ライフサイエンスコーパス: alanine

1 y 2-fold weaker affinity to that of l- and d-alanine.

2 120 interface were systematically mutated to alanine.

3 these mice exhibit normal responses to beta-alanine.

4 ngly altered when this residue is mutated to alanine.

5 receptor for the itch-inducing chemical beta-alanine.

6 by the transmembrane domain of CD74 or by 21 alanines.

7 s subsequently achieved utilizing thioureayl alanines.

8 sidues to structurally similar glutamines or alanines.

9 trols) and underwent fluorodihydroxyphenyl-l-alanine ([18F]-DOPA) positron emission tomography to exa

10 connexin43 (Cx43) into glutamic acid (E) or alanine (A) residues.

11 (K) that is involved in ATP coordination to alanine (A) resulted in elimination of kinase activity w

12 ht to convert the l-alanine germinant into d-alanine, a spore germination inhibitor.

13 utation in the CX3C motif by insertion of an alanine, A(186), within the CX3C motif, mutating it to C

14 utation in the CX3C motif by insertion of an alanine, A(186), within the CX3C motif, mutating it to C

15 /kg of DHA and either alanine or proline and alanine added.

16 GLY, alanine (ALA), and serine (SER) all resulted in remarkab

17 Mutation of D62 to alanine alone, or in combination with an E181-to-alanine

18 Surprisingly, d-alanine also functioned as a co-germinant.

19 midase_3 domain-containing N-acetylmuramyl-L-alanine amidase, a peptidoglycan remodelling enzyme impl

20 al adduct formation, oxidative stress, serum alanine amino transferase, expression of tumor necrosis

21 ]), vomiting (125 [66%]), and an increase in alanine aminotransferase (114 [60%]) in the ceritinib gr

22 ), colitis (19 [5%] vs nine [2%]), increased alanine aminotransferase (12 [3%] vs two [1%]), and hypo

23 verse events were increases in lipase (15%), alanine aminotransferase (12%), and aspartate aminotrans

24 roup versus the placebo group were increased alanine aminotransferase (146 [25%] of 573 patients vs s

25 (affecting >/=2% of patients) were increased alanine aminotransferase (17 [3%] of 573 vs one [<1%] of

26 nsferase (32.4 +/- 17.4 vs 21.5 +/- 6.9U/L), alanine aminotransferase (39.9 +/- 28.6U/L vs 23.8 +/- 1

27 criteria, those with CFLD had higher median alanine aminotransferase (42 versus 27, P = 0.005), aspa

28 ubjects with a FibroScan >6.8 kPa had higher alanine aminotransferase (42 versus 28U/L, P = 0.02), AS

29 e aminotransferase (65 [26%]), and increased alanine aminotransferase (47 [19%]).

30 uparlisib versus placebo group were elevated alanine aminotransferase (63 [22%] of 288 patients vs fo

31 rica were more likely to have elevated serum alanine aminotransferase (72% vs. 50%; P < 0.01) and hig

32 r inhibitor-1 (markers for fibrinolysis) and alanine aminotransferase (ALT) (marker of ischemia-reper

33 brosis significantly reduced serum levels of alanine aminotransferase (ALT) and liver steatosis and f

34 grade 4 aspartate aminotransferase (AST) or alanine aminotransferase (ALT) elevation with fevers, an

35 defined as viral DNA levels >2000 IU/mL and alanine aminotransferase (ALT) levels >80 U/mL, respecti

36 liver fibrosis, inflammation, steatosis, and alanine aminotransferase (ALT) levels and viscoelastic a

37 ular injury is identified internationally by alanine aminotransferase (ALT) levels equal to or exceed

38 erum insulin, fasting serum lipids and serum alanine aminotransferase (ALT) levels were measured and

39 Observational studies of the association of alanine aminotransferase (ALT) levels with ischaemic hea

40 index (APRI), fibrosis-4 index (FIB-4), AST/alanine aminotransferase (ALT) ratio (AAR), and age-plat

41 aspartate aminotransferase, alanine aminotransferase (ALT), acute kidney injury (AKI

