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4 ation constant of ca. >10(10) M(-l) in DMSO) aggregate in a diverse manner depending on, e.g., variat
9 red phases with O/Ti ratios around 1.37 that aggregate in a ~100 nm highly localized region electrica
11 uce seeding of alpha-syn monomers to produce aggregates in a dose-and time-dependent manner under sta
16 ion of the dye in the form of supramolecular aggregates in a preformed polymer matrix; the second inv
18 n the spatial distribution of red blood cell aggregates in a T-shaped bifurcation on the scale of a l
23 These proteins accumulate in cytoplasmic aggregates in affected brain regions, including the fron
26 oma (FUS) are RNA-binding proteins that form aggregates in ALS and FTLD, and when mutated can drive t
31 that optimally reactivated stable luciferase aggregates in an ATP- and DNAJA1-dependent manner, in a
32 n and PLEKHM1 regulates clearance of protein aggregates in an autophagy- and LIR-dependent manner.
36 led that Hsp90 prevents alpha-synuclein from aggregating in an ATP-independent manner and that it for
37 nized that many drug-like molecules can self-aggregate in aqueous media and have physicochemical prop
39 ntion networks, confirming that amyloid-beta aggregates in areas of high intrinsic connectivity on a
40 the mixing time was increased, the number of aggregates in as-spun TES-ADT thin films were increased
41 antibiotics--the sequestration of IOPs into aggregates in association with the chaperone ClpB, follo
42 veloped fewer beta-amyloid precursor protein aggregates in axons of the corpus callosum after traumat
45 served increased levels of platelet-monocyte aggregates in blood samples from patients with dengue, e
49 e core measures approximately 2.2 x 1.0 nm), aggregates in CDCl3 and toluene-d8 to give stacked dimer
51 ilament formation defect causing cytoplasmic aggregates in cell lines and of the isolated recombinant
53 gs indicate that the rate at which alpha-syn aggregates in cells may be a significant factor in how i
59 ame slightly deformed, and finally it became aggregated in conventional DOPC, POPC, and DMPC membrane
60 ase that solubilizes and reactivates protein aggregates in cooperation with the DnaK/Hsp70 chaperone
64 ndant presence of ubiquitin and p62-positive aggregates in degenerating Purkinje cells coupled with t
65 plaining the recurrent observation of TDP-43 aggregates in degenerative diseases of both the brain an
66 in pancreatic beta cells to form crystalline aggregates in dense core vesicles (DCVs), which are rele
68 was the continuous phase whilst whey protein aggregated in discontinuous inclusions within the pressu
69 tissues, but the role of these proteinaceous aggregates in disease onset and progression is still unc
70 and B) can arise; however, the role of these aggregates in disease pathogenesis has not been fully ch
73 Specific protein fragments were found to be aggregated in disorders including Alzheimer's disease, a
74 kDa (TDP-43) characterizes insoluble protein aggregates in distinct subtypes of frontotemporal lobar
76 beta-synuclein formed proteinase K-resistant aggregates in dopaminergic neurons in vivo, leading to p
77 or types of AD-relevant tau pathologies: tau aggregates in dystrophic neurites surrounding Abeta plaq
80 mbly demonstrate the presence of oligo-chain aggregates in early stages of copolyelectrolyte assembly
82 ad formation of EBS-like cytoplasmic keratin aggregates in epithelial and non-epithelial fly tissues.
