ライフサイエンスコーパス: airflow obstruction

1 NO2 levels can be associated with increased airflow obstruction.

2 the presence of comorbidities compared with airflow obstruction.

3 y, cell adhesion, epigenetic regulation, and airflow obstruction.

4 the lungs that leads to progressive chronic airflow obstruction.

5 erapy in 5,887 smokers with mild to moderate airflow obstruction.

6 der characterized by incompletely reversible airflow obstruction.

7 r (3) maldistribution of inspired gases with airflow obstruction.

8 ding onto the development and persistence of airflow obstruction.

9 d implicate the HTR4 gene in the etiology of airflow obstruction.

10 scular inflammation and largely irreversible airflow obstruction.

11 compartments correlated with the severity of airflow obstruction.

12 xacerbations, independent of the severity of airflow obstruction.

13 l as mucus hypersecretion, which can lead to airflow obstruction.

14 vital capacity (FEV(1)/FVC), an indicator of airflow obstruction.

15 , spirometry should be performed to diagnose airflow obstruction.

16 re most evident in patients with more severe airflow obstruction.

17 ikely amplifies inflammation and progressive airflow obstruction.

18 d biosynthesis correlated with the degree of airflow obstruction.

19 lead to bronchial lymphedema and exaggerated airflow obstruction.

20 ated with exposure intensity, independent of airflow obstruction.

21 re asthma, likely contribute to irreversible airflow obstruction.

22 well as mucus hypersecretion with subsequent airflow obstruction.

23 ure intensity, independent of ex-smoking and airflow obstruction.

24 derate airflow obstruction and 2.61 for mild airflow obstruction.

25 group may disclose novel mechanisms of fixed airflow obstruction.

26 n and did not correlate with the severity of airflow obstruction.

27 rment of the diffusion capacity (DL(CO)) and airflow obstruction.

28 n is not a major risk factor for progressive airflow obstruction.

29 /- 15 yr (mean +/- SD) with fixed expiratory airflow obstruction.

30 PRM(FSA) and age in subjects with or without airflow obstruction.

31 guish between infants with and those without airflow obstruction.

32 arly evident in patients with severe chronic airflow obstruction.

33 a risk factor for the development of chronic airflow obstruction.

34 way remodeling seen in patients with chronic airflow obstruction.

35 ce by 2 weeks of age and was associated with airflow obstruction.

36 asthma with a history of smoking and chronic airflow obstruction.

37 ased risk of developing chronic irreversible airflow obstruction.

38 ts with mild to moderate post-bronchodilator airflow obstruction.

39 iation contributing to emphysema with severe airflow obstruction.

40 stratified by asthma symptom control and by airflow obstruction.

41 ncreased in both groups with the severity of airflow obstruction.

42 with increased cough, sputum production, and airflow obstruction.

43 links between asthma and subsequent chronic airflow obstruction.

44 co smoking are risk factors for irreversible airflow obstruction.

45 a have additive or multiplicative effects on airflow obstruction.

46 io are considered the standard assessment of airflow obstruction.

47 ol, and apoB are associated with more severe airflow obstruction.

48 richment analysis to a meta-analyzed GWAS of airflow obstruction.

49 r human study subjects developed significant airflow obstruction 10 min postexposure which persisted

50 Undiagnosed airflow obstruction (12.0%) was more common than doctor-

51 However, among females with airflow obstruction, 12.2% to 35.2% never smoked.

52 COPD (198 [4%] of 4439) and smokers without airflow obstruction (255 [5%] of 5547).

53 To examine sex differences in the risk of airflow obstruction (a COPD hallmark) in relation to smo

54 Perform meta-analyses of GWAS for airflow obstruction, a key pathophysiologic characterist

55 nchodilators was associated with more severe airflow obstruction, a predominantly solid pattern of LA

56 ntial shared genetic architecture underlying airflow obstruction across individuals, irrespective of

57 In subjects without airflow obstruction, acute respiratory events were not a

58 acute respiratory events in smokers without airflow obstruction affect lung function decline is unkn

59 ogeneic hematopoietic stem cell transplants, airflow obstruction (AFO) remains a significant complica

60 s that may be involved in the development of airflow obstruction after hematopoietic cell transplanta

61 that could be related to symptom control and airflow obstruction after standardized treatment.

