ライフサイエンスコーパス: aggregation

1 esults to OC exposure and consequent amyloid aggregation.

2 GSL clearance plays a key role in alpha-syn aggregation.

3 ity against amyloid-beta (Abeta)1-42 peptide aggregation.

4 ies to reduce Abeta concentration or inhibit aggregation.

5 edicts the effects of CysC and CatB on Abeta aggregation.

6 action explain its dominant influence on tau aggregation.

7 n of VLA3 to support neutrophil swarming and aggregation.

8 ific antibodies were not able to induce IAPP aggregation.

9 ns present a physical barrier to para-casein aggregation.

10 developed for the detection of beta-amyloid aggregation.

11 state permits NETosis but prevents homotypic aggregation.

12 isengages tau from MTs and also promotes tau aggregation.

13 inhibitors in trans of simple polyQ peptide aggregation.

14 ecular triple helix formation or fiber-fiber aggregation.

15 s of Sm proteins over pICln, promoting their aggregation.

16 erfering with homodimerization or by causing aggregation.

17 prone to interact with Abeta and affect its aggregation.

18 brillar integrity, and the consequent myosin aggregation.

19 spontaneous folding of PepQ is not caused by aggregation.

20 uding the role of Pro(301) in inhibiting Tau aggregation.

21 nt causes bacterial envelope damage and cell aggregation.

22 mechanism leading to self-propagating Sup35 aggregation.

23 ded C-terminal domains to drive pathological aggregation.

24 esting a mechanism for how N17 regulates Htt aggregation.

25 usly and occur independent of neuronal ATXN3 aggregation.

26 substantially changing the final product of aggregation.

27 dopaminergic cell death and alpha-synuclein aggregation.

28 s of proteins associated with misfolding and aggregation.

29 ly decreased thrombin-induced human platelet aggregation.

30 r alpha-synuclein promotes or inhibits Abeta aggregation.

31 in local tau conformations and irreversible aggregation.

32 les on specific microscopic steps in Abeta42 aggregation.

33 cts of mutations on kinetics and products of aggregation.

34 protein evolution to limit unwanted protein aggregation.

35 examined for releasability after FcepsilonRI aggregation.

36 target specific microscopic steps in Abeta42 aggregation.

37 motor neurons in layer V), mutant profilin1 aggregation, abnormally ubiquitinated proteins, reduced

38 Here we show that AuNPs aggregation also causes a significant enhancement of che

39 e disorders caused by misfolding followed by aggregation and accumulation of protein deposits in neur

40 resulting in, operator-dependant yields, EV aggregation and altered EV morphology, and moreover is t

41 stages: substratum attachment, intercellular aggregation and architecture maturation.

42 Protein aggregation and axonal transport deficits have been impl

43 AFSM accumulation correlates with CSPalpha aggregation and both are susceptible to pharmacological

44 during lithiation/delithiation due to phase aggregation and cracking.

45 The extent of droplet aggregation and creaming was largely independent of anti

46 ed and acts, at least in part, by preventing aggregation and degradation of Nebulin, an essential com

47 ys a role in regulating amyloid-beta (Abeta) aggregation and degradation.

48 Amyloid aggregation and deposition are associated with many intr

49 teraction with androgen receptor, induces AR aggregation and endoplasmic reticulum stress in the pros

50 G175R is highly prone to aggregation and has greatly reduced activity.

51 of traditional nanoparticles contributing to aggregation and inhomogeneity.

52 Ia) is the key receptor involved in platelet aggregation and is a validated target for therapeutic ap

53 ms, full-length MAVS is prone to spontaneous aggregation and Nix-mediated mitophagic degradation.

54 d aggregation of Httex1 and suggest that its aggregation and possibly its function(s) are controlled

55 sion of certain chaperones abrogates protein aggregation and protects a UPR mutant against ER stress

56 Thrombin- or collagen-induced platelet aggregation and secretion are increased in TRAF3 knockou

57 probable long-term destination of QDs due to aggregation and sedimentation.

58 ssions for the half-times of degradation and aggregation and show that their ratio can be used to est

59 lass of substrates in which the rates of LDA aggregation and solvation events are comparable to the r

60 ids of Swi1 (Swi11-32) can decorate [SWI(+)] aggregation and stably maintain and transmit [SWI(+)] in

61 conditions and where failures cause material aggregation and sticking to rock surfaces.

