ライフサイエンスコーパス: alcohol drinking

1 ort for a neuroimmune mechanism of excessive alcohol drinking.

2 id receptor (MR) activation drive compulsive alcohol drinking.

3 ms mediate environmental changes that affect alcohol drinking.

4 an rhythmicity and explored its relevance to alcohol drinking.

5 y of the ACC during withdrawal and excessive alcohol drinking.

6 essary roles for mGluR5/Homer2/PI3K in binge alcohol drinking.

7 gh alcohol consumption (SHAC) model of binge alcohol drinking.

8 al tegmental area (VTA) negatively regulates alcohol drinking.

9 ng in a genetically selected rodent model of alcohol drinking.

10 e concentrated sweet solutions and excessive alcohol drinking.

11 gets reduces excessive and harmful levels of alcohol drinking.

12 environmental contexts associated with prior alcohol drinking.

13 with Daun02 produced a long-term decrease in alcohol drinking.

14 dependent C57BL/6J mice following 24 days of alcohol drinking.

15 g a potential mechanistic basis for habitual alcohol drinking.

16 ptations gate or drive excessive, compulsive alcohol drinking.

17 also selectively reduced aversion-resistant alcohol drinking.

18 ior and the abstinence-induced escalation of alcohol drinking.

19 gs indicated a protective effect of moderate alcohol drinking (2-30 drinks/month for women and 2-60 d

20 Binge alcohol drinking, a behavior characterized by rapid repe

21 Chronic alcohol drinking accelerates liver fibrosis in patients

22 king period was terminated by 20 min of free alcohol drinking access that achieved significant blood

23 the authors investigated whether history of alcohol drinking affected risks of NHL and multiple myel

24 ated pathways in the regulation of excessive alcohol drinking after a history of dependence.

25 reclinical animal models of either excessive alcohol drinking, alcohol-seeking, or relapse-like drink

26 he first time that Grm7 is a risk factor for alcohol drinking and a new target in addiction therapy.

27 Repeated cycles of binge alcohol drinking and abstinence are key components in th

28 Furthermore, alcohol drinking and anxiety-like behaviors in CREB-hapl

29 Associations between alcohol drinking and cardiovascular disease mortality co

30 The authors evaluated alcohol drinking and cigarette smoking in relation to ri

31 ent with mifepristone also blocked escalated alcohol drinking and compulsive responding during protra

32 ationship between plasma aldosterone levels, alcohol drinking and craving was investigated in alcohol

33 ase mortality could be confounded by diet if alcohol drinking and diet are related.

34 POE) locus modulates the association between alcohol drinking and LDL cholesterol.

35 Substantial evidence links alcohol drinking and serotonin (5-HT) functioning in ani

36 The effects of alcohol drinking and smoking on pancreatic ductal adenoc

37 ronal ensemble in the CeA reversed excessive alcohol drinking and somatic signs of alcohol dependence

38 T We examined the relationship between binge alcohol drinking and spike timing-dependent plasticity i

39 ts selectively block emotionality, excessive alcohol drinking and stress-induced reinstatement of alc

40 ed the negative association between lifetime alcohol drinking and superior frontal gyrus volume.

41 which neuroimmune pathways mediate excessive alcohol drinking and these findings will help to priorit

42 animal models were used to examine excessive alcohol drinking and to discover genes that may contribu

43 NAc and CeA is a major contributor to binge alcohol drinking and to the genetic propensity to consum

44 after a history of repeated cycles of binge alcohol drinking and withdrawal.

45 ut not in the BLA, are crucial in regulating alcohol-drinking and anxiety-like behaviors in rats.

46 on and participates in mechanisms underlying alcohol-drinking and reconsolidation of alcohol-related

47 literature showing CRF knockout (KO) induces alcohol drinking, and central administrations of CRF red

48 of sexual partners, use of hormonal creams, alcohol drinking, and condom use by a sexual partner.

49 for age, body mass index, cigarette smoking, alcohol drinking, and dietary nutrient intake, the diffe

50 were adjusted for age, sex, tobacco smoking, alcohol drinking, and hypertension.

51 evel, body mass index, status of smoking and alcohol drinking, and intracranial volume.

