ライフサイエンスコーパス: airway epithelial cell

1 levels of silencing, particularly in primary airway epithelial cells.

2 induced IL-33 in the induction of CXCL-10 in airway epithelial cells.

3 is study, we deleted the mouse Kif3a gene in airway epithelial cells.

4 s and dendritic cells, transfer infection to airway epithelial cells.

5 given the strict tropism of HBoV1 for human airway epithelial cells.

6 atory effects of R507 were analyzed on human airway epithelial cells.

7 y dependent on IL-33/ST2/IRAK-1 signaling in airway epithelial cells.

8 type-II interferon-gamma (IFNgamma) in human airway epithelial cells.

9 ,3-linked sialic acids on complex glycans on airway epithelial cells.

10 y observed in lung airway using primary lung airway epithelial cells.

11 es but can also inhibit influenza entry into airway epithelial cells.

12 fluenza virus replication in human bronchial airway epithelial cells.

13 ell-differentiated primary cultures of human airway epithelial cells.

14 d release of chemokines, including CCL20, by airway epithelial cells.

15 on TNF-regulated gene expression in cultured airway epithelial cells.

16 d its degradation in the proteasome of human airway epithelial cells.

17 racts with RV RNA and poly(I.C) in polarized airway epithelial cells.

18 ected differentiation of hPSCs into lung and airway epithelial cells.

19 ion are due to infection of nectin4-positive airway epithelial cells.

20 e and regulator of inflammatory signaling in airway epithelial cells.

21 ansepithelial resistance (R(T)) in polarized airway epithelial cells.

22 shedding of the ADAM17 substrate TNFR1 from airway epithelial cells.

23 CFTR by attenuating its endocytosis in human airway epithelial cells.

24 -mediated sodium transport in cultured human airway epithelial cells.

25 vD1 receptors, were expressed on human small airway epithelial cells.

26 various cell types, including primary human airway epithelial cells.

27 ecipitated PP2A in vitro isolated from human airway epithelial cells.

28 10 mRNA, and expression was apparent only in airway epithelial cells.

29 ocrine cells (PNECs) are the only innervated airway epithelial cells.

30 TR and phosphorylates CFTR-Ser(737) in human airway epithelial cells.

31 ibition in both A549 and primary human small airway epithelial cells.

32 ar histones are cytotoxic to endothelial and airway epithelial cells.

33 ly, little to no caspase-1 was detectable in airway epithelial cells.

34 endent CGRP synthesis and secretion by human airway epithelial cells.

35 n led to enhanced binding of conidia to A549 airway epithelial cells.

36 g and release, we examined its expression in airway epithelial cells.

37 compartment or selectively lacking the GR in airway epithelial cells.

38 protein quantification analysis in cultured airway epithelial cells.

39 sing and responding to injured and apoptotic airway epithelial cells.

40 TR loss causes abnormal ion transport across airway epithelial cells.

41 expression, and (3) binding of GR to GREs in airway epithelial cells.

42 own about TGF-beta1 effects on CFTR in human airway epithelial cells.

43 ncreases oxidative and nitrosative stress in airway epithelial cells.

44 odulation following a mechanical stimulus in airway epithelial cells.

45 cocorticoids in regulation of BK channels in airway epithelial cells.

46 g this innate immune response in human small airway epithelial cells.

47 2 in Clara cell secretory protein-expressing airway epithelial cells.

48 rus spreads rapidly and efficiently in human airway epithelial cells.

49 ced CXCL-10 via IRAK-1 depletion at least in airway epithelial cells.

50 s that are infectious in well-differentiated airway epithelial cells.

51 induced expression of both ST2 and IL-33 in airway epithelial cells.

52 ation of beta-catenin to induce EMT in human airway epithelial cells.

53 sm of a discrete population of multiciliated airway epithelial cells.

54 n of noggin, BAMBI, and FSTL1 in human small airway epithelial cells.

55 rity to the transcriptome for intrapulmonary airway epithelial cells.

56 2 strain three times in differentiated swine airway epithelial cells.

57 E shRNA inhibited HMGB1-induced EMT in human airway epithelial cells.

58 EMT-related gene expression in human primary-airway epithelial cells.

59 excessive levels at the apical surface of CF airway epithelial cells.

