ライフサイエンスコーパス: aging process

1 ple develop presbyopia as part of the normal aging process.

2 trophes but also rescues and can reverse the aging process.

3 f biological systems is the true root of the aging process.

4 changes of some key proteins relevant to the aging process.

5 may lead to new insights into the human skin aging process.

6 GnRH neuronal output is modulated during the aging process.

7 the best-understood proteins involved in the aging process.

8 length and, therefore, potentially with the aging process.

9 sease encompasses more than just the natural aging process.

10 hat the 4 allele may particularly affect the aging process.

11 re help to uncover general principles of the aging process.

12 precedented microscopic imaging of the whole aging process.

13 nature of the CSF proteome during the normal aging process.

14 ls, a radical shift in our perception of the aging process.

15 age-related diseases is that it inhibits the aging process.

16 m and in the systemic adjustments during the aging process.

17 y cohort allowed agent-based modeling of the aging process.

18 In contrast, MCAK eliminated the aging process.

19 for memory deficits that often accompany the aging process.

20 o how progerin may participate in the normal aging process.

21 monodisperse product by means of a prolonged aging process.

22 plays a role in disease development and the aging process.

23 anges with alterations that occur during the aging process.

24 on skin are also reminiscent of the natural aging process.

25 ment and also plays an important role in the aging process.

26 cline is a virtually universal aspect of the aging process.

27 letions, which have been associated with the aging process.

28 ur in subjects with schizophrenia during the aging process.

29 normal chromatin packing contributes to the aging process.

30 om the intervening disease to the underlying aging process.

31 ations that can prevent, stop or reverse the aging process.

32 s one of the most distressing aspects of the aging process.

33 en proposed to play an important role in the aging process.

34 as a viable method to curtail the cognitive aging process.

35 s network of communication may relate to the aging process.

36 t-6 play an important functional role in the aging process.

37 res are considered integrated markers of the aging process.

38 e progressively more prooxidizing during the aging process.

39 d, potentially, for our understanding of the aging process.

40 immune declines associated with the natural aging process.

41 e an effect on metabolic pathways during the aging process.

42 he correlation between tumorigenesis and the aging process.

43 he thermodynamically favored shape during an aging process.

44 spond to central energy needs throughout the aging process.

45 ects during fetal development and during the aging process.

46 ausing similar mitotic defects in the normal aging process.

47 re both conserved across species to regulate aging process.

48 es are an integral part of the physiological aging process.

49 lammatory processes that increase during the aging process.

50 s been recognized as a causal factor for the aging process.

51 described as being associated with premature aging process.

52 ne and the nuclear lamina contributes to the aging process.

53 g-term outcome for several indicators of the aging process.

54 ormal growth and development and also in the aging process.

55 , indicating that these compounds retard the aging process.

56 ong-lived, has its natural limitation in the aging process.

57 r signal transduction at synapses during the aging process.

58 ikely a result of acceleration of the normal aging process.

59 n protein oxidation were changing during the aging process.

60 ecules are believed to play key roles in the aging process.

61 controls, during oxidative stress and early aging process.

62 nuclear architecture occur during the normal aging process.

63 s of the LDT and PPT as a consequence of the aging process.

64 are thought to be a major contributor to the aging process.

65 g the role of several genes in the mammalian aging process.

66 llustrating the multifactorial nature of the aging process.

67 ing thymic integrity and function during the aging process.

68 to affect aging in mice do indeed alter the aging process.

69 ic mutations is thought to contribute to the aging process.

70 herefore central to our understanding of the aging process.

71 proven useful in elucidating aspects of the aging process.

72 rt for both the models playing a role in the aging process.

73 normal aging represent general events in the aging process.

74 ive stress, which has been implicated in the aging process.

75 t of DAF-16 has opened a new window into the aging process.

76 osed on the old heart independently from the aging process.

77 ourse, and appears to be associated with the aging process.

78 s, SOD1 has been shown to play a role in the aging process.

79 cardiac death, as well as to monitoring the aging process.

