ライフサイエンスコーパス: agonist

1 c ER agonist) or genistein (ERbeta-selective agonist).

2 rs gating independently of activation by any agonist.

3 ugmented by the addition of a long-acting ss-agonist.

4 ified as either a full or partial muscarinic agonist.

5 ioid receptor antagonists, while 6 was a MOR agonist.

6 ccharide (LPS), a Toll-like receptor (TLR)-4 agonist.

7 exposed to spinal administration of a D1/D5 agonist.

8 g in its activity as a kappa-opioid receptor agonist.

9 low m.w. moieties were removed, it became an agonist.

10 re labeled with the antagonist than with the agonist.

11 didate for the treatment of T2DM as a GLP-1R agonist.

12 in cis, that is shared with a BTLA antibody agonist.

13 d by thermal pain or a kappa opioid receptor agonist.

14 arget neuroendocrine tumors (NETs) than sst2 agonists.

15 but variable aggregation defects with other agonists.

16 which requires intracellular delivery of its agonists.

17 tial between soluble and membrane-bound CD40 agonists.

18 Some flavones are also T2R agonists.

19 e Dectin-1 antagonists and two were Dectin-1 agonists.

20 a functional switch from agonists to inverse agonists.

21 or resting receptors activate and then bind agonists.

22 athways similar to those activated by opioid agonists.

23 as a new series of potent and selective TLR7 agonists.

24 hanges in vascular tone induced by vasomotor agonists.

25 to impart full efficacy to the partial GABA agonists.

26 creased SOCE, particularly at lower doses of agonists.

27 ning the range of full, partial, and inverse agonists.

28 c administration of mu-opioid receptor (MOR) agonists.

29 gonists compared with clinically widely used agonists.

30 hannels, and this occurred in the absence of agonists.

31 designed as potential liver X receptor (LXR) agonists.

32 as it utilizes a covalently tethered inverse agonist (11-cis-retinal) as the native ligand.

33 ted whether peripherally administered GLP-1R agonists access the LDTg to affect feeding.

34 systemically administered fluorescent GLP-1R agonist accesses the LDTg and is juxtaposed with neurons

35 ther as antagonist, partial agonist, or full agonist according to the receptor, the enantiomer, and t

36 In contrast, there was very little agonist action of I942 towards EPAC2 or protein kinase A

37 we identify that cold temperatures and Adrb3 agonists activate distinct cellular populations that exp

38 We show that agonist activation of the group I metabotropic glutamate

39 5-HT2C agonist with potent 5-HT2B and 5-HT2A agonist activities, which is approved for treating obesi

40 DDEPLT (Pep19), with slightly better inverse agonist activity at cannabinoid type 1 receptors.

41 covery of a minor enantiomeric impurity with agonist activity led to the finding that enantiomers (R,

42 ed using PAMs that also exhibited allosteric agonist activity, leaving open the possibility that dire

43 ices similar to previous compounds with more agonist activity.

44 Immunogenicity of the TLR8 agonist adjuvanted antigen 85B (Ag85B)/peptide 25-loaded

45 The combination of the two TLR agonists allows for significant dose reductions of each

46 Although soluble receptor agonist alone could not induce death, combinatorial trea

47 8a activation assay, we show that TLR3 and 9 agonists also activate Rab8a.

48 Chemoimmunomodulation with a TLR-7 agonist and albumin bound paclitaxel is effective in ind

49 n for myoclonus and striking coactivation of agonist and antagonist muscles.

50 , these studies identify tapinarof as an AhR agonist and confirm that its efficacy is dependent on Ah

51 tate cancers, none had sst2 binding with the agonist and only 4 had a weak binding with the antagonis

52 atorial treatment incorporating soluble CD40 agonist and pharmacological inhibition of Trx-1 was func

53 ve fashion, not seen for classical nicotinic agonists and antagonists.