60 cle DNA with plasmid DNA in transfections of airway epithelial cells.

61 P-regulated ion and fluid transport in human airway epithelial cells.

62 ent them from differentiating into proximal (airway) epithelial cells.

63 In addition, human airway epithelial cells (16HBE) were challenged with HDM

64 mary rat alveolar epithelial cells and human airway epithelial cells (20-100 microg/cm(2)), primary r

65 We report that in airway epithelial cells a threshold of p38alpha mitogen-

66 action of extracellularly released HMGB1 in airway epithelial cells (A549 and small airway epithelia

67 separated by a permeable membrane from human airway epithelial cells (A549) infected with RSV with ei

68 Thus, HBoV1 infection of human airway epithelial cells activates antiapoptotic proteins

69 basophil degranulation assays, and in vitro airway epithelial cell activation assays.

70 status in early pregnancy is associated with airway epithelial cell (AEC) responses in new born infan

71 Airway epithelial cell (AEC) signaling might regulate HL

72 Airway epithelial cells (AEC) are increasingly recognize

73 that air-liquid interface cultures of murine airway epithelial cells (AECs) also actively synthesize

74 estigated TLR expression and polarization in airway epithelial cells (AECs) and the consequences of T

75 Innate immune responses to allergens by airway epithelial cells (AECs) help initiate and propaga

76 Airway epithelial cells (AECs) play a critical role in t

77 Airway epithelial cells (AECs) provide the first line of

78 In airway epithelial cells (AECs), stimulation of PAR2 by a

79 ate and maintain intracellular H2S levels in airway epithelial cells (AECs).

80 of chronic asthma and in vitro human primary airway epithelial cells (AECs).

81 Airway epithelial cells also undergo apoptosis after enc

82 In human airway epithelial cells, alternative splicing of the IL-

83 of P. aeruginosa grown in sputum gels using airway epithelial cells and a murine infection model.

84 sed expression of inhibitory ligands by both airway epithelial cells and APCs, further establishing a

85 Primary human lung fibroblasts, small airway epithelial cells and blood monocytes were treated

86 genic mice conditionally expressing Foxa3 in airway epithelial cells and developed human bronchial ep

87 ent data has highlighted the cross talk with airway epithelial cells and environmental factors (aller

88 and osmotic stress were assessed in primary airway epithelial cells and ex vivo murine lung tissue.

89 Influenza A virus (IAV) targets airway epithelial cells and exploits the host cell machi

90 We used the primary human airway epithelial cells and found that the antibodies to

91 l role for p52 in cell survival/apoptosis of airway epithelial cells and implicate noncanonical NF-ka

92 a new role for Rac1-dependent engulfment by airway epithelial cells and in establishing the anti-inf

93 n expression was determined in primary human airway epithelial cells and in mice.

94 expression of pro-inflammatory mediators in airway epithelial cells and in the lung of mice by enhan

95 viruses replicated to higher titre in human airway epithelial cells and in the respiratory tract of

96 as attenuated in two models of primary human airway epithelial cells and in the upper and lower airwa

97 inducible Siglec-F ligand expression by lung airway epithelial cells and inflammatory cells in wild-t

98 element with enhancer activity in 16HBE14o- airway epithelial cells and is enriched for monomethylat

99 human surfactant protein A and annexin A2 on airway epithelial cells and is internalized, leading to

100 ssion in bronchial biopsies was increased in airway epithelial cells and lamina propria inflammatory

101 avage products that acted as TLR4 ligands on airway epithelial cells and macrophages.

102 sociated kinase-1 (IRAK-1) depletion in both airway epithelial cells and macrophages.

103 ge of mammalian cell cultures, human primary airway epithelial cells and mice, but poorly in avian ce

104 s for presentation at the plasma membrane of airway epithelial cells and recognition by CD8(+) T cell

105 on for TREM-1 in neutrophil migration across airway epithelial cells and suggest that it amplifies in

106 Using in vitro cocultures of airway epithelial cells and T cells and in vivo models o

107 severe asthma and primarily associated with airway epithelial cells and tissue neutrophils.