42 YCHT treatment substantially reduced serum alanine aminotransferase (ALT), alkaline phosphatase (AS

43 including gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), and aspartate aminotrans

44 pathological changes and increases in serum alanine aminotransferase (ALT), aspartate aminotransfera

45 damage, high aspartate (AST, >49.9 IU/L) and alanine aminotransferase (ALT, >56.1 IU/L), to the relat

46 ]), thrombocytopenia (five [28%]), increased alanine aminotransferase (five [28%]), and hypokalaemia

47 cell count (HR 2.45, p 0.011), raised serum alanine aminotransferase (HR 4.22, p 0.016), raised seru

48 X-82 including leg cramps (n = 2), elevated alanine aminotransferase (n = 2), diarrhea (n = 1), and

49 participants developed a transaminase rise (alanine aminotransferase 4.5-5.9 times the upper limit o

50 steine treatment beyond the standard course (alanine aminotransferase [ALT] activity >100 U/L).

51 ects were classified as presumed NAFLD (pNF; alanine aminotransferase [ALT] level >/= 20 for women or

52 y histology, propidium iodide injection, and alanine aminotransferase after IRI.

53 with 200 mg twice a day (grade 3 increase of alanine aminotransferase and aspartate aminotransferase)

54 concentrations in liver; and serum levels of alanine aminotransferase and aspartate aminotransferase.

55 ling (TUNEL) staining, circulating levels of alanine aminotransferase and lactate dehydrogenase, and

56 No patients had elevations in alanine aminotransferase and no patients prematurely dis

57 steatosis, inflammation, and serum levels of alanine aminotransferase compared with mice given a cont

58 events in the ceritinib group were increased alanine aminotransferase concentration (24 [21%] of 115

59 One patient was ineligible (alanine aminotransferase concentration was above the req

60 Elevations of aspartate and alanine aminotransferase concentrations of three or more

61 ons in plasma aspartate aminotransferase and alanine aminotransferase concentrations; hepatic steatos

62 V reactivation in this cohort exhibited peak alanine aminotransferase elevations >2 times the upper l

63 Limited, asymptomatic, and transient alanine aminotransferase elevations in the low-dose (n =

64 should be followed up on a monthly basis for alanine aminotransferase followed by quantitative HBV DN

65 We also measured levels of TNF and alanine aminotransferase in serum from mice.

66 occurring in more than two patients included alanine aminotransferase increase (five [14%]), pyrexia

67 4 adverse events were pyrexia (four [11%]), alanine aminotransferase increase (four [11%]), hyperten

68 uzumab), fatigue (three [1%] vs seven [3%]), alanine aminotransferase increase (three [1%] vs four [2

69 y quantitative HBV DNA testing in those with alanine aminotransferase increase.

70 loped fully reversible, asymptomatic grade 3 alanine aminotransferase increases (one on 50 mg, two on

71 Elevations in the alanine aminotransferase level (to >3 times the upper li

72 1 incident each of grade 4 adverse events of alanine aminotransferase level elevation and rectal hemo

73 adverse event was an elevation in the serum alanine aminotransferase level to 1.5 times the upper li

74 ith hepatitis C virus, persons with elevated alanine aminotransferase levels (>/=19 IU/L for women an

75 diarrhoea (19 [8%] vs two [1%]), and raised alanine aminotransferase levels (two [1%] vs 19 [8%]).

76 Abnormal alanine aminotransferase levels at admission can indicat

77 Alanine aminotransferase levels increased in ALGS after

78 Four of the 6 patients (67%) had increased alanine aminotransferase levels of more than 1.5 times t

79 while 4 of 22 patients (18%) with increased alanine aminotransferase levels showed positive reactivi

80 Notably, increases in alanine aminotransferase levels, apoptotic markers, and

81 Five (42%) patients had raised alanine aminotransferase levels, four (33%) had raised a

82 nt liver injury dramatically decreased serum alanine aminotransferase levels, histological injury, th

83 nt amelioration of ferritin, fibrinogen, and alanine aminotransferase levels.

84 ge was assessed by hematoxylin and eosin and alanine aminotransferase levels.

