ライフサイエンスコーパス: aggregated

1 nd the data we have are often geographically aggregated.

2 equences (ER3 (AEEERRR) and EK1R2 (AEEEKRR)) aggregated.

3 ls that are helically oriented and laterally aggregated.

4 herical or irregularly shaped, and some were aggregated.

5 The oxidation potential for aggregated 4 and 15 nm diameter Au NPs shifts positive b

6 A self-aggregated 48-membered dansyl library was screened again

7 xidation potential does not shift at all for aggregated 50 nm diameter Au NPs.

8 tic plasticity, without affecting soluble or aggregated Abeta levels.

9 e in ROS associated with the accumulation of aggregated Abeta or alphaS does not result from a partic

10 CRP and SAP interacted with fresh and aggregated Abeta(1-40) and D76N beta2-m on the fibril-fo

11 ex [Re(CO)3(dppz)(Py)](+) in the presence of aggregated Abeta.

12 monoclonal antibody that selectively targets aggregated Abeta.

13 rain capillaries to 100 nm Abeta40, Abeta40, aggregated Abeta40, and Abeta42.

14 multifaceted ability to target monomeric and aggregated Abeta42 species, this candidate holds promise

15 Mortality declines aggregated across all age groups mask uneven gains acros

16 Aggregated across all genotypes, we find that increasing

17 Results CoV aggregated across all studies was 4.1% (range for each s

18 erage percentage value for each CpG site (or aggregated across CpG sites).

19 equently includes only adverse event results aggregated across multiple trials.

20 retrospective analyses of incidence records aggregated across space and, in particular, over whole c

21 Results are aggregated across training cohorts.

22 e signature miRNA, miR-126, high bioactivity aggregated all in vivo patient sample LSC activity into

23 from embryonic stem cells actively transfer aggregated alpha-SYN to nearby astrocytes via direct con

24 show that human astrocytes actively transfer aggregated alpha-synuclein (alpha-SYN) to healthy astroc

25 hologically defined by inclusions containing aggregated alpha-synuclein (alphaS).

26 nts with Parkinson's disease (PD) often have aggregated alpha-synuclein (aSyn) in enteric nervous sys

27 re, we discover aberrant HSF1 degradation by aggregated alpha-synuclein (or alpha-synuclein-induced p

28 disease patients and controls when using the aggregated alpha-synuclein immunohistochemistry techniqu

29 egation; for example, in the accumulation of aggregated alpha-synuclein into the Lewy bodies present

30 he CNS, both of which are composed mainly of aggregated alpha-synuclein phosphorylated at Ser129.

31 formation of Lewy body inclusions containing aggregated alpha-synuclein.

32 ein E4 exacerbated the brain accumulation of aggregated amylin and vascular pathology in HIP rats.

33 brain tissues and studied the effects of the aggregated amylin on endothelial cells ex vivo.

34 ockout (AKO) rats intravenously infused with aggregated amylin were used for in vivo phenotyping.

35 a, in HIP rats, and in AKO rats infused with aggregated amylin.

36 zens of proteins are known to convert to the aggregated amyloid state.

37 have investigated the effect of soluble and aggregated amyloid-beta (Abeta) and alpha-synuclein (alp

38 brain deposits of amyloid plaques containing aggregated amyloid-beta (Abeta) peptides.

39 itic spine loss induced by Alzheimer-related aggregated amyloid-beta peptides in primary neurons.

40 n fraction of these containing p53 in a self-aggregated amyloid-like state.

41 key features of human tauopathies, including aggregated and abnormally phosphorylated tau, progressiv

42 tin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in

43 al comparators, US and Canadian indices were aggregated and compared to existing national and state e

44 aques as distinct 3D structures that include aggregated and fused lipoprotein particles and cholester

45 f secondary walls in which the deposition of aggregated and helically oriented microfibrils is couple

46 rgent to solubilize and purify wild-type non-aggregated and homogenous KCC2.

47 e proteasome to allow for the degradation of aggregated and misfolded proteins.