62 In never- and ever-smokers without airflow obstruction, aging is associated with increased

63 etric abnormalities, and was correlated with airflow obstruction, air trapping, and diffusing capacit

64 COPD is defined by irreversible airflow obstruction; airflow obstruction is typically de

65 isease of the lung characterized by variable airflow obstruction, airway hyperresponsiveness (AHR), a

66 common chronic lung disease characterized by airflow obstruction, airway hyperresponsiveness (AHR), a

67 Asthma is characterized by variable airflow obstruction, airway inflammation, airway hyper-r

68 vel of CerS2 was associated with significant airflow obstruction, airway inflammation, and increased

69 irways hyperresponsiveness (AHR), reversible airflow obstruction, airway remodeling, and episodic exa

70 arette smoking correlated more strongly with airflow obstruction among PI*SZ than PI*ZZ subjects.

71 ted a maximum LOD score of 2.09 for moderate airflow obstruction and 2.61 for mild airflow obstructio

72 but not total IgE, is associated with fixed airflow obstruction and a number of radiological abnorma

73 Our findings suggest that early airflow obstruction and air trapping in infants with cys

74 se characterized by intermittent, reversible airflow obstruction and airway hyperresponsiveness (AHR)

75 a is heightened and related to the degree of airflow obstruction and airway hyperresponsiveness.

76 s are chronic lung diseases characterized by airflow obstruction and airway inflammation.

77 nses were then compared with measurements of airflow obstruction and airway responsiveness.

78 8 (LOD = 1.36) and 19 (LOD = 1.09) for mild airflow obstruction and chromosomes 19 (LOD = 1.21) and

79 vided increased evidence for linkage of mild airflow obstruction and chronic bronchitis to several ge

80 tives of these early-onset COPD probands for airflow obstruction and chronic bronchitis was performed

81 t PiMZ heterozygotes have significantly more airflow obstruction and COPD than PiMM individuals and c

82 control subjects and influenced by worsening airflow obstruction and corticosteroid use.

83 al dysfunction, which results in progressive airflow obstruction and debility.

84 apoA-I and large HDLNMR particles can reduce airflow obstruction and disease severity in asthma.

85 iated with a significantly increased risk of airflow obstruction and emphysema but the risk of chroni

86 medium-dose inhaled corticosteroids reduces airflow obstruction and improves asthma control in patie

87 human deoxyribonuclease 1 (rhDNase) reduces airflow obstruction and improves mucociliary clearance i

88 racterize the kinetics of grain dust-induced airflow obstruction and inflammation in the lower respir

89 begins in infancy or childhood with variable airflow obstruction and intermittent wheezing, cough, an

90 response (BDR) reflects the reversibility of airflow obstruction and is recommended as an adjunctive

91 Both groups developed significant airflow obstruction and lower airway inflammation after

92 ingle inhalation challenge of CDE results in airflow obstruction and lower respiratory tract inflamma

93 e (COPD) is characterized by the presence of airflow obstruction and lung destruction with airspace e

94 early-onset nonsevere asthma and reversible airflow obstruction and normal airway structure.

95 ung function are at increased risk for fixed airflow obstruction and possibly COPD in early adulthood

96 constrict airway smooth muscle, but elicits airflow obstruction and pulmonary inflammation in patien

97 mmunological biomarkers are related to fixed airflow obstruction and radiological abnormalities in mo

98 Fixed airflow obstruction and radiological abnormalities were

99 Understanding the genetic basis of airflow obstruction and smoking behaviour is key to dete

100 ve effects of etoricoxib on allergen-induced airflow obstruction and sputum eosinophils, basal lung f

101 In adults, differences in airflow obstruction and symptoms between SA and NONSA pe

102 inophilic airway inflammation contributes to airflow obstruction and symptoms in some patients with C

