ライフサイエンスコーパス: agonistic

1 imer with a 12-carbon linker was dual TLR7/8 agonistic.

2 IL1RN by the C116F mutation did not make it agonistic.

3 Binding studies indicated that an agonistic (5B8) and an antagonistic (1C6) mAb bound equa

4 orticoid-induced TNFR family-related protein agonistic Ab DTA-1 (rat or murinized IgG2a) can induce t

5 se that could be substantially rescued by an agonistic Ab to the receptor OX40.

6 costimulation and antitumor activity of CD27 agonistic Abs have been well documented in mouse models.

7 efore, much effort has been made to generate agonistic Abs targeting members of the TNFR superfamily,

8 d costimulation by combining anti-PD-L1 with agonistic Abs to the TNFR superfamily members, OX40 and

9 mmunity, the activity of TNFRSF4 and TNFRS25 agonistic Abs was compared in the context of both tradit

10 dual treatment with PD-L1 blockade and 4-1BB agonistic Abs when the amount and timing of 4-1BB costim

11 everal weeks following T cell transfer, both agonistic Abs, but especially anti-CD27, demonstrated sy

12 ogether with a single low dose of anti-4-1BB agonistic Abs, there is an enhanced and stable expansion

13 the single-channel level, MBED mimicked the agonistic action of caffeine on cardiac RyR gating (i.e.

14 hether the disulfide linkage plays a role in agonistic action of IL-1beta.

15 ns reduced, but did not completely abrogate, agonistic action of IL-1beta.

16 drugs primarily have serotonin(2A) receptor agonistic actions, we conclude that the negative associa

17 a novel, alternate chemotype with pure TLR8-agonistic activities and will likely prove useful not on

18 vities of TNFR antibodies by enhancing their agonistic activities and/or effector functions.

19 Anti-Fn14 antibodies elicit agonistic activities differing from those of the natural

20 these structurally simpler analogues display agonistic activities with human, but not murine, TLR2.

21 oavailable vasopressin antagonists devoid of agonistic activity (vaptans) has made possible the selec

22 ately 2 nM) and exhibits potent TrkB partial agonistic activity and neuroprotective effects in cultur

23 pa-/-) mice also resulted in increased PAF-R agonistic activity and skin inflammation in comparison w

24 lay an alternative NFkappaB pathway-specific agonistic activity but fail to phenocopy other activitie

25 Agonistic activity can be transferred from h2 to h1 by s

26 ibited nearly an order of magnitude improved agonistic activity compared to wild-type NK1, approachin

27 reduced antagonistic activity and increased agonistic activity compared with reference antagonists i

28 Whereas CXCL10 displayed full agonistic activity for Galphai activation and extracellu

29 C108297 displays partial agonistic activity for the suppression of hypothalamic c

30 tive oxygen species and PAF receptor (PAF-R) agonistic activity in comparison with gene-corrected cel

31 r kappa-opioid receptor affinity, full kappa agonistic activity in the [(35)S]GTPgammaS assay, and hi

32 induces the generation of a transient PAF-R agonistic activity in the blood of mice.

33 r oxidized glycerophosphocholines with PAF-R agonistic activity in this process.

34 UE3 were used to evaluate the cAMP singaling agonistic activity of (-)-alotaketal A and elucidate its

35 Behavioral studies also support the biased agonistic activity of Colly in that it exhibits approxim

36 G2 and HeLa cells were used to determine the agonistic activity of EDCs on ERalpha and ERbeta via the

37 We examined the agonistic activity of EDCs through ERalpha and ERbeta.

38 and FcgammaR interactions in controlling the agonistic activity of the anti-mouse CD40 mAb 3/23.

39 1beta, but effectively reduced the remaining agonistic activity of the Lys mutants.

40 e diabetic (NOD) mice, which results in weak agonistic activity of the peptide MHC complex.