48 pproach to chemically map small molecules in aggregated and single Escherichia coli cells, with appro

49 Most of the particles were aggregated, and some connected to needle-shaped or sheet

50 from G85R SOD1YFP and G85R SOD1CFP mice were aggregated, and spinal cords of adult chimeric progeny w

51 ion of rate-limited toxicodynamic processes, aggregated as a progressive effect from an initiating mo

52 During this process, VirE2 was aggregated as filamentous structures and was present on

53 ompares ovalbumin's allergenicity when it is aggregated as large particles to ovalbumin in its native

54 l religious beliefs and practices spread and aggregated as these successful groups expanded, or were

55 rporating Structure (PARIS)' that determines aggregated association signals generated from genome-wid

56 ients carrying wild type (WT) aSyn also have aggregated aSyn in Lewy bodies.

57 oxylase immunoreactivity in gut neurons with aggregated aSyn, comparable with our prior findings in t

58 All county-level variables were aggregated at the county level from the Behavioral Risk

59 sed scores were calculated for all patients, aggregated at the hospital level, divided into quartiles

60 Immunodepletion of the large aggregated AT8-positive tau strongly reduced seeding; mo

61 ation and favors the maintenance of strongly aggregated atmospheric states at high temperatures.

62 chado-Joseph disease and effectively reduced aggregated ATXN3 species in flies and in brains of trans

63 om red to purple in solution and finally the aggregated AuNPs is kept on the detection pad through ve

64 Aggregated bands located at 1683 and 1616cm(-1) became e

65 stances as well as for subsets of substances aggregated based on their toxic Mode of Action (MoA).

66 ggregated tau with modest selectivity versus aggregated beta-amyloid (Abeta).

67 The accumulation of aggregated beta-amyloid and tau proteins into plaques an

68 lix and beta-sheet contents decreased, while aggregated beta-sheet, turns and random coil contents in

69 sticated immunotherapy targeting soluble and aggregated brain amyloid-beta (Abeta) continues to domin

70 or 26546503 US births through June 30, 2013, aggregated by month and state of birth.

71 Recombinant NCPs aggregated by multivalent cations form various ordered p

72 Interpretations are aggregated by variant-condition combination and assigned

73 Resulting estimates were aggregated by WHO region.

74 lical supramolecular aggregates comprising H-aggregated CBTs are formed.

75 anscriptome dynamics through the analysis of aggregated cell-cell statistical distances within biomol

76 gregation) versus staying vegetative (as non-aggregated cells).

77 Mutant Nrp2 islets aggregated centrally and failed to disperse radially.

78 Isolated or aggregated cocci were probable in 18.8% of IOL optic sur

79 Aggregated coexpression network analysis identified cand

80 greater for the WP group, indicating a more aggregated collagen.

81 tem that enables the integrative analysis of aggregated collections of tagged gene expression signatu

82 e C region to form aberrantly multimeric and aggregated complexes with an unstable secondary structur

83 es, E46K alphaS polymers are likely distinct aggregated conformers that may represent a unique prion-

84 dividual level, and income inequality at the aggregated, contextual, and ecological level.

85 e ion channels is most often described as an aggregated continuous-time Markov process with discrete

86 CSPalpha WT, mutant and aggregated CSPalpha are degraded mainly by the ALP but t

87 limitation is that relationships apparent in aggregated data analyses cannot be assumed to operate at

88 Furthermore, aggregated data for 127 patients with idiopathic multice

89 We likewise aggregated data for lung and pancreatic cancers, which h

90 Using aggregated data from 9,246 families with autism spectrum

91 We aggregated data from a systematic review (n = 108) and s

92 then combined with those from Thailand using aggregated data meta-analysis with a random effects mode

93 ever, population studies often use spatially aggregated data to draw inferences about population tren

94 atmospheric CO2 concentrations using yearly aggregated data.

