ライフサイエンスコーパス: aggregate

1 mutations distinct from their propensity to aggregate.

2 eased propensity of de novo Arg-rich SAHs to aggregate.

3 tite was only detected in the high-P subsoil aggregate.

4 equences (ER3 (AEEERRR) and EK1R2 (AEEEKRR)) aggregated.

5 ls that are helically oriented and laterally aggregated.

6 ed mutants form both amyloids and nonamyloid aggregates.

7 f HD140Q KI mice reduces the density of mHtt aggregates.

8 , as essential for the formation of TRIOBP-1 aggregates.

9 ding activity compared to recombinant alphaS aggregates.

10 echanisms driving cell sorting in Hydra cell aggregates.

11 and structurally similar amyloid cross-beta aggregates.

12 nor complex size but reduced the density of aggregates.

13 changes the morphology of assembled amyloid aggregates.

14 contribute to the neurotoxic effect of Abeta aggregates.

15 which subsequently convert into amyloid-like aggregates.

16 into porous carbon without the formation of aggregates.

17 librate it to measured variation in regional aggregates.

18 that fluoresces upon AgHalo forming soluble aggregates.

19 and transmission properties of synthetic PrP aggregates.

20 related with the formation of intermolecular aggregates.

21 by the internalization of exogenous protein aggregates.

22 folding proteins by integrating into forming aggregates.

23 greater accumulation of pore space in larger aggregates.

24 guish between the soluble and more insoluble aggregates.

25 he case of humic acid, incorporation into HA aggregates.

26 e of gluten proteins concerning formation of aggregates (1604cm(-1)), H-bonded parallel- and antipara

27 The oxidation potential for aggregated 4 and 15 nm diameter Au NPs shifts positive b

28 xidation potential does not shift at all for aggregated 50 nm diameter Au NPs.

29 Aggregating 500 iterations of the model reveals a high-r

30 a result of electronic coupling within these aggregates, a redshift both in the absorption and emissi

31 cular dimers, crystalline films or molecular aggregates absorb a photon to produce a singlet exciton,

32 Ocean feedback management, and suggest that aggregating abundance across space provides the fastest

33 zed ribosomes, ultimately preventing protein aggregate accumulation within mitochondria.

34 Results are aggregated across training cohorts.

35 ring neuronal function, and clearing protein aggregates across the lifespan.

36 LC from all patients formed amyloid-like aggregates, albeit with individually different kinetics.

37 The TER statistically aggregates all misclassification error rates (MER) by ta

38 resources provide only summary statistics or aggregate allele frequencies.

39 ein E4 exacerbated the brain accumulation of aggregated amylin and vascular pathology in HIP rats.

40 ockout (AKO) rats intravenously infused with aggregated amylin were used for in vivo phenotyping.

41 associated with the accumulation of protein aggregates; amyloid-beta (Abeta) and tau in the brain du

42 For rare variant aggregate analysis, an exome-wide significant associatio

43 ents enriched in organic material; they then aggregate and form ordered aragonitic structures through

44 pproach to chemically map small molecules in aggregated and single Escherichia coli cells, with appro

45 alphaII/betaII aggregates and alphaII spectrin in the insoluble protein

46 evisiae solubilizes stress-induced amorphous aggregates and amyloids.

47 wever, circulating neutrophils form unstable aggregates and are unexpectedly primed to respond robust

48 ons disentangle individual proteins from the aggregates and assist in their refolding to the native s

49 sites from limited proteolysis of harvested aggregates and effects of mutations on kinetics and prod

50 l chelate unit has a significant impact on J-aggregates and fluorescence of BODIPYs.

51 on of interferon-inducible GTPase-containing aggregates and hampered recruitment of interferon-induci

52 and RO6924963-that bind specifically to tau aggregates and have the potential to become PET tracers

53 important for the formation of amyloid-like aggregates and long-term memory in vivo.

54 characterized by the accumulation of protein aggregates and mitochondrial dysfunction.

