ライフサイエンスコーパス: aggrecanase-1

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1 profiles, the pursuit of inhibitors for both aggrecanase 1 (a disintegrin and metalloproteinase with

2 Aggrecanase-1 [a disintegrin and metalloproteinase with

3 Aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5) ha

4 We have recently cloned human aggrecanase-1 (ADAMTS-4) and herein demonstrate that in

5 Aggrecanase-1 (ADAMTS-4) is a member of the a disintegri

6 lu(373)-Ala(374) site is cleaved in vitro by aggrecanase-1 (ADAMTS4) and aggrecanase-2 (ADAMTS5), whe

7 iption-polymerase chain reaction analyses of aggrecanase-1, aggrecanase-2 (ADAM-TS4, ADAM-TS5, respec

8 Aggrecanase-1 and -2 (ADAMTS-4 and ADAMTS-5) are zinc me

9 Therefore, aggrecanase-1 and -2 are differentially regulated in FLS

10 NF-kappaB activity resulting in induction of aggrecanase-1 and aggrecanase-2 expression, with consequ

11 n or expression of the two key aggrecanases (aggrecanase-1 and aggrecanase-2) in synovial tissue (ST)

12 inc metalloproteases commonly referred to as aggrecanase-1 and aggrecanase-2, respectively.

13 We examined the expression patterns of aggrecanases 1 and 2 (ADAMTS 4 and 5, respectively) in B

14 other TIMPs, is a strong inhibitor of human aggrecanases 1 and 2, with K(i) values in the subnanomol

15 down of cartilage aggrecan include ADAMTS-4 (aggrecanase 1) and ADAMTS-5 (aggrecanase 2).

16 2), which has extensive homology to ADAMTS4 (aggrecanase-1) and the inflammation-associated gene ADAM

17 0188, a homolog of angiopoietin-2, ADAMTS-4 (aggrecanase-1), and stanniocalcin were revealed.

18 of matrix metalloproteinases-3, -9, and -13, aggrecanase-1, and the matrix protease regulator cycloox

19 SP-1) motif located within the C terminus of aggrecanase-1 binds to the glycosaminoglycans of aggreca

20 gions of the TSP-1 motif effectively blocked aggrecanase-1 cleavage of aggrecan by preventing the enz

21 toward the target substrate in a commercial aggrecanase 1 enzyme-linked immunosorbent assay and was

22 trated that TGF-beta significantly increased aggrecanase-1 gene expression in FLS.

23 The aggrecanase-1 gene was constitutively expressed by both

24 Aggrecanase-1 induction peaked after 24 h of TGF-beta st

25 , these data suggest that the TSP-1 motif of aggrecanase-1 is critical for substrate recognition and

26 Both are constitutively expressed, but aggrecanase-1 is induced by cytokines, especially TGF-be

27 Aggrecanase-1 is one of two ADAMTS cartilage-degrading e

28 ADAMTS-4 (aggrecanase-1) is implicated in the breakdown of articul

29 ADAMTS-4, also referred to as aggrecanase-1, is a glutamyl endopeptidase capable of ge

30 1) A truncated form of aggrecanase-1 lacking the TSP-1 motif was not effective

31 rom patients with arthritis, suggesting that aggrecanase-1 may be important in diseases involving car

32 The expression of aggrecanase-1 mRNA was significantly greater in RA ST th

33 ing recombinant human ADAMTS-4 (rHuADAMTS-4; aggrecanase 1) or rHuADAMTS-5 (aggrecanase 2).

34 everal studies indicate that this binding of aggrecanase-1 to aggrecan through the TSP-1 motif is nec

35 3) Aggrecanase-1 was not effective in cleaving glycosaminog

36 pological substrate specificity of ADAMTS-4 (aggrecanase-1) was examined using triple-helical or sing

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