ライフサイエンスコーパス: alcohol dependence

1 ntribute to various deficits associated with alcohol dependence.

2 ssociated with the psychological symptoms of alcohol dependence.

3 ion in the prefrontal cortex in persons with alcohol dependence.

4 sly unidentified target in the management of alcohol dependence.

5 -to-brain interactions in the development of alcohol dependence.

6 eversible, minimally invasive treatments for alcohol dependence.

7 efforts aimed at reducing the occurrence of alcohol dependence.

8 plicated in psychiatric disorders, including alcohol dependence.

9 inhibition is a key feature of patients with alcohol dependence.

10 educing alcohol consumption in patients with alcohol dependence.

11 p), may moderate naltrexone (NTX) effects in alcohol dependence.

12 l is a promising target for the treatment of alcohol dependence.

13 plays a critical role in the development of alcohol dependence.

14 tion of mood symptoms with the occurrence of alcohol dependence.

15 mmercial development of medications to treat alcohol dependence.

16 ecently been approved in Europe for treating alcohol dependence.

17 ution in schizophrenia, major depression and alcohol dependence.

18 issues in the conduct of clinical trials in alcohol dependence.

19 may be an early index of neuroadaptation in alcohol dependence.

20 in human brain, some of which contribute to alcohol dependence.

21 ticipants, consistent with prior findings in alcohol dependence.

22 r in people with a family history of drug or alcohol dependence.

23 rate stress resilience and susceptibility to alcohol dependence.

24 identifying genetic variants associated with alcohol dependence.

25 or patients with co-occurring depression and alcohol dependence.

26 1q have been implicated in human studies of alcohol dependence.

27 usly associated with increased risk of adult alcohol dependence.

28 isease in Mestizo subjects with a history of alcohol dependence.

29 terations in the binding to NOP receptors in alcohol dependence.

30 ymptoms; 254 participants were found to have alcohol dependence.

31 combinations for the outpatient treatment of alcohol dependence.

32 d receptor, are associated with the risk for alcohol dependence.

33 least part of the association of OPRK1 with alcohol dependence.

34 lar to those observed following a history of alcohol dependence.

35 that has been performed for the treatment of alcohol dependence.

36 te individual differences in the etiology of alcohol dependence.

37 receptor antagonist used to treat opiate and alcohol dependence.

38 ications could be useful in the treatment of alcohol dependence.

39 disability was particularly associated with alcohol dependence.

40 varenicline may prove to be a treatment for alcohol dependence.

41 Topiramate is a promising treatment for alcohol dependence.

42 t ethanol treatment, which leads to signs of alcohol dependence.

43 ol-dependent patients than for those without alcohol dependence.

44 ,222 (12.2%) had a diagnosis consistent with alcohol dependence.

45 mate is a safe and efficacious treatment for alcohol dependence.

46 rventions have some benefits for people with alcohol dependence.

47 redicted only by ADHD probands with comorbid alcohol dependence.

48 d documenting association of NRXN3 SNPs with alcohol dependence.

49 IP is a promising candidate for treatment of alcohol dependence.

50 present a therapeutic target for alleviating alcohol dependence.

51 orders, Fourth Edition, diagnoses of primary alcohol dependence.

52 factor for excessive alcohol consumption and alcohol dependence.

53 vels and subsequent reduction in the risk of alcohol dependence.

54 ut alterations in nociceptin transmission in alcohol dependence.

55 ects of acute ethanol and the development of alcohol dependence.

56 d with an improved response to naltrexone in alcohol dependence.

57 contribute to the behavioral consequences of alcohol dependence.

58 riatal dopamine release and D2R binding with alcohol dependence.

59 brain regions that play a functional role in alcohol dependence.

60 rs in rats 3 weeks into abstinence following alcohol dependence.

61 g that high D2R function may protect against alcohol dependence.

62 ether nicotine facilitates the transition to alcohol dependence.

63 a that is recruited during the transition to alcohol dependence.

64 in the development of pharmacotherapies for alcohol dependence.