55 riatal excitatory synapses, clearance of Htt aggregates and preserves body mass compared with HD mice

56 the disaggregase Hsp104 helps to dissociate aggregates and thereby enables refolding or degradation

57 ls of C-terminal truncation, soluble protein aggregates, and glycation that all likely have a limited

58 her number of circulating platelet-leukocyte aggregates, and neutrophils displayed a greater tendency

59 ity to aggregate, searching for co-occurring aggregates, and uncovering a group of coalescing RBPs th

60 es, from near-random mating in protandry, to aggregate- and harem-spawning in protogyny.

61 rrently used for characterization of protein aggregates are prone to a number of limitations and usua

62 regates were located, indicating that desmin aggregates are rigid.

63 mission X-ray microscopy revealed that these aggregates are strongly associated with a protein-rich b

64 The sizes of the resulting aggregates are tunable and can be controlled by the conc

65 During this process, VirE2 was aggregated as filamentous structures and was present on

66 is complicated by the propensity of mAbs to aggregate at elevated concentrations, which can lead to

67 f styrene-maleic acid copolymers that do not aggregate at low pH or in the presence of polyvalent cat

68 Aggregated bands located at 1683 and 1616cm(-1) became e

69 ce itself.SIGNIFICANCE STATEMENT Forecasting aggregate behavior with individual neural data has prove

70 The accumulation of aggregated beta-amyloid and tau proteins into plaques an

71 cluding high basal ATPase activity, a unique aggregate binding domain, and almost exclusive expressio

72 sticated immunotherapy targeting soluble and aggregated brain amyloid-beta (Abeta) continues to domin

73 or 26546503 US births through June 30, 2013, aggregated by month and state of birth.

74 blue-, green-, yellow-, and red-emitting CD aggregates by tuning the concentration of fatty acids.

75 e tissue, the omentum also contains lymphoid aggregates, called milky spots (MSs), that contribute to

76 similar to ionic micelles, on one hand, such aggregates can disrupt native hydrophobic interactions,

77 lease in solution, suggesting that assembled aggregates can serve as nuclei for aggregation in bulk s

78 t the ability of neural features to forecast aggregate choice, which could inform applications releva

79 connections among glucosylceramide, protein aggregate clearance, and autophagy.

80 at micromolar concentrations in vitro, have aggregate-clearing activity in a cellular model of Hunti

81 In aggregate, common single-nucleotide polymorphisms (SNPs)

82 s is known to affect temporal variability of aggregate community properties.

83 l community and are more pronounced in macro-aggregate compared with micro-aggregate sizes.

84 at slow dewatering would create more compact aggregates compared to fast dewatering.

85 h type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IA

86 es, E46K alphaS polymers are likely distinct aggregated conformers that may represent a unique prion-

87 dis, and electron microscopy showed cellular aggregates connected by discrete surface linkages.

88 hology of the particles; approximately 15 nm aggregates consisting of 5-7 nm faceted crystals in the

89 anges in the opposite direction, with larger aggregates containing less pore space than under control

90 Aggregates containing sHsps facilitate the access of Hsp

91 Myh6-sTNF mice develop protein aggregates containing ubiquitin-tagged proteins within c

92 he corresponding authors of 17 cohorts, with aggregate data from 2 cohorts.

93 population, and a mathematical model fit to aggregate data from that sample population.

94 Simulated aggregate data from the trials were used as model inputs

95 A previous aggregate data meta-analysis of randomised controlled tr

96 Routine aggregate data suggest a large treatment gap (pre-treatm

97 Using this aggregate data, we identified a statistically significan

98 ubstantially reduces the amount of insoluble aggregates, decreases muscle fibrosis, reverts muscle st

99 and the hairpin assembles into non-fibrillar aggregates, demonstrating that the hairpin fold dramatic

100 ent non-living membrane vesicles and protein aggregates derived from blood.

101 lso called (18)F-AV-1451) PET, targeting tau aggregates, detects these differences, and we compared t

102 toxicity or through the production of toxic aggregating dipeptide repeat proteins.