108 ease inhibitor (SLPI), which is expressed by airway epithelial cells, and IFN-gamma inversely correla

109 lveolar macrophages, monocytes, neutrophils, airway epithelial cells, and in mouse lungs.

110 KCa3.1 was detected in T cells, airway epithelial cells, and myofibroblasts.

111 ctivation was assessed in human neutrophils, airway epithelial cells, and peripheral blood monocytes

112 transcription factor NF-kappaB in conducting airway epithelial cells, and used a combination of in vi

113 Moreover, we show that in human airway epithelial cells AP-2 is not essential for CFTR r

114 ndicating that Runx3 plays a crucial role in airway epithelial cell apoptosis induced by IAV infectio

115 s study, we investigated the hypothesis that airway epithelial cells are a source of CTSS, and mechan

116 Airway epithelial cells are the first to encounter aeroa

117 Although human airway epithelial cells are the main target of respirato

118 Airway epithelial cells are the major target for rhinovi

119 Airway epithelial cells are the primary targets of RSV i

120 ecule controlling mucus granule secretion by airway epithelial cells as well as directed migration of

121 up-regulated during ciliogenesis in cultured airway epithelial cells, as was DRC2 in C. reinhardtii f

122 multicycle replication in cultures of human airway epithelial cells at 32 degrees C.

123 , was used to monitor EGSH in cultured human airway epithelial cells (BEAS-2B cells) undergoing expos

124 of isoprene SOA on gene expression in human airway epithelial cells (BEAS-2B) through an air-liquid

125 accinia virus (VACV) initially replicates in airway epithelial cells before spreading to secondary si

126 t shown to preserve the barrier integrity of airway epithelial cells better than the human AMP LL-37.

127 We further show that airway epithelial cells bind chitin in vitro and produce

128 In airway epithelial cells, blocking TLR2 enhanced RV-induc

129 Using cell lines and primary airway epithelial cells (both submerged and well-differe

130 ) luciferase reporter transfected into human airway epithelial cells [both bronchial epithelium + ade

131 ic mucin MUC1 is elevated by inflammation in airway epithelial cells, but the contributions of MUC1 t

132 ductance regulator (CFTR) abundance in human airway epithelial cells by a mechanism that requires ser

133 This study indicates that HBoV1 kills airway epithelial cells by activating genes that suppres

134 und that 25HC inhibits in vitro infection of airway epithelial cells by influenza.

135 atural killer T cells responded to apoptotic airway epithelial cells by secreting cytokines, which me

136 an in vitro model of HRV infection of human airway epithelial cells (Calu-3 cells) and subsequent ex

137 Here we present evidence that differentiated airway epithelial cells can revert into stable and funct

138 inished ENaC-mediated Na(+) absorption in CF airway epithelial cells caused by internalization of a p

139 Air-liquid interface culturing of airway epithelial cells caused widespread changes in miR

140 Mechanical stimulation of airway epithelial cells causes apical release of ATP, wh

141 dexamethasone to modulate gene expression in airway epithelial cells coincided with its potency to re

142 thylation levels from DNA derived from nasal airway epithelial cells collected from 12 African Americ

143 Activation of NF-kappaB activation in airway epithelial cells correlated with interleukin-8 co

144 An airway epithelial cell culture infection model was utili

145 lled direct pH measurements in primary human airway epithelial cell culture models, which also sugges

146 authentic well-differentiated primary human airway epithelial cells cultured at an air-liquid interf

147 Airway epithelial cells cultured at an air-liquid interf

148 Differentiated primary airway epithelial cell cultures (F508del homozygotes) we

149 Exposure of primary human airway epithelial cell cultures to IFN-gamma for 48 h di

150 Human and murine airway epithelial cell cultures were also infected with

151 nfant and adult lungs, rhesus monkey primary airway epithelial cell cultures were infected with pande

152 Intracellular infection of airway epithelial cell cultures with S. aureus led to de

153 tion, and RNA and protein synthesis in human airway epithelial cell cultures, primary lung fibroblast

154 roarray studies using infected primary human airway epithelial cell cultures.

155 composition for dry, direct deposition onto airway epithelial cell cultures.

156 n mice or its inactivation in vitro in human airway epithelial cell cultures.

157 (PLA2G10) expression was examined in primary airway epithelial cell cultures.