62 tural control strategy to suppress alpha-syn aggregation and suggest potential therapeutic approaches

63 roteostasis network actively combats protein aggregation and that such an efficient system can fail i

64 ing in the inhibition of nfGNPs salt-induced aggregation and the stabilization of purified VLPs.

65 development of strategies to prevent TDP-43 aggregation and to uncover previously unexplored roles o

66 gulatory mechanism governing alpha-synuclein aggregation and toxicity, demonstrating the potential th

67 ane interactions in regulating Tau function, aggregation and toxicity.

68 roteostasis characterized by diffuse protein aggregation and ubiquitination.

69 nd fibronectin, with VLA3 inducing homotypic aggregation and VLA5 regulating NETosis.

70 Because ZnO-NPs formed larger aggregations and released less zinc ions (Zn(2+)) at gre

71 and metal-containing particle precipitation, aggregation, and dissolution.

72 vascular thrombin activity, reduced platelet aggregation, and improved microvascular perfusion.

73 ylated TDP-43 was not associated with TDP-43 aggregation, and p-T153/Y155 remained soluble under cond

74 often challenging due to inefficient mixing, aggregation, and the advanced instrumentation required f

75 that, in yeast, cytosolic proteins prone to aggregation are imported into mitochondria for degradati

76 dence of Alzheimer's disease-related protein aggregation as an underlying mechanism of age-related me

77 o have chaperone-like activity in an insulin aggregation assay, which we propose facilitates preprote

78 ce microscopy and validated by multicellular aggregation assays.

79 degrees C, followed by partial refolding and aggregation at even higher temperatures.

80 d selective removal of Fe (oxy)hydroxides by aggregation at increasing salinity, while organically co

81 conclude that the hamster prion is prone to aggregation at pH 4.4 because its reconfiguration rate i

82 Platelet aggregation at the site of vascular injury is essential

83 It further displayed aggregation behavior at higher concentration and excitat

84 The key to the observed aggregation behavior is the diminished ability of disulf

85 role of temperature and concentration in the aggregation behavior of chromonics.

86 In this work the aggregation behavior of Rumenic acid (RA) is presented f

87 These results show that the aggregation behavior of this protein is similar in vivo

88 cking phosphorylation at T3 decreased HTTex1 aggregation both in larvae and adult flies.

89 Higher N:P ratios can lead to aggregation, but this can be circumvented by coating ins

90 the freeze-concentration event and particle aggregation by employing correlative imaging techniques,

91 n occurs, whereas the rabbit sequence avoids aggregation by reconfiguring 10 times faster than the ha

92 r findings suggest that PP1 modulates HTTex1 aggregation by regulating phosphorylation on T3.

93 -synuclein by PIAS2 promotes alpha-synuclein aggregation by two mutually reinforcing mechanisms.

94 (gDNA) nanosensor, exploiting dispersion and aggregation characteristics of d-AuNPs, in the presence

95 een BDI and BDII by assessing their familial aggregation/coaggregation and by assessing the coaggrega

96 rmation for a variety of particle shapes and aggregation conditions.

97 c frequencies of LQT6 mutations in the Exome Aggregation Consortium database, and absence of previous

98 ce data from 60,706 people through the Exome Aggregation Consortium has prompted the analyses present

99 ar how mitochondrial dysfunction and protein aggregation could be related.

100 data raise the possibility that pathological aggregation could compromise the function of LSD1 in AD

101 5'-diphosphate and epinephrine, but variable aggregation defects with other agonists.

102 tastability may underlie devastating protein aggregation diseases.

103 Analogous to protein aggregation disorders, our results suggest that the sequ

104 tical resampling to measure the Eph receptor aggregation distribution within each pixel of an image.

105 n motif-dependent mechanisms irrespective of aggregation during skin and lung inflammation.

106 cal laws by applying methods and concepts of aggregation dynamics of aerosol physics.

107 entify cell behaviors affecting the observed aggregation dynamics without full knowledge of the under

108 Data aggregation efforts often face the challenge of record m

109 Polymorphism observed within the aggregation end products of fibrils are known to arise d

110 regates in human cells, we visualized alphaS aggregation, endo-lysosome distribution, and endo-lysoso

111 more, 6C5 slowed down the progression of tau aggregation even after uptake had begun.