103 brains by the presence of key misfolded and aggregated disease proteins, but cellular processes lead

104 chiral organic semiconductors from helically aggregated dyes as sensitizers; Zn-porphyrins and triary

105 Gene-based tests were used to assess the aggregate effect of SNPs on outcome.

106 All aggregate effect sizes and moderator variables were test

107 ng the future risks of GDM in the temporally aggregated EHRs.

108 The aggregate emission rate (aE) of the nonbiogenic VOCs ran

109 omposed of noncrystal nanospheric vancomycin aggregates entangled with uromodulin explained the vanco

110 rmance in this crowding task more generally: aggregate errors cannot be neatly labelled because they

111 f the alpha-synuclein misfolding and why the aggregates escape cellular degradation under disease con

112 cavity mediated hybridization of GaAs and J-aggregate excitons in the strong coupling regime under e

113 The multichain aggregates exhibit a decrease of photon antibunching con

114 to provide a set of consistent primary PM2.5 aggregated exposure factors.

115 Weight-averaged aggregate first-trimester DBP exposures were assigned to

116 tonic circuits using spatially organized dye aggregates for use in coherent nanoscale energy transpor

117 solution and attach to the electrode in the aggregated form.

118 Static platelet aggregate formation on extracellular matrix was similarl

119 from early synaptic dysfunction prior to Tau aggregate formation, but the underlying mechanism is unc

120 mainly consisting in rolling, adhesion, and aggregate formation.

121 conserved proteins that positively regulates aggregate formation.

122 We demonstrate that aggregates formed by association of coiled-coil proteins

123 We describe the structure and morphology of aggregates formed by the P23T human gammaD-crystallin mu

124 n of a specific type of fibril by binding to aggregates formed early on one of multiple pathways, the

125 This heterogeneity could be due to tau aggregates forming distinct structural conformations, or

126 ressive accumulation of hyperphosphorylated, aggregated forms of tau.

127 Amyloid aggregates found in the brain of patients with neurodege

128 Through an analysis of soil aggregate fractal properties supported by 3D microtomogr

129 anic matter associated with soil mineral and aggregate fractions in some of the ecosystems they invad

130 The plant biomarkers were lower in the aggregate fractions of the P. lobata-invaded soils, comp

131 e productive spreading of prion-like protein aggregates from a "donor cell" that is the source of mis

132 istinguish infectious and pathogenic protein aggregates from more innocuous ones are poorly understoo

133 the expression profiles of the glue-forming aggregate glands were divergent from fiber-forming gland

134 rtilin-independent sorting mechanisms target aggregated Golgi membrane proteins for lysosomal degrada

135 venous plasma glucose concentrations in the aggregate group were 152 +/- 10 and 178 +/- 9 mg/dL, res

136 Acrolein was the dominant contributor to the aggregate harm.

137 are only detected after irreversible protein aggregates have formed.

138 and enhances the formation of fibrillar tau aggregates, highlighting both loss and gain of tau funct

139 We aggregated hourly blocks of time, using previously defin

140 anaphylaxis was induced by injection of heat-aggregated human intravenous immunoglobulin and active s

141 ating produced by concentration quenching in aggregated ICG imbedded in the mesopourous silica shell

142 ormula: see text] that may form pathological aggregates if not effectively cleared.

143 tibunching contrast compared to single-chain aggregates, implying rather weak interchain excitonic co

144 Causal variants that aggregate in families usually have larger effect sizes t

145 In solutions below pH 3.0, the Au NPs aggregate in solution and attach to the electrode in the

146 I) actually share pathogenesis and should be aggregated in the same diagnostic group remains an open

147 omising PET tracers for visualization of tau aggregates in AD.

148 sues and may play a role in the formation of aggregates in disease.

149 eding mechanisms of alpha-synuclein (alphaS) aggregates in human cells, we visualized alphaS aggregat

150 iaryl chelate unit have been found to form J-aggregates in methanol-water solvent mixture and brightl

151 The presence of nonphysiological aggregates in purified properdin preparations and experi

152 iculties, proximal limb weakness and nuclear aggregates in skeletal muscles.

153 l cross-seeding between DISC1 and mutant HTT aggregates in the brains of HD patients as well as in a

154 n a complex and poorly understood manner and aggregates in the cytoplasm of degenerating neurons in P

155 The inserted peptides formed aggregates in the membrane core leading to further struc

156 vivo selective and reliable detection of tau aggregates in these non-Alzheimer tauopathies.

