ライフサイエンスコーパス: agouti

1 nternal agonist (alpha-MSH) and antagonists (Agouti).

2 chromosome 13, close to the candidate locus Agouti.

3 remia (U) was induced in female dilute brown agouti/2 mice by partial renal ablation.

4 s coat color in mouse offspring carrying the agouti A(vy) allele have received considerable attention

5 creased DNA methylation at the viable yellow agouti (A(vy)) locus in a sex-specific manner (P=0.004).

6 With viable yellow agouti (A(vy)) mice, which harbor a transposable element

7 Similarly, on the lethal yellow agouti (A(y)) background, FABP4-Wnt10b mice have 50-70%

8 r by a high fat diet or by the lethal yellow agouti (A(y)) mutation, and this protective action was d

9 Agouti (A(y)/a) mice did not respond to ADP or leptin, i

10 the somatosensory and visual cortices of the agouti, a diurnal rodent with a relatively big brain, us

11 and activates Corin, a negative regulator of Agouti activity.

12 if2s2, and induces the ectopic expression of agouti, all of which are potential TGCT-modifying mutati

13 we combined mutant alleles of Dnmt1 with an agouti allele (A(iapy)), which provided a coat color rea

14 thermore, our data suggest that this derived Agouti allele arose de novo after the formation of the S

15 ny of which were mosaic, transmitted altered Agouti alleles to F1 pups to yield an allelic series of

16 he negative regulator of adult pigmentation, Agouti, also plays a key developmental role in color pat

17 y two known endogenous antagonists of GPCRs, agouti and agouti-related protein (AGRP).

18 The coordinate and inverse regulation of Agouti and Corin renders pelage pigmentation sensitive t

19 y by a mechanism that is independent of both Agouti and Corin.

20 s in the lymph nodes of EAE-susceptible Dark Agouti and EAE-resistant Piebald Virol Glaxo rats during

21 and that the epistatic relationship between Agouti and K depends on the alleles being tested.

22 reated Lewis strain recipient rats from Dark Agouti and Lewis strain donors, respectively (unmodified

23 at have been studied to date, two key genes, Agouti and Melanocortin 1 receptor (Mc1r), encode a liga

24 In most vertebrates, two key genes, Agouti and Melanocortin 1 receptor (Mc1r), encode a liga

25 strains (Sprague-Dawley, Brown Norway, Dark Agouti and PVG) were given access to running wheels (1 o

26 transplantations were performed between Dark Agouti and Wistar Furth rats.

27 ectly associated with the promoter region of agouti, and genotypes at this locus obey simple Mendelia

28 putative candidate genes for melanism (ASIP [agouti] and MC1R) and identified three independent delet

29 ing PKA signaling pathways downstream of the agouti antagonism of MC4R in the hypothalamus.

30 the coat color distribution of viable yellow agouti (Avy) mouse offspring toward yellow by decreasing

31 sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob).

32 no circulating leptin and infertile, obese, agouti (Ay/a) mice with high circulating leptin levels,

33 Dark Agouti, Brown Norway, and Fischer 344 kidneys were trans

34 ocortin receptor 1 (Mc1r) and its antagonist Agouti, but the genetic and developmental mechanisms tha

35 Taken together, these results reveal that agouti can regulate adipogenesis at several levels and s

36 To simplify breeding schemes, the dominant agouti coat color gene was restored in JM8 cells by targ

37 ver, rather than eating the recovered seeds, agoutis continued to move and recache the seeds, up to 3

38 Fischer-344 (F-344 Rat) or Dark Agouti (DA Rat) donor animals were either treated with M

39 y, liver transplants from Lewis rats to dark agouti (DA) rats survive indefinitely without immunosupp

40 r germline competence by injection into Dark Agouti (DA) X Sprague Dawley (SD) blastocysts.

41 ozotocin (STZ)-induced diabetic Dilute Brown Agouti (DBA) and arginase-2-deficient mice (Arg2(-/-)).