95 were statistically significant in only one (aggregated data: OR, 0.5; 95%% CI, 0.3-1.01; IPD, unstra

96 lation growth in South America using a newly aggregated database of 1,147 archaeological sites and 5,

97 ese results, we propose five initiatives: an aggregated database of paediatric biological tumour drug

98 brains by the presence of key misfolded and aggregated disease proteins, but cellular processes lead

99 Inclusion bodies (IBs) containing aggregated disease-associated proteins and polyubiquitin

100 Hsp104 binding to aggregates but not to non-aggregated, disordered protein substrates.

101 cer patients, we develop analytic methods of aggregated distances to identify five differentially exp

102 chiral organic semiconductors from helically aggregated dyes as sensitizers; Zn-porphyrins and triary

103 We aggregated each country's estimates to generate total he

104 Conversely, the aggregated effect of all 170 disease susceptibility loci

105 rchical regularities and dependencies in the aggregated EHRs of about 700,000 patients from the Mount

106 ng the future risks of GDM in the temporally aggregated EHRs.

107 cale to elucidate the structural ensemble of aggregated elastin-like peptides.

108 to provide a set of consistent primary PM2.5 aggregated exposure factors.

109 As aggregated fertilizer data generate underestimation bias

110 her, GD1a overcomes the inhibiting effect of aggregated fibronectin on OPC maturation by activating a

111 side GD1a overcomes the inhibiting effect of aggregated fibronectin on OPC maturation, both in vitro

112 GD1a, but not other gangliosides, overcomes aggregated fibronectin-induced inhibition of myelin memb

113 eed to balance weight components assigned to aggregated fitness functions during optimization.

114 vated for these functions when receptors are aggregated following the binding of IgG-opsonized target

115 viduals across communities and are generally aggregated for both ethical and pragmatic reasons that m

116 At the dispersed phase, the aggregated form of TPE-mercury ions recovers planarity b

117 Abeta may be present in an aggregated form prior to cellular uptake.

118 solution and attach to the electrode in the aggregated form.

119 physico-chemical properties of the different aggregated forms of proteins, and of their interactions

120 Misfolded and aggregated forms of tau produce pathological structures

121 ressive accumulation of hyperphosphorylated, aggregated forms of tau.

122 ple forms of Abeta, with higher affinity for aggregated forms, and that blocks Abeta aggregation, and

123 mented with the 0- to 11-year-old forest map aggregated from the 30 m resolution contemporary record

124 for authors to obtain RRIDs, resources were aggregated from the appropriate databases and their RRID

125 Array and combined with existing data for an aggregated genome-wide association study (GWAS) analysis

126 res with a broad size range (30-100 nm), and aggregated gold NPs with a primary size of 40 nm.

127 rtilin-independent sorting mechanisms target aggregated Golgi membrane proteins for lysosomal degrada

128 ZG16 bound to and aggregated Gram-positive bacteria via binding to the bac

129 urface-enhanced Raman spectroscopy (SERS) of aggregated graphene oxide/gold nanoparticle hybrids with

130 eature a uniform and open-networked array of aggregated graphene sheets.

131 the relationship between platelet usage and aggregated hospital-wide patient data over a recent cons

132 We aggregated hourly blocks of time, using previously defin

133 at amylin, studied normal mice injected with aggregated human amylin, and developed in vitro cell mod

134 anaphylaxis was induced by injection of heat-aggregated human intravenous immunoglobulin and active s

135 ar tau aggregation only when large (>10 mer) aggregated, hyperphosphorylated (AT8- and AT100-positive

136 ating produced by concentration quenching in aggregated ICG imbedded in the mesopourous silica shell

137 ther induced degranulation of eosinophils on aggregated IgG via increased production and activation o

138 In the absence of EV71, AuNS-SCARB2 aggregated in biological media and produced four enhance

139 When the installation was illuminated, birds aggregated in high densities, decreased flight speeds, f

140 are derived from alpha-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epit

141 I) actually share pathogenesis and should be aggregated in the same diagnostic group remains an open

142 mers: a beta-sheet-rich, protease-resistant, aggregated, inactive form (Mcc(ia)), and a soluble, prot

143 We aggregated individual results by year, identified seven

144 ks are typically constructed from temporally aggregated interaction data, thereby implicitly assuming

145 Abeta40 aggregated into amyloid fibrils, whereas Abeta42 assembl

146 We observed that many of the plasmids aggregated into large clusters, although most of the pla

147 These motions can be aggregated into systems with multiple degrees of freedom

148 The aggregated Kaplan-Meier analysis of immunotherapy trials

149 en PPIs and specific fracture sites using an aggregated knowledge-enhanced database, the Food and Dru

150 designed for a worldwide community to access aggregated large-scale genetic data sets, as one paradig

151 suspensions E10 and E11, on the other hand, aggregated less, did not form self-supporting gels and h

152 The clusters were composed of aggregated local areas (neighbourhoods) that had been id

153 Assay development included using an aggregated mAb as bait for screening of phage display pe

154 The accumulation of aberrantly aggregated MAPT (microtubule-associated protein Tau) def

155 in multispecies structures, but also as self-aggregated microcolonies.

