ライフサイエンスコーパス: aldehyde dehydrogenase

1 oxidase, and FeaB is a cytosolic NAD-linked aldehyde dehydrogenase.

2 y the kinetic data with NAD+-dependent yeast aldehyde dehydrogenase.

3 , and betaB2-crystallins; alpha-enolase; and aldehyde dehydrogenase.

4 ) L-lactaldehyde conversion to L-lactate via aldehyde dehydrogenase.

5 DH, the first model of a membrane-associated aldehyde dehydrogenase.

6 e and a structural and functional homolog of aldehyde dehydrogenases.

7 ture is conserved across membrane-associated aldehyde dehydrogenases.

8 sphere assay and flow cytometric analysis of aldehyde dehydrogenase 1 (ALDH1) activity and the CD44(h

9 mor-derived xenografts (PDXs) also expressed aldehyde dehydrogenase 1 (ALDH1) and had a greater capac

10 ding proteome identified two human proteins, aldehyde dehydrogenase 1 (ALDH1) and quinone reductase 2

11 The role of aldehyde dehydrogenase 1 (ALDH1) as an ovarian cancer st

12 an target these DCIS stem-like cells, reduce aldehyde dehydrogenase 1 (ALDH1) expression, and decreas

13 Aldehyde dehydrogenase 1 (ALDH1) has been suggested as a

14 Accordingly, aldehyde dehydrogenase 1 (ALDH1) was investigated as a p

15 A relatively rare aldehyde dehydrogenase 1 (ALDH1)-positive "stem cell-lik

16 ancer stem cell associated markers including aldehyde dehydrogenase 1 (ALDH1).

17 reased activity of stem cell markers such as Aldehyde Dehydrogenase 1 (ALDH1).

18 Aldehyde dehydrogenase 1 (ALDH1A1)-positive dopaminergic

19 wo subpopulations based on the expression of aldehyde dehydrogenase 1 (ALDH1A1).

20 the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the ma

21 of CD49f+/CD24- stem-like cells that possess aldehyde dehydrogenase 1 activity.

22 Using a tumor-specific CTL, aldehyde dehydrogenase 1 family member A1 (ALDH1A1) was

23 glutamate transporter 1 (GLT1), aquaporin-4, aldehyde dehydrogenase 1 family member L1, and other pro

24 d the decreased expression of only one gene, aldehyde dehydrogenase 1 family, member A2 (ALDH1a2), wa

25 Other markers such as aldehyde dehydrogenase 1 family, member L1 (ALDH1L1) sho

26 t a striking enrichment in the expression of aldehyde dehydrogenase 1 isoform A3 (ALDH(+)) as beta ce

27 Aldehyde dehydrogenase 1 L1 and glutamine synthetase wer

28 by amorpha-4,11-diene 12-hydroxylase and/or aldehyde dehydrogenase 1 to artemisinic acid, a precurso

29 The high expression of aldehyde dehydrogenase 1, also known as retinaldehyde de

30 ons in alphaA-crystallin, alphaB-crystallin, aldehyde dehydrogenase 1, betaS-crystallin, betaB2-cryst

31 CD34(+)CD38(-) cells not only highly express aldehyde dehydrogenase 1, but also the RA receptor alpha

32 ression of stem cell surface markers such as aldehyde dehydrogenase 1, side population and by in vitr

33 dication of clonality, was restricted to the aldehyde dehydrogenase 1-positive fraction in MECs but n

34 mine transporter 2, dopamine transporter and aldehyde dehydrogenase 1.

35 demonstrated a novel inducible expression of aldehyde dehydrogenase 1/2 and phospho-STAT3.

36 structure agrees well with that of mammalian aldehyde dehydrogenases 1, 2, and 6.

37 ) characterized by high levels of CD44v3 and aldehyde dehydrogenase-1 (ALDH1) expression.

38 characterized by a high level of CD44v3 and aldehyde dehydrogenase-1 (ALDH1) expression.