54 review the cardiovascular actions of GLP-1R agonists and DPP-4 inhibitors, with a focus on the trans

55 lled despite treatment with long-acting beta-agonists and medium-to-high doses of inhaled glucocortic

56 e use of pathogen recognition receptor (PRR) agonists and the molecular mechanisms involved have been

57 Exposure of bdMphi to TLR agonists and/or bdIFNgamma resulted in upregulated cytok

58 blood, stimulated with Toll-like receptor 7 agonist, and analyzed by means of extracellular flux ana

59 ficacy agonist, buprenorphine a low efficacy agonist, and diprenorphine an antagonist at the MOPr.

60 thrombin and factor Xa, which are known PAR agonists, and cause microthrombosis in liver microcircul

61 ceptor selectivity acting as full or partial agonists, and one as an antagonist.

62 Cells were stimulated with agonists, and secretion of Hsp90, urokinase, and TPA was

63 tive, suggesting new modes of binding at the agonist-antagonist site and perhaps an allosteric action

64 n established endocrine disruptor with mixed agonist/antagonist activity acting via endogenous estrog

65 The agonist anti-mouse GITR antibody DTA-1 has demonstrated

66 Treatment of aged NZB/W F1 mice with agonist anti-Ox40 mAbs potently exacerbated renal diseas

67 effect begins several minutes after initial agonist application.

68 Muscarinic receptor agonists are characterized by apparently strict restrain

69 Glucagon-like peptide 1 receptor (GLP-1R) agonists are increasingly being used as treatment for ty

70 Radiolabeled somatostatin (sst) receptor agonists are integral to the diagnosis of gastroenteropa

71 hyperlipidemia and hypothalamic injury, MC4R agonists are nevertheless more effective to reduce food

72 norphine-naloxone (BUP-NX), a partial opioid agonist, are pharmacologically and conceptually distinct

73 The dopamine partial agonist aripiprazole is increasingly used to treat patho

74 e potential therapeutic application of a p53 agonist as a treatment to accelerate this process in pat

75 Notably, cannabinoid receptor agonists as well as inhibitors of endocannabinoid-regula

76 ociated with surface AMPARs, CNQX, a partial agonist at AMPARs associated with Type I TARPs, evoked w

77 AICP is a full agonist at GluN1/2A (100% response compared with glycine

78 % response compared with glycine), a partial agonist at GluN1/2B and GluN1/2D (10% and 27%, respectiv

79 recently reported that tianeptine is a full agonist at the mu opioid receptor (MOR).

80 TLR5 agonists, bacterial flagellin and engineered flagellin d

81 directed effects of the retinoid X receptor agonist bexarotene in an aggressive model of AD.

82 CD40 agonists bind the CD40 molecule on antigen-presenting ce

83 f two pathways that connect to form a cycle: Agonists bind to resting receptors that then become acti

84 als the mechanism by which Cmpd-15 modulates agonist binding affinity and signalling.

85 on and recycling to the plasma membrane with agonist binding inducing receptor retention along the in

86 oviding only complementary components to the agonist binding site.

87 act on elements of the pathways that couple agonist binding to channel gating.

88 and a distinct, independently regulated, co-agonist-binding site.

89 However, with dinucleotide Ap4A as an agonist, BPTU suppressed the Emax insurmountably in all

90 med that norbuprenorphine is a high efficacy agonist, buprenorphine a low efficacy agonist, and dipre

91 sight for the action of a VDRM compared with agonists by employing hydrogen/deuterium exchange.

92 ively, our data support the idea that opioid agonists can be combined with peripheral MOR antagonists

93 (DCS), which is a glycine site NMDA receptor agonist, can enhance extinction of conditioned fear resp

94 use tumors using HMGN1, a DC-activating TLR4 agonist capable of inducing anti-tumor immunity.