103 Preliminary studies have shown that both airflow obstruction and systemic inflammation may contri

104 positively with the severity of inflammatory airflow obstruction and the level of methacholine airway

105 nd to lesser extent of Twist, was related to airflow obstruction and to expression of a canonical EMT

106 m the association between skin wrinkling and airflow obstruction and to identify genetic polymorphism

107 particular showed a direct correlation with airflow obstruction and treatment requirement in patient

108 We found no association between airflow obstruction and use of solid fuels for cooking o

109 pulmonary disease, who had at least moderate airflow obstruction and were taking part in PR, were ran

110 nstrated reduced diffusing capacity; 20% had airflow obstruction, and 20% had chest restriction.

111 and 80% had late-onset asthma, 50% had fixed airflow obstruction, and 66% showed a Th2-high phenotype

112 The presence of air trapping, airflow obstruction, and airway size reduction in newbor

113 yper-responsiveness, incompletely reversible airflow obstruction, and asthma-related school and work

114 al-appearing lung regions in smokers without airflow obstruction, and it is associated with respirato

115 smooth muscle bronchoconstriction leading to airflow obstruction, and mucous hypersecretion are clini

116 ously that lower respiratory tract symptoms, airflow obstruction, and neutrophilic airway inflammatio

117 d in lungs of never smokers, smokers without airflow obstruction, and patients with COPD by reverse t

118 ovel candidate gene in emphysema with severe airflow obstruction, and rs61754411 is a previously unre

119 ilic inflammation, the attributes of chronic airflow obstruction, and the notion of corticosteroid in

120 Air trapping and airflow obstruction are being increasingly identified in

121 as detected on computed tomography (CT), and airflow obstruction are inversely related to left ventri

122 se findings help to explain heterogeneity of airflow obstruction as well as why, in people with asthm

123 Airflow obstruction assessed from post-bronchodilator sp

124 eling and contributes to the mucus plugs and airflow obstruction associated with severe asthma phenot

125 acute exacerbation (AE) in patients without airflow obstruction (Asthma AE group).

126 osing COPD in patients with mild to moderate airflow obstruction at baseline.

127 rsible airflow obstruction, in some patients airflow obstruction becomes irreversible.

128 Smokers with airflow obstruction benefit from quitting despite previo

129 is similar to cluster T2 in terms of chronic airflow obstruction but is composed of nonsmokers.

130 before age 18 years were more likely to have airflow obstruction, but a sex difference in this associ

131 ve or multiplicative effects on the risk for airflow obstruction, but this has not been demonstrated

132 us by goblet cells, which leads to worsening airflow obstruction by luminal obstruction of small airw

133 d-onset persistent asthma is associated with airflow obstruction by mid-adult life, but this does not

134 for INtrinsic and EXtrinsic skin Aging) and airflow obstruction by spirometry, using the ratio of fo

135 essure support ventilation in the setting of airflow obstruction can be accompanied by marked variati

136 revalence of the broader category of chronic airflow obstruction (CAO), defined as asthma, chronic br

137 tation (SLT) is widely used to treat chronic airflow obstruction (CAO).

138 LOD = 1.70) and 19 (LOD = 1.54) for moderate airflow obstruction, chromosomes 8 (LOD = 1.36) and 19 (

139 atopoietic stem cell transplantation-related airflow obstruction, consensus diagnostic criteria, and

140 ight into the specific mechanisms underlying airflow obstruction, COPD, and tobacco addiction, and sh

141 ontrol, recurrent exacerbations, and chronic airflow obstruction despite adequate and, in many cases,

142 a have frequent exacerbations and persistent airflow obstruction despite treatment with inhaled gluco

143 ng was strongly associated with all types of airflow obstruction, diagnosed or not.

144 roduction in asthma is an important cause of airflow obstruction during severe exacerbations.