157 lded species that are prone to forming toxic aggregates, including soluble oligomers and fibrillar am

158 e to increases in both soluble and insoluble aggregates, including subvisible particles.

159 orage material (AFSM) accumulation, CSPalpha aggregates, increased levels of lysosomal proteins and l

160 ctly measured (correlative proxies), or that aggregate information about multiple soil characteristic

161 ks are typically constructed from temporally aggregated interaction data, thereby implicitly assuming

162 in water after which the chains collapse and aggregate into bigger globules when passing to above its

163 chiral adsorbates on surfaces preferentially aggregate into heterochiral rather than homochiral domai

164 show that in these ecosystems plant species aggregate into two major clusters that are each defined

165 The porosity of clay aggregates is an important property governing chemical r

166 Formation and stability of these mutant aggregates is linked to palmitoylation of the cysteine-s

167 of proteopathic alpha-synuclein (alpha-syn) aggregates is thought to underlie the progression of neu

168 Further, we demonstrate that alphaS aggregates isolated from postmortem human brains with di

169 TMDs) of t-SNARE complexes are shown to form aggregates leading to formation of lipid nanodomains, wh

170 Formation of these protein aggregates leads to AD-like neurodegeneration.

171 ay deformation that scales linearly with the aggregate length becomes prohibitive for lower concentra

172 parameters independently verify the trend in aggregate lengths and provide a physical picture of the

173 formance in several species, and also at the aggregate level (G); however, there is ambiguous evidenc

174 ere able to mediate significant decreases in aggregate levels.

175 These frequencies appear to aggregate local neuronal activity, but it is unclear how

176 The clusters were composed of aggregated local areas (neighbourhoods) that had been id

177 In aggregate, maintenance of Orai activation required not o

178 Recent studies have shown that tau aggregates may form distinct structural conformations, k

179 e structures on the surface of multicellular aggregates (MCAs) are removed by treatment with LPA.

180 When evaluated according to aggregate measurements, treatment efficacy is generally

181 that are based on country-level reporting or aggregate measures of emissions, we present the identifi

182 gle-cell or fMRI responses and obtained only aggregate measures that combined the activity to individ

183 Results of a Cochrane aggregate meta-analysis of the relative efficacy and saf

184 nt of the metabolic syndrome, issues such as aggregate microvascular perfusion resistance, mass trans

185 ed peridotites (synthetic antigorite-olivine aggregates, minerals representative of subduction zones

186 he protein populating less compact forms and aggregating more readily.

187 Diversity in aggregate morphology correlates with the differences in

188 ted associations of individual-level safety, aggregated neighborhood-level safety, and police-recorde

189 anol, a solvent in which the sensor does not aggregate, no fluorescence response to fructose was obse

190 The aim of this analysis was to evaluate the aggregate of hemocompatibility-related clinical adverse

191 In a multicellular aggregate of hPSCs, intracellular apicosomes from multip

192 iginate from a structural similarity between aggregates of Abeta and hIAPP.

193 67161 slowed the accumulation of hippocampal aggregates of alpha-synuclein, ubiquitin, and tau, and i

194 uted to the existence of regions depleted by aggregates of certain sizes in the parent branch, and to

195 Deposition of aggregates of hyperphosphorylated tau protein is a hallm

196 Circulating platelets, aggregates of monocytes and platelets, and activation of

197 n's disease is the presence of intracellular aggregates of mutant huntingtin, the pathological signif

198 recruits Parkin proximal to focal misfolded aggregates of the mitochondrial-localized mutant ornithi

199 Nearly all patients with ALS have aggregates of the RNA-binding protein TDP-43 in their br

200 Aggregates of viruses can have a significant impact on q

201 whether the pathogenesis is associated with aggregated or more soluble forms of the protein.