52 , the manner by which STDP responds to binge alcohol drinking, and its sensitivity to dopamine recept

53 DAR modulators can reduce aversion-resistant alcohol drinking, and support testing of D-serine and D-

54 autophosphorylation in the establishment of alcohol drinking as an addiction-related behavior in mic

55 Nicotine produced an early escalation of alcohol drinking associated with compulsive alcohol drin

56 Escalations in alcohol drinking associated with experiencing stressful

57 We identified far more alcohol-drinking associated bacterial species than tradi

58 ted the association of maternal and paternal alcohol drinking before and early in pregnancy with infa

59 dings indicate that the hPer1 gene regulates alcohol drinking behavior during stressful conditions an

60 s) in hPer1 were tested for association with alcohol drinking behavior in 273 adolescents and an adul

61 ification of candidate genes associated with alcohol drinking behavior in human populations.

62 e difference may contribute to the disparate alcohol drinking behavior of the P and NP rats.

63 cilitating mechanism in the establishment of alcohol drinking behavior with changing the DA-5-HT bala

64 erstanding of genetic mechanisms influencing alcohol drinking behavior.

65 ty that contributes to mechanisms underlying alcohol drinking behavior.

66 be functionally involved in, mediating high alcohol drinking behavior.

67 y involved in alcohol reinforcement and high alcohol drinking behavior.

68 d stimuli (CSs), need to be dissociated from alcohol drinking behavior.

69 amatergic neurotransmission is implicated in alcohol-drinking behavior in animal models.

70 may be associated with the predisposition to alcohol-drinking behavior seen in Lewis rats.

71 sm underlies high anxiety-like and excessive alcohol-drinking behavior.

72 ere is substantial individual variability in alcohol drinking behaviors in the population, the neural

73 a neural circuit responsible for individual alcohol drinking behaviors.

74 neuron burst activity in HAD mice decreases alcohol drinking behaviors.

75 Our findings suggest that GDNF reduces alcohol-drinking behaviors by reversing an alcohol-induc

76 sed DSD, thereby increasing anxiety-like and alcohol-drinking behaviors in control rats.

77 The present investigation evaluated alcohol-drinking behaviors in mice that are haplodeficie

78 gnaling pathway involved in anxiety-like and alcohol-drinking behaviors in rats.

79 however, the causal role of the CREB gene in alcohol-drinking behaviors is unknown.

80 n maintaining the high anxiety and excessive alcohol-drinking behaviors of P rats.

81 EB) in genetic predisposition to anxiety and alcohol-drinking behaviors using alcohol-preferring (P)

82 Anxiety-like and alcohol-drinking behaviors were measured after infusion

83 the causal role of HDAC2 in anxiety-like and alcohol-drinking behaviors.

84 in neuroadaptations that underlie excessive alcohol-drinking behaviors.

85 ntributor to molecular mechanisms underlying alcohol-drinking behaviors.

86 rocesses as well as in mechanisms underlying alcohol-drinking behaviors.

87 ol dependence and comorbidity of anxiety and alcohol-drinking behaviors.

88 molecular mechanisms underlying anxiety and alcohol-drinking behaviors.

89 f the CREB gene is associated with increased alcohol-drinking behaviors.

90 and GSK-3beta, that in turn drives excessive alcohol-drinking behaviors.

91 ubiquitous Arf6 in the PFC to modulate human alcohol-drinking behaviors.

92 vide evidence for the involvement of FGF2 in alcohol-drinking behaviors.

93 y in a part of the brain (DMS) that controls alcohol-drinking behaviors.

94 ytes isolated from healthy subjects after an alcohol drinking binge showed enhanced apoptosis (before

95 Y1R) activation in the BNST suppressed binge alcohol drinking by enhancing inhibitory synaptic transm

96 The signal was sustained during alcohol drinking by increased expression of corticotropi

97 Age, male sex, alcohol drinking, cigarette smoking, elevated alanine am

98 -inhibition task in matched heavy- and light-alcohol-drinking college students.

99 for age, race, sex, study center, education, alcohol drinking, current smoking, prevalent coronary he

100 memory impairments associated with excessive alcohol drinking during acute (24-72 h) but not protract

101 icotropin-releasing factor) are modulated by alcohol drinking during cohabitation.