85 lobin (45 [22%] patients), and elevations in alanine aminotransferase or aspartate aminotransferase (

86 itis B surface antigen (HBsAg), HBV DNA, and alanine aminotransferase results obtained while on DAA t

87 seline and hepatitis flare as an increase in alanine aminotransferase to >/=3 times the upper limit o

88 lirubin, international normalized ratio, and alanine aminotransferase within 3 days posttransplant.

89 ine phosphatase, aspartate aminotransferase, alanine aminotransferase) and areas of liver parenchymal

90 ure cytokines and a marker of liver failure (alanine aminotransferase); liver tissues were collected

91 erse events were transaminase increases (40% alanine aminotransferase, 17% aspartate aminotransferase

92 creased necrosis, infiltrating CD8(+) cells, alanine aminotransferase, and proinflammatory cytokines.

93 tation significantly reduced plasma glucose, alanine aminotransferase, aspartate aminotransferase, AG

94 virus-infected patients was the elevation in alanine aminotransferase, aspartate aminotransferase, al

95 ripts, including XDH1, glutamine synthetase, alanine aminotransferase, catalase, superoxide dismutase

96 ood count, serum chemistry profile, level of alanine aminotransferase, rheumatoid factor activity, C4

97 and no relevant laboratory abnormalities in alanine aminotransferase, total bilirubin, or hemoglobin

98 on markers such as increased level of serum alanine aminotransferase.

99 iated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; ga

100 Also, we assessed serum levels of alanine-aminotransferase (ALT), liver histology, hepatic

101 Alanine and arginine substitutions were used to determin

102 Elevated alanine and aspartate aminotransferase concentrations an

103 r injury, as demonstrated by decreased serum alanine and aspartate aminotransferase levels and number

104 rinates 11 and 12 followed by heating with l-alanine and crystallization afforded (R,R,S)-13 (27%).

105 9/3 structures efficiently inserted serine, alanine and cysteine in response to stop and sense codon

106 d-Alanine and d-glutamic acid derived from peptidoglycan d

107 diabetes associates with increased levels of alanine and decreased levels of phosphatidylcholine alky

108 The enzymatic assay targets alanine and employs alanine transaminase (ALT), pyruvate

109 The alanine and glutamic acid substitutions reduced actin-ac

110 teristic muscle di-peptides composed of beta-alanine and histidine derivatives such as anserine are e

111 be the ionization state of the amino-acids l-alanine and l-proline at the air/water surface and in th

112 and d-ribose with glycine, alpha-l- or beta-alanine and l-valine in pH 7.0 phosphate buffer at ca. 1

113 antioselective recognition response toward L-Alanine and limit of detection (LOD) value is determined

114 diacylglyceryl-hydroxymethyl-trimethyl-beta-alanine and phosphatidyldimethylpropanethiol, both hallm

115 sildenafil, including decreased amino acids (alanine and proline; median change [25th-75th], -38.26 [

116 ased concentrations of 3-hydroxybutyrate and alanine and reduced concentrations of mannose and urea w

117 2.47 and 4.53, which are highly conserved as alanine and serine, respectively.

118 tination and Rqc2p-mediated Carboxy-terminal Alanine and Threonine (CAT) tail elongation-can be recap

119 nt polypeptide by adding a carboxyl-terminal alanine and threonine (CAT) tail through a noncanonical

120 iphatic- and aromatic-substituted thioureayl alanines and aromatic-substituted amino tetrazolyl alani

121 tabolites (eg malonate, phenylacetylglycine, alanine) and mucosal immunoglobulin (IgM) and cytokine (

122 fferences are noted with respect to lactate, alanine, and CO2 production.

123 lymorphisms encode functional (PAV: proline, alanine, and valine at positions 49, 262, and 296, respe

124 Products of the reaction of OPA with alanine are detected in single droplets using paper spra

125 We also found no effects with alanine, arginine, or a mixture of both amino acids.

126 ores more readily germinate in response to l-alanine as a co-germinant.