41 within primary human cancers or insufficient agonistic activity of the TRAIL-receptor (TRAIL-R)-targe

42 linkage by the F117C mutation did not affect agonistic activity of WT IL-1beta, but effectively reduc

43 de libraries derived from the ectodomain for agonistic activity on the receptors.

44 We observed a pure TLR8-agonistic activity profile in select furo[2,3-c]quinolin

45 1F5hIgG1, varlilumab, showed balanced agonistic activity that was prominent at lower doses and

46 human IgG2 (h2) imparts FcgammaR-independent agonistic activity to immune-stimulatory mAbs such as an

47 Surprisingly, a pronounced inverse agonistic activity was seen on the growth plate height,

48 consideration in clinical trials, showed no agonistic activity with respect to IL8 production and ce

49 The biased agonistic activity, along with an easily modifiable stru

50 y for the urotensin II receptor (UT) without agonistic activity, azasulfuryl-UII((4-11)) derivatives

51 singly, none of the test chemicals showed GR agonistic activity, but 12 chemicals exhibited apparent

52 betes drug, metformin, which carries an AMPK-agonistic activity, drastically inhibited the expression

53 azolyl)phenoxy]-2-propanol], which showed no agonistic activity, had only a marginal or no effect.

54 lacking ERalphaAF-2, resulting in no effect, agonistic activity, or inverse agonistic activity.

55 in no effect, agonistic activity, or inverse agonistic activity.

56 required heparin, an HSPG analogue, for full agonistic activity.

57 small TrkB receptor agonist, is critical for agonistic activity.

58 d ester carbonyl group is essential for TLR2-agonistic activity.

59 terol E is an FXR modulator endowed with PXR agonistic activity.

60 er signifying that NK1 dimerization mediates agonistic activity.

61 and Wnt3a-mediated signaling without showing agonistic activity.

62 ), which is an IL-1beta homologue but has no agonistic activity.

63 pyl appendages at C5 displayed dominant TLR8-agonistic activity.

64 to evaluate the therapeutic potential of an agonistic agent for BTLA on CHS, the effects of an agoni

65 which may guide the application of receptor agonistic agents as vaccine adjuvants for infectious dis

66 esults suggest that stimulation of BTLA with agonistic agents has therapeutic potential in CHS.

67 vation of the 4-1BB (CD137) pathway using an agonistic alpha-4-1BB antibody is known to provide stron

68 factor or FLT3 ligand) and costimulation by agonistic alpha-4-1BB or TLR 9 ligand, antibody-mediated

69 Treatment of mice with an agonistic alpha-EphA3 antibody inhibits tumor growth by

70 tion in vitro and in vivo, using GHRH or its agonistic analog MR-409.

71 The potential therapeutic effects of agonistic analogs of growth hormone-releasing hormone (G

72 the fatty acyl chains of LOS present in TLR4-agonistic and -antagonistic binary and ternary complexes

73 Agonistic and antagonistic activities of the monoclonal

74 biological complexity that is generated from agonistic and antagonistic Ang/Tie signaling.

75 e calculated the binding affinity to MD-2 of agonistic and antagonistic LPS variants including lipid

76 fragment derivatives of TBPB identified both agonistic and antagonistic moieties, one of which, 1-(1-

77 non and points to specific instances of both agonistic and antagonistic pleiotropy.

78 s and the peptide mimetics RF9 and BIBP3226, agonistic and antagonistic properties were characterized

79 The requirement of FcR engagement for the agonistic and antitumor activities of 1F5 was demonstrat

80 The mouse IgG1 3/23 was highly agonistic and outperformed the parental Ab when promotin

81 One agonistic and seven antagonistic mAbs to canine (ca)CD28

82 c fish use elaborate electrical displays for agonistic and sexual communication.

83 Agonistic angiotensin II type 1 receptor autoantibodies

84 in biological processes or during ozonation, agonistic/antagonistic endocrine activities, mutagenic/g

85 Our findings suggest that adding an agonistic anti-4-1BB antibody during the time of TIL REP

86 However, addition of an exogenous agonistic anti-4-1BB IgG4 (BMS 663513) to the REP signif

87 tic agent for BTLA on CHS, the effects of an agonistic anti-BTLA antibody (6A6) on CHS were examined.