102 of the glucocorticoid receptor in excessive alcohol drinking during protracted alcohol abstinence.

103 ody mass index, district, cigarette smoking, alcohol drinking, education, occupation, use of vitamin

104 Binge alcohol drinking elevated p(Ser729)-PKCepsilon levels in

105 6-April 2002) using Medical Subject Headings alcohol drinking, ethanol, cerebrovascular accident, cer

106 However, Nf1(+/-) mice failed to escalate alcohol drinking following chronic intermittent ethanol

107 exone showed only modest effects in reducing alcohol drinking for the 12 weeks of treatment.

108 A 30-day history of binge alcohol drinking (for example, 4-5 g kg(-1) per 2 h(-1))

109 ed according to age, sex, race, smoking, and alcohol drinking) for the presence of mutant p53 protein

110 suggest unique neuroadaptations between the alcohol drinking groups.

111 ctedly, VTA dopamine neuron activity in high alcohol drinking (HAD) mice does not differ from alcohol

112 Alcohol-preferring (P) rats and high alcohol-drinking (HAD) rats are selectively bred for hig

113 Alcohol drinking has been extensively studied in relatio

114 x, study center, education, tobacco smoking, alcohol drinking, hepatitis B surface antigen, and/or an

115 and that the altered pattern is specific to alcohol drinking history.

116 FTI-276, produced a robust decrease of rats' alcohol drinking; however, sucrose consumption was unalt

117 rom alcohol is causally related to excessive alcohol drinking in alcohol-dependent rats, whereas a si

118 monstrated that naltrexone (50 mg/d) reduces alcohol drinking in alcohol-dependent subjects.

119 le during abstinence significantly decreased alcohol drinking in both groups.

120 tween NPY and CRF in the regulation of binge alcohol drinking in both mice and monkeys.

121 FosB was investigated during acquisition of alcohol drinking in C57BL/6J mice.

122 alcohol drinking associated with compulsive alcohol drinking in dependent, but not in nondependent r

123 tic strategy for the treatment of compulsive alcohol drinking in humans carrying the Met66BDNF allele

124 ifically, a mouse paradigm that mimics binge alcohol drinking in humans produced a robust reduction i

125 ped a method to assess long-term patterns of alcohol drinking in mice housed in groups using the Inte

126 For long-term studies of alcohol drinking in mice we used IntelliCages.

127 are part of an endogenous system that keeps alcohol drinking in moderation.

128 during abstinence is required for excessive alcohol drinking in nondependent rats that binge drink a

129 tudies have shown that nicotine can increase alcohol drinking in nondependent rats, yet it is unknown

130 nic nicotine will speed up the escalation of alcohol drinking in rats and that this effect will be ac

131 Sustained voluntary alcohol drinking in rats has been associated with an upr

132 because increased CRF system activity drives alcohol drinking in rodents, we examined whether it pred

133 ved in neuroadaptations that drive escalated alcohol drinking in rodents.

134 le in establishing a high level of voluntary alcohol drinking in these mouse models.

135 Accordingly, alcohol drinking increased alpha-amino-3-hydroxy-5-methy

136 Alcohol drinking increased the expression of genes invol

137 Moderate alcohol drinking increases the activity and function of

138 ality was seen for frequency of non-beverage alcohol drinking independent of volume of beverage ethan

139 therapeutic targets for HCV infection and/or alcohol drinking-induced liver injury.

140 Despite the fact that binge alcohol drinking (intake resulting in blood alcohol conc

141 Binge alcohol drinking is a tremendous public health problem b

142 stulate that a genetic predisposition toward alcohol drinking is accompanied by increased responsiven

143 Alcohol drinking is an established risk factor for sever

144 er that initiates with episodes of excessive alcohol drinking known as binge drinking.

145 rophysiological techniques, we find that low alcohol drinking (LAD) mice have dramatically higher ven

146 ely, alcohol-nonpreferring (NP) rats and low alcohol-drinking (LAD) rats.