127 Glutamine serves, with alanine, as a major nontoxic interorgan ammonia carrier.

128 for determination of six amino acids namely (alanine, asparagine, glutamine, proline, serine and vali

129 e, leucine, iso-leucine; aminoacyl-tRNA; and alanine, aspartate, glutamate.

130 t glutamic acid is a nitrogen acceptor while alanine, aspartic acid and proline are nitrogen donors i

131 s were noticed in the case of glutamic acid, alanine, aspartic acid and proline between cancer and he

132 ion is not suppressed by a substitution of D-alanine at Gly77, even though this modification is belie

133 mino acid substitution from aspartic acid to alanine at position 168 (D168A) reduced the potency of g

134 be predicted by the presence of a lysine or alanine at residue 240.

135 s of unnatural amino acids, amino tetrazolyl alanines ((ATz)Ala = Ata), in a very good yield was subs

136 SM residues Phe-35/Ser-37/Leu-65/Ile-69 into alanine, based on the key residues in Deg1, blunted SM c

137 .Of the 10 dietary biomarkers analyzed, beta-alanine (beef) (P-raw < 0.001), alkylresorcinols C17 and

138 s in melanoidins formed from d-glucose and l-alanine between 130 and 200 degrees C.

139 beta-methylamino-L-alanine (BMAA) has been linked to several interrelated n

140 beta-N-Methylamino-L-alanine (BMAA), a probable cause of the amyotrophic late

141 Truncation of these residues to alanine causes significant falloffs in TIM's catalytic a

142 low concentration of amino acids (threonine, alanine, citrulline and GABA) and organic acids (malic a

143 codon 110 and the arginine at codon 111 with alanine codons failed to replicate, and the pUL33 mutant

144 the arginine-containing dipeptides, but not alanine-containing dipeptides, produces toxic phenotypes

145 action of the PTC inhibitor madumycin II, an alanine-containing streptogramin A antibiotic, in the co

146 tudies here we show that the inhibition of D-alanine:D-alanine ligase by the antibiotic D-cycloserine

147 biosynthesis enzymes: alanine racemase and D-alanine:D-alanine ligase.

148 Mutation of these amino acids to alanine decreased affinity of NMS for the allosteric bin

149 Mutation of these leucines to alanines decreased the magnitude of arrestin-mediated si

150 tion and catalytic loops, respectively, with alanine dramatically changed PI3Kalpha kinetics.

151 int mutation converting lysine 44 of Dyn2 to alanine (Dyn2K44A) disrupts its GTPase activity.

152 is study, the colorimetric discrimination of alanine enantiomers is examined and, more importantly, A

153 odel of OPMD (Pabpn1+/A17) that contains one alanine-expanded Pabpn1 allele under the control of the

154 tify proteins that could be sequestered with alanine-expanded PABPN1 in the nuclear aggregates found

155 logy in the presence of endogenous levels of alanine-expanded PABPN1.

156 s have employed transgenic overexpression of alanine-expanded PABPN1.

157 rotein that was degraded in vivo Mutation to alanine gave milder effects but still strongly diminishe

158 d these enzymes are thought to convert the l-alanine germinant into d-alanine, a spore germination in

159 Only alanine, glutamate, isoleucine, and valine, but not leuc

160 ine, phenylalanine, valine, GABA, glutamine, alanine, glycine and taurine were separated and detected

161 ing branched-chain and aromatic amino acids (alanine, glycine, histidine, phenylalanine, leucine, iso

162 abolism, arises from mutations in the enzyme alanine-glyoxylate aminotransferase.

163 inked to disease: cancer-associated NQO1 and alanine:glyoxylate aminotransferase, mutated in primary

164 e when an ancestral threonine was mutated to alanine, greatly increasing resistance to DCV.

165 It is important to note that alanine has a significantly higher concentration than ar

166 effects, mutation of the cysteine residue to alanine has minor effects on overall protein function.

167 Mutants with 3-5 residues changed to alanine have no measurable differences from wild-type IL

168 the pore-lining transmembrane helix S6 at an alanine hinge just below the selectivity filter.

169 in van der Waals contact with a conserved di-alanine in AP-1 dimer (Ala265 and Ala266 in Jun), or wit

170 efficiency of the LIS device for detecting L-Alanine in human serum.