158 acking MIWI2 exhibited an altered balance of airway epithelial cells, demonstrating fewer multiciliat

159 reatment-resistant asthma via neutrophil and airway epithelial cell-dependent pathways.

160 m donated blood and (ii) well-differentiated airway epithelial cells derived from donor lungs.

161 initiation of TH 2 responses is regulated by airway epithelial cell-derived factors, including TRAIL

162 In siRNA-MUC4 BEAS-2B airway epithelial cells dexamethasone produced higher an

163 Further analysis showed that airway epithelial cells did not produce glucocorticoids

164 Finally, HMGB1 released by airway epithelial cells due to RSV infection appears to

165 ve Rhizopus and Mucor strains and with human airway epithelial cells during fungal invasion, to revea

166 to potentiate its cytoprotective signals in airway epithelial cells during influenza infection.

167 Here we show that airway epithelial cells efficiently engulf apoptotic epi

168 RNA was extracted from primary airway epithelial cells either immediately after cell pr

169 Knockdown of TRIM29 in airway epithelial cells enhances type I interferon produ

170 gulated after allergen challenge, notably in airway epithelial cells, eosinophils, and neutrophils.

171 Here we report that in human airway epithelial cells Epstein-Barr virus induces TRIM2

172 CTSS activity with the demonstration that CF airway epithelial cells express and secrete significantl

173 Airway epithelial cells express arginine-specific ADP ri

174 Human airway epithelial cells express pannexin 1 (Panx1) chann

175 suggested that, when approximately 10-50% of airway epithelial cells expressed CFTR, they generated n

176 Increased airway epithelial cell expression of CGRP, together with

177 ial cells are committed to the Sox2-positive airway epithelial cell fate, Fgf10 prevents ciliated cel

178 Airway epithelial cells form a barrier to the outside wo

179 In cultured airway epithelial cells, FP treatment inhibited IL-13-in

180 Consistent with this observation, airway epithelial cells from asthmatic children a produc

181 -148b levels were significantly increased in airway epithelial cells from asthmatic subjects with an

182 Although isolated airway epithelial cells from Beclin-1(+/-) mice demonstr

183 Studies using pendrin knockout mice and airway epithelial cells from hearing-impaired subjects w

184 t in well-differentiated primary cultures of airway epithelial cells from human donors (HAE), MV infe

185 d to primary cultures of well-differentiated airway epithelial cells from human donors (HAE).

186 The ability to generate lung and airway epithelial cells from human pluripotent stem cell

187 accumulate on the luminal membrane of upper-airway epithelial cells from mice and humans with CF.

188 ell-differentiated primary cultures of human airway epithelial cells from non-CF and CF subjects, tre

189 However, in airway epithelial cells from patients with cystic fibros

190 miR-148b, and miR-152) transcript levels in airway epithelial cells from the same subjects.

191 Airway epithelial cell gene expression from 155 subjects

192 d a microarray platform to analyze bronchial airway epithelial cell gene expression in relation to th

193 Lung and airway epithelial cells generated in vitro from human pl

194 and CCDC65-specific shRNA transduced normal airway epithelial cells had stiff and dyskinetic cilia b

195 ne IL-13 on beta2AR desensitization in human airway epithelial cells (HAECs) and determine whether 15

196 e phosphatase (PTP) activity in single human airway epithelial cells (hAECs) using capillary electrop

197 Loss of Rac1 in airway epithelial cells has demonstrated its participati

198 that intrinsic developmental differences in airway epithelial cell immune function may contribute to

199 deletion of Rac1 expression specifically in airway epithelial cells in a mouse model resulted in def

200 domain-only protein, Bmf, in human and mouse airway epithelial cells in a p53-dependent manner.

201 s were shown to transform immortalized human airway epithelial cells in a sorafenib-sensitive manner.

202 IL-8 and other proinflammatory mediators by airway epithelial cells in an ALX/FPR2 (formyl peptide r

203 ylation, was up-regulated in mouse and human airway epithelial cells in association with air-space en

204 egulatory mechanisms of ferroptotic death in airway epithelial cells in asthma, kidney epithelial cel

205 we show that expression of SPDEF or FOXA3 in airway epithelial cells in neonatal mice caused goblet c

206 epithelial progenitors into Sox2-expressing airway epithelial cells in part by activating epithelial

207 irway expression, and ATF4 overexpression in airway epithelial cells in vitro recapitulates COPD-asso

208 UA promoted secretion of IL-33 by airway epithelial cells in vitro, and administration of

209 protein either incubated with cultured human airway epithelial cells in vitro, or provided as an aero

210 ir effects on innate interferon responses of airway epithelial cells in vitro.