147 Furthermore, chronic alcohol drinking led to persistent alterations in Y1R fu

148 d H&N cancer patients, especially those with alcohol drinking, lower BMI, and advanced stage of prima

149 past smoking (pack-years <5), no or moderate alcohol drinking (</=1 drink/d for women, </=2 drinks/d

150 These results suggest that heavy alcohol drinking may increase the risk for stroke in Chi

151 Early binge-like alcohol drinking may promote the development of hazardou

152 GABAergic strength in DMS D1- and D2-MSNs of alcohol-drinking mice and control mice.

153 the amygdala proteome in mice after moderate alcohol drinking (n = 12/group) followed by behavioral s

154 l, we determined the impact of preconception alcohol drinking of the mother on offspring stress respo

155 The effect of alcohol drinking on LDL-cholesterol concentrations is un

156 In addition, the role of alcohol drinking on outcomes in patients with cancer is

157 f dopamine in mediating the effects of binge alcohol drinking on synaptic plasticity of NAc MSNs diff

158 in the CeA is causally related to excessive alcohol drinking or if it represents a consequence of ex

159 ), smoking (p < 0.0001), evidence of harmful alcohol drinking (p = 0.0001), and ART non-adherence (p

160 reased risk of breast cancer associated with alcohol drinking (P for interaction = 0.02).

161 NSCLC, and with a greater number of years of alcohol drinking (P=0.02) in HNSCC.

162 human Met66BDNF allele (Met68BDNF) and used alcohol-drinking paradigms in combination with viral-med

163 mer2-PI3K signaling predisposes a high binge alcohol-drinking phenotype.

164 mily history of diabetes, cigarette smoking, alcohol drinking, physical activity, and diet.

165 bottle choice paradigm that models excessive alcohol drinking produces a mobilization of DLS p75 neur

166 stores dopaminergic dysfunction in long-term alcohol-drinking rats and shows promise as a novel treat

167 etic stimulation of mPFC-NAcore terminals in alcohol-drinking rats, similar to reported effects of th

168 -preferring, alcohol-nonpreferring, and high-alcohol-drinking replicate 1 line of rats (Indiana Unive

169 ogether, our results indicate that the first alcohol drinking session induces synaptic plasticity in

170 hibition of mTORC1 activity during the first alcohol drinking session reduced alcohol consumption and

171 t FGF2 in the DMS is a positive regulator of alcohol drinking.SIGNIFICANCE STATEMENT Long-term alcoho

172 For different smoking and alcohol drinking status, only subjects who are both curr

173 ion in the mPFC increased aversion-resistant alcohol drinking, supporting a mechanistic role of Syt2

174 isk of developing uncontrolled and excessive alcohol drinking that can be reversed by directly activa

175 ice were tested in two models of free-choice alcohol drinking: the continuous and intermittent access

176 inking in the dark (DID) as a model of binge alcohol drinking to assess its effects on spike timing-d

177 titis B virus, cirrhosis, diabetes, obesity, alcohol drinking, tobacco smoking, and host genetic poly

178 on of diabetes, diabetes treatment, smoking, alcohol drinking, total energy intake, and physical acti

179 Age, sex, education, smoking status, alcohol drinking, waist circumference, dental visit freq

180 ogic characteristics, cigarette smoking, and alcohol drinking was abstracted from hospital charts.

181 In contrast, heavy alcohol drinking was associated with higher cardiovascul

182 We found that alcohol drinking was initially diminished in alphaCaMKII

183 serum LPS, sCD14, sCD163 and the quantity of alcohol drinking was observed after adjusting for covari

184 Conversely, alcohol drinking was predicted by gonadal phenotype inde

185 ng continuous or intermittent access or when alcohol drinking was tested in the context of aversive o

186 ing in the rural area, cigarette smoking and alcohol drinking were associated with insomnia.

187 eptidase (GGTP), a liver enzyme indicator of alcohol drinking, were determined.

188 ) are critical for promoting compulsion-like alcohol drinking, where rats consume alcohol despite pai

189 r binding exhibited a 50% reduction in binge alcohol drinking, which was related to reduced NAC basal

190 deprivation effect (ADE) model in long-term alcohol drinking Wistar rats, two behavioral models for

191 Systemic D-serine reduced aversion-resistant alcohol drinking, without altering consumption of quinin

192 e duct cancers) in 69,310 nonsmoking and non-alcohol-drinking women.