202 natural aquatic environment as loosely bound aggregates or "flocs" and is responsible for the transpo

203 In aggregate, our analyses suggested a tightly synchronized

204 In aggregate, our findings highlight the complexity of the

205 In aggregate, our findings implicate MYLK as a gene involve

206 In P-rich areas of all investigated soil aggregates, P was predominantly co-located with aluminiu

207 decomposition of the PdOy active phase into aggregated Pd(0) NPs.

208 SVScore aggregates per-base single nucleotide polymorphism (SNP)

209 Furthermore, the same aggregate phenological curves can be composed of individ

210 during, and after the winter holidays among aggregated physician medical claims in the United States

211 n on PL and a photon correlation analysis of aggregate PL reveal that triplets are quenched by interm

212 N fertilization induced an increase in intra-aggregate porosity and a simultaneous shift toward great

213 Fibrillar aggregates possessing distinct structures that differ in

214 w roles for Tom1 in protein quality control, aggregate prevention, and, therefore, proteostasis maint

215 post-translational modifications impact the aggregated prion protein properties and disease phenotyp

216 Fibrils and oligomers are the aggregated protein agents of neuronal dysfunction in ALS

217 amptic nano-vesicles may be removing a toxic aggregated protein from the placenta, they may also be d

218 neurodegenerative diseases characterized by aggregated protein inclusions.

219 p small-molecule binding sites for a rapidly aggregating protein.

220 AAA+ disaggregases solubilize aggregated proteins and confer heat tolerance to cells.

221 brain are the intracellular accumulation of aggregated proteins and inflammation.

222 ammation, we argue that old, age-associated, aggregated proteins in neurons can induce inflammation,

223 Proteomic analysis of the aggregated proteins revealed enrichment for intrinsicall

224 ydrophobic regions of incompletely folded or aggregated proteins.

225 Misfolded prion protein aggregates (PrP(Sc)) show remarkable structural diversit

226 erage AI to become a center of intelligently aggregated, quantitative, diagnostic information.

227 This model aggregates R d to whole-plant respiration R p, driven wi

228 d through digital peer-review processes that aggregate ratings into reputation scores.

229 Our model, composed of 3-D EEC aggregates, recapitulates several functional/structural

230 l storage, enhances clearance of proteolipid aggregates, reduces neuropathology and prolongs survival

231 -DNP ratios, DNP charge is reversed, and DNP aggregates remain stable in suspension.

232 Detoxification of aggregated reporter polypeptides as well as misfolded en

233 itly interpreting population activity as the aggregate response of many single neurons with known tun

234 HCCS with or without rMSC aggregates resulted in less bone formation, indicating a

235 Neuronal inclusions of aggregated RNA-binding protein fused in sarcoma (FUS) ar

236 igins of the universal super- and sub-linear aggregate scaling laws and accurately predict kilometre-

237 teins (RBPs) by tracking their propensity to aggregate, searching for co-occurring aggregates, and un

238 ates, The HCCS-PDA particulates without rMSC aggregates showed limited osteoconductivity.

239 to heat-stress and do not accumulate protein aggregates showing that ClpXP is dispensable for degrada

240 A particular silica nanoprobe composed of aggregated silver nanoparticles with Raman reporters on

241 We identified several different aggregating sites from limited proteolysis of harvested

242 Our results provide evidence that different aggregate size classes support distinct microbial habita

243 ent practices on soil C is modulated by soil aggregate sizes and their associated microbial community

244 unced in macro-aggregate compared with micro-aggregate sizes.

245 folded state and formation of misfolded and aggregated species.

246 mitophagy stabilizes full-length MAVS, which aggregates spontaneously and induces the subsequent expr

247 an amyloid-like structure occurs within the aggregate state.

248 sources can be temporally limited, spatially aggregated, subjective, and burdensome for the patient t

249 toluene mainly affected formation of larger aggregates such as tetramers.

250 sed in the neuroretina, absence of prominent aggregates suggests altered function as the likely cause

251 P and different specific P binding forms in aggregates taken from a high-P clay-rich soil and a low-

252 JNJ64349311, a tracer with high affinity for aggregated tau (inhibition constant value, 8 nM) and hig

253 1), dramatically increased the production of aggregated tau.