65 nd molecular changes induced by a history of alcohol dependence.

66 on, likely contributing to the transition to alcohol dependence.

67 dict the response to naltrexone treatment of alcohol dependence.

68 g the neuroimmune system as therapeutics for alcohol dependence.

69 or occasionally using alcohol and those with alcohol dependence.

70 ent evidence for the involvement of XRCC5 in alcohol dependence.

71 ir presynaptic afferents in the evolution of alcohol dependence.

72 emotional and motivational state observed in alcohol dependence.

73 nce had to meet the criteria from DSM-IV for alcohol dependence.

74 that drives excessive alcohol consumption in alcohol dependence.

75 ANP might be involved in the symptomology of alcohol dependence.

76 , 7.9%; posttraumatic stress disorder, 9.8%; alcohol dependence, 11.2%; and nonalcohol psychoactive s

77 D was found among 30.1% of participants with alcohol dependence, 30.8% with cannabis use disorder, an

78 Alcohol dependence (AD) and major depression (MD) are le

79 meeting current diagnostic criteria for both alcohol dependence (AD) and PTSD were randomly assigned

80 ns (EAs) affected with substance dependence [alcohol dependence (AD) and/or drug dependence (DD)] and

81 Major depressive disorder (MDD) and alcohol dependence (AD) are heritable disorders with sig

82 Studies of alcohol dependence (AD) have consistently found evidence

83 and aldehyde dehydrogenase (ALDH) genes and alcohol dependence (AD) have long been studied in many p

84 We report a GWAS of alcohol dependence (AD) in European-American (EA) and Af

85 Alcohol dependence (AD) is a common, chronic, relapsing

86 Alcohol dependence (AD) is a multiorgan disease in which

87 Randomized trials of medications for alcohol dependence (AD) often report no differences betw

88 sociation studies in the literature with two alcohol dependence (AD) samples, including 1691 cases an

89 espite a significant genetic contribution to alcohol dependence (AD), few AD-risk genes have been ide

90 terplay of risky sexual behaviors (RSBs) and alcohol dependence (AD), we conducted genome-wide gene-b

91 orders, Fourth Edition (DSM-IV) criteria for alcohol dependence (AD), we conducted structural equatio

92 AS) data sets reported several risk loci for alcohol dependence (AD), which have not yet been well re

93 m to identify novel genes affecting risk for alcohol dependence (AD).

94 rning the association of the DRD2 locus with alcohol dependence (AD).

95 g dependence (DD) is commonly co-morbid with alcohol dependence (AD).

96 as environmental factors in the etiology of alcohol dependence (AD).

97 To determine the association between alcohol dependence (alcoholism not in remission and/or a

98 d region on chromosome 4q has been linked to alcohol dependence (alcoholism).

99 Patients with alcohol dependence also had fewer hospital-free days.

100 modafinil as an adjunct in the treatment of alcohol dependence, although clinical studies are needed

101 We explored genetic influences on alcohol dependence among 1,897 European-American and Afr

102 Drinkers at risk for alcohol dependence among the 43 093 adults surveyed in 2

103 MGLUR5 have the greatest relevance for human alcohol dependence among the genes selected with odds ra

104 n NR2A have the greatest relevance for human alcohol dependence among the glutamatergic genes selecte

105 Sixteen participants with alcohol dependence and 16 healthy control subjects under

106 bstance-naive youth with a family history of alcohol dependence and 20 well-matched controls without

107 ission in 21 recently abstinent persons with alcohol dependence and 21 matched healthy comparison sub

108 population of 1333 male patients with severe alcohol dependence and 939 controls.

109 By contrast, a detailed review of alcohol dependence and a briefer review of major depress

110 neurocircuitry may be a major consequence of alcohol dependence and a key pathophysiological mechanis

111 iched for genome-wide association signals in alcohol dependence and a meta-analysis of alcohol self-a

112 Alcohol dependence and alcohol abuse or harmful use caus

113 ay be involved in the molecular processes of alcohol dependence and comorbidity of anxiety and alcoho

114 he DYN/KOR system is heavily dysregulated in alcohol dependence and contributes to the excessive alco

115 st a role for ghrelin in the neurobiology of alcohol dependence and craving.