171 and sixfold increase in (13)C enrichment of alanine in KATPHI islets, suggesting increased rates of

172 can be reversed by substituting glycine for alanine in position 2, forming [YG(L)PAA+H](+).

173 Mutation of D836 to alanine in the activation loop of phosphorylation site m

174 inhibition or the exchange of threonine for alanine in the C-terminal PDZ-binding motif conferred DA

175 ubiquitously conserved residue leucine 29 to alanine in the pore-forming region increased its single-

176 The reaction of o-phthalaldehyde (OPA) with alanine in the presence of dithiolthreitol is measured u

177 y 40% in response to insulin exposure, while alanine increased by 46% and taurine increased by 37%.

178 We tested TrpC3 null mice for beta-alanine induced itch, and found that these mice exhibit

179 ate that mouse TrpC3 is dispensable for beta-alanine-induced acute itch.

180 esized that Alr2 could affect C. difficile l-alanine-induced spore germination in a defined medium.

181 ular level, calcium influx triggered by beta-alanine is also unchanged in cultured DRG neurons from T

182 Of these, l-alanine is an effective co-germinant and is also a germi

183 ylic acid (Aze), a dual mimic of proline and alanine, is activated by both human prolyl- and alanyl-t

184 765-2R framework, replacing this lysine with alanine (K265A), glutamic acid (K265E) or glutamine (K26

185 Metformin increases alanine levels and reduces the phospholipid content in v

186 cose metabolism showed a twofold increase in alanine levels and sixfold increase in (13)C enrichment

187 tients (28.89% versus 38.79%; P=7.5x10(-5)); alanine levels were higher in the metformin group (0.46

188 e we show that the inhibition of D-alanine:D-alanine ligase by the antibiotic D-cycloserine proceeds

189 is enzymes: alanine racemase and D-alanine:D-alanine ligase.

190 Glutamic acid and alanine make up more than 60 per cent of the total amino

191 However, l-glutamine and l-alanine model reactions showed the same browning index.

192 Alanine mutagenesis of each of the six phosphorylation s

193 Alanine mutagenesis of some of these residues disrupted

194 etail by NMR and confirmed by truncation and alanine mutagenesis.

195 Overexpression of the YBX1-S176A (serine-to-alanine) mutant in either HEK293 cells or colon cancer H

196 Therefore, we analyzed NiV F CT deletion and alanine mutants and report that several but not all regi

197 ine alone, or in combination with an E181-to-alanine mutation (D62A E181A), dramatically reduced the

198 egion of M2, and in particular a tyrosine-to-alanine mutation at residue 76 (Y76A), were essential fo

199 A cysteine-to-alanine mutation in LLO rendered the protein completely

200 Comprehensive alanine mutational analysis across 553 residues of E1E2

201 ine phosphatases (PTP) by creation of single alanine mutations in the catalytic acid loop of PTP1B an

202 Alanine mutations on the hydrophilic face of the helix s

203 nduced membrane fusion since mutating N58 to alanine (N58A) caused extensive virus-induced cell fusio

204 explored unnatural amino acid, isothiocyanyl alanine ((NCS)Ala = Ita), for the synthesis of another c

205 Mutation of these residues one at a time to alanine or a combination of all four (mPDE-4A) affected

206 utants with both an ITIM mutation and either alanine or arginine substitutions had reduced titers and

207 tration (70 [19%] vs one [1%]) and increased alanine or aspartate aminotransferase concentration (39

208 ble increased concentrations of asymptomatic alanine or aspartate aminotransferase, or gamma-glutamyl

209 identified phosphorylation sites with either alanine or aspartate residues.

210 m-domain of cMyBP-C were replaced by either alanine or aspartic acid, mimicking the fully nonphospho

211 Mutation of E73 to either alanine or glutamine severely reduces oligomerization, d

212 , we substituted each amino acid residue for alanine or more conservative residues, glutamine or aspa

213 icial honey with 2000mg/kg of DHA and either alanine or proline and alanine added.

214 he selenocysteine can be deselenized into an alanine or serine, resulting in nonselenoproteins.

