravated TA.

231 ir follicle cycling and that its absence may aggravate the clinical manifestations of ABCA12 mutation

232 s is underway, the use of norepinephrine may aggravate the development, extent, and duration of sepsi

233 gh clinical relevance because hemorrhage may aggravate the disease state and increase mortality.

234 reatment of specific inflammatory cells that aggravate the disease.

235 hat these peptides may directly interact and aggravate the disease.

236 pending on the HDM extract used, but did not aggravate the eosinophilic airway inflammation or airway

237 ge surface area, however, did not noticeably aggravate the fouling problem.

238 thal effect in M. robertsii; however, it did aggravate the fungal apoptotic effect of farnesol.

239 is hypothesized that p,p'-DDE exposure could aggravate the harm of an obesogenic context.

240 emplifies how poor nutritional condition can aggravate the life-history costs of resistance and eleva

241 e shows full rescue, but three other rescues aggravate the phenotype.

242 Phacoemulsification surgery may aggravate the signs and symptoms of dry eye and affect d

243 ere, we tested the hypothesis that PNE would aggravate the SLCF-mediated apnea and bradycardia via up

244 efective refolding of TDP-43 is predicted to aggravate the TDP-43 proteinopathy.

245 glucose ingestion increased QT interval and aggravated the cardiac repolarization disturbances in LQ

246 gene encoding the cognate receptor of SLIT3, aggravated the defect in vascular development in the dia

247 a, Pde1c, or Pde3a but not of Pde1b or Pde3b aggravated the development of PKD and was associated wit

248 ely, the inhibition of miR-199a-3p functions aggravated the myeloid proliferation defect in the Ercc1

249 eutic IKK2 inhibition during ongoing disease aggravated the nephritogenic immune response and disease

250 (phospho-S2448-mTOR) with rapamycin further aggravated the RB defect.

251 This has aggravated the risk of contaminating agricultural fields

252 titis induced by both bacteria significantly aggravated the severity of collagen-induced arthritis.

253 of this enzyme causes neurodegeneration and aggravates the AD features of the 3xTgAD mouse, inducing

254 mory deficits, whereas neprilysin deficiency aggravates the behavioral phenotypes.

255 itional loss of beta3 integrins dramatically aggravates the bleedings and severely compromises smooth

256 in landfills without proper recycling, which aggravates the burden of waste disposal in landfill.

257 Thus, preexisting CKD aggravates the cardiac dysfunction caused by sepsis or e

258 w that high-fat diet-induced steatohepatitis aggravates the inflammation in psoriasiform dermatitis,

259 cNAcylation pharmacologically or genetically aggravates the ischemia-induced brain damage, motor defi

260 n portal venous and hepatic arterial inflow, aggravates the liver damage, and delays the recovery pro

261 ermore, the loss of Hog1 MAP kinase function aggravates the loss of RNA polymerase II from housekeepi

262 g the early phase of sepsis development that aggravates the outcome of severe bacterial infection.

263 on of Scly in conjunction with Sepp1 further aggravates the phenotype of Sepp1(-/-) mice, as these mi

264 esistance, especially among Candida species, aggravates the problem.

265 odel, in which we found that SGK1 inhibition aggravates the severity of multiple organ damage and enh

266 the electric field used for electroporation aggravates the toxicity of hydroxyl because the electrop

267 xpression is itself an oncogenic lesion that aggravates the tumorigenesis induced by p53 loss.

268 get to surgery, hampering access to care and aggravating the lack of inpatient beds.

269 rbates PC12 cell death at least partially by aggravating the mitochondrial impairment and ER stress a

270 in is invariant regardless of blood glucose, aggravating the potential to cause hypoglycemia.

271 ation altered assemble of complex I, thereby aggravating the respiratory phenotypes associated with m

272 Our results suggest that PNE is capable of aggravating the SLCF-mediated apnea and bradycardia thro

273 of patients with atopic dermatitis (AD) and aggravates their disease.

274 y, mTOR inhibition by rapamycin dramatically aggravates their PMN RB defect, which may increase patie

275 as CD40-TRAF6 interactions in MHCII(+) cells aggravate these complications.

276 restricted to renal tubular epithelial cells aggravated these effects.

277 he emergence of new pathotypes of the fungus aggravate this agricultural problem.

278 the titanium surfaces, i.e., corrosion, that aggravate this inflammatory response.

279 h enucleation alone, and adding chemotherapy aggravated this effect.

280 these abnormalities in skeletal muscle, but aggravated those in the heart also causing cardiac fibro

281 le in hemostasis and arterial thrombosis, it aggravates thrombo-inflammatory diseases such as stroke

282 ir dysregulated production and signaling can aggravate tissue damage during infection, inflammatory d

283 diated pyroptosis and IL-1beta release could aggravate tissue injury.

284 nous danger signal, driving inflammation and aggravating tissue injury.

285 B) p65 phosphorylation, while AAT1 knockdown aggravated TNF-alpha-activated NF-kappaB pathway, which

286 ein in vivo and that this is associated with aggravated toxicity of alpha-synuclein and its downstrea

287 g by suppressing ABA sensitivity, which then aggravates transpiration further.

288 kappaB activation in renal tubular epithelia aggravates tubular injury and exacerbates a maladaptive

289 restriction under normoxia that are further aggravated under hypoxia.

290 This phenotype was further aggravated upon repeated injections of CTLs.

291 e, V-ATPase dysfunction either results in or aggravates various other diseases, but little is known a

292 Given its potential role in aggravating vascular dysfunction, we examined the role o

293 S1P deficiency aggravated vasoplegia in this model, arguing a vital rol

294 inhibition or deficiency diminished HPV and aggravated ventilation-perfusion mismatch.

295 acts of HI mostly occur upstream, whereas HI aggravate water scarcity downstream; HI cause water scar

296 e the critical dimensions of water scarcity, aggravating water scarcity for 8.8% (7.4-16.5%) of the g

297 e (xenograft-versus-host disease), which was aggravated when murine subjects were administered clinic

298 sing finding that CD40 deficiency on T cells aggravates whereas activation of CD40 signaling improves

299 These deficits were aggravated with aging.

300 consequence, loss of SEDT2 in the intestine aggravated Wnt/beta-catenin signaling effects, thereby l