88 LA in GVHD by applying the newly established agonistic anti-BTLA monoclonal antibody that stimulates

89 ypothesized that treatment of aged mice with agonistic anti-CD137 (41BB) mAb will partially restore T

90 nation therapy with PLX4720 and anti-CCL2 or agonistic anti-CD137 antibodies demonstrated significant

91 echanistically distinct stimuli (ZOL, HMBPP, agonistic anti-CD277 mAb).

92 diated activation of human CD4(+) T cells by agonistic anti-CD3 mAb or by HLA class II-presented pept

93 regimen of murine IL-15 administered with an agonistic anti-CD40 Ab (FGK4.5) that led to increased IL

94 Administration of agonistic anti-CD40 Ab to activate host APCs enhanced ac

95 odies and, together with previous reports on agonistic anti-CD40 antibodies, establish a common requi

96 er exposure to licensing stimuli, such as an agonistic anti-CD40 antibody or Toll-like receptor 3 lig

97 Furthermore, agonistic anti-CD40 antibody treatment mimicked the effe

98 R-dependent activation of dendritic cells by agonistic anti-CD40 antibody was compromised in chronica

99 ment of autoimmunity and suggest that use of agonistic anti-CD40 for tumor therapy could result in au

100 This study shows that agonistic anti-CD40 induces strong and sustained prolife

101 We have previously shown the synergy of an agonistic anti-CD40 mAb (anti-CD40) and CpG-oligodeoxynu

102 CD40 was expressed on FRC and agonistic anti-CD40 mAb activated FRC, which supported C

103 In this article, we reveal that agonistic anti-CD40 mAbs have an absolute requirement fo

104 Here, we report that combining agonistic anti-CD40 monoclonal antibodies (mAb) to drive

105 ibodies and CSF-1R inhibition) or stimulate (agonistic anti-CD40 or inhibitory anti-CD47 antibodies)

106 ion development is accelerated in mice given agonistic anti-CD40.

107 nization with peptide Ags adjuvanted with an agonistic anti-CD40Ab, with or without the TLR3 ligand p

108 Therapeutic application of TRAIL or agonistic anti-DR5 mAb (MD5-1) dramatically improved sur

109 protected the mice against a lethal dose of agonistic anti-Fas antibody (P < .001) and the protected

110 ated apoptosis-inducing ligand (rhTRAIL), or agonistic anti-Fas antibody.

111 Modulating Fas signaling using agonistic anti-Fas augmented TLR4- and TLR5-mediated TNF

112 utic stimulation of GITR at this stage using agonistic anti-GITR Ab.

113 cines based on delivering Ags to DCs with an agonistic anti-hDectin-1 mAb could elicit CD8(+) T cell-

114 imulating monocytes from apoE(-/-) mice with agonistic anti-LTbR antibody or the natural ligand lymph

115 in were protected from the lethal effects of agonistic anti-mouse Fas antibody (Jo2) and had lower ra

116 ripheral blood eosinophils were treated with agonistic anti-Siglec-8 antibody and IL-5, and cell deat

117 sts increased TACI expression and whether an agonistic anti-TACI antibody could induce activation-ind

118 croarray analysis of T cells stimulated with agonistic anti-TIGIT Ab revealed that TIGIT can act dire

119 By generating an agonistic anti-TIGIT Ab, we demonstrate that TIGIT can i

120 Using an agonistic anti-TIGIT mAb, we demonstrate a direct inhibi

121 Agonistic anti-TNF receptor (TNFR) superfamily member an

122 omponents, we now demonstrate that different agonistic anti-TNFR antibodies have specific requirement

123 engagement for optimal biological effects of agonistic anti-TNFR antibodies.

124 informed the design of more potent antitumor agonistic, anti-TNFR therapies, the underlying mechanism

125 resent an effective strategy for discovering agonistic antibodies against other enzyme targets.