95 Varlilumab is a novel, first-in-class, agonist CD27 antibody that stimulates the CD27 pathway,

96 Finally, injection of A2aR agonist, CGS21680, following immunization suppressed T f

97 on ECG phenotypes before and following beta-agonist challenge, and upon fibrotic change.

98 ling and contrasted with responses to an end agonist chemoattractant (C5a), for which a stable gradie

99 elial cell cultures and intestine after cAMP agonists, cholera toxin, or heat-stable enterotoxin of E

100 n channel whose deactivation is sensitive to agonist concentrations that do not directly activate the

101 rovide evidence that ASICs show such steeply agonist-dependent deactivation because of strong coopera

102 f 18 compounds (mixture of anabolics, beta-2 agonists, diuretics, stimulants, narcotics, and beta-blo

103 The endogenous agonist dopamine binds with preference to D2/3 HIGH rece

104 th C-terminal CB1R domains that could affect agonist-driven, beta-arrestin-mediated internalization o

105 erial infusion of phenylephrine (PE; alpha1 -agonist) during ATP or control vasodilatator infusion, b

106 Gonadotropin-releasing hormone (GnRH) agonists (e.g., triptorelin) are used for androgen suppr

107 s discovery of nine compounds that were MC3R agonists (EC50 < 1000 nM) and MC4R antagonists (5.7 < pA

108 arallel manner without affecting the maximum agonist effect (Emax) but antagonized insurmountably (su

109 mechanisms other than stimulant or dopamine agonist effects.

110 nsory neurons contributes to this low deltaR agonist efficacy in vivo by limiting surface deltaR expr

111 imal GABA-evoked Popen , suggesting impaired agonist efficacy.

112 brain barrier-impermeant PPARgamma-selective agonist, elicited antidepressant- and anxiolytic-like be

113 ) but antagonized insurmountably (suppressed agonist Emax) in signaling events such as guanosine 5'-3

114 derived DCs enabled benchmarking of the TLR8 agonist-encapsulating polymersome formulations against c

115 Rapid syntheses of 5-HT2C agonist, (-)-enduracididine and azido-cholesterol deriva

116 The peptide agonist engages the receptor by binding to an extended h

117 Cotreatment with the GLP-1 receptor agonist exendin-4 reversed the lysosomal dysfunction, re

118 ollowing intra-PVT delivery of either GLP-1R agonist, exendin-4 (Ex4), or GLP-1R antagonist, exendin-

119 ceptor antagonist (experiment 2), or a PACAP agonist (experiment 3) without footshock.

120 eceptors at the cell surface despite chronic agonist exposure.

121 on in the peak GIRK current after minutes of agonist exposure.

122 peutic potential of BAR501, a small molecule agonist for GPBAR1.

123 Seladelpar is a potent, selective agonist for the peroxisome proliferator-activated recept

124 study provides the first selective surrogate agonists for the orphan GPR27.

125 of the clinical use of nicotine and related agonists for treating cognitive deficits, these data sug

126 The beta2 adrenoceptor agonists formoterol and salbutamol mediated suppression

127 assay, we observed that several constrained agonists generated by a cycloaddition reaction displayed

128 ecessary for the effects of exogenous GLP-1R agonists (GLP-1RA) or endogenous GLP-1 on these paramete

129 Receptor co-agonists, glycine and D-serine, have intriguingly emerge

130 e who receive gonadotropin-releasing hormone agonist (GnRHa) therapy.

131 ion is elevated and sensitive to the inverse agonist, GR113808 in the PFC of CK2alpha KO mice.

132 obilization regimen utilizing a unique CXCR2 agonist, GRObeta, and the CXCR4 antagonist AMD3100.

133 Here, we show that a highly selective TLR7 agonist, GS-9620, activated HIV from peripheral blood mo

134 an osmotic gradient and the selective TRPV4 agonist GSK1016790A, enhanced TRPV4 activation was obser

135 , a glucagon-like peptide-1 (GLP-1) receptor agonist, has been shown to reduce food intake and to inc

136 the treatment of diabetes, but few selective agonists have been reported.