42 tained from transgenic mice that overexpress agouti demonstrated that melanocortin receptor (MCR) sig

43 Agoutis dispersed an estimated 35% of seeds for >100 m.

44 responder rejection strain combination (Dark Agouti donors and Lewis recipients).

45 Agouti lethal yellow (A(y)) mice express agouti ectopically because of a genetic rearrangement at

46 hat ventral-specific embryonic expression of Agouti establishes a prepattern by delaying the terminal

47 beta-Catenin activity in the DP suppresses Agouti expression and activates Corin, a negative regula

48 individual hairs produced by an increase in Agouti expression caused by a cis-acting mutation (or mu

49 s in moderately obese mice, the link between agouti expression in human adipose tissue and obesity/ty

50 ease in both the level and spatial domain of Agouti expression prevents melanocyte maturation in a re

51 acting, tissue-specific changes in embryonic Agouti expression to produce large changes in adult colo

52 further regulates pigmentation via patterned agouti expression.

53 sts, a unique physiological function for the agouti family of proteins, and define a neuroendocrine a

54 rder of dominance, these are the unpatterned agouti form called "Abyssinian" or "ticked" (T(a)), foll

55 specifying coat color and acts downstream of agouti gene expression as a suppressor of the agouti pat

56 ates dermal papilla-specific enhancer of the Agouti gene in primary dermal fibroblasts.

57 to stable transcriptional activation of the agouti gene in the adult.

58 Here, we demonstrate that an agouti gene unique to teleosts, agrp2, is specifically e

59 , which harbor a transposable element in the agouti gene, we tested the hypothesis that the metastabl

60 NPY and agouti gene-related protein (AgRP) mRNA expression after

61 xpression of hypothalamic neuropeptide Y and agouti gene-related protein.

62 as nonagouti) as a Cys115Tyr mutation in the Agouti gene.

63 l A particle retrotransposon upstream of the Agouti gene.

64 Dark agouti hearts were transplanted to Lewis or control dark

65 se tissue and that the ectopic expression of agouti in adipose tissue results in moderately obese mic

66 The regulation of agouti in cultured human adipocytes revealed that insuli

67 in gene-trap mice nor ectopic expression of agouti in transgenic or viable-yellow (A(vy)) mutants af

68 We performed ITX from Dark Agouti into Lewis rats applying single-dose tacrolimus (

69 Given that agouti is expressed in human adipose tissue and that the

70 and excretion in bile of healthy Long-Evans agouti (LEA) rats versus LEC rats modeling Wilson diseas

71 Hepatocytes from healthy Long-Evans Agouti (LEA) rats were transplanted intrasplenically int

72 etime of LEC versus the wild-type Long-Evans Agouti (LEA) rats.

73 Agouti lethal yellow (A(y)) mice express agouti ectopica

74 here are functional consequences of elevated agouti levels in human adipose tissue.

75 We identified distinct regions within the Agouti locus associated with each color trait and found

76 tion revealed that TALEN pairs targeting the Agouti locus induced site-directed DNA breaks in zygotes

77 ain mutations elsewhere in the > or = 125-kb agouti locus that either reduce the level or alter the t

78 ly because of a genetic rearrangement at the agouti locus.

79 thylation status of the IAP insertion in the agouti locus.

80 It is well recognized that the agouti/melanocortin system is an important regulator of

81 (Dcc) mutations, and identified mutations in Agouti (Met1Leu, Dcc4), Sox18 (Leu220ter, Dcc1), Keratin

82 A dominantly acting K14-agouti minigene tags both rearrangements, which enables

83 otes, and a keratin-14 (K14) promoter-driven agouti minigene was introduced onto the inverted chromos

84 c coinjection of TALEN mRNAs directed to the Agouti, miR-205, and the Arf tumor suppressor loci yield

85 protected cardiomyocyte contractility in the agouti model of type 2 diabetes.

86 h there was no apparent relationship between agouti mRNA levels and BMI, agouti mRNA levels were sign

87 tionship between agouti mRNA levels and BMI, agouti mRNA levels were significantly elevated in subjec

88 cytes revealed that insulin did not regulate agouti mRNA, whereas dexamethasone treatment potently in

89 e treatment potently increased the levels of agouti mRNA.