39 ferase omega) and bases/acids (e.g., E269 in aldehyde dehydrogenase-1; D204 in enoyl CoA hydratase-1)

40 Aldehyde dehydrogenase 1A1 (ALDH1A1) activity is used as

41 Aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of a su

42 ethylation at the promoter of the CSC marker aldehyde dehydrogenase 1A1 (ALDH1A1), stimulating its ge

43 candidate stem cell marker genes, CD133 and aldehyde dehydrogenase 1A1 (ALDH1A1), to be directly reg

44 conserved GABA synthesis pathway mediated by aldehyde dehydrogenase 1a1 (ALDH1a1).

45 enzymes, including alcohol dehydrogenase 1, aldehyde dehydrogenase 1A1, and catalase, as well as the

46 type, expressing IL-10, TGF-beta, IL-27, and aldehyde dehydrogenase 1A2 but not IL-12 or IL-35; IL-10

47 pressing the retinoic acid synthesis enzyme, aldehyde dehydrogenase-1a2, in the ventricle.

48 rystallin of the scallop lens is an inactive aldehyde dehydrogenase (1A9).

49 roteomic search, we identified mitochondrial aldehyde dehydrogenase 2 (ALDH2) as an enzyme whose acti

50 r a high-frequency deficiency allele for the aldehyde dehydrogenase 2 (ALDH2) enzyme, a critical prot

51 Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme that el

52 Aldehyde dehydrogenase 2 (ALDH2) is the major enzyme tha

53 These include mitochondrial aldehyde dehydrogenase 2 (ALDH2), ATP synthase, acyl-CoA

54 One such mutation is in aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2.

55 Aldehyde dehydrogenase 2 (ALDH2), one of 19 ALDH superfa

56 t has recently been shown that mitochondrial aldehyde dehydrogenase 2 (mtALDH) catalyzes the formatio

57 ed Mendelian randomization analysis with the aldehyde dehydrogenase 2 gene (ALDH2) as an instrumental

58 e and extracellular superoxide dismutase and aldehyde dehydrogenase 2 were reduced, whereas the NADPH

59 receptor, activating transcription factor 3, aldehyde dehydrogenase 2, and protein kinase Cdelta.

60 s included those involved in metabolism (eg, aldehyde dehydrogenase 2, ubiquinone biosynthesis protei

61 Here we show that a selective aldehyde dehydrogenase-2 (ALDH-2) inhibitor, ALDH2i, sup

62 Aldehyde dehydrogenase-2 (ALDH2) catalyzes the bioactiva

63 Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioa

64 Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioa

65 hrough systemic transgenic overexpression of aldehyde dehydrogenase-2 (ALDH2) on chronic alcohol inge

66 Aldehyde dehydrogenase-2 levels were unaltered in respon

67 hat both nonenzymatic chemical reactions and aldehyde dehydrogenase-2-mediated enzymatic activity rel

68 duced suppressed activities of mitochondrial aldehyde dehydrogenase, 3-ketoacyl-CoA thiolases, and ad

69 Aldehyde dehydrogenase 3A1 (ALDH3A1) is a NAD(P)+-depend

70 ax6 coding sequences fused downstream of the aldehyde dehydrogenase 3a1 (Aldh3a1) promoter were gener

71 Aldehyde dehydrogenase 3a1 (Aldh3a1) represents approxim

72 decreased Smad3 nuclearization and increased aldehyde dehydrogenase 3A1 expression, with favorable ex

73 ALDH3A1 (aldehyde dehydrogenase 3A1) is abundant in the mouse cor

74 s lines of evidence have shown that ALDH3A1 (aldehyde dehydrogenase 3A1) plays a critical and multifa

75 nd expressed high levels of keratan sulfate, aldehyde dehydrogenase 3A1, and keratocan, molecular mar

76 one reductase, glutathione S-transferase and aldehyde dehydrogenase 3A1.