116 Both alcohol dependence and drug dependence bred true in fami

117 inking medical inpatients with treatment for alcohol dependence and for changing alcohol consumption.

118 comprehensive miRNA expression data set for alcohol dependence and identify the causal miRNAs for al

119 mptoms is associated with the development of alcohol dependence and its persistence once dependence d

120 calisation of tracts potentially affected in alcohol dependence and its recovery.

121 appears to be involved in the development of alcohol dependence and may represent a potential pharmac

122 traumatic stress disorder, and past 12-month alcohol dependence and nonalcohol psychoactive substance

123 ed in four groups (n = 22): individuals with alcohol dependence and periodontitis (ADP), individuals

124 Cigarette smoking predicts more severe alcohol dependence and poorer treatment response in gene

125 ld underlie the behavioral manifestations of alcohol dependence and potentially contribute to the pat

126 In this study of patients with alcohol dependence and PTSD, naltrexone treatment result

127 nt role of the CeA in the pathophysiology of alcohol dependence and represents a new potential avenue

128 nce is probably inapplicable to persons with alcohol dependence and selective reporting may have occu

129 -Penn genetic studies of opioid, cocaine and alcohol dependence and the Study of Addiction: Genetics

130 function often observed in those at risk for alcohol dependence and those who develop alcohol use dis

131 mediator of behavioral stress responses, in alcohol dependence and treatment.

132 ree patients who met the DSM-IV criteria for alcohol dependence and who were admitted for medically s

133 our results can facilitate human research on alcohol dependence and withdrawal.

134 ce and periodontitis (ADP), individuals with alcohol dependence and without periodontitis (ADNP), ind

135 penditure, peak blood alcohol concentration, alcohol dependence, and access to help and information.

136 There is a large treatment gap in alcohol dependence, and current treatments are only mode

137 r ADHD, psychoactive substance use disorder, alcohol dependence, and drug dependence after stratifyin

138 conduct disorder, adult antisocial behavior, alcohol dependence, and drug dependence) on childhood di

139 as alterations in pain sensitivity, drug and alcohol dependence, and social behaviors.

140 sion, diabetes, obesity, dyslipidemia, gout, alcohol dependence, and tobacco use).

141 der, and married; an earlier age of onset of alcohol dependence; and self-reported depression symptom

142 e, attention-deficit hyperactivity disorder, alcohol dependence, anorexia nervosa, autism spectrum di

143 ts in GABRA2 have been associated with adult alcohol dependence as well as phenotypic precursors, inc

144 gnoses of depression, anxiety disorders, and alcohol dependence at age 45; psychological distress and

145 ssociated with an increased odds of incident alcohol dependence at follow-up (adjusted odds ratio [AO

146 processes associated with the transition to alcohol dependence at the molecular level.

147 -0.15] for two levels), and among those with alcohol dependence at Wave 1 (0.29 [0.15-0.57] for one l

148 level predicted significantly lower odds of alcohol dependence at Wave 2, particularly among very-hi

149 nking risk levels between Waves 1 and 2, and alcohol dependence at Wave 2.

150 l consumption (WHO drinking risk levels) and alcohol dependence (at least three of seven DSM-IV crite

151 al medications have been approved for use in alcohol dependence but have only limited effectiveness a

152 ve been implicated in the pathophysiology of alcohol dependence, but the specific molecular mechanism

153 we applied our methods to a family study of alcohol dependence (COGA) and performed individual genot

154 cent trial for comorbid major depression and alcohol dependence, combination treatment with a medicat

155 eiotropic genes contributing to the risk for alcohol dependence commonly expressed by four correlated

156 Alcohol dependence comorbid with posttraumatic stress di

157 -American and African-American subjects with alcohol dependence compared with 1,932 unrelated, alcoho