112 g pluripotency loss and ectoderm, and slower aggregation favoring mesoderm and endoderm.

113 was only detected in 8% (4 out of 48) of the aggregation fidelity assays run.

114 Lineage- and species-specific aggregation fidelity was only detected in 8% (4 out of 4

115 tant, thereby differentiating the process of aggregation from maturation.

116 Cell aggregation, gtfP gene expression and water-insoluble gl

117 ions of tau, PHF6 and PHF6*, in transient as aggregation happens.

118 Familial aggregation has been described for primary mitral regurg

119 relationship between Tau phosphorylation and aggregation has proven a challenge owing to the multiple

120 he regions of the mutant proteins that drive aggregation have not been determined.

121 es by assessing the effects of seeded alphaS aggregation in alphaS transgenic mice through intracereb

122 assembled aggregates can serve as nuclei for aggregation in bulk solution.

123 ivity and inducing aberrant localization and aggregation in cells.

124 elatively high stability to salinity-induced aggregation in estuaries.

125 ver, we show that phosphomimetic FUS reduces aggregation in human and yeast cell models, and can amel

126 omimic mutations completely abolished HTTex1 aggregation in human cells.

127 dium 4-phenylbutyrate (PBA), reduces protein aggregation in neural stem cells in vitro and in embryos

128 Platelets displayed reduced aggregation in response to adenosine 5'-diphosphate and

129 tors of ERK5 blunted platelet activation and aggregation in response to oxLDL and targeted genetic de

130 n takes place at a concentration at which no aggregation in solution is observed.

131 a gradient of phosphorylated alpha-synuclein aggregation in synapses (pre > pre + post > postsynaptic

132 is essential to limit their accumulation and aggregation in the absence of Rqc1; however, its E3 ubiq

133 l for acetylation-mediated inhibition of tau aggregation in vitro and a molecular tactic for preventi

134 TR) is known to inhibit amyloid-beta (Abeta) aggregation in vitro and suppress the Alzheimer's-like p

135 the apoE4 pro-fibrillogenic effects on Abeta aggregation in vitro as well as apoE4 potentiation of Ab

136 on formation in Saccharomyces cerevisiae and aggregation in vitro could be predicted entirely based o

137 hat addition of IAPP seeds accelerates Abeta aggregation in vitro in a seeding-like manner and the re

138 ssed in Drosophila, the mutation accelerates aggregation in vitro, and the mutant prion-like domain c

139 ngosine-1-phosphate) promote alpha-synuclein aggregation in vitro, glucosylsphingosine triggers the f

140 Consistent with this prediction, protein aggregation in yeast and worms was observed to increase

141 We define this new phenomenon as aggregation-induced electrochemiluminescence (AIECL).

142 (PET), intramolecular charge transfer (ICT), aggregation-induced emission (AIE) and disaggregation-in

143 nhanced antibacterial activities, as well as aggregation-induced emission (AIE) enhancement that was

144 This property, in addition to them being aggregation-induced emission luminogens, enabled us to p

145 nsymmetrically substituted triarylalkenes as aggregation-induced emission-active fluorogens (AIEgens)

146 ly restrict the molecular dynamics to create aggregation-induced enhanced emission.

147 amine-stabilized Pt NPs induced nanoparticle aggregation, inhibiting their catalytic activity.

148 of protein G (HTB1), into a highly specific aggregation inhibitor (designated HTB1M) of two familial

149 onstrate that methylene blue, a reported tau aggregation inhibitor, modulates tau acetylation, a nove

150 Interestingly, we observed the aggregation inhibitory efficacy of alpha/beta and alpha/

151 in ligases, and causing its accumulation and aggregation into inclusions.

152 Here, the dynamics of AQP4e aggregation into OAPs and its role in the regulation of

153 alpha-Synuclein (alpha-syn) aggregation is a key event in Parkinson's disease (PD).

154 st that this membrane-mediated microparticle aggregation is a reason behind reported long retention t

155 hat widespread amorphous and amyloid protein aggregation is an unanticipated outcome of such stress.