77 ntensity of Smad7 and the corneal crystallin aldehyde dehydrogenase 3A1.

78 Aldehyde dehydrogenase 5A1 (ALDH5A1) which is an enzyme

79 isolation, as a previously described enzyme, aldehyde dehydrogenase 6 (ALDH6).

80 ased mRNA abundance in PCOS theca cells were aldehyde dehydrogenase 6 and retinol dehydrogenase 2, wh

81 First, we show that aldehyde dehydrogenase 6, which synthesizes the ligand,

82 xpression of another metabolic-related gene, aldehyde dehydrogenase 7A1 (ALDH7A1), was validated at t

83 of the REF1 gene revealed that it encodes an aldehyde dehydrogenase, a member of a large class of NAD

84 sed cell-surface protein CD90 expression and aldehyde dehydrogenase A1 (ALDHA1) activity, and provide

85 pAADB1 for the overexpression of the alcohol-aldehyde dehydrogenase (aad) gene and downregulation of

86 as glyceraldehyde-3-phosphate dehydrogenase, aldehyde dehydrogenase, aconitase, and FeS cluster-conta

87 Hepatic alcohol dehydrogenase and aldehyde dehydrogenase activities and expression were lo

88 ase activity, whereas the full hydrolase and aldehyde dehydrogenase activities were retained.

89 umbilical cord blood-derived cells with high aldehyde dehydrogenase activity (ALDH(hi)Lin(-)) into ir

90 age depletion and purification based on high aldehyde dehydrogenase activity (ALDH(hi)Lin- cells).

91 Here, we used aldehyde dehydrogenase activity and CD44 expression to s

92 Monocyte-derived AAMs had high levels of aldehyde dehydrogenase activity and promoted the differe

93 (MLN), which correlated with a reduction in aldehyde dehydrogenase activity by SI-derived MLN DCs, a

94 Multipotent epithelial cells with high Aldehyde dehydrogenase activity have been previously rep

95 Aldehyde dehydrogenase activity represents a novel simpl

96 Growth studies indicated that the aldehyde dehydrogenase activity was growth phase depende

97 pregulation of pluripotency genes, increased aldehyde dehydrogenase activity, and enhanced expression

98 l-terminal domain (residue 420-902) bears an aldehyde dehydrogenase activity, and the full-length FDH

99 VEGF increased tumor spheres and aldehyde dehydrogenase activity, both proxies for stem c

100 here, expression of pluripotency-factors and aldehyde dehydrogenase activity.

101 Slug upregulation, mammosphere formation and aldehyde dehydrogenase activity.

102 ng factor and markedly decreased activity of aldehyde dehydrogenase; activity of this enzyme has been

103 uinoline quinone (PQQ)-dependent alcohol and aldehyde dehydrogenase (ADH and AldDH) enzymes for biofu

104 es generated from lipid peroxidation include aldehyde dehydrogenases, alcohol dehydrogenases and aldo

105 Aldehyde dehydrogenase (Ald) is required for IAA synthes

106 acid burst is dependent on the mitochondrial aldehyde dehydrogenase Ald4p.

107 sphate dehydrogenase (Zwf1p) and a cytosolic aldehyde dehydrogenase (Ald6p).

108 s cells expressing high levels of the enzyme aldehyde dehydrogenase (ALDH bright [ALDH(br)]), along w

109 Breast cancer cells positive for aldehyde dehydrogenase (ALDH(+)) had increased ability t

110 properties (SSC(lo)) and high expression of aldehyde dehydrogenase (ALDH(br)).