90 TALEN-Agouti mRNAs injected into zygotes of brown FvB x C57BL/

91 eveal that Mc1r is epistatic to variation at Agouti or K and that the epistatic relationship between

92 on (180 nmol) of either GSH adduct into Dark Agouti or Sprague-Dawley rats only 5-(glutathion-S-yl)-a

93 gouti gene expression as a suppressor of the agouti pathway.

94 The agouti peptide is a potent antagonist of the melanocorti

95 hat BMP signaling controls the expression of Agouti protein in the hair follicle and provide evidence

96 pic hormone, melanocyte stimulating hormone, agouti protein ligands (in rodents), c-Kit, and the endo

97 We transplanted cardiac allografts from Dark Agouti rat and Balb mouse donors to fully major histocom

98 In this study we show that dark Agouti rat NK cells inhibit syngeneic T cell proliferati

99 ey transplantations were performed from dark agouti rat strain (DA) to Wistar furth rat strain rats a

100 ey rats (associated with deficits) with Dark Agouti rats (associated with null effects).

101 grey matter demyelination was set up in Dark Agouti rats and analysed using quantitative immunohistoc

102 EAE was induced in Dark Agouti rats by immunization with recombinant myelin olig

103 Thirty-seven Dark Agouti rats had elevated IOP induced in the left eye by

104 s were transplanted to Lewis or control dark agouti rats on subtherapeutic doses of cyclosporin.

105 a into the subarachnoid space of female Dark Agouti rats pre-immunized with a subclinical dose of mye

106 Five-week-old, dark agouti rats were administered 50 mM ATP into the vitreou

107 MRI and PET/CT scans were obtained in Dark agouti rats with EAE and healthy control rats.

108 n structural/pathological correlates in Dark Agouti rats with experimental autoimmune encephalomyelit

109 utside the CNS and AZD8797 treatment in Dark Agouti rats with myelin oligodendrocyte glycoprotein-ind

110 OHT was surgically induced in 20 Dark Agouti rats.

111 yte glycoprotein immunization in female Dark Agouti rats.

112 The orexigenic peptide Agouti Related Peptide (AgRP) also produces hyperphagia

113 This analysis revealed that CFLIR in agouti related peptide-expressing orexigenic ARC neurons

114 ed expression of the orexigenic neuropeptide agouti related protein (AgRP) in the BMPR1A-deficient AR

115 Agouti related protein (AGRP)-expressing neurons are a k

116 hypothalamus (ARH) that contains orexigenic agouti-related peptide (AgRP) and anorexigenic pro-opiom

117 g-responsive hypothalamic neurons expressing agouti-related peptide (AgRP) and neuropeptide Y (Npy).

118 Agouti-related peptide (AGRP) and Neuropeptide Y are pot

119 w leptin-sensing neuron population, multiple agouti-related peptide (AgRP) and pro-opiomelanocortin (

120 Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiatin

121 te time periods, and measured the density of Agouti-Related Peptide (AgRP) containing projections fro

122 ing view is that the orexigenic neuropeptide agouti-related peptide (AgRP) exerts the opposite action

123 ivate or inhibit ArcN NPY neurons expressing agouti-related peptide (AgRP) in mice, we have demonstra

124 Expression of agouti-related peptide (AGRP) in the hypothalamus is inc

125 Agouti-related peptide (AgRP) is a naturally occurring M

126 M glucose concentrations, more inhibition of agouti-related peptide (AgRP) mRNA and AMP-activated pro

127 ine leptin inhibits neuropeptide Y (NPY) and agouti-related peptide (AgRP) neuronal activity, resulti

128 Hypothalamic Agouti-related peptide (AgRP) neurons are critical regul

129 Agouti-related peptide (AgRP) neurons in the arcuate nuc

130 Agouti-related peptide (AgRP) neurons in the arcuate nuc

131 Agouti-related peptide (AgRP) neurons of the arcuate nuc

132 Agouti-related peptide (AgRP) neurons of the hypothalamu

133 hysiologic regulation.SIGNIFICANCE STATEMENT Agouti-related peptide (AgRP) neurons play an important