215 PR) compared with the lowest-affinity double-alanine peptide (Kd(app) = 3.8 mum).

216 tution of the D1 residue at position 87 with alanine perturbs the chloride-binding site in the proton

217 r double mutation of Ser-1916 or Ser-1943 to alanine potently blocks recruitment of GFP-NM-IIA filame

218 m Synechocystis sp. PCC 6803 (wildtype) with alanine, present in higher plants, or with aspartic acid

219 rines in SR/RS clusters are substituted with alanines, primarily localizes to the cytoplasm in buddin

220 ere fitted first, then multiple perturbants (alanine, proline and iron, and combinations of these) we

221 nstead, the (L)P stereocenter promotes a cis-alanine-proline amide bond.

222 Mutation of the distal His(64) residue to alanine promotes rapid binding of H2S and its efficient

223 Mutating Gln-282 to alanine (Q282A) doubled the Km(app) for 2-deoxy-d-glucos

224 rug phosphoramidate diastereochemistry (D-/L-alanine, R-/S-phosphoryl) in vitro and in vivo.

225 ell wall peptidoglycan biosynthesis enzymes: alanine racemase and D-alanine:D-alanine ligase.

226 Many endospore-forming bacteria embed alanine racemases into their spore coats, and these enzy

227 Mechanistically, IAFGP binds the terminal d-alanine residue of the pentapeptide chain of bacterial p

228 Replacement of the LIZ with alanine resulted in dramatically reduced TM-TM associati

229 ng the effector domain (ED) of myristoylated alanine-rich C kinase substrate (MARCKS) which interacts

230 The release of phosphorylated myristoylated alanine-rich C kinase substrate and its subsequent diffu

231 e show that phosphorylation of myristoylated alanine-rich C kinase substrate by membrane-localized PK

232 ein kinase C substrate MARCKS (myristoylated alanine-rich C kinase substrate) as a potential target m

233 ed that the phosphorylation of Myristoylated alanine-rich C-kinase substrate (MARCKS) and LAMC2 prote

234 binding domain of the protein myristoylated alanine-rich C-kinase substrate (MARCKS) bind to phospha

235 ase 4 (WNK4) and STE20/SPS1-related, proline alanine-rich kinase (SPAK) in human urinary exosomes.

236 ase phosphorylation of Ste20-related proline/alanine-rich kinase (SPAK), a kinase that directly phosp

237 WNK signaling pathway, Ste20-related proline-alanine-rich kinase (SPAK).

238 ates the kinases SPAK (Ste20-related proline alanine-rich kinase) and OSR1 (oxidative stress responsi

239 hosphorylation site (serine 2814) mutated to alanine (S2814A).

240 as abolished by the mutation of serine 32 to alanine (S32A).

241 Using a systematic alanine scan approach, fluorescence spectroscopy, and ot

242 finely mapped using recombinant viruses and alanine scan mutation array techniques.

243 causing variation, we performed a systematic alanine-scan mutagenesis of FoxP3, assessing mutational

244 s is also in line with systematic, in silico Alanine scanning free-energy simulations, which indicate

245 In this work, we performed alanine scanning mutagenesis of aromatic residues locate

246 Alanine scanning mutagenesis was performed for the resid

247 nal mutagenesis, carbohydrate shielding, and alanine scanning mutagenesis.

248 Alanine scanning mutation of Epep revealed residues crit

249 Finally, alanine scanning of CDR1 and CDR2 sequences of TRBV4-1 r

250 Alanine scanning revealed that hydrophobic amino acids i

251 Through alanine scanning, immunofluorescence cell staining and c

252 Alanine-scanning assays suggested the absence of known h

253 Alanine-scanning mutagenesis revealed that the affinitie

254 An unbiased alanine-scanning screen covering the entire region combi

255 photochemical oxidation of proteins (FPOP), alanine shave mutagenesis, and binding analytics.