126 elated apoptosis-inducing ligand (TRAIL) and agonistic antibodies against TRAIL death receptors (DR)

127 Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors (DR4 and DR

128 Agonistic antibodies directed against immunostimulatory

129 Crosslinking CD28 by agonistic antibodies or myeloid dendritic cells (DC; the

130 re rarely developed because the discovery of agonistic antibodies remains elusive.

131 SF receptor(s) cross-linking by CD40 and Fas agonistic antibodies resulted in dose-limiting liver tox

132 However, agonistic antibodies that enhance the activities of the

133 In particular, agonistic antibodies that target tumor necrosis factor r

134 Agonistic antibodies to apoptosis-inducing TNFRs, such a

135 alter the viability of human neutrophils via agonistic antibodies to Fas and Siglec-9.

136 on has direct implications for the design of agonistic antibodies to TNFR as therapeutics.

137 One of the resultant agonistic antibodies, 27C3, binds to and substantially e

138 iNPs), each containing multiple copies of an agonistic antibody (FGK45) to the APC receptor CD40, gre

139 therwise lethal liver failure induced by Fas-agonistic antibody (Jo2), concanavalin A (ConA), or D-ga

140 nd downstream signaling mediated by TLR4/MD2 agonistic antibody (UT12) and synthetic small-molecule T

141 ancer cell lines highly sensitive to the DR5 agonistic antibody AMG655 have either Ras or B-Raf mutat

142 optotic response induced by TRAIL or the DR5 agonistic antibody AMG655 or cell killing by activated T

143 poptosis when combined with TRAIL or the DR5 agonistic antibody AMG655; these effects are DR5-depende

144 e, we report that a combination of alphaCD40 agonistic antibody and the ATP-competitive mTOR kinase i

145 in antitumor immunity generated by the GITR agonistic antibody DTA-1.

146 ng the co-stimulatory receptor CD137 with an agonistic antibody enhanced CD4+ T cell cytotoxicity.

147 Treatment with FasL or Fas agonistic antibody induced apoptosis in 661W cells.

148 growth factor receptor (HGFR/c-MET) with an agonistic antibody resulted in distinct cBLI signal patt

149 Triggering TACI by an agonistic antibody showed loss of activation-induced cyt

150 g antigen-specific adoptive T-cell transfer, agonistic antibody therapy (anti-CD137/4-1BB), and check

151 dent manner similar to CTLA4-Ig, whereas the agonistic antibody to caCD28 enhanced MLR.

152 effect can be blocked by the inclusion of an agonistic antibody to Tim-3.

153 661W cells were treated with FasL or Fas agonistic antibody, or exposed to light with/without pha

154 B cells to Fas ligand (FasL)-induced and Fas agonistic antibody-induced apoptosis through enhanced bi

155 to apoptosis by extracellular PAR-4 or GRP78 agonistic antibody.

156 age-related changes can be rescued by a TIE2 agonistic antibody.

157 study highlights the importance of studying agonistic as well as affiliative relationships to unders

158 at the C4, C8, and N(1)-aryl positions were agonistic at TLR7; only the N(1)-aryl dimer with a 12-ca

159 AT(1) agonistic autoantibodies are also highly abundant among

160 examples extend the clinical impact of AT(1) agonistic autoantibodies beyond pregnancy.

161 These autoantibodies, termed AT(1) agonistic autoantibodies have been extensively character

162 However, the occurrence of AT(1) agonistic autoantibodies is not restricted to pregnancy.

163 showing that angiotensin II type I receptor-agonistic autoantibody is a novel causative factor respo

164 is to discuss the potential role of a novel agonistic autoantibody to the angiotensin II type I rece

165 Noting that cells responding to low pO2 or agonistic bacterial molecules often decrease pHo by secr

166 sniffing frequency shortened the latency for agonistic behavior by dominant rats, reflecting that dec

167 unction and supports previously hypothesized agonistic behavior in pachycephalosaurids.