111 uman bone marrow (BM) cells purified by high aldehyde dehydrogenase (ALDH(hi)) activity, a progenitor

112 Previously we demonstrated that aldehyde dehydrogenase (ALDH) 1a1 is the major ALDH expr

113 es of cancer stem cells by quantitating both aldehyde dehydrogenase (ALDH) activities and 5 signaling

114 as determined by tumor sphere formation and aldehyde dehydrogenase (ALDH) activity (Aldefluor) assay

115 ers such as melan-A and tyrosinase, enhanced aldehyde dehydrogenase (ALDH) activity and upregulation

116 tain stem-like characteristics, such as high aldehyde dehydrogenase (ALDH) activity due to ALDH1A1 ex

117 Selection of cells positive for aldehyde dehydrogenase (ALDH) activity from a green-fluo

118 High levels of aldehyde dehydrogenase (ALDH) activity have been propose

119 High aldehyde dehydrogenase (ALDH) activity is a marker commo

120 Aldehyde dehydrogenase (ALDH) activity is a reported CSC

121 In this study, we show that aldehyde dehydrogenase (ALDH) activity is indicative of

122 Intermediate (int) levels of aldehyde dehydrogenase (ALDH) activity reliably distingu

123 either sarcosphere generation, chemodrug or aldehyde dehydrogenase (ALDH) activity selection.

124 In this issue of Blood,Gerber et al use aldehyde dehydrogenase (ALDH) activity to further subdiv

125 n this model, human melanoma cells with high aldehyde dehydrogenase (ALDH) activity were enriched 16.

126 nitor cell (LPC) isolation strategy based on aldehyde dehydrogenase (ALDH) activity, a common feature

127 ogenous progenitor cell (EPC) assay based on aldehyde dehydrogenase (ALDH) activity, and to define th

128 -)) followed by selection of cells with high aldehyde dehydrogenase (ALDH) activity.

129 defined by the expression of the CSC markers aldehyde dehydrogenase (ALDH) and CD133.

130 ssays and the expression of stem cell marker aldehyde dehydrogenase (ALDH) as well as by generation o

131 n 90% loss of tissue transketolase (TKT) and aldehyde dehydrogenase (ALDH) class 1.

132 ignment of all known, diverse members of the aldehyde dehydrogenase (ALDH) extended family revealed o

133 The glycolytic pathway, comprising aldehyde dehydrogenase (ALDH) family genes and in partic

134 between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and alcohol dependen

135 of both 1,4-dioxane monooxygenase (dxmB) and aldehyde dehydrogenase (aldH) genes.

136 Aldehyde dehydrogenase (ALDH) is a candidate marker for

137 Aldehyde dehydrogenase (ALDH) is an enzyme that is expre

138 Aldehyde dehydrogenase (ALDH) overexpression is characte

139 ism in which alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) play central roles.

140 The aldehyde dehydrogenase (ALDH) superfamily member Delta(1

141 The rf2a gene encodes a mitochondrial aldehyde dehydrogenase (ALDH) that is capable of oxidizi

142 The contribution of various isozymes of aldehyde dehydrogenase (ALDH) to the oxidation of LDAs h

143 cancer whose tumors expressed high levels of aldehyde dehydrogenase (ALDH), a detoxifying enzyme char

144 of the colonic epithelial cells positive for aldehyde dehydrogenase (ALDH), a putative marker of prec

145 ificant percentage of MARY-X cells expressed aldehyde dehydrogenase (ALDH), a stem cell marker.

146 Markers such as aldehyde dehydrogenase (ALDH), CD133, and CD44 have been

147 ls catalyzed by alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), flavin-containing monooxy

148 enotype was determined by immunostaining for aldehyde dehydrogenase (ALDH), keratocan, and CD34 and b

149 thiocarbamate sulfoxide metabolite, inhibits aldehyde dehydrogenase (ALDH), leading to accumulation o

150 n to myofibroblasts was identified with anti-aldehyde dehydrogenase (ALDH)-1 and alpha-smooth muscle

151 In this study, we characterized STAT3 in aldehyde dehydrogenase (ALDH)-positive (ALDH(+)) and CD1

152 ibition of the PPARgamma pathway reduces the aldehyde dehydrogenase (ALDH)-positive population in ERB

153 pairs both MS formation and the expansion of aldehyde dehydrogenase (ALDH)-positive population, sugge

154 ating the cancer stem-like associated enzyme aldehyde dehydrogenase (ALDH).