83 s regulation considerably reduces toxic mHtt aggregates in eye imaginal discs and partially restores
86 ardiomyopathy in younger persons (<50 years) aggregates in families at the population level is unclea
87 und that obsessive-compulsive disorder (OCD) aggregates in families but have typically relied on samp
91 itive cores increased with the sum of scores aggregated in five classes as follows: For summed PI-RAD
92 ns selectively stain nuclear and cytoplasmic aggregates in FXTAS patients and colocalize with ubiquit
93 cessibility of zeaxanthin from these tubular aggregates in goji berries as compared to protein-comple
94 a-Synuclein is a key pathogenic protein that aggregates in hallmark lesions in Parkinson's disease an
96 for influenza virus transmission when birds aggregate in high concentrations in the post-breeding, m
97 When the installation was illuminated, birds aggregated in high densities, decreased flight speeds, f
98 eding mechanisms of alpha-synuclein (alphaS) aggregates in human cells, we visualized alphaS aggregat
102 ions, forms exceptionally strong biofilmlike aggregates in human synovial fluid (SF), to an extent si
103 to be deposited as amyloid or other types of aggregates in human tissues and the disorders with which
104 characterization of prefibrillar myocardial aggregates in humans and the first report to link cofili
106 e therefore investigated how ASD and ADHD co-aggregate in individuals and in families to test for the
107 ls of a remA mutant, neither of which formed aggregates in isolation, aggregated when they were mixed
109 sp104 engagement with heat-induced non-prion aggregates in late cell-cycle stage cells, which promote
111 disease has been that the pathologic protein aggregates in live tissue are not amenable to structural
113 spontaneous formation of cytosolic Myddosome aggregates in lymphoma cell lines, mimicking the effect
115 repeat-containing protein (PFI1155w) formed aggregates in mammalian cells at febrile temperatures, a
118 iaryl chelate unit have been found to form J-aggregates in methanol-water solvent mixture and brightl
119 , ubiquitin conjugates, and aberrant protein aggregates in mice with CryAB(R120G)-based desmin-relate
120 ligation assay labels very early perikaryal aggregates in morphologically intact neurons that may pr
121 Given the persistent presence of fibronectin aggregates in MS lesions, ganglioside GD1a might act as
122 We found that mucoadhesive particles (MAP) aggregated in mucus in the center of the GI lumen, far a
125 Here we investigated the clearance of prion aggregates in muscle of transgenic mice that develop pri
127 ery poorly soluble and the B-chain is highly aggregating in nature which, together, makes their posts
129 ne reason is that the amount of pathological aggregates in neural tissue is exceedingly low, precludi
130 protein and, given the role of toxic protein aggregates in neurodegeneration, a toxic gain-of-functio
132 real-time and to detect and quantify alphaS aggregates in neuroglioma cells, thereby providing a nov
133 ression (ASOX) drives the formation of toxic aggregates in neurons vulnerable in Parkinson's disease
134 causes the formation of larger pathological aggregates in neurons, accompanied by impairments in its
137 ompartment (6) and accumulation of fibrillar aggregates in NFTs mediates neurodegeneration underlies
139 RIOK3 was localised to distinct cytoplasmic aggregates in normoxic cells and underwent redistributio
140 Mutant r(GGGGCC)n-containing transcripts aggregate in nuclear foci possibly sequestering repeat-b
141 GCC)n- and r(GGCCCC)n-containing transcripts aggregate in nuclear foci, possibly sequestering repeat-
142 rophy is the accumulation of alpha-synuclein aggregates in oligodendrocytes, forming glial cytoplasmi
143 obtain heat-induced beta-lactoglobulin (BLG) aggregates in order to test them as carriers of a model
146 are derived from alpha-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epit
147 els of alpha-synuclein, a protein present as aggregates in Parkinson disease and related synucleinopa
148 alphaS) self-assembles into toxic beta-sheet aggregates in Parkinson's disease, while it is proposed
151 ocardial tissue showed no abnormal filamin C aggregates in patients with truncating FLNC mutations.