137 TAAR1 agonists have been shown to reduce multiple behavioral e

138 In animal models of FXS and of ASD, GABA-B agonists have improved both brain and behavioral phenoty

139 GPR120 agonists have therapeutic potential for the treatment of

140 prevented by combination with T-cell immune agonist immunotherapies resulting in superior therapeuti

141 Apelinergic agonists improved 72-hour survival after sepsis inductio

142 On treatment with the toll-like receptor 7 agonist imquimod (IMQ), Trim32 knockout mice displayed c

143 a partial agonist in other assays to a full agonist in all assays.

144 antagonist for cell migration and a partial agonist in other assays to a full agonist in all assays.

145 Because tamoxifen acts as an agonist in the postmenopausal endometrium, similar to es

146 g concentration-response curves of all three agonists in a parallel manner for all signaling pathways

147 s (binding free energies) of these and other agonists in adult-type mouse AChRs having a mutation(s)

148 st) receptor antagonists perform better than agonists in detecting neuroendocrine tumors (NETs).

149 ggest a therapeutic potential of alpha7nAChR agonists in early re-programming of microglia in neonate

150 onclude that increased effectiveness of MC4R agonists in obesity may be an unexpected outcome of neur

151 tory effect of bitter taste receptor (TAS2R) agonists in various models.

152 m donors with highly responsive platelets to agonists in vitro assessed by flow cytometry (high-respo

153 AJs are sensitive to pressure and vasomotor agonists in VSMCs and support a functional role of N-cad

154 nduced by injection of several different TLR agonists, including those for TLR2, TLR7, and TLR9.

155 This suggests that upon agonist-independent internalization, GPRC6A is recycled

156 rast, PKC activation caused a lower level of agonist-independent KOPR internalization, compared with

157 ion, PKC activation by phorbol ester induced agonist-independent KOPR phosphorylation.

158 man B cells, BCR ligands that deliver a TLR9 agonist induce an initial proliferative burst that is fo

159 Particulate beta-glucan (a DECTIN-1 agonist) induced mast cell degranulation in mesenteric w

160 depletion from the PM was achieved either by agonist-induced activation of phospholipase C beta or wi

161 The compounds modulated the hypertrophic agonist-induced cardiac gene expression.

162 IGF-1R, but protecting the receptor against agonist-induced degradation.

163 Model results show that agonist-induced intracellular calcium dynamics can be mo

164 eatment, GRKs, but not PKC, were involved in agonist-induced KOPR internalization.

165 ine the involvement of individual kinases in agonist-induced P-UAEC proliferation.

166 hat receptor internalization is required for agonist-induced phosphorylation of extracellular signal-

167 ect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes.

168 nth-old C57BL/6J mice with the FXR-TGR5 dual agonist INT-767 induced caloric restriction-like effects

169 injection of small amounts of GABAA-receptor agonists into an upper brainstem region named the mesopo

170 or alpha (Ppara), and treatment with a Ppara agonist is sufficient to rescue the loss of beige adipoc

171 the body, obtaining highly specific receptor agonists is essential.

172 harmacodynamically diverse beta-adrenoceptor agonists, isoproterenol and salmeterol.

173 tor 2 antagonist AM630 (10 mg/kg) or inverse agonist JTE907 (3 mg/kg) during immunization heightens t

174 ence showing that activation of PPARdelta by agonist L165041 in mice increased hepatic LPCAT3 mRNA ab

175 Treatment with the small-molecule CD11b agonist LA1 led to partial integrin activation, reduced

176 nduced by the gonadotropin-releasing hormone agonist, leuprolide acetate; leuprolide plus estradiol;

177 Indeed, agonist ligands are required for a plethora of GPCRs for

178 PPAR-gamma agonists, like pioglitazone, appear antiproteinuric.

179 hallenged with the TLR4 agonist LPS and TLR2 agonists lipoteichoic acid and zymosan.