156 e resulting hydrophilic, deformable, and non-aggregated microspheres were mono-disperse and roughly 2

157 Three aggregated mixed methods syntheses were developed: 1) Me

158 two daily inactivity periods in the people's aggregated mobile phone calling patterns and infer these

159 an spectra and DFT calculations, we proposed aggregated model for the explanations of the acetone C=O

160 Aggregated model-based SAEs were consistent with nationa

161 s-annotated miRNAs in miRBase based on their aggregated modification profiles.

162 We aggregated mortality data for breast cancer in women, pr

163 cular chaperone for alpha-synuclein and that aggregated Munc18-1 EIEE-causing mutants promote alpha-s

164 tors stimulated the intracellular removal of aggregated mutant UMOD.

165 se, 33% NUE improvement, and 47% decrease in aggregated N loss (sum of NO3(-) , NH3 , and N2 O, total

166 -time and found that heat generated from the aggregated nanoparticles absorbing near-infrared (NIR) l

167 ation of national HIV programs often rely on aggregated national level data.

168 icit purpose of informing future action, the aggregated nature of their findings make them difficult

169 e effects on the supramolecular structure of aggregated NCPs due to lysine histone H4 tail acetylatio

170 ted associations of individual-level safety, aggregated neighborhood-level safety, and police-recorde

171 IL-8 axis is involved in MSU crystal-induced aggregated NET formation, but MRS2578 could have additio

172 ions and calcium carbonate crystals, induce aggregated NET formation.

173 Ductal occlusion by aggregated NETs emerges as a pathomechanism with relevan

174 rmation of MSU crystal-NET aggregates called aggregated NETs.

175 logical phase transition from homogeneous to aggregated networks.

176 acterized oligomers; and (4) differentiating aggregated NPs and nonaggregated states based on the "ap

177 The aggregated number of genotyped humans is currently on th

178 ate of these ENMs is to mostly remain either aggregated or dissolved in agricultural lands receiving

179 whether the pathogenesis is associated with aggregated or more soluble forms of the protein.

180 m, but a significant fraction were spatially aggregated or segregated.

181 been reported to exhibit fluorescence in the aggregated or solid-state through the excited-state intr

182 We find that aggregated Orb2 in a subset of mushroom body neurons can

183 d the degranulation capacities of native and aggregated ovalbumin were measured with sera from egg-al

184 ildren and from mice sensitized to native or aggregated ovalbumin.

185 temperature at either spatial scale: neither aggregated over the entire India/Tropical Indian Ocean a

186 Aggregated pairs dominated from the Carboniferous period

187 METHODS AND This ecological analysis aggregated patient and hospital characteristics from the

188 decomposition of the PdOy active phase into aggregated Pd(0) NPs.

189 g from filamentous forms in the cytoplasm to aggregated perinuclear tubules that form a cage-like str

190 easonal patterns at this site, implying that aggregated phenology explains the larger scale remotely

191 during, and after the winter holidays among aggregated physician medical claims in the United States

192 The aggregated platelets released collagen IV, a critical BL

193 We reported aggregated pre- and post-intervention weight and cardiom

194 We aggregated primary International Classification of Disea

195 post-translational modifications impact the aggregated prion protein properties and disease phenotyp

196 This is accomplished via an aggregated probabilistic scenario-aware analysis, follow

197 Fibrils and oligomers are the aggregated protein agents of neuronal dysfunction in ALS

198 pleomorphic pathology including deposits of aggregated protein and neuronal degeneration.