153 /th1) mice with RAP-536 reduced alpha-globin aggregates in peripheral red cells, decreased the elevat
155 colocalizes with alpha-synuclein in amyloid aggregates in post-mortem tissue of patients with sporad
156 s have an accumulation of cytoplasmic TDP-43 aggregates in postmortem brain and spinal cord (SC), it
157 , a transporter of thyroxine and retinol, is aggregated in preeclampsia and is present at reduced lev
159 but tissue studies assessing binding to tau aggregates in progressive supranuclear palsy (PSP) have
162 While the formation of non-physiological aggregates in purified properdin preparations and the pr
163 e functional significance of these homotypic aggregates in regulating T cell function remains unknown
167 myelin sheath and has been found mutated and aggregated in several peripheral neuropathies, we predic
168 ted the transcellular propagation of protein aggregates in several major neurodegenerative diseases,
169 t genomes where protein coding genes tend to aggregate in significantly biased (p < 0.001) manner com
170 eveal the fibrillary structure of huntingtin aggregates in situ and show that huntingtin fibrils inte
171 a lithographic technique capable of creating aggregates in situ by printing protein-based walls aroun
172 ion diseases, the prion protein misfolds and aggregates in skeletal muscle in addition to the brain a
173 degeneration of myofibers and large tubular aggregates in skeletal muscle, consistent with impaired
176 termination of the structure and quantity of aggregates in small tissue samples, circumventing the ab
177 ns suggest that these lipopeptides prefer to aggregate in solution and alter the intrinsic order of t
179 ding a linker sequence (lnC2AB) was found to aggregate in solution and was proposed to bridge membran
181 tion also results in an enhanced tendency to aggregate in solution, which is ascribed to a more co-pl
185 lic PB chains stabilized the PDMAEMA/H(3)PMo aggregates in solution and reliably prevented macrophase
187 how that lnC2AB containing impurities indeed aggregates in solution, but properly purified lnC2AB is
189 he simulations reveal formation of molecular aggregates in solution, which on coming in contact with
191 Telomeres and centromeres were observed to aggregate in sperm nuclei, forming an average of 20 and
193 hese oligomers differ from the classic prion aggregates in that they are soluble and less resistant t
195 deling of membranes suggests these compounds aggregate in the center of the lipid bilayer, potentiall
196 Two RNA-binding proteins, TDP-43 and FUS, aggregate in the degenerating motor neurons of ALS patie
197 -s] prion propagates as a functional amyloid aggregate in the filamentous fungi Podospora anserina, a
199 mRNAs) with expanded CUG repeats (CUG(exp)) aggregate in the nucleus and become toxic to cells by se
200 polyethilenimine (bPEI)-coated AgNPs tend to aggregate in the presence of algae and interact with tes
203 0R) import into mitochondria, AGT(P11LG170R) aggregated in the cytosol, and cells subsequently died.
204 lysis revealed that the majority of variants aggregated in the MAPK, ErbB and RAS signaling pathways.
207 I) actually share pathogenesis and should be aggregated in the same diagnostic group remains an open
209 ar chaperone can be used to overcome protein aggregates in the absence of external energy input from
212 erative tauopathies exhibit pathological tau aggregates in the brain along with diverse clinical feat
213 by the formation of pathological tau protein aggregates in the brain and progressive neurodegeneratio
214 bule binding protein that forms pathological aggregates in the brain in Alzheimer's disease and other
216 ques containing amyloid beta (Abeta) peptide aggregates in the brain of Alzheimer's disease (AD) pati
218 ative difference between Abeta40 and Abeta42 aggregates in the brain tissue of patients with Alzheime
219 sease (AD), the amyloid beta (Abeta) peptide aggregates in the brain to form progressively larger oli
220 l cross-seeding between DISC1 and mutant HTT aggregates in the brains of HD patients as well as in a
222 lpha-Synuclein, a protein that forms ordered aggregates in the brains of patients with Parkinson's di
224 Our results reveal that the major source of aggregates in the case of Abeta40 is a fibril-catalyzed
227 ion diseases, the prion protein misfolds and aggregates in the central nervous system and sometimes i