134 Activation of Agouti-related peptide (AgRP) neurons potently promotes

135 Hypothalamic agouti-related peptide (AgRP) neurons potently stimulate

136 ns, including proopiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons, also release amin

137 ns, including proopiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons, also release amin

138 ic proopiomelanocortin (POMC) and orexigenic agouti-related peptide (AgRP) neurons, electrophysiologi

139 as recently reported to be a Foxo1 target in agouti-related peptide (AGRP) neurons.

140 eurons [e.g., proopiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons], and as a result,

141 euron populations specified by expression of agouti-related peptide (AGRP) or pro-opiomelanocortin (P

142 Hypothalamic neurons expressing agouti-related peptide (AgRP) regulate eating and glucos

143 Syndecans potently modulate agouti-related peptide (AgRP) signaling in the central m

144 conversely, administration of the antagonist Agouti-related peptide (Agrp) to wild-type mice enhanced

145 neurons expressing neuropeptide Y (NPY) and agouti-related peptide (AgRP) via GABA-dependent signali

146 gnaling from hypothalamic neurons expressing agouti-related peptide (AgRP) was genetically inactivate

147 of hypothalamic 'hunger neurons' (expressing agouti-related peptide (AgRP)) bypasses these signals to

148 Expression of 3 neuropeptide genes, agouti-related peptide (Agrp), neuropeptide Y (Npy), and

149 iomelanocortin (POMC), neuropeptide Y (NPY), agouti-related peptide (AGRP), somatostatin, and dopamin

150 a-MSH) and to an antagonist/inverse agonist, agouti-related peptide (AgRP), which are released by ups

151 ific Cre-driver mice to reexpress RIIbeta in agouti-related peptide (AgRP)-, proopiomelanocortin (POM

152 es the activity of neuropeptide Y (NPY)- and agouti-related peptide (AgRP)-co-producing (NPY/AgRP) ne

153 Agouti-related peptide (AgRP)-expressing neurons are act

154 Hypothalamic agouti-related peptide (AgRP)-expressing neurons are cri

155 expressing and hunger signaling (orexigenic) agouti-related peptide (AgRP)-expressing neurons are key

156 Agouti-related peptide (AgRP)-expressing neurons in the

157 Agouti-related peptide (AgRP)-expressing neurons in the

158 Pro-opiomelanocortin (POMC)- and agouti-related peptide (AgRP)-expressing neurons of the

159 occurred primarily within neurons expressing agouti-related peptide (AgRP).

160 hibition of neural melanocortin receptors by agouti-related peptide also attenuated rhythmicity in th

161 A expression of the orexigenic neuropeptides Agouti-related peptide and melanin-concentrating hormone

162 kinase kinase beta or AMPK greatly increases Agouti-related peptide and melanin-concentrating hormone

163 e excited orexigenic neurons that synthesize agouti-related peptide and neuropeptide Y but inhibited

164 coadministration of the alpha-MSH antagonist agouti-related peptide blocked the anorexigenic effects

165 2-null mice, while the density of orexigenic agouti-related peptide fibers in the mutant mice appeare

166 des proopiomelanocortin, neuropeptide Y, and agouti-related peptide in T1D mice.

167 increased pro-opiomelanocortin and decreased agouti-related peptide in the hypothalamus.

168 and prevents starvation in adult mice whose agouti-related peptide neurons are ablated.

169 ause starvation after ablation of orexigenic agouti-related peptide neurons in adult mice.