168 The biological data, highlighting the potent agonistic behavior of [Tiq(4)]URP and [Tpi(4)]URP, also

169 In contrast to the weak agonistic behavior of aripiprazole, these ligands are ca

170 Some, such as eusocial insects, may use agonistic behavior to partition available foraging habit

171 activity in several brain regions governing agonistic behavior to territorial song production in fem

172 in regions in which catecholamines stimulate agonistic behavior.

173 c expression of a neuropeptide that controls agonistic behaviors across phylogeny.

174 ith established social hierarchies abolished agonistic behaviors and reciprocal sniffing displays.

175 ion causes a range of deficits in sexual and agonistic behaviors that normally rely on the posterior

176 sing of social stimuli and the expression of agonistic behaviors.

177 ng data, relative testes mass, and male-male agonistic behaviour between two species of hissing cockr

178 vity is continuously required during ongoing agonistic behaviour.

179 potential to promote type 1 immunity through agonistic binding to neurokinin-1 receptor (NK1R).

180 it an agonistic response such as a threat or agonistic call within 2 s of intrusion.

181 this variant revealed both antagonistic and agonistic canonical WNT stimuli, dependent on cell type.

182 resting MDS-NK cells were triggered with an agonistic CD16 monoclonal antibody.

183 Although agonistic CD40 antibodies have been developed for immuno

184 Supporting this result, agonistic CD40 antibody was sufficient to evoke antitumo

185 wed by a composite vaccination, including an agonistic CD40 antibody, soluble antigen, and a TLR3 ago

186 Agonistic CD40 mAb promotes stromal degradation and, in

187 found that coengagement of the Fc domain of agonistic CD40 monoclonal antibodies (mAbs) with the inh

188 placement, RCD) or interspecific aggression (agonistic character displacement, ACD).

189 s and serum-starved, followed by exposure to agonistic compounds targeting various receptors, while r

190 r shape of its carbohydrate backbone in the "agonistic" conformation attained by a rigid alphaGlcN(1<

191 In contrast, success of agonistic costimulatory antibodies has thus far been lim

192 Thus, booster vaccinations with agonistic costimulatory antibodies represent an ideal me

193 rane-bound IL-6 alpha-receptor (IL-6R) as an agonistic cytokine but also as a gp130 beta-receptor ant

194 r, we demonstrate that murine p28 acts as an agonistic cytokine via the murine and human IL-6R, indic

195 ) and Low (bLR) novelty-seeking rats exhibit agonistic differences, with bHRs acting in a highly aggr

196 dynamics, and tumor retention kinetics of an agonistic DR5 antibody in a brain tumor xenograft model,

197 cts robustly with the TrkB receptor, and its agonistic effect may be mediated by neuronal development

198 nding site of the human P2X3 receptor on the agonistic effect of nucleotide analogs.

199 Furthermore, the specific agonistic effect of the estrogen receptor activation cou

200 chol-containing molecules and to elevate the agonistic effect of the lead compound, we initiated the

201 tetrabromobisphenol A, and PCB170 had a weak agonistic effect on pbPPARG, while hexabromocyclododecan

202 This inverse agonistic effect was fully blocked by the specific MOR n

203 d inhibited activation, partially due to its agonistic effect.

204 properties as a result of their potent Nod2-agonistic effect.

205 2) in intact CHO cells to identify potential agonistic effects as well as the ability to allosterical

206 due to stimulation of MnSOD activity through agonistic effects at mitochondrial ERbeta.

207 e further increases the magnitude of inverse agonistic effects at the MOR, suggesting enhanced MOR co

208 MDMA effect rather than by the serotonin(2A) agonistic effects of MDMA.

209 hamphetamine (MDMA or "ecstasy") have direct agonistic effects on postsynaptic serotonin(2A) receptor

210 In contrast, it lacks agonistic effects on the expression of CRH in the centra

211 Agonistic encounters are powerful effectors of future be

212 Winning or losing in agonistic encounters can have striking, long-term effect

213 othesise that individuals need experience of agonistic encounters to become proficient at mutual asse

214 s induced by winning and losing bouts during agonistic encounters.