155 -cell antigen CD27, and the stem cell marker aldehyde dehydrogenase (ALDH).

156 g of NAD can bind with multiconformations to aldehyde dehydrogenase (ALDH).

157 vidence establish that the RF2 protein is an aldehyde dehydrogenase (ALDH).

158 by expression of the cancer stem-like marker aldehyde dehydrogenase (ALDH).

159 growth and motility in a RCC cell line, but aldehyde dehydrogenase (ALDH)1 and ALDH7 had no effect.

160 ad increased phosphorylation and activity of aldehyde dehydrogenase (ALDH)2, an enzyme that detoxifie

161 have identified the monoamine oxidase (MAO)-aldehyde dehydrogenase (ALDH-2) pathway of the mitochond

162 Aldehyde dehydrogenases (ALDH) catalyze the irreversible

163 Aldehyde dehydrogenases (ALDH) participate in multiple m

164 h can be detoxified to carboxyphosphamide by aldehyde dehydrogenases (ALDH), especially ALDH1A1 and A

165 tic mechanism of hydrolytic NAD(P)-dependent aldehyde dehydrogenases (ALDH).

166 n used to identify a mutant of human class 1 aldehyde dehydrogenase (ALDH1) that was no longer inhibi

167 ssion of the ABCG2 transporter and increased aldehyde dehydrogenase (ALDH1), have been associated wit

168 We now present genetic evidence that aldehyde dehydrogenase Aldh1a1, also known as retinaldeh

169 hly up-regulated antioxidant genes including aldehyde dehydrogenases (ALDH1A1 and ALDH1A7), glutathio

170 dehydrogenase (RDH11) and cytosolic soluble aldehyde dehydrogenases (ALDH1As) involved in the synthe

171 The common mitochondrial aldehyde dehydrogenase (ALDH2) ALDH2(*)2 polymorphism is

172 The inactive aldehyde dehydrogenase (ALDH2) and the super-active alco

173 Mitochondrial aldehyde dehydrogenase (ALDH2) is the major enzyme that

174 g the inactive variant form of mitochondrial aldehyde dehydrogenase (ALDH2) protects nearly all carri

175 ic attack on propanal in human mitochondrial aldehyde dehydrogenase (ALDH2) yielded an unexpected res

176 he gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2-2), present in some Asian

177 E)-hexadecenoic acid by the long-chain fatty aldehyde dehydrogenase ALDH3A2 (also known as FALDH) pri

178 Hepatic cytochromes P450, aldehyde dehydrogenase (ALDH3A2), and 21-hydroxysteroid

179 Aldehyde dehydrogenases (ALDHs) are members of NAD(P)(+)

180 Aldehyde dehydrogenases (ALDHs) catalyze the NAD(P)(+)-d

181 Human aldehyde dehydrogenases (ALDHs) comprise a family of 17

182 Aldehyde dehydrogenases (ALDHs) metabolize reactive alde

183 2a and rf2b genes both encode homotetrameric aldehyde dehydrogenases (ALDHs).

184 Cs through Oct-1, a transcription factor for aldehyde dehydrogenases (ALDHs).

185 ansformation catalyzed by monoamine oxidase, aldehyde dehydrogenase and aldehyde reductase.