158 variant has the strongest effect on risk for alcohol dependence compared with any other tested varian

159 and women aged 18 to 65 years diagnosed with alcohol dependence, conducted between January 27, 2004,

160 se to naltrexone hydrochloride treatment for alcohol dependence could improve clinical care for patie

161 For alcohol, we provide data on alcohol dependence, damage to families, and the document

162 OEt were recently identified as relevant for alcohol dependence, DCUK-OEt should be further evaluated

163 Alcohol dependence disrupts this LTCC-based mechanism; i

164 dings suggest that poor treatment outcome in alcohol dependence does not simply result from a shift f

165 Naltrexone, an efficacious medication for alcohol dependence, does not work for everyone.

166 rapy for the treatment of mood disorders and alcohol dependence, drugs such as LSD showed initial the

167 riate management includes measures to reduce alcohol dependence (eg, behavioral or pharmacological th

168 Consistent with this finding, alcohol dependence enhanced the intrinsic excitability o

169 th alcohol intake levels in BXD strains, and alcohol dependence enhanced the strength of this associa

170 Alcohol dependence exacts a toll on brain white matter m

171 Mood disorders and alcohol dependence frequently co-occur.

172 Yale-Penn study of the genetics of drug and alcohol dependence from February 14, 1999, to January 13

173 ons endorsing psychiatrists for treatment of alcohol dependence (from 61% in 1996 to 79% in 2006) and

174 Collectively, our data indicate that alcohol dependence functionally alters the molecular mec

175 306),>/=18 years of age, with a diagnosis of alcohol dependence,>/=6 heavy drinking days, and average

176 Participants diagnosed with alcohol dependence had to meet the criteria from DSM-IV

177 fifty-two treatment-seeking individuals with alcohol dependence, half preselected to carry at least o

178 ity of large cohort samples for nicotine and alcohol dependence has resulted in significant progress

179 Alcohol dependence has traditionally been considered a b

180 scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample also provided its st

181 complex for association with a diagnosis of alcohol dependence in a human population identified alle

182 een implicated as a vulnerability factor for alcohol dependence in a number of studies and reviews.

183 n the CAMK2A gene for their association with alcohol dependence in a population of 1333 male patients

184 ative Study of the Genetics of Alcoholism on alcohol dependence in a sample of moderate-size pedigree

185 on associated with psychological symptoms of alcohol dependence in alcohol-dependent subjects.

186 ors associated with remission from DSM-III-R alcohol dependence in an American Indian community group

187 haplotype was also associated with increased alcohol dependence in an independent European cohort.

188 re associated with a quantitative measure of alcohol dependence in both African Americans and Europea

189 c and Statistical Manual of Mental Disorders Alcohol Dependence in COGA AA families, and two (rs13093

190 suggests an involvement of CB1 receptors in alcohol dependence in humans.

191 e the efficacy of contingency management for alcohol dependence in outpatients with serious mental il

192 essive alcohol drinking and somatic signs of alcohol dependence in rats.

193 latives irrespective of ADHD status, whereas alcohol dependence in relatives was predicted only by AD

194 g the genetic association of this locus with alcohol dependence in several populations.

195 2 locus has been found to be associated with alcohol dependence in several studies, but no functional

196 ant interaction between the intervention and alcohol dependence in statistical models predicting drin

197 early adolescence, and development of DSM-IV alcohol dependence in young adulthood.

198 RA2, a gene previously associated with adult alcohol dependence, in a community sample of children fo

199 p effects were found except among those with alcohol dependence, in whom CCM was associated with fewe

200 increased negative affect, other symptoms of alcohol dependence include compromised impulse control.

201 r another genetic variant linked to it, with alcohol dependence indicates a multigene causality for t

202 Recent data indicate that alcohol dependence induces long-term neuroadaptations th

203 of naltrexone vs placebo in individuals with alcohol dependence (intent-to-treat analysis).