156 monstrate, that the suppression of alpha-syn aggregation is dependent on the molecular chaperone Hsp7

157 nto these DNAJB6-KO HEK293T-alpha-syn cells, aggregation is reduced to the level of the parental cell

158 irectional TDP-43 processing in which TDP-43 aggregation is targeted by a coordinated chaperone respo

159 beta-Amyloid (Abeta) aggregation is thought to initiate a cascade of neurodeg

160 Combining Raman spectroscopy with aggregation kinetics and transmission electron microscop

161 The model accurately predicted Abeta aggregation kinetics at various CatB and CysC concentrat

162 ical modeling provided estimates of receptor aggregation kinetics based on FcepsilonRI occupancy with

163 The aggregation kinetics data were in good agreement with th

164 hese NPs was investigated by measuring their aggregation kinetics in different aqueous solution chemi

165 rm and the fibrillar pentamer in the Abeta40 aggregation landscape disappears for Abeta42, suggesting

166 1 fragments having 20 or 30 glutamines, the aggregation landscape for fragments with 40 repeats has

167 to infer missing data, and show that spatial aggregation leads to more robust inference regarding dyn

168 ns in HTT exon 1 fragment leads to a complex aggregation mechanism with a basic core that resembles t

169 tween protein/peptide folding, unfolding and aggregation mechanisms, with the resulting amyloid struc

170 We show that aggregation method instructs EB lineage bias, with faste

171 Further, we couple the calibrated platelet aggregation model with a tissue-factor/contact pathway c

172 mmobilized and clustered, limiting access to aggregation-modulating antibodies.

173 Here, we report HuR aggregation (multimerization) in glioma and the analysis

174 Neither homotypic aggregation nor NETosis occurs when human neutrophils ar

175 0.7, and shell thickness of 5.45 A, with an aggregation number of 74.

176 The abnormal aggregation of a small number of known proteins underlie

177 mer's disease due to its ability to seed the aggregation of Abeta.

178 hat most FAD mutations increased the rate of aggregation of Abeta.

179 Aggregation of amyloid beta (Abeta) peptides is a signif

180 Aggregation of amyloid-beta peptides into fibrils or oth

181 utyrylcholinesterase (BChE), could cause the aggregation of Au NPs and the corresponding recovery of

182 with the DNA probes results in instantaneous aggregation of AuNPs into nanoballs, leading to a signif

183 on of bacteria in real matrices based on the aggregation of AuNPs without requiring any readout devic

184 ity of the occipital cortex and the peculiar aggregation of cerebellar regions to form a closed core.

185 The assay is based on inducing aggregation of citrate AuNPs decorated with a specific n

186 n sHsps analyzed except HspB7 suppressed the aggregation of cytosolic proteins of HEK293 cells.

187 tive analyses of therapeutic options and the aggregation of data from clinical trials across differen

188 odifications in regulating the structure and aggregation of Httex1 and suggest that its aggregation a

189 Aggregation of huntingtin protein arising from expanded

190 The aggregation of hypertrophic macrophages constitutes the

191 opose that fibers generically arise from the aggregation of irregular particles with short-range inte

192 We show that NUCB1 inhibits aggregation of islet-amyloid polypeptide associated with

193 id membranes interact with and influence the aggregation of many amyloid-forming proteins.

194 degrees of internal order by the cooperative aggregation of molecular subunits, which endows these SP

195 een these modifications on the structure and aggregation of mutant huntingtin exon1 (Httex1).

196 Previous studies have shown that the aggregation of N-terminal fragments (encoded by HTT exon

197 Akaganeite particles are constituted by the aggregation of nanorods of akaganeite.

198 HSJ1 overexpression can reduce aggregation of neurodegeneration-associated proteins in

199 ely, activation of protein kinase C promoted aggregation of neurons into clusters, local connectivity

200 being synthesized in the system, along with aggregation of newly synthesized AuNPs onto larger ones

201 studies revealed severe mislocalization and aggregation of NUPs and defective nucleocytoplasmic tran

202 gh RNA:protein ratio (>/=1:8), the amorphous aggregation of p53C is clearly suppressed.

203 med that can act as seeds nucleating de novo aggregation of p53C.