199 cer Genome Atlas (TCGA) Research Network has aggregated protein expression profiles for 3,467 patient

200 amptic nano-vesicles may be removing a toxic aggregated protein from the placenta, they may also be d

201 neurodegenerative diseases characterized by aggregated protein inclusions.

202 The accumulation of large amounts of aggregated protein is thought to be initiated by the for

203 mum possible concentration of Abeta) for the aggregated protein rather than to longer-term spreading

204 homogeneity at the atomic level and that the aggregated protein retains a native-like conformation, w

205 Cross-seeding, where one aggregated protein templates the misfolding of a heterol

206 and WPI+NaCl solutions had higher levels of aggregated protein, due to more covalent interactions be

207 te (WPI) solutions, with different levels of aggregated protein, were prepared by heating (5% protein

208 AAA+ disaggregases solubilize aggregated proteins and confer heat tolerance to cells.

209 brain are the intracellular accumulation of aggregated proteins and inflammation.

210 e has been viewed as a disease of abnormally aggregated proteins by pathologists and molecular biolog

211 and the Hsp104 disaggregase to misfolded and aggregated proteins during aging, but not heat stress.

212 ammation, we argue that old, age-associated, aggregated proteins in neurons can induce inflammation,

213 Clearance of misfolded and aggregated proteins is central to cell survival.

214 Proteomic analysis of the aggregated proteins revealed enrichment for intrinsicall

215 ds to a variety of deposited, denatured, and aggregated proteins, in addition to binding to PCh-conta

216 ases are associated with the accumulation of aggregated proteins, it is possible that any therapeutic

217 activity, the relationships among these two aggregated proteins, neural function, and brain structur

218 n for cellular proteostasis and clearance of aggregated proteins, these results raise the question of

219 causes a marked delay in the degradation of aggregated proteins.

220 ydrophobic regions of incompletely folded or aggregated proteins.

221 erage AI to become a center of intelligently aggregated, quantitative, diagnostic information.

222 hat DR5 clusters are more than just randomly aggregated receptors.

223 Detoxification of aggregated reporter polypeptides as well as misfolded en

224 When compared to reported values, aggregated resistance values for the United States and C

225 this end, we created MARRVEL (model organism aggregated resources for rare variant exploration).

226 unt for variability in data availability, we aggregated results by subregion and estimated surgical m

227 ion to reporting 5 x 5 km estimates, we also aggregated results obtained from these estimates into th

228 It has been suggested before that annually aggregated results of passive air monitoring may be used

229 The aggregated results show that our methods significantly o

230 Neuronal inclusions of aggregated RNA-binding protein fused in sarcoma (FUS) ar

231 cients for components from the global (i.e., aggregated sample set) model and local (i.e., single pou

232 relation with precipitation persist at large aggregated scales.

233 anner by interacting with both monomeric and aggregated sCT.

234 terminated transcription efficiently and an aggregated, self-propagating prion form that was functio

235 NV analysis termed SMASH, for short multiply aggregated sequence homologies.

236 with a metal surface, using spermine induced aggregated silver nanoparticles as the SERS substrate, i

237 A particular silica nanoprobe composed of aggregated silver nanoparticles with Raman reporters on

238 pen or shut: states of equal conductance are aggregated, so transitions between them have to be infer

239 o small geographies and linked to area-level aggregated socioeconomic and demographic data.

240 n rate of SOD1 in vivo and in vitro, whereas aggregated SOD1 did not exert any effect in both experim

241 f SOD1, and plaques containing misfolded and aggregated SOD1 have been found in the motor neurons of

242 from the Complex Emergency Database and then aggregated spatially and temporally with drought exposur

243 tments needed to give rise to non-native and aggregated species.

244 folded state and formation of misfolded and aggregated species.

245 h the entropic nature of elastic recoil, the aggregated state is stabilized by the hydrophobic effect

246 A self-assembled aggregated state of Drosophila Orb2A protein is required

247 of emission intensities was observed in the aggregated state.

248 that rescues stress-damaged proteins from an aggregated state.

249 wever, the mechanisms leading from folded to aggregated states are still incompletely understood.

250 h phase diagram displaying high diversity in aggregated states.

251 sed Twister approach, and combines them into aggregated strings endowed with offsets.