256 ive phosphorylation residues were mutated to alanine showed that serine 93 is a site of phosphorylati

257 s of N-H, C-N, and C-H oscillations in the l-alanine spectrum are prone to inhomogeneous broadening i

258 e analysis of knock-in mice with cysteine-to-alanine substitution at the palmitoylated residues (4CA

259 An alanine substitution for Ile-85 specifically interfered

260 ting phosphorylation of the S936-TRP site by alanine substitution in transgenic Drosophila (trp(S936A

261 Alanine substitution of E171 (within the consensus motif

262 Disruption of the-fold by d-alanine substitution of the conserved central Gly(6)-Gln

263 Alanine substitution of the phosphorylation site Thr166

264 nsitive version of PAH1 with a serine 162 to alanine substitution represses PC biosynthesis and also

265 IL-23 mutant differs from wild-type by five alanine substitutions and represents the dominant energe

266 Previous analysis of leucine and alanine substitutions at the Val-65-equivalent site (Val

267 Single alanine substitutions for Ser-497, Thr-500, Ser-502, Ser

268 Consistent with these results, the alanine substitutions in the viral genome caused exagger

269 dues was necessary for fusion regulation, as alanine substitutions induced a 440% increase in fusion

270 d transgenic mice expressing an alpha1C with alanine substitutions of all conserved serine or threoni

271 Alanine substitutions of key residues in the interface s

272 at low-glycine levels which is alleviated by alanine supplementation.

273 n amino acid sequence including several beta-alanines that occurred in a repeating alphaalphabeta mot

274 and Ser-113 (in PiT2), were substituted with alanine, the PiT1-PiT2 heterodimerization was no longer

275 tors of ATP-PRT and identify 3-(2-thienyl)-L-alanine (TIH) as an allosteric activator of this enzyme.

276 periment revealing that in one case a single alanine to glycine point mutation suffices to more than

277 eptor activation, we designed point-mutants (alanine to phenylalanine) in the predicted, tightly pack

278 ce carrying this mutation by introducing the alanine to threonine mutation at position 778 of mouse H

279 ation in the APP gene that corresponds to an alanine to valine substitution at position 673 in APP (A

280 aemia than the FSS13025 strain because of an alanine-to-valine amino acid substitution at residue 188

281 We use (13)C alanine tracers to quantify this back-flux in single and

282 enzymatic assay targets alanine and employs alanine transaminase (ALT), pyruvate oxidase (POx), and

283 events occurred in 84% of neutropenia (32%), alanine transaminase increase (20%), aspartate transamin

284 = 2 x 10(-10)) was associated with levels of alanine transaminase, an indicator of liver damage.

285 like total leucocyte count, urea, bilirubin, alanine transaminase, aspartate transaminase, internatio

286 reater inflammatory cell infiltration, serum alanine transaminase, expression of hepatic inflammatory

287 ntent correlated with waist-to-height ratio, alanine transaminase, uric acid, serum triglycerides, an

288 r BMI, waist circumference, waist-hip ratio, alanine transaminase, white blood cell count and lower h

289 r class of unnatural amino acids, thioureayl alanines ((TU)Ala = Tua).

290 IAS derivatives bearing the (S) alanine unit, (S)-23, (S,R)-25, (S)-31, and (S)-33, were

291 d 296, respectively) or non-functional (AVI: alanine, valine, isoleucine at positions 49, 262, and 29

292 ide chains are tolerated including those for alanine, valine, leucine, methionine, lysine, phenylalan

293 rget genes in four metabolism pathways: beta-alanine; valine, leucine, iso-leucine; aminoacyl-tRNA; a

294 L. monocytogenes expressing the cysteine-to-alanine variant of LLO was able to infect and replicate

295 nd dose groups, while glucose, pyruvate, and alanine varied.

296 es and aromatic-substituted amino tetrazolyl alanines were successfully synthesized in good to excell

297 bumin, neurotensin, creatinine, glycine, and alanine) were retained in the samples for subsequent ana

298 rprisingly, in AOX1A, replacement of CysI by alanine, which cannot form a (thio)hemiacetal, led to ev

299 he bimolecular rate constant for reaction of alanine with OPA is found to be 84 +/- 10 and 67 +/- 6 M

300 ucose model reactions with l-glutamine and l-alanine yielded similar colored solutions.