186 nes, encoding choline dehydrogenase, betaine aldehyde dehydrogenase and choline sulfatase, respective

187 rospectively isolated based on expression of aldehyde dehydrogenase and integrin alpha-6, and that th

188 Cytosolic aldehyde dehydrogenase and keratocan accumulated in the

189 The keratocyte markers aldehyde dehydrogenase and keratocan were maintained aft

190 solated PLCSCs were characterized by markers aldehyde dehydrogenase and keratocan, cultured, and anal

191 Keratocytes normally express high levels of aldehyde dehydrogenase and keratocan.

192 thanol is suppressed by inhibiting CYP2E1 or aldehyde dehydrogenase and requires an elevated NADH/NAD

193 he keratocytes, the fibroblasts possessed no aldehyde dehydrogenase and synthesized significantly hig

194 esis, proliferating NK cells did not express aldehyde dehydrogenase and were killed by Cy in vitro.

195 hydratase, its putative reactivating factor, aldehyde dehydrogenase, and ATP cob(I)alamin adenosyltra

196 identified, mitochondrial HMG-CoA synthase, aldehyde dehydrogenase, and catalase as the primary auto

197 iated protein/B12D-related protein1, Betaine aldehyde dehydrogenase, and Unknown protein5.

198 ing ALD6, which encodes an NADP(+)-dependent aldehyde dehydrogenase, and UTR1, which encodes an NAD+

199 Aldehyde dehydrogenases are isolated as dimers or tetram

200 dehyde dehydrogenases (Aldhs), also known as aldehyde dehydrogenases, are rate-limiting enzymes that

201 The zRalDH gene encodes an aldehyde dehydrogenase associated with the conversion of

202 disruption and barrier dysfunction, whereas aldehyde dehydrogenase attenuated acetaldehyde-induced t

203 report here high-level expression of betaine aldehyde dehydrogenase (BADH) in cultured cells, roots,

204 d efficacy of autologous bone marrow-derived aldehyde dehydrogenase bright (ALDHbr) cells in patients

205 CSC markers (CD24(+)/CD44(+), CD133(+), and aldehyde dehydrogenase(bright)) from a wide variety of h

206 ma-null (NSgamma) mice with lineage-depleted aldehyde dehydrogenase-bright CD34(+) human cord blood p

207 Aldehyde dehydrogenase-bright cell numbers were inversel

208 Aldehyde dehydrogenase-bright cells expressed CD34 or CD

209 Aldehyde dehydrogenase-bright cells were easily identifi

210 such aldehydes by oxidation is attributed to aldehyde dehydrogenases but never to aldehyde oxidases.

211 be adjacent to the catalytic cysteine in the aldehyde dehydrogenase catalytic center.

212 Aldehyde dehydrogenases catalyze the oxidation of aldehy

213 g mammary stem/progenitor markers, including aldehyde dehydrogenase, CD24, CD29, and CD61, we further

214 the known preferential expression of rabbit aldehyde dehydrogenase class 1 (ALDH1A1) in the cornea.

215 er-soluble proteins, transketolase (TKT) and aldehyde dehydrogenase class 1A1 (ALDH1A1), in vivo and

216 abundant protein and mRNA for keratocan and aldehyde dehydrogenase class 3 and secreted proteoglycan

217 ctivating enzyme and, in conjunction with an aldehyde dehydrogenase, converts 1,2-propanediol to prop

218 l hydrolase domain and the carboxyl-terminal aldehyde dehydrogenase domain.

219 the formyl group to CO(2) in the C-terminal aldehyde dehydrogenase domain.

220 tial activities of proline dehydrogenase and aldehyde dehydrogenase domains.

221 on patterns that fully overlap with those of aldehyde dehydrogenases during development.

222 purified enzyme identified the latter as an aldehyde dehydrogenase encoded by aldB, which was though

223 ment, controlled in part by an RA-generating aldehyde dehydrogenase encoded by Aldh1a2 (Raldh2) expre

224 t report of the structure of CoA bound to an aldehyde dehydrogenase enzyme and our crystallographic m

225 Here we analyse the kinetics of the aldehyde dehydrogenase enzyme from the fucose/rhamnose u

226 Aldehyde dehydrogenase enzymes irreversibly oxidize alde

227 and allow the efficient action of acylating aldehyde dehydrogenase enzymes to produce an acyl-CoA th

228 and mitochondria, making it unique among the aldehyde dehydrogenase enzymes.