80 powerful molecular description of the normal aging process.

81 o determine if caloric restriction slows the aging process.

82 th age, and is proposed to be causal for the aging process.

83 ed reactive oxygen species formation and the aging process.

84 d as an effective approach to delay the skin aging process.

85 ne in cellular proliferation observed in the aging process.

86 cellular pathways that are important to the aging process.

87 tosis appear to be central components of the aging process.

88 nd an advanced understanding of the cellular aging process.

89 in sleep pattern are typical for the normal aging process.

90 ar how GAG structures are changed during the aging process.

91 andom attacks and thus may contribute to the aging process.

92 ity of NiS in surface sediments early in the aging process.

93 ssion of cancer and diabetes, as well as the aging process.

94 sistance pathways as critical players in the aging process.

95 hological conditions such as cancer, and the aging process.

96 ins and Klotho, which further accelerate the aging process.

97 mmasome-mediated caspase-1 activation in the aging process.

98 and why we age-and possibly how to delay the aging process.

99 ne DNA methylation is compromised during the aging process.

100 unction may be particularly sensitive to the aging process.

101 variants or networks that contribute to the aging process.

102 sights into the role age-dMS may have in the aging process.

103 rities between the fibrotic disorder and the aging process.

104 malian health, and perhaps in modulating the aging process.

105 occurrence and hormonal activity during the aging process.

106 ong-term protein persistence to the cellular aging process.

107 rlie the central role of mitochondria in the aging process.

108 t and differentially vulnerable to normative aging processes.

109 at the crossroads of genomic instability and aging processes.

110 n cellular energy metabolism, apoptosis, and aging processes.

111 ysregulations during normal and pathological aging processes.

112 by chemical mutagens, x-rays, or endogenous aging processes.

113 e Alzheimer type may be coupled to intrinsic aging processes.

114 ithin the brain are also highly sensitive to aging processes.

115 nation of changing sources and photochemical aging processes.

116 ated marker compound that is associated with aging processes.

117 mutation frequency and tumorigenesis in the aging process?

118 to genetic manipulations that slow down the aging process?

119 omatous tissues supports that an accelerated aging process accompanies neurodegeneration in glaucomat

120 ly sensitive to both normal and pathological aging processes across adulthood.

121 The aging process affects all aspects of the immune system,

122 c insults, and also involutes as part of the aging process, albeit at a faster rate than many other t

123 However, the aging process also occurs in dividing cells undergoing r

124 d elevated, resulting in a highly compressed aging process and accelerated formation of several prote

125 he molecular pathways that contribute to the aging process and age-related disease is progressing thr

126 extracellular matrix, all implicated in the aging process and age-related disease risk.

127 sults suggest a mechanistic link between the aging process and aggregation-mediated proteotoxicity.

128 ng prospects for medical intervention in the aging process and also suggest different approaches in a

129 tions about, and exclusive reference to, the aging process and any associated disease.

130 t due to the implication of telomeres in the aging process and cancer.

131 showing that dietary restriction delays the aging process and decreases the incidence of many age-as

132 he complex role of metabolic pathways in the aging process and highlight important paradoxes that hav

133 d cellular signaling events that control the aging process and how can this knowledge help design the

134 ed signaling through this pathway during the aging process and in OA chondrocytes is known to contrib

135 it is possible to therapeutically target the aging process and increase health span.

136 e a system of four stages that describes the aging process and is useful for the analysis of genetic

137 omarkers provide detailed description of the aging process and its contribution to Alzheimer's diseas

138 goal of broadening our understanding of the aging process and its meaning as a 'risk factor' in dise

139 However, a mechanistic understanding of the aging process and its role in ionic nutrient adsorption

140 ized form of amyloidosis associated with the aging process and may be of pathophysiologic import.

141 drial dysfunction is a core component of the aging process and may play a key role in atherosclerotic

142 ntribute to organ dysfunctions including the aging process and other disease processes.