215 nse to viewing the positive anticipation and agonistic facial expressions.

216 Angiopoietin 1 (Ang-1) is agonistic for Tie2, plays a key role in blood vessel mat

217 Lexatumumab is an agonistic, fully human monoclonal antibody against tumor

218 tial for resolving the paradoxes among their agonistic function, antidiabetic activities, and side ef

219 more potent and selective inhibitors without agonistic function.

220 uding antagonistic monoclonal antibodies and agonistic fusion proteins to inhibit or potentiate these

221 8(+) T-cell exhaustion was dependent on both agonistic GITR signaling and Treg depletion, as neither

222 27C3 and other agonistic human anti-human LCAT monoclonal antibodies de

223 to the Fab (fragment antigen binding) of an agonistic human antibody (1C1; IgG1/kappa).

224 the sensitivity of myeloma cells to the DR5 agonistic human antibody lexatumumab but not the DR4 ant

225 n of FcmuR and Fas/CD95 on Jurkat cells with agonistic IgM anti-Fas mAb was shown to inhibit Fas-indu

226 beta to integrins is primarily important for agonistic IL-1beta signaling, and that the disulfide lin

227 The TLR7-agonistic imidazoquinolines are of interest as vaccine a

228 ure-activity study was conducted on the TLR7-agonistic imidazoquinolines, starting with 1-(4-amino-2-

229 sufficient structural similarity with TLR7/8-agonistic imidazoquinolines.

230 Here, we describe a strongly agonistic insulin mimetope that effectively converts nai

231 upon subimmunogenic vaccination with strong agonistic insulin mimetopes in vivo.

232 Subimmunogenic vaccination with strongly agonistic insulin mimetopes might represent a novel stra

233 at Drosophila exchange information during an agonistic interaction and choose appropriate actions bas

234 at the difference can be seen soon after the agonistic interaction establishing winners and losers.

235 ocument the systematic use of signals during agonistic interactions among octopuses.

236 corded air-breathing behaviour, activity and agonistic interactions at varying levels of hypoxia.

237 Agonistic interactions were relatively rare and were res

238 re we report that, when mason bees engage in agonistic interactions, a species-typical interactive be

239 ange of visible displays are produced during agonistic interactions, and these displays correlate wit

240 nous air-breathing is strongly influenced by agonistic interactions, which may expose subordinate ind

241 e context of strategic action choices during agonistic interactions.

242 More precisely, we propose that its agonistic, internalizing properties are the result of li

243 orylation mapping of HER2 indicated that the agonistic isomers produced a distinct phosphorylation pa

244 Determinants required for agonistic ligand activity were identified.

245 GabR support the conclusion that AFPA is an agonistic ligand capable of triggering GabR-mediated tra

246 The agonistic ligand CITCO binds directly to the CAR homodim

247 NK1 homodimerization interface to create an agonistic ligand, or that further disrupted this interfa

248 The receptor binds structurally diverse agonistic ligands, which mainly regulate chemotaxis and

249 they would have to more readily habituate to agonistic-like predatory actions, communicate intentions

250 Toll-like receptor 2-agonistic lipopeptides typified by S-[2,3-bis(palmitoylo

251 Furthermore, activation of CD137 with an agonistic mAb enhanced NK cell degranulation and cytotox

252 he present study, we show that an anti-CD137 agonistic mAb enhances the antilymphoma activity of ritu

253 previously that single injection of a PD-1H agonistic mAb protected mice from graft-versus-host dise

254 trastuzumab-activated human NK cells with an agonistic mAb specific for CD137 killed breast cancer ce

255 mbinant human TRAIL and drozitumab (anti-DR5 agonistic mAb) were used to explicitly verify the contri

