ライフサイエンスコーパス: aggregated Abeta

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1 ex [Re(CO)3(dppz)(Py)](+) in the presence of aggregated Abeta.

2 sly known amyloid-binding small molecules to aggregated Abeta.

3 re it enhanced microglial internalization of aggregated Abeta.

4 tect neurons against the toxicity induced by aggregated Abeta.

5 monoclonal antibody that selectively targets aggregated Abeta.

6 the source points for measuring distances in aggregated Abeta.

7 peptide is proximate to Lys16 of another in aggregated Abeta.

8 ment of rat cortical astrocyte cultures with aggregated Abeta 1-42 peptide induces activation, as ass

9 CRP and SAP interacted with fresh and aggregated Abeta(1-40) and D76N beta2-m on the fibril-fo

10 we found that the Cu(II) binding strength of aggregated Abeta(1-42) has been elevated by more than 2

11 P (APPsw, PSEN1dE9) mice were immunized with aggregated Abeta(1-42) peptide plus CT.

12 trate that t.c. immunization of WT mice with aggregated Abeta(1-42) plus the adjuvant cholera toxin (

13 began this process by treating monomeric and aggregated Abeta(1-42) with three cross-linking agents:

14 at in PC12 cells sublethal concentrations of aggregated Abeta(25-35) inhibit DNA-PK kinase activity,

15 Aggregated Abeta accumulates as both dense core plaques

16 Microglial cells surround aggregated Abeta and are believed to play a role in AD p

17 at some effects of antibodies that recognize aggregated Abeta are rapid, involve microglia, and provi

18 ally to stimulate microglial phagocytosis of aggregated Abeta, but is opposed by the continued aggreg

19 Previous studies have shown that aggregated Abeta can induce caspase-dependent apoptosis

20 Two conformers of aggregated Abeta, i.e., fibrils and oligomers, have been

21 method can directly provide quantitation of aggregated Abeta in absolute terms (i.e., microg/ml).

22 n, likely because of direct interaction with aggregated Abeta in the IL-10-expressing APP mice.

23 Accumulation of aggregated Abeta in the media can then promote apoptosis

24 aggregation, but those selected using highly aggregated Abeta increase the rate of aggregation drasti

25 Aggregated Abeta induced IFN-gamma production from co-cu

26 Our results showed that pre-aggregated Abeta induced the generation of a 17 kDa tau

27 Aggregated Abeta is toxic to neurons, but the mechanism

28 tic plasticity, without affecting soluble or aggregated Abeta levels.

29 ion but also eliminated any toxic effects of aggregated Abeta on the human neuroblastoma cell line, S

30 e in ROS associated with the accumulation of aggregated Abeta or alphaS does not result from a partic

31 between Abeta aggregation (+300 and +800% of aggregated Abeta peptide in chronically inflamed and old

32 Because exogenous application of aggregated Abeta peptide is neurotoxic in vitro and extr

33 eta dimers, which are the smallest cytotoxic aggregated Abeta peptide species, we use united atom imp

34 ying the interaction of small molecules with aggregated Abeta peptides overcomes many limitations of

35 oblastoma cells to cytotoxic preparations of aggregated Abeta peptides results in significant intrace

36 volves the direct and harmful interaction of aggregated Abeta peptides with enzymes responsible for m

37 tion of molecules with insoluble deposits of aggregated Abeta peptides.

38 eimer's disease, which consist of abnormally aggregated Abeta protein.

39 antially inhibited the formation of soluble, aggregated Abeta species, as well.

40 nd decreased for freshly prepared or heavily aggregated Abeta, suggesting that TTR binds selectively

41 red an anti-Abeta antibody (m3D6) that binds aggregated Abeta to PDAPP mice, an AD mouse model that w

42 intain the desired beta-sheet content of the aggregated Abeta upon immobilization of these peptides o

43 ility that the plasmin pathway is induced by aggregated Abeta, which can lead to Abeta degradation an

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