180 We found that the 5-HT2CR agonist lorcaserin significantly reduced both ad libitum

181 te/macrophage cells challenged with the TLR4 agonist LPS and TLR2 agonists lipoteichoic acid and zymo

182 nists Pam3CSK4 or FSL-1, as well as the TLR4 agonist LPS in the absence of additional ATP.

183 ast, IL-1beta release stimulated by the TLR4 agonist LPS is independent of both pannexin-1 and P2X7 a

184 se studies suggest that an RARalpha specific agonist may afford a new strategy for lipid-lowering and

185 l proof of principle that an apelin receptor agonist may be of therapeutic use in PAH in humans.

186 mmunized with NPs containing TLR4 and TLR7/8 agonists mixed with soluble recombinant SIVmac239-derive

187 not respond to either EGFR antagonist or DR agonist monotherapies.

188 (STZ-rats) were treated with 15 mug/kg GHRH agonist, MR-409, or GHRH antagonist, MIA-602.

189 (the parent cysLT) or the selective CysLT2R agonist N-methyl LTC4 to allergen sensitized wild-type m

190 nhibit receptor activation by the endogenous agonist norepinephrine.

191 These results suggest that Ln(3+) acts as an agonist of both Ca(2+)-binding sites.

192 NADA is also an agonist of cannabinoid receptors 1 and 2.

193 o treatment with either lithium chloride, an agonist of canonical Wnt signaling, or the DKK inhibitor

194 ronic treatment with R-baclofen, a selective agonist of GABAB receptors.

195 , a novel brain-penetrant antagonist/inverse agonist of H3 receptors, on AHN (proliferation, maturati

196 Palmitoylethanolamide is an agonist of PPAR-alpha and an important regulator of pain

197 Unlike Rosi, VSP-51 is a partial agonist of PPARgamma with improved insulin sensitivity d

198 eal that TRV120027, a beta-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), st

199 -moderate AD, with other PDE4 inhibitors, an agonist of the aryl hydrocarbon receptor, Janus kinase i

200 Partial agonists of PPARgamma, such as INT131 (1), have displaye

201 throughput screen to identify small-molecule agonists of TFEB and discover three novel compounds that

202 as emerged as a new therapeutic target since agonists of this receptor induce rapid antidepressant-li

203 ce we now report that the effects of mGlu2/3 agonists on betaAR-mediated increases in cAMP accumulati

204 ith affinity for AChBP showed only two to be agonists on the alpha7-nAChR below 10 muM concentration.

205 e others were weaker antagonists (or partial agonists) on these receptors.

206 ), a sphingosine-1-phosphate receptor (S1PR) agonist, on 2 mouse models of PD.

207 , guanosine 5'-O-(thiotriphosphate) and GPCR agonists only weakly activate the TRPC5R593A mutant, whe

208 TMBPF did not show estrogen-agonist or antagonist activity in the estrogen receptor-

209 tructure-based drug design to identify novel agonist or antagonist leads.

210 s show that pilocarpine can act as either an agonist or antagonist of M3R, depending on the cell type

211 hedgehog pathway by addition of a Smoothened agonist or by addition of exogenous Shh, or neutralizing

212 onal mimetics of H2-RLX with selective, full agonist or positive allosteric modulator activity agains

213 concentrations of estradiol (nonspecific ER agonist) or genistein (ERbeta-selective agonist).

214 35625 that act either as antagonist, partial agonist, or full agonist according to the receptor, the

215 pared with 17.8, 12.0, and 9.9 %IA/g for the agonist (P < 0.05).