211 t receptor 1-related protein y expression in airway epithelial cells in vitro.

212 s is associated with NF-kappaB activation in airway epithelial cells in vivo.

213 3(Delta2-3/Delta2-3)/CC10 mice as well as in airway epithelial cells in which ORMDL3 was inhibited wi

214 RNA isolated from primary normal human small airway epithelial cells indicated that IL-17A (100 ng/ml

215 g results showed that RSV infection of human airway epithelial cells induced a significant release of

216 ling, and production of new viral progeny in airway epithelial cells infected with adenovirus type 2.

217 ors find a deficiency in IFN production from airway epithelial cells infected with human rhinovirus i

218 In addition, conditioned media from human airway epithelial cells infected with Pseudomonas aerugi

219 he transcriptional response of primary mouse airway epithelial cells infected with rhinovirus at 33 d

220 canic ash had minimal effect on alveolar and airway epithelial cell integrity.

221 Airway epithelial cells interface innate and adaptive im

222 hat stimulation of EGFR activation by ATP in airway epithelial cells is closely associated with dynam

223 ivity of Vero cell-derived virus for primary airway epithelial cells is increased 5-fold if the virus

224 control and IFN response to these viruses in airway epithelial cells is remarkably similar between su

225 However, the role of HMGB1 in EMT of human airway epithelial cells is still unclear.

226 he potential dysregulation of methylation in airway epithelial cells is unknown.

227 observations, deletion of IGF-1 receptor in airway epithelial cells led to exacerbated lung inflamma

228 Human airway epithelial cell lines (BEAS-2B and A549) and huma

229 SPAG1 was present in human airway epithelial cell lysates but was not present in is

230 IL-13 levels were increased in airway epithelial cells, macrophages, type 2 innate lymp

231 When applied directly to polarized airway epithelial cells, mature aCif triggers a reductio

232 ed interferon response to viral infection by airway epithelial cells may be a mechanism leading to lu

233 d, ozone (O3) interacts with cholesterols of airway epithelial cell membranes or the lung-lining flui

234 Airway epithelial cells mount a tolerogenic microenviron

235 Thus, in airway epithelial cells, MV spread requires the nectin-4

236 A549 cells and were all cytotoxic for small airway epithelial cells, NCI-H441, and normal human lung

237 ted in gene expression profiles of bronchial airway epithelial cells obtained by bronchoscopy.

238 so used to reconstitute ORMDL3 expression in airway epithelial cells of Ormdl3 knockout mice.

239 ed the impact of Hsp27, an sHsp expressed in airway epithelial cells, on the common protein misfoldin

240 Cultured human or murine airway epithelial cells or mice were subjected to acute

241 to supernatants from IL-1beta-stimulated CF airway epithelial cells (P < .01).

242 Together, these results suggest beta2ARs on airway epithelial cells promote the asthma phenotype and

243 The results show that airway epithelial cells regulate local immune responses,

244 Therefore, airway epithelial cells release less ATP in response to

245 ced, CCR4-dependent release of CGRP by human airway epithelial cells represents a novel inflammatory

246 itivity regions in lung fibroblasts or small airway epithelial cells, respectively.

247 Many cells, including murine airway epithelial cells, respond to a variety of inflamm

248 However, the molecular mechanisms of airway epithelial cell responses to viral infection are

249 Transfection of caspase-1 into airway epithelial cells restored their ability to secret

250 channel (VDCC)-intervened calcium influx in airway epithelial cells, resulting in a rapid IGF2 secre

251 Treatment of small airway epithelial cells (SAEC) or lung fibroblasts ex vi

252 nt stem cells (iPSC) from normal human small airway epithelial cells (SAEC) to investigate epigenetic

253 l/tracheal epithelial cells (NHBE) and small airway epithelial cells (SAEC).