204 s (CLABPs), has been shown to interfere with aggregation of particular misfolded amyloid peptides or

205 We also found that N-BODIPY detects aggregation of peroxisomes during final stages of progra

206 panies use significant resources to mitigate aggregation of pharmaceutical drug products.

207 ein-protein interactions to drive controlled aggregation of polystyrene microparticles, either throug

208 basic core that resembles that found for the aggregation of pure polyQ repeats using AWSEM.

209 tau can transfer between cells and seed the aggregation of soluble tau.

210 h as stress granules and those seeded by the aggregation of specific ASO-binding proteins such as FUS

211 The aggregation of st-AuNPs, which produces the indication s

212 as bifunctional linkers (BLs) to mediate the aggregation of streptavidin-functionalized gold nanopart

213 The decrease in ataxin-2 reduced aggregation of TDP-43, markedly increased survival and i

214 The aggregation of the amyloid beta peptide (Abeta) into amy

215 topics related to Alzheimer's disease is the aggregation of the amyloid-beta peptide, which was shown

216 he hydrogel framework collapses resulting in aggregation of the C-dots and quenching of their lumines

217 ent processes and is independent of possible aggregation of the chiral entity.

218 ence, length, and origin on the mechanism of aggregation of the core domain of p53 (p53C) using light

219 esolve an oligomeric intermediate during the aggregation of the human islet amyloid protein (hIAPP or

220 heat denaturation is probably caused by the aggregation of the initially unfolded protein molecules.

221 logy, Saad et al. (2017) identify reversible aggregation of the metabolic enzyme pyruvate kinase unde

222 yn transmits from neuron-to-neuron and seeds aggregation of the protein in the recipient cells.

223 The starvation-induced aggregation of the social amoeba Dictyostelium discoideu

224 generated during ROS exposure as a result of aggregation of the Sup35 translation termination factor,

225 er, using a flexible spacer, facilitates the aggregation of these modules in DCM-d2 solution, through

226 ng the mechanisms promoting the pathological aggregation of this protein.

227 The increased aggregation of transthyretin in preeclampsia occurs at t

228 ncentration of both analytes, confirming the aggregation of Tyr-Au NPs induced by spermine and spermi

229 gger complex cellular responses that prevent aggregation of unassembled Sm proteins.

230 ck proteins (sHsps) prevent the irreversible aggregation of unfolding proteins by integrating into fo

231 an were young cells because of age-dependent aggregation of Whi3, an RNA-binding protein controlling

232 acrobatic lunging maneuvers to attack dense aggregations of krill or small fish, and their large fli

233 element and the viral Rev protein; transient aggregations of RNAs into discrete foci at or near the n

234 retention by biochar, which resulted in the aggregation or alignment along the edges of multisheets

235 , CatB, or CysC concentration, whether Abeta aggregation or degradation will result.

236 t, GsMTx-4 had no effect on collagen-induced aggregation or on Ca(2+) influx via TRPC6 or Orai1 chann

237 d by various factors such as cell damage, QD aggregation or the level of reactive oxygen species, whi

238 e elevated IL-34 itself had no effect on the aggregation or the toxicity of mHTTx1 in neuronal cultur

239 maller than Swi11-32 are either incapable of aggregation or unstably propagate [SWI(+)].

240 oligomer-induced toxicity by modulating the aggregation pathway, without substantially changing the

241 The huntingtin aggregation pathways are of therapeutic and diagnostic i

242 of biological interfaces in modulating Abeta aggregation pathways.

243 ex1, we identified and mapped three distinct aggregation pathways: 1) unseeded in solution; 2) seeded

244 One mystery in the mechanism of platelet aggregation pertains to how resting platelets ignore sol

245 ed Abeta species (AbetapE3) exhibit enhanced aggregation potential and propensity to form toxic oligo

246 nucleation theories used to describe amyloid aggregation predict low oligomer concentrations and do n

247 ieved to be responsible for the onset of the aggregation process leading to amyloid formation.

248 Oligomeric species populated during the aggregation process of alpha-synuclein have been linked

249 soluble comparing to creatine due to a self-aggregation process that occurs at GAA concentrations hi

250 erized the effect of the hairpin fold on the aggregation process using a model beta hairpin structure

251 Because of the complexity of this aggregation process, effective therapeutic inhibitors wi

252 neurons and tested their contribution to the aggregation process.