204 Alcohol dependence is a chronic relapsing illness; stres

205 Alcohol dependence is a common, complex and debilitating

206 Alcohol dependence is a complex disorder that initiates

207 Alcohol dependence is a disease that impacts millions of

208 Alcohol dependence is a heterogeneous psychiatric disord

209 Physiological alcohol dependence is a key adaptation to chronic ethano

210 Alcohol dependence is a major public health challenge in

211 Alcohol dependence is associated with a widespread reduc

212 Alcohol dependence is associated with impaired control o

213 Alcohol dependence is associated with inhibitory control

214 Alcohol dependence is associated with time-dependent cha

215 Alcohol dependence is characterized by excessive consump

216 cutely increases GABA release in the CeA and alcohol dependence is characterized by increased baselin

217 A key deficit in alcohol dependence is disrupted prefrontal function lead

218 dify responsiveness to pharmacotherapies for alcohol dependence is important for treatment planning.

219 Alcohol dependence is independently associated with seps

220 rs, whereas the association between ADHD and alcohol dependence is most consistent with the hypothesi

221 Alcohol dependence is often untreated.

222 als, but their potential role in humans with alcohol dependence is poorly understood.

223 des the full spectrum from risky drinking to alcohol dependence, is a leading cause of preventable de

224 fied a functional role of DNA methylation in alcohol dependence-like behavioral phenotypes and a cand

225 I present four paradigmatic cases involving alcohol dependence, major depression, general externaliz

226 on to factors associated with remission from alcohol dependence may be important in designing more ef

227 symptoms in individuals with depression and alcohol dependence, most studies have not found antidepr

228 medications for depression (sertraline) and alcohol dependence (naltrexone) in treating patients wit

229 Hazards for alcohol dependence, nicotine dependence, and nondependen

230 mood, anxiety, and personality disorders and alcohol dependence (odds ratios, 2.1-4.8) were reduced i

231 ificant associations between CAMK2A SNPs and alcohol dependence, one of which in an autophosphorylati

232 whom had at least one member diagnosed with alcohol dependence or abuse, carriers for the G allele i

233 ALDH2 on lifetime measures, such as risk of alcohol dependence, our study adds further evidence of t

234 Generalized anxiety disorder (P = 0.003) and alcohol dependence (P = 0.02) were five times more likel

235 [(11)C]PBR28 data revealed a main effect of alcohol dependence (P=0.034), corresponding to 10% lower

236 Here, we found that a history of alcohol dependence persistently decreased the expression

237 outpatients with serious mental illness and alcohol dependence receiving treatment as usual complete

238 Alcohol dependence recruits neurons in the central nucle

239 Alcohol dependence reduces CeA LTCC membrane abundance a

240 d jcBNST LTP-IE in animals with a history of alcohol dependence; repeated, but not acute, administrat

241 d the associations of NF1 polymorphisms with alcohol dependence risk and severity in humans.

242 or = 60 years vs 18-29 years), and lifetime alcohol dependence (RR, 1.34; 95% CI, 1.14-1.57).

243 levels in the hippocampus and striatum with alcohol dependence severity (P<0.035).

244 ngly correlated (R(2) = 0.48, P < .001) with alcohol dependence severity.

245 bstance-naive youth with a family history of alcohol dependence show less frontoparietal functional c

246 Youth with a family history of alcohol dependence showed significantly less functional

247 Individuals with alcohol dependence showed worse periodontal status and h

248 cotherapies and Behavioral Interventions for Alcohol Dependence) study, a randomized, double-blind pl

249 m that may be required for the transition to alcohol dependence, suggesting that focusing on the neur

250 urobiological mechanism that is required for alcohol dependence, suggesting that targeting dependence

251 f53 that are strongly associated with DSM-IV alcohol-dependence symptom counts (P=4.5 x 10(-8), infla

252 NPs) and haplotypes were more likely to have alcohol dependence symptoms (rs279858, P=0.01; rs279826,

253 on Test (indication of alcohol-related harm, alcohol dependence symptoms, or score >/=8).