145 to -13.2]; p=0.006), higher Body Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity (BOD

146 total score (SGRQ), and the body mass index, airflow obstruction, dyspnea, and exercise capacity (BOD

147 to -8.556; P < 0.001), and body mass index, airflow obstruction, dyspnea, and exercise capacity inde

148 ore, -0.6 points; and BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) ind

149 OPD assessment test scores, Body-mass index, airflow Obstruction, Dyspnea, and Exercise index, or Glo

150 The BODE index (including body-mass index, airflow obstruction, dyspnoea, and exercise capacity) wa

151 ecreased lung function and increased odds of airflow obstruction, even in participants who had never

152 esent in symptomatic infants with reversible airflow obstruction, even in the presence of atopy.

153 c airway disease characterized by paroxysmal airflow obstruction evoked by irritative stimuli on a ba

154 Patients with moderate chronic airflow obstruction experienced a reduction in exacerbat

155 predicted, FEV(1)/FVC < 90% predicted], mild airflow obstruction (FEV(1) < 80% predicted, FEV(1)/FVC

156 ion, the patients with LDA continued to show airflow obstruction (FEV(1)% predicted = 65.4 +/- 2.9).

157 ed physical activity (multisensory armband), airflow obstruction (FEV1), health status (St. George's

158 Moderate/severe airflow obstruction (FEV1/forced vital capacity <0.70 an

159 health and functional impact of undiagnosed airflow obstruction for subjects in the general populati

160 f lung for carbon monoxide (Dlco%) than with airflow obstruction (forced expiratory volume in 1 secon

161 or qualitative phenotypes including moderate airflow obstruction [forced expiratory volume at one sec

162 cts with asthma who smoke or who have severe airflow obstruction from linkage analysis, as well as in

163 fied ADO index (including age, dyspnoea, and airflow obstruction) from the Swiss cohort, and validate

164 Asthmatics with persistent airflow obstruction had greater airway smooth muscle (As

165 A proportion of 26.3% of smokers without airflow obstruction had ND-E/I greater than the 90th per

166 f of the estimated 24 million Americans with airflow obstruction have received a COPD diagnosis, and

167 tantial proportion of subjects without overt airflow obstruction have significant respiratory morbidi

168 morbidity, more severe BDR and BHR, greatest airflow obstruction, high smoking prevalence, higher sym

169 acity (FVC) ratio is used as a criterion for airflow obstruction; however, the test characteristics o

170 isease characterized, in part, by reversible airflow obstruction, hyperresponsiveness and inflammatio

171 Cluster analysis of adults with symptomatic airflow obstruction identifies 5 disease phenotypes, inc

172 tly responsible for the development of fixed airflow obstruction in asthma.

173 f the gut-lung axis can be targeted to treat airflow obstruction in asthma.

174 Spirometry should not be used to screen for airflow obstruction in asymptomatic individuals.

175 all conducting airways are the major site of airflow obstruction in chronic obstructive pulmonary dis

176 y therapy caused significant improvements in airflow obstruction in eosinophilic asthma, but not in p

177 fferences in gene expression were related to airflow obstruction in epithelial cells (C3, ALOX5AP, CC

178 Spirometry should not be used to screen for airflow obstruction in individuals without respiratory s

179 be a marker of neutrophilic inflammation and airflow obstruction in patients with asthma, who have a

180 ar-capillary membrane function and increases airflow obstruction in patients with LVD but not in norm

181 We conclude that airflow obstruction in patients with OSA causes an acute

182 at spirometry should be obtained to diagnose airflow obstruction in patients with respiratory symptom

183 hyperreactivity (AHR, defined by exaggerated airflow obstruction in response to bronchoconstrictors),

184 ated in relation to both symptom control and airflow obstruction in severe asthmatics.

185 nchitis to several genomic regions; for mild airflow obstruction in smokers only, the maximum LOD was

186 function, greater risk of the development of airflow obstruction in smokers, a predisposition to lowe

187 en Pneumocystis colonization and severity of airflow obstruction in smokers, suggesting a possible pa

188 usceptible (n = 64) to emphysema with severe airflow obstruction in the Pittsburgh Specialized Center

189 Data on the prevalence of airflow obstruction in the U.S. population were used to

190 ched among genes associated with more severe airflow obstruction in these COPD cohorts (P < 0.001), s

191 ammation and remodeling, although persistent airflow obstruction in these patients was associated wit

192 known about the pathophysiology of the fixed airflow obstruction in these subjects.