216 om human monocytes is stimulated by the TLR2 agonists Pam3CSK4 or FSL-1, as well as the TLR4 agonist

217 e shown that treatment with the KATP channel agonist pinacidil increases survival of bees while decre

218 elling and mutagenesis studies indicate that agonist positive allosteric modulators target the same g

219 D2/3 agonist positron emission tomography radiotracer [(11)C]

220 lays significantly increased MOR binding and agonist potency and a distinct binding mode compared wit

221 gnificant reduction in glutamate and glycine agonist potency, whilst D731N was non-responsive.

222 MC5R receptor subtypes without compromising agonist potency.

223 hat glucagon-like peptide 1 (GLP-1) receptor agonists prevent beta-cell loss.

224 Treating with agonists prior to radiation enhances survival by activat

225 surrogates present in the beta2-adrenoceptor agonists procaterol and BI-167107 (4), we designed and s

226 ve as sigma1 antagonists, exhibited a sigma1 agonist profile.

227 h subsaturating stimuli, indicating that the agonist promotes channel opening similar to that of volu

228 f non-cyclic-nucleotide small molecules with agonist properties towards EPAC1.

229 e (NMDA) modulator with glycine-like partial agonist properties; like the NMDA receptor antagonist ke

230 The TLR7 agonists R-837 and R-848 were used to mimic a viral insu

231 to the pathophysiology of FXS as the GABABR agonist (R)-baclofen rescued the imbalances between exci

232 ne phenylpropionate (Nandrosol) and the beta-agonist ractopamine administration in veal calves, and i

233 Guanfacine, a noradrenergic alpha2a agonist, reduced tobacco smoking in a 4-week trial and i

234 sed models demonstrate that commensal GPR119 agonists regulate metabolic hormones and glucose homeost

235 s of ATP, whereas cells stimulated with TLR2 agonists released high levels of ATP.

236 The stable mode persists for minutes after agonist removal.

237 Agonist-replacement therapies have been successfully use

238 rofile to currently available GLP-1 receptor agonists, representing a potential treatment option for

239 e or concurrently with somatostatin receptor agonists represents a potential therapeutic approach in

240 TLR2 agonists required pannexin-1 and P2X7 receptor activatio

241 In order to develop novel kappa agonists restricted to the periphery, a diastereo- and e

242 ression and enhanced responsiveness to GLP1R agonists, resulting in improved glucose tolerance, cAMP

243 nitrile, an estrogen receptor beta selective agonist, results in NRF2 activation, normalization of gl

244 The TAAR1 partial agonist RO5263397 also promoted wakefulness and suppress

245 were given three doses of the TAAR1 partial agonist RO5263397, caffeine, or vehicle p.o.

246 imidazoquinoline Toll-like receptor (TLR) 8 agonists robustly activate newborn DCs but can result in

247 nteraction between this benzene ring and the agonist's quaternary ammonium (QA) and (2) AChRs respond

248 ves differentiation of cells with a distinct agonist-selected phenotype.

249 ression can promote autoimmunity by limiting agonist selection of self-reactive thymocytes into the T

250 MCs from MS patients stimulated with a TLR-9 agonist showed reduced expression of general control non

251 Poly(I:C)], TLR4 (LPS), and TLR7 (imiquimod) agonists showed decreased proliferation and a reduced to

252 a rapidly acting peripheral beta-adrenergic agonist similar to adrenaline, to induce sensations of p

253 c current was enhanced by dopamine or the D1 agonist SKF81297 but not quinpirole, whereas the amplitu

254 Agonist-stimulated phosphorylation of the SERCA regulato

255 These results indicate that beta-agonist stimulation is a novel therapeutic strategy for

256 malin test (A3AR antagonist blocked and A3AR agonist strongly potentiated).