256 Furthermore, the agonistic mAb, 5B8, together with anti-CD3 mAb induced 1

257 Elevating cAMP signaling either by the agonistic MC1R ligand melanocyte stimulating hormone (MS

258 Agonistic monoclonal antibodies (mAb) targeting the T-ce

259 Agonistic monoclonal antibodies targeting 4-1BB have bee

260 whereas neither of these IVIG fragments, nor agonistic monoclonal antibodies to human Fas or Siglec-9

261 a-related apoptosis inducing ligand (TRAIL), agonistic monoclonal antibodies to TRAIL receptors, and

262 SLAMF1 ligation with an agonistic monoclonal antibody increased ROS accumulation

263 r HCV core as well as treatment with a gC1qR agonistic monoclonal antibody.

264 equirement for in vivo antitumor activity of agonistic mouse anti-CD40 monoclonal antibodies (mAbs),

265 he development of a panel of anti-human OX40 agonistic mouse mAbs that could promote effector CD4(+)

266 human exposure warrants further studies into agonistic or antagonistic activities and their potential

267 ose-related effects that differ depending on agonistic or antagonistic drug characteristics and on lo

268 ptor more effectively to produce an enhanced agonistic or antagonistic effect.

269 mouse anti-caCD28 mAbs can be generated with agonistic or antagonistic function.

270 nd absence of erythropoietin and a series of agonistic or antagonistic mimetic peptides free in solut

271 Moreover, covalent NK1 dimers formed from agonistic or antagonistic monomeric subunits elicited si

272 a combination of stress factors may require agonistic or antagonistic responses or responses potenti

273 se studies support a critical role for PAF-R agonistic Ox-GPCs in the pathophysiology of XPA photosen

274 horse but that the PR evolved with increased agonistic potency for DHP at the expense of potency towa

275 The high agonistic potency may result from interaction with an ac

276 t relationship between alkyl length and TLR7-agonistic potency with the optimal compound bearing a C2

277 Despite partially agonistic properties and the inability to block CD40 bin

278 The ligands' agonistic properties are substantially driven by the pre

279 antagonistic properties at alpha1GABAARs and agonistic properties at the other three benzodiazepine-s

280 ne], pindolol, and timolol, which displayed agonistic properties toward the beta(1)AR in either the

281 kynurenine, a tryptophan metabolite with AhR agonistic properties, is an endogenous ligand that media

282 nerates homogenous h2 variants with distinct agonistic properties.

283 affinity (IC(50) = 27 nM) and potent inverse agonistic properties.

284 d TNFR family-related protein-induced T cell agonistic properties.

285 ting that this class of compounds could have agonistic properties.

286 ifferent mechanisms, direct tumor targeting, agonistic receptor engagement, or receptor-ligand blocka

287 mbining PD ligand 1 (PD-L1) blockade with an agonistic regimen that induces 4-1BB costimulation durin

288 st antisense and control waxbills exhibit an agonistic response such as a threat or agonistic call wi

289 )-1H-benzo[d]imidazol-2(3H)-1 (VCP794), lost agonistic selectivity for the M(1) mAChR.

290 ein-coupled receptor (aGPCR) family carry an agonistic sequence within their large ectodomains.

291 ty of our results to an influential model of agonistic signaling [13].

292 catecholamines strongly influence motivated, agonistic social behaviors.

293 lection of aggressive CD-1 mice, followed by agonistic social confrontations between the CD-1 and C57

294 binding, mechanical force, and the tethered agonistic Stachel sequence, as well as implications on t

295 LPS stimulation is reversed with alpha7nAChR agonistic stimulation.

296 AMG655 to introduce a highly active TRAIL-R2-agonistic therapy into the cancer clinic.

297 antagonistic antibody, and EHD2-scTNFR2, an agonistic TNFR2-selective TNF, respectively, in a mouse

298 racellular domain of TREM-1 (rTREM-1) and an agonistic TREM-1 antibody were used to inhibit and activ

299 Using an agonistic tumor necrosis factor-receptor super family (T

300 Treatments with either an agonistic VD3 analog or RA dissociate the repressing com