193 ay inflammation, airway wall remodeling, and airflow obstruction in this prevalent disease syndrome.

194 th should be recognised as a risk factor for airflow obstruction in young adults.

195 Although asthma typically induces reversible airflow obstruction, in some patients airflow obstructio

196 tive associations with emphysema with severe airflow obstruction, including a suggestive association

197 Airflow obstruction is a rare but fatal complication fol

198 Undiagnosed airflow obstruction is common in the general population

199 If airflow obstruction is consistent with obliteration hist

200 Cohort studies suggest that airflow obstruction is established early in life, manife

201 exposed to organic dusts, the progression of airflow obstruction is related to the endotoxin concentr

202 In asthma, airflow obstruction is thought to result primarily from

203 defined by irreversible airflow obstruction; airflow obstruction is typically determined by reduction

204 isorder marked by inflammation and recurrent airflow obstruction, is associated with elevated levels

205 subjects with the SZ phenotype demonstrated airflow obstruction less frequently than those with with

206 ed, which provided additional support for an airflow obstruction locus in that region with a non-para

207 te airflow obstruction (LOD = 2.13) and mild airflow obstruction (LOD = 1.43).

208 -parametric multipoint approach for moderate airflow obstruction (LOD = 2.13) and mild airflow obstru

209 EBC LXA4 levels correlate with the degree of airflow obstruction measured by using FEV1 (r = 0.28, P

210 The cardinal feature of COPD is persistent airflow obstruction, measured by reductions in quantitat

211 hort: the body-mass index (B), the degree of airflow obstruction (O) and dyspnea (D), and exercise ca

212 the two study groups by Day 6 for indices of airflow obstruction obtained from gamma-camera images of

213 ndent association between skin wrinkling and airflow obstruction of the lung.

214 Documenting reversible airflow obstruction on lung function, allergen sensitiza

215 t in contrast to asthma there is no variable airflow obstruction or airway hyperresponsiveness.

216 th all-cause mortality among persons without airflow obstruction or COPD in a general population samp

217 or more genes influencing the development of airflow obstruction or dysanapsis.

218 with isolated diaphragm weakness but without airflow obstruction or hyperinflation, a group that woul

219 e unable to demonstrate that rhDNase reduces airflow obstruction or improves mucociliary clearance.

220 ot appear to be a significant determinant of airflow obstruction or lower airway inflammation followi

221 iratory tract disease can manifest itself as airflow obstruction or viral pneumonia, which can be fat

222 ute worsening of asthma symptoms, reversible airflow obstruction, or bronchial hyperresponsiveness af

223 presented 5.7% of total referrals with fixed airflow obstruction over 2 years.

224 th muscle function and may contribute to the airflow obstruction phenotype observed in human CF.

225 h severe uncontrolled asthma and the chronic airflow obstruction phenotype.

226 exacerbations include previous exacerbation, airflow obstruction, poor overall health, home oxygen us

227 linear regression, for participants without airflow obstruction, PRM(fSAD) but not PRM(emph) was ass

228 Their effects in patients with milder airflow obstruction remain unclear.

229 n men and women is similarly associated with airflow obstruction, respiratory symptoms, more emphysem

230 cal CT can accurately demonstrate reversible airflow obstruction resulting from airway hyperreactivit

231 ations of asthma are thought to be caused by airflow obstruction resulting from airway inflammation,

232 .16, 1.03-1.32), and incompletely reversible airflow obstruction (RR 1.28, 1.04-1.57) than did those

233 odeling and narrowing, which account for the airflow obstruction similar to asthma.

234 Keywords: airflow obstruction; spirometry; health impact; screenin

235 r matrix (ECM) processes specifically in the airflow obstruction study.