257 ng glucagon-like peptide-1/glucagon receptor agonists such as G49 represent a novel therapeutic appro

258 henylephrine (PE), a well known hypertrophic agonist, suppresses autophagy and that activation of foc

259 els, and cyst growth in response to (1) TGR5 agonists (taurolithocholic acid, oleanolic acid [OA], an

260 TPA release was not augmented by any of the agonists tested but urokinase was released by IL-1, TNF-

261 TLR1/2, TLR2/6, TLR4, TLR7, and TLR8 (R848) agonists tested, and to IL-1beta.

262 We engineered a mechanism-based SCF partial agonist that impaired c-Kit dimerization, truncating dow

263 iew evidence suggesting that low doses of DA agonists that effectively treat TS decrease both phasic

264 complex with iperoxo, we explored potential agonists that lacked the highly conserved functionalitie

265 Weak partial agonists that promote a desensitized state of the alpha7

266 series of potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotal

267 are physiologic mediators and pharmacologic agonists that stimulate resolution of inflammation and i

268 Specific diets or agonists that target these chemosensory signaling pathwa

269 palate phenotype to test small-molecule Wnt agonist therapies.

270 rventions with demonstrated efficacy: opioid agonist therapy (OAT), needle and syringe programs (NSPs

271 pment sharing and lower prevalence of opioid agonist therapy were associated with HCV incidence in ci

272 mice, rendering them sensitive to anti-4-1BB agonist therapy.

273 nt of PD treatment and can tolerate dopamine agonist therapy.

274 e in the ability of mu-opioid receptor (MOR) agonists to inhibit sIPSCs in POMC neurons when MORs wer

275 ections, leading to a functional switch from agonists to inverse agonists.

276 sts alone-and to develop immunoresolvents as agonists to test resolution pharmacology and their role

277 We observe that binding of agonists to VFD2 of TAS1R2 leads to major conformational

278 Our results demonstrate how resistance to agonist toxins can evolve and that such genetic changes

279 he K(d)M282-90 CD8(+) T cell response in TLR agonist-treated neonates could be blocked with Abs again

280 yroid cancer reported between GLP-1 receptor agonist treatment and placebo.

281 ence, and is long-term maintenance of opioid agonist treatment associated with differences in efficac

282 We investigated responses to cholinergic agonist treatment vs. neurostimulation by electric field

283 Combining D2 receptor agonist treatment with rM3Ds-dSPN stimulation reproduced

284 NOS) mRNA following Toll-like receptor (TLR) agonist treatment.

285 Clinical Question: Are different opioid agonist treatments (eg, methadone vs buprenorphine) asso

286 We reported previously that the selective agonist U50,488H promoted phosphorylation of the mouse k

287 D3 or calcitriol), a naturally occurring VDR agonist, VDR 4-1 therapy even at high doses did not indu

288 Here we develop surrogate Wnt agonists, water-soluble FZD-LRP5/LRP6 heterodimerizers,

289 sity, 844 +/- 168 dpm/mg of tissue) with the agonist whereas 12 had a high binding (mean density, 4,4

290 rmore, pharmacological treatment with a Drd3 agonist, which increases Drd3(LS) neuronal activity, nor

291 esponses to Toll-like receptor-2, -3, and -4 agonists, which associated with decreased reactive oxyge

292 tra-PL injection of corticosterone, the CB1R agonist WIN 55,212-2, or the monoacylglycerol lipase inh

293 doxically, the nonselective CB1/CB2 receptor agonist WIN55212 inhibited GABAergic mIPSCs in both naiv

294 thiomorpholin-1-ium triflate, a weak partial agonist with a sulfonium isostere of the ammonium pharma

295 that is mediated through the presence of an agonist with an appropriate vibrational state to accept

296 ise had no MOR or DOR activity but was a KOR agonist with moderate affinity.

297 ects were observed with lorcaserin, a 5-HT2C agonist with potent 5-HT2B and 5-HT2A agonist activities

298 mproved or novel new compounds, including D1 agonists with better pharmacokinetics, functionally sele

299 the location and distribution of five beta2 agonists with distinct clinical durations and onsets of

300 The Piezo1 agonist, Yoda1, potentiated shear-dependent platelet Ca(