143 iated ALS, with possible applications to the aging process and other late-onset neurodegenerative dis

144 Lastly, changes in mtDNA repair during the aging process and possible biological implications are d

145 model highlights specific components of the aging process and provides a quantitative readout for st

146 o the role of somatic mtDNA mutations in the aging process and raise the specter of progressive iatro

147 n structure is critical for slowing down the aging process and reveals that increasing the histone su

148 ence for phosphate toxicity accelerating the aging process and suggest a novel role for phosphate in

149 ions offer valuable insights into the normal aging process and the complex biology of cardiovascular

150 lifespan could offer insights into both the aging process and the development of aging-related neuro

151 nduced gene regulation may contribute to the aging process and the premature aging in WS.

152 The natural aging process and traumatic events such as lower-limb lo

153 Klotho is a key modulator of the aging process and, when overexpressed, extends mammalian

154 since telomere attrition is associated with aging processes and accelerates after a recurrent exposu

155 me of reinforcement that is similar for both aging processes and BW813U administration.

156 may inherit biological factors that modulate aging processes and disease susceptibility.

157 Calorie restriction (CR) influences aging processes and extends average and maximal life spa

158 gen species, are both associated with normal aging processes and linked to cardiovascular disease, ca

159 Understanding BBA aging processes and quantifying the size-resolved mass a

160 Aging processes and surface contamination especially wit

161 Advances in understanding aging processes and their consequences are leading to th

162 ion in stress tolerance is a hallmark of the aging process, and the lowered functional capacity obser

163 The mechanisms underlying the aging process are not understood.

164 Skin aging processes are modeled by treating keratinocytes wi

165 f genes and molecular pathways to aging, the aging process as a whole still remains poorly understood

166 NF-L) were found to be characteristic of the aging process as reported in vivo.

167 e oxygen species have been implicated in the aging process as well as a wide range of hereditary and

168 emonstrated to ameliorate and decelerate the aging process as well as blunt end organ damage from obe

169 eport increased forgetfulness earlier in the aging process, as they transition to menopause.

170 We studied adults early in the aging process, as women transition into menopause, to id

171 vulnerability to unhealthy developmental and aging processes, as exemplified by schizophrenia and Alz

172 ed from the binary kernel series indicate an aging process at an early stage in the visual system.

173 To define the C. elegans aging process at the molecular level, we used DNA microa

174 asis should be placed on research into basic aging processes, because interventions that slow aging w

175 ed NAD homeostasis that accompany the normal aging process but also, elucidate the merits and potenti

176 The results offer insights into the aging process, but also offer a new approach to studying

177 em may not entirely be due to a degenerative aging process, but are the result of developmental and s

178 Mitochondria deteriorate during the aging process, but the underlying mechanisms for the dec

179 oxic dose-response by H. azteca early in the aging process; but only Burntwood, for which Ni was prim

180 interorgan macroenvironment can regulate the aging process by integrating both "activator" and "inhib

181 e that protein quality control exerts on the aging process by using CHIP-/- mice.

182 The aging process can be recapitulated by Col17a1 deficiency

183 Here, we investigated whether the aging process can induce changes in the myocardial GAG c

184 Identifying factors that accelerate the aging process can provide important therapeutic targets

185 During chronic infections and the normal aging process, CD28 expression is lost, compromising the

186 rly adulthood, which suggests an accelerated aging process compared with other postmitotic tissues.

187 deterioration of meiotic cohesion during the aging process compromises the segregation of achiasmate

188 osteoarthritis and the understanding of how aging processes contribute to the development of osteoar

189 translational research to understand how the aging process contributes to the onset and/or progressio

190 The accumulation of loose deposits and the aging process create variable microenvironments inside l

191 We chose ERCC6 because of its roles in the aging process, DNA repair, and ocular degeneration from

192 e locally generated particles, together with aging processes, dramatically affected aerosol compositi

193 framework for asking new questions about the aging process emerges.

194 for understanding the mechanisms driving the aging process(es).