254 lipoprotein(a) levels and neutrophil count, aggregate tests of low-frequency and rare variation were

255 Prions are self-propagating protein aggregates that act as protein-based elements of inherit

256 -type and mutated WDR1 Mutant protein formed aggregates that appeared to accumulate pyrin; this could

257 form of small phosphorylated alpha-synuclein aggregates that are associated with changes in synaptic

258 From the picosecond side chain motions to aggregates that form over the course of minutes, charact

259 In dividing yeast cells, protein aggregates that form under stress or during ageing are p

260 ein (Abeta), self-associates to form soluble aggregates that impair synaptic and network activity.

261 e recognition lead to the generation of bulk aggregates that induce fluorescence enhancement.

262 At physiological pH, the protein forms aggregates that look amorphous and disordered by electro

263 A primary goal of polygenic scores, which aggregate the effects of thousands of trait-associated D

264 rful than single-locus analyses because they aggregate the variant information within a gene/region.

265 In aggregate, the 39 independent markers identified to date

266 d around the HCCS-PDA particulates with rMSC aggregates, The HCCS-PDA particulates without rMSC aggre

267 This variant produces desmin aggregates, the main pathological symptom of myofibrilla

268 location of mutant huntingtin protein (mHTT) aggregates-the pathological hallmark of Huntington disea

269 tify amyloid secondary structure even if the aggregates themselves are too small to be resolved with

270 lens, which we hypothesize sequesters small aggregates, thereby preventing long fibers from forming.

271 erpes zoster and postherpetic neuralgia, and aggregated these data to estimate vaccine coverage and i

272 In aggregate, these findings provide evidence that nutrient

273 In aggregate, these strategies should help ICU managers and

274 cificity is the ability of such anchors when aggregated to sort subsets of phospholipids into nanoclu

275 on cross-beta-sheet structure of protofibril aggregates to "cap" and stabilize soluble macromolecular

276 "donor cell" that is the source of misfolded aggregates to an "acceptor cell" in which misfolding is

277 that allow the formation of pathological tau aggregates to be measured in situ within 24 h in the pre

278 ing to synapses and binding of soluble Abeta aggregates to synapses requires the expression of APP.

279 chains, while above 10% MC, water molecules aggregate together and create nano-droplets inside the m

280 differences in cell-type specificity of tau aggregate transmission were observed between tau strains

281 om the placenta, they may also be delivering aggregated transthyretin to specific maternal organs, co

282 Increased levels of aggregated transthyretin were specifically associated to

283 ible to death than WT neurons and formed Htt aggregates under the condition of oxidative stress.

284 We estimated global incidence by aggregating up from every country, using a survey for th

285 Study specific relative risks (RRs) were aggregated using random-effects models and were grouped

286 scence imaging of a single carbon dot and CD aggregate was simply achieved using filter-free dark-fie

287 DA or HCCS particulates with or without rMSC aggregates were implanted into rat critical-sized calvar

288 er Young's moduli were measured where desmin aggregates were located, indicating that desmin aggregat

289 of 3-6 cm(2) s(-1) for the tubular molecular aggregates, which are 3-5 times higher than a theoretica

290 asis can lead to the accumulation of protein aggregates, which are associated with aging and many hum

291 e mice did not develop de novo insoluble tau aggregates, which are characteristic of human AD and rel

292 adiotracer developed for imaging tau protein aggregates, which are implicated in neurologic disorders

293 all ATG8 proteins accumulate cytoplasmic UB aggregates, which are resolved following ectopic express

294 certain limit, against hydrolysis when it is aggregated with a strongly polar partner such as LiCl, L

295 uman pluripotent stem cells into organoids - aggregates with multiple tissue-specific cell types and

296 the visualization of spherical nanoparticle aggregates with size up to 200 nm within intact C. elega

297 surface monolayer as dispersed cells or cell aggregates with strong and specific expression of POU5F1

298 leads to development of widespread cellular aggregates, with histology and marker expression mimicki

299 Within these wells, the cells re-aggregated within hours, forming tight retinal organoids

300 se episomes that did respond to stimulation, aggregated within large domains that appear to function