253 2R abolished TDP-43 activity in splicing and aggregation processes, and even the rather mild L28A mut

254 ethod instructs EB lineage bias, with faster aggregation promoting pluripotency loss and ectoderm, an

255 oteins revealed enrichment for intrinsically aggregation-prone proteins rather than proteins which ar

256 lt to produce recombinantly, like many other aggregation-prone proteins.

257 gates promote rapid proteasomal clearance of aggregation-prone proteins.

258 at huge concentrations by sequestering their aggregation-prone regions in micellar structures, where

259 Often, a unique aggregation-prone sequence polymerizes to form regular f

260 In contrast, the population of aggregation-prone tau as induced by the complexation wit

261 Intriguingly, FUS's nearly uncharged, aggregation-prone, yeast prion-like, low sequence-comple

262 ically, structurally stable mutants show low aggregation propensity and moderately destabilized sw Ap

263 In neuroblastoma cells it was found that the aggregation propensity of TRIOBP-1 arises from its centr

264 s that regulate both secondary structure and aggregation propensity.

265 Following studies of aggregation properties of probes using dynamic light sca

266 ffect on the particles formed with decreased aggregation rate and increased critical coagulant concen

267 effects is essential for determining how the aggregation reaction could be modulated to favor nontoxi

268 Upon bacterial aggregation, recombinantly produced TCPs induce permeabi

269 hibited both reaction- and diffusion-limited aggregation regimes with rates depended upon solution ch

270 ackle the molecular basis of all the protein-aggregation-related diseases.

271 y imaging reveals the dynamic process of gNP aggregation responses upon biomolecular binding.

272 creased propensity to undergo seed-dependent aggregation, revealing a potential role for tau acetylat

273 Control of lateral size, aggregation state (single vs. few layers) and oxidation

274 Peptides undergo changes in conformation and aggregation state in the presence of membranes; converse

275 st prions, developing sensors to track their aggregation states and employing prion fusions to encode

276 hydroalane adducts as well as DIBAL-H in its aggregation states support this experimental finding.

277 to track dynamic changes that occur in Abeta aggregation states, which result from the formation of l

278 stabilizing conditions used in many in vitro aggregation studies are shown to yield qualitatively dif

279 n this population-based, case-control family aggregation study, all 202 patients included in the Iris

280 al assembly and prevent pathological protein aggregation, suggesting a potential treatment pathway am

281 AFM) to demonstrate directly that on-surface aggregation takes place at a concentration at which no a

282 l roles in solution and in membrane-mediated aggregation, the N17 represents an attractive target for

283 ing different pH-induced susceptibilities to aggregation: the susceptible hamster prion (GHaPrP) and

284 -granule secretion, Ca(2+) mobilization, and aggregation through PI3K class Ibeta (PI3K-Ibeta).

285 We propose that structured RNAs prevent p53C aggregation through surface interaction and play a signi

286 lation models involving spatial data and its aggregation to different spatial scales.

287 concentration required for diffusion-limited aggregation to occur.

288 e TRIOBP-1 protein that is essential for its aggregation to occur.

289 Although such mutant proteins are prone to aggregation, toxicity is also associated with soluble fo

290 Concurrently, this dermal cell aggregation triggers the mechanosensitive activation of

291 hermodynamic stabilities and monitored their aggregation under physiological conditions by thioflavin

292 thione peptides, utilizing gold nanoparticle aggregation via 3-Aminopropyltreithoxysilane.

293 onments could control beta-synuclein (betaS) aggregation via altering its charge distribution, thus o

294 Thrombin-induced aggregation was decreased in PP1calpha(-/-) murine plate

295 mixing and associated mixing energy on floc aggregation was examined for a surface water source char

296 Meta-aggregation was performed to synthesize the findings.

297 rance of alpha-synuclein was re-established, aggregation was reduced, and motor phenotypes in Drosoph

298 n and integrin alphaIIbbeta3 activation, and aggregation were abrogated in ck2beta(-/-) platelets.

299 Lipopolysaccharide (LPS) surface charge and aggregation were unaltered in the presence of OligoG CF-

300 nitude of the shift depends on the extent of aggregation, which was controlled by the solution pH and