195 ic restriction (CR) has been shown to retard aging processes, extend maximal life span, and consisten

196 pproach that can isolate crucial features of aging processes for further study may be a productive av

197 ata also have important implications for the aging process, forensic identifications, and anthropolog

198 rtyl residues arise spontaneously during the aging process from the deamidation of protein asparaginy

199 hat resemble premature aging--and the normal aging process has been a source of debate in the aging r

200 es cancer development and contributes to the aging process has progressed rapidly.

201 nse to high-fat diet regimens and during the aging process; however no studies to date have elucidate

202 have identified major roadblocks that normal aging processes impose on tissue regeneration.

203 The aging process imposes a threat to diversity, because thy

204 phosphorylation diminished during the normal aging process in both humans and flies.

205 patterns that are highly correlated with the aging process in both of the two species.

206 ranscriptional circuit that guides the rapid aging process in C. elegans and indicate that this circu

207 nfluences DAF-16-dependent regulation of the aging process in C. elegans by regulating the transcript

208 ine the expression of SK channels during the aging process in GnRH neurons.

209 ermine if calorie restriction attenuates the aging process in humans.

210 First described as regulators of the aging process in invertebrate model organisms, Forkhead

211 drial DNA mutations play a major role in the aging process in mammals is that clear loss-of-function

212 esults would predict that MsrA regulates the aging process in mammals.

213 SIR2 is a key regulator of the aging process in many model organisms.

214 Metabolic imbalances accompany the aging process in many organisms, and signaling mechanism

215 of immediate working memory processes to the aging process in mice may be related to their need for m

216 The aging process in rodents is associated with learning and

217 Although the intrinsic aging process in skin is phenotypically distinct from SS

218 Caloric restriction retards the aging process in small mammals; however, no information

219 Among these, the aging process in the central nervous system is criticall

220 omeostasis with perturbations induced by the aging process in the function of the main intracellular

221 ed signatures, thus allowing modeling of the aging process in vitro, and they identify impaired NCC a

222 c brown carbon; however, their formation and aging processes in atmospheric waters are unknown.

223 Not all osteoarthritis is due to aging processes in joint tissues, but the age-related ch

224 ore the potential role of BFSP1 and BFSP2 in aging processes in the lens.

225 ondria contribute to specific aspects of the aging process, including cellular senescence, chronic in

226 adult and aged rats and suggest that taking aging processes into account when assessing stroke may i

227 sease processes of clinical interest and the aging process involve oxidative stress in their underlyi

228 t that impaired erectile function during the aging process involves increased RhoA/Rho-kinase signali

229 f wild type and "aged" NmHO reveal that the "aging" process involves cleavage of the Arg208His209 dip

230 to generate transcriptional profiles of the aging process is a powerful tool for identifying biomark

231 The aging process is associated with various morphological a

232 A cellular mechanism postulated to drive the aging process is cellular senescence, mediated in part b

233 While the aging process is central to the pathogenesis of age-depe

234 The aging process is characterized metabolically by insulin

235 rown fat activity observed during the normal aging process is currently unknown.

236 The central importance of epigenetics to the aging process is increasingly being recognized.

237 potentially early event in the normal human aging process is microsatellite instability accumulation

238 ermining if a given intervention affects the aging process is not straightforward since, for instance

239 However, whether MSRA plays a role in the aging process is poorly understood.

240 nt and identity of epigenetic changes in the aging process is therefore potentially important for und

241 her a cloned animal undergoes an accelerated aging process is yet to be answered.

242 aging, research suggests that targeting the aging process itself could ameliorate many age-related p

243 Animal experiments also reveal that the aging process itself, in the absence of significant nois

244 et pathways specifically associated with the aging process itself.

245 en limited by the lack of a way to assay the aging process itself.

246 The progression of the aging process leads to a decreased margin of homeostatic

247 athways, and reflect on which aspects of the aging process may be reversible.

248 ies to intervene in aspects of the stem cell aging process may have significant clinical relevance.