252 ynamic of the transformation from monomer to aggregated structure can be easily controlled by tuning

253 tion of the p62/SQSTM1 protein and ubiquitin-aggregated structures in the cerebellum of Mecp2 knockou

254 self-assemble into a variety of extended and aggregated structures, the binary platinum carbonyl clus

255 rved variability including the 'off-pathway' aggregated structures.

256 Meta-analyses on aggregated study data (random-effects model) and individ

257 sources can be temporally limited, spatially aggregated, subjective, and burdensome for the patient t

258 rs from Sup35 polymers, no monomerization of aggregated Sup35 which is not accounted for by the propo

259 e presence of H2O2, forming CO2 and strongly aggregated SWCNT products that precipitated.

260 Remarkably, in contrast to in vitro aggregated synthetic Abeta, homogenates of Abeta deposit

261 ons throughout the brain, is associated with aggregated synuclein deposits in the substantia nigra of

262 JNJ64349311, a tracer with high affinity for aggregated tau (inhibition constant value, 8 nM) and hig

263 In vivo, this led to lower levels of aggregated tau and improvements in cognitive performance

264 fferent molecular conformers (or strains) of aggregated Tau exist.

265 2 shifts its solubility and colocalizes with aggregated Tau in AD brains, similar to chaperones, whic

266 antly reduced levels of hyperphosphorylated, aggregated tau in brain tissue of P301S-tg mice, associa

267 The interneuronal propagation of aggregated tau is believed to play an important role in

268 Aggregated tau protein is associated with over 20 neurol

269 mpetent sucrose gradient fractions contained aggregated tau species ranging from ring-like structures

270 mine 10 as a novel potent binder to human AD aggregated tau with modest selectivity versus aggregated

271 1), dramatically increased the production of aggregated tau.

272 variability (enhanced predictability at the aggregated temporal scales) with respect to the mean hyd

273 tyl-modified SiO2 NPs, though initially more aggregated than uncoated SiO2 NPs, reduced PA6 hydrolysi

274 When data from different settings were aggregated, the FIB levels in different source types bro

275 erpes zoster and postherpetic neuralgia, and aggregated these data to estimate vaccine coverage and i

276 diovascular risk factors have relied on data aggregated to counties.

277 oblasts (FB) and endothelial cells (EC) were aggregated to create mixed cell spheroids.

278 Most silver was reduced to Ag(0) and aggregated to form crystalline silver nanoparticles of f

279 lted in agricultural improvement genes being aggregated to genomic 'agro islands', and in genotype-to

280 e definitions at the census block levels and aggregated to larger administrative and geographic areas

281 Ultimately, data were aggregated to obtain the pooled effect size of efficacy,

282 cificity is the ability of such anchors when aggregated to sort subsets of phospholipids into nanoclu

283 ding individual-level patient and nurse data aggregated to the unit level.

284 -hydropyridine or intranigral inoculation of aggregated toxic alpha-SYN.

285 This pattern was evident when analysing the aggregated tracks despite a wide diversity of individual

286 om the placenta, they may also be delivering aggregated transthyretin to specific maternal organs, co

287 Both total and aggregated transthyretin were present in higher levels i

288 Increased levels of aggregated transthyretin were specifically associated to

289 that promote the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for

290 f the cube, whereas the nanoparticle rapidly aggregated under the harsh seawater conditions.

291 aving the nanoparticles unprotected and thus aggregated upon exposure to a high electrolytic medium.

292 Study specific relative risks (RRs) were aggregated using random-effects models and were grouped

293 No prior analyses have aggregated weight and cardiometabolic risk factor change

294 sed for various lengths of time to variously aggregated wild-type TTR, a condition that characterizes

295 certain limit, against hydrolysis when it is aggregated with a strongly polar partner such as LiCl, L

296 various methods for transplantation of PGCs aggregated with gonadal somatic cells and showed that re

297 nd formed pedestals on endothelial cells and aggregated with mouse neutrophils in the lumen.

298 Within these wells, the cells re-aggregated within hours, forming tight retinal organoids

299 se episomes that did respond to stimulation, aggregated within large domains that appear to function

300 Mean aggregated within-MSA differences in mortality and readm