228 on of proteinase K-resistant alpha-synuclein aggregates in the CNS and was accompanied by the normali
229 -amyloid and amyloid precursor protein (APP) aggregates in the cortex, hippocampus, stratum and subst
230 in is increased and accumulated as insoluble aggregates in the cortical area of LD brain biopsy sampl
231 al activities of the largely synthetic Abeta aggregates in the culture are very similar to those obse
233 ce and homo-polymerization of DNM1L, forming aggregates in the cytoplasm and on highly tubulated mito
234 dox systems resulted in an increase of hSOD1 aggregates in the cytoplasm of cells transfected with mu
235 n a complex and poorly understood manner and aggregates in the cytoplasm of degenerating neurons in P
236 ified missense mutations caused formation of aggregates in the cytoplasm or near membrane protrusions
238 fluorescent tag to monitor the spreading of aggregates in the Drosophila brain in a model of Hunting
239 the porous medium and detection of nano-size aggregates in the effluent show that the solubilization
240 ss, a progressive locomotor defect, abnormal aggregates in the ER and increased levels of the ER stre
241 al of injected mice was determined, and SOD1 aggregates in the facial nuclei were quantified during d
242 Viruses may form crystal like structures and aggregates in the host cell during replication or may fo
246 suggests the presence of some CaCl2/lactose aggregates in the media, which are influenced by the tem
248 nduces the formation of large nisin-Lipid II aggregates in the membrane of bacteria as well as in Lip
250 Here we investigated the clearance of prion aggregates in the muscle of a transgenic mouse model tha
251 aused accumulation of the ubiquitin-reactive aggregates in the mutant hippocampus, and early formatio
254 en TDP-43, an RNA-binding protein that forms aggregates in the neuromuscular disease, amyotrophic lat
255 olocalize near large central heterochromatin aggregates in the OSN nucleus, Taar genes are located pr
257 t localize to the intestine but instead form aggregates in the peritoneum where they produce immunore
258 a glycolytic enzyme that can form fibrillar aggregates in the presence of acidic membranes, but its
259 t networks with reduced size of whey protein aggregates in the presence of high levels of glucose syr
260 ce of polyriboadenilic acid (poly(rA)) and J aggregates in the presence of polyribocytidinic acid (po
261 161H), we identified well-organized lymphoid aggregates in the retina and examined them for TLT chara
265 ation, reduction in levels of misfolded SOD1 aggregates in the spinal cord, and a significant suppres
267 in mouse brain and is present in nuclear Htt aggregates in the striatum of R6/1 transgenic mice.
277 o our devices, we follow the growth of these aggregates in time and show that their length does not d
278 d to NEFH caused prominent and toxic protein aggregates in transfected cells and disrupted motor neur
279 other membrane proteins, as well, and desmin aggregates in transfected cells expressing the mutant de
280 of brain extracts containing amyloid or tau aggregates in transgenic animals can induce cerebral amy
282 de (IAPP, the peptide comprising the amyloid aggregates in type II diabetes) and an amyloidogenic det
283 roscopic images indicated presence of larger aggregates in unstabilised powder (RC) compared to well-
286 )), the latter having a higher propensity to aggregate in vitro and being the main component of the p
287 icus (Sso AcP) is a globular protein able to aggregate in vitro from a native-like conformational ens
289 been demonstrated to form insoluble protein aggregates in vitro and in human post-mortem brain tissu
290 ents coinciding with mutant huntingtin exon1 aggregate in vivo and induce HD-like pathology in mouse
291 e investigate the mechanism by which Sso AcP aggregates in vivo to form bacterial inclusion bodies af
296 s quenched (slowed) the photoreaction of C60 aggregates in water (aqu/nC60), but sensitized (accelera
298 Rigid clusters of similar size tend to form aggregates, in which cholesterol molecules are regularly
299 to a synergic role of Ag and Pt in ultranano-aggregates, in which Pt anchors the clusters to the supp
300 y we have defined the range of proteins that aggregate in yeast cells during normal growth and after
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