249 Therapeutic targeting of the aging process may therefore represent an innovative stra

250 Therapeutic approaches that target aging processes may be beneficial for halting the progre

251 In conclusion, skin aging processes may involve ROS-induced protein dysfunct

252 o explain how protein aggregation and normal aging processes might be involved in polyglutamine disea

253 es of nuclear architecture during the normal aging process of a multicellular organism, but also sugg

254 if collagen plays a significant role in the aging process of fossil materials, a simpler and more ac

255 ut the role MMR pathway failure plays in the aging process of human HPCs.

256 ised tannins was sufficient to guarantee the aging process of sweet wines.

257 myelin abnormalities characterize the normal aging process of the brain and that an age-associated re

258 as been implicated as a causal factor in the aging process of the heart and other tissues.

259 immune system over-activity may underlie the aging process of the human brain, and that potential ant

260 fection with CMV) in the acceleration of the aging process of the immune system, leading to 'immunose

261 tin antioxidant effects may slow the natural aging process of the lens.

262 and downregulation of mTORC1 could delay the aging process of the RPE.

263 ructures, and correlates positively with the aging processes of many organisms, including Alzheimer d

264 dicals are among the most important chemical aging processes of organic aerosol particles in the atmo

265 Aging processes of secondary organic aerosol (SOA) may b

266 whether SCN1A modifies the vulnerability to aging processes of the human brain.

267 e studies concerning BDNF involvement in the aging processes of the teleost brain.

268 anges in HSCs may reflect the effects of the aging process on individual HSCs or a shift in the clona

269 We examined the effects of the aging process on the frontal and temporal lobes.

270 r the apoptosis results from normal cellular aging processes or accelerated cell loss upon granulocyt

271 ations in IMCL metabolism are related to the aging process per se.

272 iabetes may accelerate the underlying kidney aging process present in old mice.

273 or (mGluR) antagonists or lithium during the aging process prevented the onset of these deficits, and

274 rk structure of genes and miRNAs involved in aging processes promises to advance our understanding of

275 dal hormones in women combined with cellular aging processes promote sex biases in stress dysregulati

276 me) properties that remain stable during the aging process, rather than white matter microstructure t

277 dult to influence aging, indicating that the aging process remains plastic during adulthood.

278 exact role of the SOD1 protein in the human aging process remains to be resolved.

279 tochondrial dysfunctions associated with the aging process significantly modify nonlinear dynamical s

280 During the aging process, stem cells undergo both quantitative and

281 ious pathologies associated with the general aging process such as Alzheimer disease and the long-ter

282 diffusion processes in directed networks, or aging processes such as in fragmentation processes.

283 cells, are devoid of replicative associated aging processes, such as senescence and telomere shorten

284 mained constant in somatic tissues along the aging process, suggesting a lack of quality control mech

285 However, molecular geneticists propose an aging process that is programmed (like other development

286 ases and highlights molecular markers of the aging process that might drive disease comorbidities.

287 lt-to-modify cultural and dietary habits and aging processes that are modifiable.

288 a visible, intuitive, top-down framework of aging processes that fosters knowledge-building and coll

289 During the natural aging process the immune system undergoes many alteratio

290 components of the inflammatory process, the aging process, therapeutics, and drug or alcohol abuse.

291 The aging process therefore results in both a shift in the b

292 reverses cellular age, but alteration of the aging process through reprogramming has not been directl

293 h models are applicable to understanding the aging process throughout the 80-100 years of human life

294 he mechanisms by which DR interacts with the aging process to improve health in old age are poorly un

295 esting that these proteins couple the normal aging process to this type of age-related disease.

296 CD-1 mice maintain FoxM1B levels during the aging process, we conducted the current study to determi

297 re the role of mitochondrial activity in the aging process, we have lowered the activity of the elect

298 unctionalization reactions might be the main aging process were initiated by the cumulative effect of

299 y increasing, an open visual encyclopedia of aging processes will be useful to both the new entrants

300 s) provide a window into the neurobiology of aging processes within the brain and a potential biomark