170 etrogradely labeled neurons contained either agouti-related peptide or cocaine/amphetamine-regulated

171 wise, treatment of WT mice with intracranial agouti-related peptide reversed the cachexic effects of

172 ter (that controlling the Agrp gene encoding agouti-related peptide) responsive to BDNF-induced physi

173 Neurons coexpressing neuropeptide Y, agouti-related peptide, and GABA (NAG) play an important

174 Hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocoritin (POMC)

175 subsets (proopiomelanocortin, neuropeptide Y/agouti-related peptide, and steroidogenic factor 1), tho

176 ding those producing pro-opiolemelanocortin, agouti-related peptide, hypocretin/orexin, melanin-conce

177 increase in the appetite-regulating proteins agouti-related peptide, neuropeptide Y, and uncoupling p

178 knockdown of Sirtuin 1 Sirt1 in hypothalamic Agouti-related peptide-expressing neurons, which renders

179 timulating neuropeptides, neuropeptide Y and Agouti-related peptide.

180 vity, and expression of pro-opiomelanocortin/agouti-related peptide/neuropeptide Y in the hypothalamu

181 se expressing proopiomelanocortin (POMC) and agouti-related peptides (AgRP).

182 ssing the endogenous melanocortin antagonist agouti-related protein (AgRP) also exhibit obesity, incr

183 Agouti-related protein (AgRP) and agouti signaling prote

184 Agouti-related protein (AgRP) and neuropeptide Y (NPY) a

185 w that changes in hypothalamic expression of agouti-related protein (Agrp) and neuropeptide Y (Npy) c

186 e expression of the orexigenic neuropeptides agouti-related protein (AgRP) and neuropeptide Y (NPY).

187 ) whether food deprivation (FD) co-increases agouti-related protein (AgRP) and PPARgamma mRNA express

188 we examined the role of insulin signaling in agouti-related protein (AgRP) and pro-opiomelanocortin (

189 Agouti-related protein (AGRP) and proopiomelanocortin (P

190 eurons that express neuropeptide Y (NPY) and agouti-related protein (AgRP) are thought to be critical

191 We found that impairment of Agouti-related protein (AgRP) circuitry by either Sirt1

192 imulating hormone (alpha-MSH) and orexigenic Agouti-related protein (AgRP) from discrete hypothalamic

193 the ability of proopiomelanocortin (POMC) or agouti-related protein (Agrp) hypothalamic neurons to se

194 ablation of hypothalamic neurons expressing agouti-related protein (AgRP) in adult mice leads to ano

195 Ablation of neurons that make agouti-related protein (AgRP) in moderately obese adult

196 ASIP, and its neuropeptide homolog the agouti-related protein (AgRP) involved in energy balance

197 Agouti-related protein (AGRP) is a potent orexigenic pep

198 The agouti-related protein (Agrp) is a powerful orexigenic p

199 The agouti-related protein (AGRP) is an endogenous antagonis

200 Agouti-related protein (AGRP) is an endogenous antagonis

201 The agouti-related protein (AgRP) is an orexigenic peptide t

202 The neuropeptide agouti-related protein (AgRP) is expressed in the arcuat

203 Agouti-related protein (AGRP) is one of only two natural

204 Agouti-related protein (AGRP) is one of two known natura

205 olves targeting the human DT receptor to the agouti-related protein (Agrp) locus so that systemic adm

206 examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also releas

207 examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also releas

208 Among these, agouti-related protein (AgRP) neurons are thought to pro

209 crease but their size increase in orexigenic agouti-related protein (Agrp) neurons during the transit

210 Agouti-related protein (AgRP) neurons in the ARC (ARC(Ag

211 Pro-opiomelanocortin (POMC) and agouti-related protein (AGRP) neurons in the hypothalamu

212 used targeted knock-ins to express InsRs in agouti-related protein (AgRP) or proopiomelanocortin (PO

213 ther, CTRP13 and the orexigenic neuropeptide agouti-related protein (AgRP) reciprocally regulate each

214 ithin the hypothalamus, neurons that express agouti-related protein (AgRP) sense orexigenic factors a

215 We used a truncated form of the Agouti-related protein (AgRP), a 4-kDa cystine-knot pept

216 The Agouti-related protein (AGRP), an appetite modulator, in

217 re, the endogenous MC3R and MC4R antagonist, agouti-related protein (AgRP), hyperpolarizes POMC and R