254 In normal primary human small airway epithelial cells (SAECs) treated with TGF-beta1 (

255 e physiologically relevant cell lines--small airway epithelial cells (SAECs), macrophages (THP-1 cell

256 nce in both human lung fibroblasts and small airway epithelial cells (SAECs).

257 ucing factor in the RSV-infected human small airway epithelial cell secretome and was differentially

258 pregnancy and aspects of stimulated neonatal airway epithelial cell secretory function that may in tu

259 Th2 cytokine-stimulated cultured airway epithelial cells showed down-regulation of t-PA,

260 wn that influenza virus infection of primary airway epithelial cells strongly enhances PDL-1 expressi

261 nt-resistant membrane fraction prepared from airway epithelial cells, suggesting that it may partitio

262 tophagy is an important adaptive response in airway epithelial cells targeted by many common adenovir

263 gamycin and quercetin is lower in CF-derived airway epithelial cells than in non-CF cells.

264 profound increase in the cytosolic E(GSH) of airway epithelial cells that is indicative of an oxidant

265 eath-receptor-induced programmed necrosis of airway epithelial cells that led to severe bronchiole ep

266 ntrinsic developmental differences in infant airway epithelial cells that may contribute to the incre

267 ed G protein are less infectious for primary airway epithelial cells, the natural RSV target.

268 iR-101 and miR-144 were transfected in human airway epithelial cells, they directly targeted the CFTR

269 we examined the molecular responses of human airway epithelial cells to B. cenocepacia infection.

270 the main risk factor for COPD, and exposing airway epithelial cells to cigarette smoke extract (CSE)

271 l type 2 (Th2) cytokine, transforms cultured airway epithelial cells to goblet cells, and this is not

272 expression is a component of the response of airway epithelial cells to innate immune activation by r

273 TNF signaled through airway epithelial cells to reprogram them and promote Th

274 and regulating the innate immune response of airway epithelial cells to viral infection.

275 moke and other environmental stimuli acts on airways epithelial cells to induce neutrophil chemotaxin

276 1 in airway epithelial cells (A549 and small airway epithelial cells) to establish its role in RSV in

277 the susceptibility of cells, especially the airway epithelial cells, to hRSV infection.

278 bunit of NF-kappaB, and RNA polymerase II in airway epithelial cells treated with dexamethasone, TNF,

279 Airway epithelial cells treated with IL-4 followed by AD

280 protein connexin43 (Cx43) in polarized human airway epithelial cells upon infection by PAO1.

281 le damage to the mitochondria in human small airway epithelial cells, using a precision microbeam irr

282 udied in Chlamydomonas reinhardtii and human airway epithelial cells, using RNA assays and immunostai

283 steroid-resistant inflammatory signature in airway epithelial cells via constitutively expressed LTb

284 to date suggest that these viruses kill the airway epithelial cells via the apoptotic or necrotic pa

285 L17-induced release of CGRP by primary human airway epithelial cells was also observed.

286 ATP-mediated EGFR transactivation in airway epithelial cells was found to involve purinergic

287 x-dependent regulation of EGFR activation in airway epithelial cells was found to strongly depend on

288 sis of Clara cell secretory protein-positive airway epithelial cells was observed in transgenic mice

289 While replication kinetics in human airway epithelial cells was on par with that of seasonal

290 proteins unique to RSV-infected human small airway epithelial cells was regulated by the transcripti

291 Numbers of necrotic airway epithelial cells were elevated and correlated wit

292 on IFN-gamma treatment, fully differentiated airway epithelial cells were exposed to ammonium chlorid

293 Airway epithelial cells, which are the first line of def

294 pressed in mouse taste buds but also in lung airway epithelial cells, which have previously been show

295 Infection of airway epithelial cells with RSV led to the production o

296 Here we show that infection of human airway epithelial cells with Streptococcus pneumoniae le

297 o do this, we examined the infection of A549 airway epithelial cells with the live vaccine strain (LV

298 he cells express markers of various lung and airway epithelial cells, with a predominance of cells id

299 y(I:C) to selectively upregulate IFN-beta in airway epithelial cells without a concomitant inflammato

300 s feasible to augment IFN-beta production in airway epithelial cells without excessive costimulation