236 sex), NO2 levels were associated highly with airflow obstruction, such that each 10-ppb increase in N

237 f an EEG arousal accentuated the response to airflow obstruction, such that the PAT amplitude decreas

238 provide evidence for significant linkage to airflow obstruction susceptibility loci on chromosomes 2

239 of the small airways leading to progressive airflow obstruction, termed bronchiolitis obliterans syn

240 se of smoking, women showed a higher risk of airflow obstruction than men.

241 syndrome (BOS) is a condition of progressive airflow obstruction that affects a majority of lung tran

242 ic obstructive pulmonary disease (COPD) have airflow obstruction that leads to dynamic lung hyperinfl

243 CHRNA5/3 region as a genetic risk factor for airflow obstruction that may be independent of smoking a

244 conclude that in the absence of significant airflow obstruction the volume of transplanted immature

245 tory and physical examination for predicting airflow obstruction; the value of spirometry for screeni

246 Study), 5,733 smokers with mild to moderate airflow obstruction underwent methacholine challenge tes

247 tics of chronic persistent asthma, including airflow obstruction, use of corticosteroid medications,

248 FEV(1) is an objective measure of airflow obstruction used in clinical practice and in the

249 In emphysema, airflow obstruction usually coexists with impairment of

250 COPD is characterised by poorly reversible airflow obstruction usually due to cigarette smoking.

251 ly, the maximum two point LOD score for mild airflow obstruction was 3.14.

252 ver diagnosed asthma and post-bronchodilator airflow obstruction was 44.8%, 19.3% and 7.5%, respectiv

253 Airflow obstruction was assessed by FEV1% predicted.

254 Health and functional impact of airflow obstruction was assessed from responses to quest

255 Increasing PRM(FSA) in subjects without airflow obstruction was associated with increased FVC (P

256 Airflow obstruction was defined as FEV(1) and its ratio

257 ealth and functional status with undiagnosed airflow obstruction was independently associated with se

258 Overall, airflow obstruction was less common and milder among PI*

259 bution relative to PRM(FSA) in those without airflow obstruction was limited by its low burden.

260 P were measured at an early time point, when airflow obstruction was most severe, and again at a late

261 rrent smokers, the frequency and severity of airflow obstruction was similar between SZ and ZZ subjec

262 The extent of airflow obstruction was similarly associated with left v

263 Lack of airflow obstruction was the principal (89%) reason patie

264 Although undiagnosed airflow obstruction was usually very mild, approximately

265 lity and the predictors of age, dyspnea, and airflow obstruction were available.

266 Categories of diagnosed and undiagnosed airflow obstruction were defined using questionnaire res

267 eparate models for subjects without and with airflow obstruction were generated using baseline clinic

268 of emphysema on CT scanning and more severe airflow obstruction were linearly related to impaired le

269 Percent emphysema and airflow obstruction were not associated with the left ve

270 The agreement was less in the infants with airflow obstruction where the N2 washout gave slightly h

271 smoked pipes or cigars had increased odds of airflow obstruction whether they had also smoked cigaret

272 sorders encompassing different phenotypes of airflow obstruction, which might differ in their respons

273 s were obese female patients with reversible airflow obstruction who exhibited airway wall thickening

274 te-onset older male subjects with persistent airflow obstruction who exhibited significant air trappi

275 edominance of patients with mild to moderate airflow obstruction who would not experience additional

276 In both sexes, the association of airflow obstruction with cigarettes per day, smoking dur

277 To assess the association of airflow obstruction with self-reported use of solid fuel

278 The association of airflow obstruction with smoking characteristics was ass

279 The association of airflow obstruction with smoking status was stronger in

280 re was also no evidence of an association of airflow obstruction with use of solid fuels (ORmen=1.00,

281 The association of airflow obstruction with use of solid fuels for cooking

282 idence supporting the association of COPD or airflow obstruction with use of solid fuels is conflicti

283 methods with GWASs of pulmonary function and airflow obstruction would identify a broader repertoire

284 alyses were conducted to identify effects on airflow obstruction, YKL-40 levels, and asthma severity.