218 The endogenous MC4R antagonist, agouti-related protein (AGRP), is expressed in the brain

219 e (alpha-MSH) and its endogenous antagonist, agouti-related protein (AgRP), is fundamental for the ce

220 Hypothalamic neurons that co-express agouti-related protein (AgRP), neuropeptide Y and gamma-

221 Neuropeptide Y (NPY) and agouti-related protein (AgRP), potent stimulants of feed

222 A expression levels of neuropeptide Y (NPY), agouti-related protein (AGRP), proopiomelanocortin (POMC

223 luding those producing neuropeptide Y (NPY), Agouti-related protein (AGRP), proopiomelanocortin (POMC

224 othalamic GHS-R1a, neuropeptide Y (NPY), and agouti-related protein (AgRP), suggesting that prolonged

225 are absent in mice lacking the gene encoding agouti-related protein (Agrp), suggesting that this func

226 Neuropeptide Y (NPY) and Agouti-related protein (AgRP), two orexigenic neuropepti

227 gonists, agouti signaling protein (ASIP) and agouti-related protein (AGRP), were assessed by studying

228 neurons containing neuropeptide Y (NPY) and agouti-related protein (AgRP), which are conditional pac

229 Ablation of inhibitory agouti-related protein (AgRP)-expressing neurons in the

230 We show that agouti-related protein (AgRP)-expressing neurons precede

231 agonists, agouti-signaling protein (ASP) and agouti-related protein (AGRP).

232 anocortin (POMC) or neuropeptide-Y (NPY) and agouti-related protein (AgRP).

233 endogenous antagonists of GPCRs, agouti and agouti-related protein (AGRP).

234 effects of ACTH were blocked by SHU9119 and agouti-related protein (AGRP).

235 ne (alpha-MSH) and the orexigenic antagonist agouti-related protein (AGRP).

236 g hormone (alpha-MSH) or antagonists such as agouti-related protein (AgRP).

237 ture-activity relationship study of chimeric agouti-related protein (AGRP)/[Nle4,DPhe7]alpha-melanocy

238 enic neuropeptides [neuropeptide Y (NPY) and agouti-related protein (AgRP)] and activates expression

239 lpha-MSH(4-10)-NH(2) (SHU9119)] and natural [agouti-related protein (AGRP)] MC3R antagonists but not

240 s neurons that co-express neuropeptide Y and agouti-related protein (NPY/AgRP neurons).

241 ing hormone, oxytocin, arginine vasopressin, agouti-related protein and alpha-melanocyte stimulating

242 orexigenic neuropeptides neuropeptide Y and agouti-related protein and down-regulation of expression

243 be mediated by leptin action on arcuate NPY/agouti-related protein and proopiomelanocortin neurons.

244 ons but has limited effect on neuropeptide Y/agouti-related protein and proopiomelanocortin neurons.

245 howed that in the DMH abundant alpha-MSH and agouti-related protein fibers are in close apposition to

246 adrenocorticotropin (ACTH)], the antagonist agouti-related protein hAGRP(87-132), and synthetic agon

247 Hypothalamic neurons that express agouti-related protein have been thought to regulate app

248 Hence, as body weight decreased and agouti-related protein is induced, microRNA expression w

249 weight, and hypothalamic neuropeptide Y and Agouti-related protein mRNA expression.

250 and elevated hypothalamic neuropeptide-Y and agouti-related protein mRNA levels.

251 1, which caused increased neuropeptide Y and agouti-related protein mRNAs in the hypothalamus, stimul

252 sm in proopiomelanocortin and neuropeptide Y/agouti-related protein neurons and links hypothalamic AM

253 ate nucleus, specifically the neuropeptide Y/agouti-related protein neurons and the dorsal medial nuc

254 CK1 in either pro-opiomelanocortin (POMC) or agouti-related protein neurons, mediators of leptin acti

255 absence of MRAP2, fasting fails to activate agouti-related protein neurons.