254 type, measured in all individuals: number of alcohol-dependence symptoms endorsed (symptom count (SC)

255 or binding was 20-30% lower in patients with alcohol dependence than in control subjects in all brain

256 BS) have a higher risk of inpatient care for alcohol dependence than those who have undergone restric

257 e central role of chromatin modifications in alcohol dependence that integrates epigenetic regulation

258 a novel neurosurgical treatment modality for alcohol dependence that is reversible and externally tit

259 ress the unmet medical need in patients with alcohol dependence that need to reduce their alcohol con

260 WS) is a potentially fatal outcome of severe alcohol dependence that presents a significant challenge

261 ation of monetary rewards and impulsivity in alcohol dependence, the current study explored whether a

262 Standard criteria for alcohol dependence-the more severe disorder-can be used

263 Together with findings in alcohol dependence, these results suggest that impulsive

264 ' for the performance of clinical trials for alcohol dependence, they vary considerably, in the type

265 s are critical factors in the development of alcohol dependence through the dysregulation of a set of

266 ome-wide association studies recently showed alcohol dependence to be associated with a single-nucleo

267 ria for schizophrenia, major depression, and alcohol dependence to explore whether more of the public

268 es ranged from 0.070 (between drug abuse and alcohol dependence) to 1.032 (between drug abuse and dys

269 Alcohol dependence treatment may include medications, be

270 We scanned 18 male in-patients with alcohol dependence twice, within 3-7 days of admission f

271 symptoms with incident and persistent DSM-IV alcohol dependence using logistic regression and the pro

272 and CREB were analyzed for association with alcohol dependence using multivariate statistical analys

273 lvement of the GATA4 gene in the etiology of alcohol dependence via its influence on ANP and amygdala

274 nd 4.7%; prevalence of lifetime and 12-month alcohol dependence was 12.5% and 3.8%.

275 Alcohol dependence was also associated with septic shock

276 Genetic association with alcohol dependence was also recently shown.

277 Remission from alcohol dependence was associated with being female, old

278 Among those with liver disease and sepsis, alcohol dependence was associated with more than two-fol

279 factors with known association with sepsis, alcohol dependence was associated with sepsis.

280 rican-American case-control studies in which alcohol dependence was defined by the Diagnostic and Sta

281 a medication for depression and another for alcohol dependence was found to reduce depressive sympto

282 egional [(11)C]NOP-1A distribution volume in alcohol dependence was not significantly different compa

283 nalysis, association of hPer1 rs3027172 with alcohol dependence was shown.

284 Alcohol dependence was significantly more prevalent amon

285 Only 24.1% of those with alcohol dependence were ever treated, slightly less than

286 nd women (n=150) who met criteria for DSM-IV alcohol dependence were recruited across four sites.

287 depressive disorder, anxiety disorders, and alcohol dependence were the most common mental, neurolog

288 349 patients who met the criteria for DSM-IV alcohol dependence when they entered residential treatme

289 suggest the existence of a gut-brain axis in alcohol dependence, which implicates the gut microbiota

290 ohol meet criteria during their lifetime for alcohol dependence, which is characterized by tolerance,

291 igation as factors to identify patients with alcohol dependence who are responsive to naltrexone.

292 nking and heavy drinking in individuals with alcohol dependence whose goal was to stop drinking.

293 ir of disorders studied while comorbidity of alcohol dependence with mood, anxiety, and personality d

294 lysis in study 2 confirmed an association of alcohol dependence with NR2A (odds ratio, 2.01) but show

295 used to predict the outcome of treatment of alcohol dependence with ondansetron.

296 Comorbidity of alcohol dependence with other substance disorders appear

297 95% confidence interval (CI) 0.24, 0.48) on alcohol dependence, with genome-wide significance (6.6 x

298 All participants met DSM-IV criteria for alcohol dependence, with no concurrent psychotic or mani

299 sessive-compulsive disorder, and smoking and alcohol dependence, with promising preliminary results.

300 Naltrexone hydrochloride treatment for alcohol dependence works for some individuals but not fo