256 ession of key orexigenic (neuropeptide Y and agouti-related protein) and anorexigenic (pro-opiomelano

257 e appetite-stimulating (neuropeptide Y, NPY; agouti-related protein, AGRP) and appetite-inhibiting (c

258 gen, decreases AMPK activity in PVH, whereas agouti-related protein, an orexigen, increases AMPK acti

259 rons were stained for a second neuropeptide, agouti-related protein, immunoreactivity was found in th

260 lls, with a notable lack of projections from agouti-related protein-expressing neurons.

261 ortin with an increase in neuropeptide Y and agouti-related protein.

262 ivation of ARC glia enhances the activity of agouti-related protein/neuropeptide Y (AgRP/NPY)-express

263 RNAs in the hypothalamus, stimulation of the agouti-related protein/neuropeptide Y neurons, and activ

264 dullin (hazard ratio per log increase 2.53), agouti-related protein; (1.48), chitinase-3-like protein

265 Agouti-related-peptide (AgRP) neurons-interoceptive neur

266 nephrectomy and received an orthotopic Dark Agouti renal allograft.

267 ed that the stepwise dispersal was caused by agoutis repeatedly stealing and recaching each other's b

268 s rats (RT1) were immunized with donor (Dark Agouti, RT1) spleen cells (day -5).

269 While the agouti's primary (V1) and secondary visual areas seemed

270 The antagonist agouti signal protein (ASP) interacts with the Mc1r and

271 ion can be antagonized by a secreted factor, agouti signal protein (ASP), which is responsible for th

272 is accompanied by strongly reduced levels of Agouti signal protein and enhanced expression of microph

273 We also show that agouti signal protein, a secreted factor known to decrea

274 and hMC4R) and their endogenous antagonists, agouti signaling protein (ASIP) and agouti-related prote

275 Agouti-related protein (AgRP) and agouti signaling protein (ASIP) are homologs that play c

276 Expression of the agouti signaling protein (ASIP) during hair growth produ

277 cortisol implants increase the expression of agouti signaling protein (ASIP) mRNA in skin, likely exp

278 In contrast, MC1R antagonists agouti signaling protein (ASIP) or human beta-defensin 3

279 lved in feather development or pigmentation: agouti signaling protein (ASIP), follistatin (FST), ecod

280 MC1R antagonists human beta-defensin 3 and agouti signaling protein blocked MSH- but not forskolin-

281 Pretreatment with agouti signaling protein or HBD3 prohibited responsivene

282 their effects were abrogated by an analog of agouti signaling protein, the physiological MC1R antagon

283 cortin gene transcript, and two antagonists, agouti-signaling protein (ASP) and agouti-related protei

284 The ubiquitous overexpression of agouti-signaling protein (ASP), a paracrine-signaling mo

285 melanocortin 1 receptor with the antagonist agouti-signaling protein decreased the proportion of mat

286 shown by blockade with a peptide analogue of agouti-signaling protein) and imitated by adrenocorticot

287 We targeted the agouti signalling protein (ASIP) gene, a positional cand

288 although the endogenous receptor antagonist, agouti signalling protein, blocks activation of human MC

289 ifferences were, however, found, as the Dark Agouti strain was often superior.

290 ly linked to a single amino acid deletion in Agouti that appears to be under selection.

291 l allogeneic aorta transplantation from Dark Agouti to Brown Norway rats was performed.

292 were orthotopically transplanted in the Dark Agouti to Brown Norway strain combination.

293 BMP-4 stimulates the expression of Agouti transcripts and protein in primary epidermal kera

294 r alter the temporal/spatial distribution of agouti transcripts.

295 regnancy induces CpG hypermethylation at the agouti viable yellow (A(vy)) allele in A(vy)/a offspring

296 Agouti viable yellow mice with their adult-onset obesity

297 We recently showed that the obese agouti viable yellow mouse has prominent astrocytic expr

298 putedly megafaunal seeds by Central American agoutis, which scatter-hoard seeds in shallow caches in

299 AT in the presence of obesity, obesity-prone agouti yellow mice (A(y)/a) on a hyperlipidemia-prone LD

300 The agouti-yellow (A(y)) deletion is the only genetic modifi