229 distinguish the acylating from non-acylating aldehyde dehydrogenase enzymes.

230 In conclusion, ALDH7A1 is a novel aldehyde dehydrogenase expressed in multiple subcellular

231 d in a cellular hierarchy in which primitive aldehyde dehydrogenase expressing mesenchymal cells regu

232 ances mammosphere formation, and upregulates aldehyde dehydrogenase expression and activity.

233 of a fatty alcohol oxidase (FAO) and a fatty aldehyde dehydrogenase (FADH) before they can be beta-ox

234 in the gene coding for membrane-bound fatty aldehyde dehydrogenase (FALDH) lead to toxic accumulatio

235 The aldehyde dehydrogenase family 1 member A3 (ALDH1A3) cata

236 was associated with increased expression of aldehyde dehydrogenase family 1 subfamily A1 (Aldh1a1).

237 s the retinoic acid (RA)-synthesizing enzyme aldehyde dehydrogenase family 1, subfamily A2 (ALDH1a2)

238 ession of the retinoic acid-producing enzyme aldehyde dehydrogenase family 1, subfamily A2 (ALDH1A2)

239 Cs synergistically induced the expression of aldehyde dehydrogenase family 1, subfamily A2, a rate-li

240 and RA receptor beta play important roles in aldehyde dehydrogenase family 1, subfamily A2, induction

241 the tyramine oxidase, TynA, and the aromatic aldehyde dehydrogenase, FeaB, whose respective activitie

242 Genetic studies have revealed that aldehyde dehydrogenases function as tissue-specific cata

243 enes (ADH2 and ADH3 on chromosome 4) and one aldehyde dehydrogenase gene (ALDH2 on chromosome 12) exh

244 yet the origin and evolution of the betaine aldehyde dehydrogenase gene (BADH2) underlying this trai

245 include overexpression of the mitochondrial aldehyde dehydrogenase gene ALD5 or disruption of the re

246 y presents evidence that the closely related aldehyde dehydrogenase genes ALD2 and ALD3 are required

247 a structure similar to that of human class 1 aldehyde dehydrogenase genes, and localizes to the centr

248 ay for MICs) and decreased the percentage of aldehyde dehydrogenase (high) cells (a marker of MICs) i

249 of a Cys302Ser mutant of human mitochondrial aldehyde dehydrogenase in binary complexes with NAD(+) a

250 The mitochondrially localized aldehyde dehydrogenase in D. melanogaster has two import

251 elial cells with the increased expression of aldehyde dehydrogenase in sporadic colon cancer correlat

252 se-contrast microscopy; (2) by the levels of aldehyde dehydrogenase in the cells, determined by SDS-P

253 ly established cancer stem cell marker ALDH (aldehyde dehydrogenase) in the maintenance of this drug-

254 olic alcohol dehydrogenase and mitochondrial aldehyde dehydrogenase, in part determine blood alcohol

255 Furthermore, the aldehyde dehydrogenase inhibitor cyanamide enhanced the

256 nt of ethanol-metabolizing VA cells with the aldehyde dehydrogenase inhibitor, cyanamide, increased t

257 , attenuated GS-DHN levels and cyanamide, an aldehyde dehydrogenase inhibitor, decreased formation of

258 ydrogenase knockout (Rdh12(-/-)) mice and by aldehyde dehydrogenase inhibitors.

259 apable of binding copper and an inhibitor of aldehyde dehydrogenase, is currently being used clinical

260 nzyme A acetyltransferase (AtoB), a probable aldehyde dehydrogenase (KauB), ribosomal protein L25 (Rp

261 ur high-resolution crystal structures of the aldehyde dehydrogenase lead to a revised reaction mechan

262 ) pathways; 4) increased side population and aldehyde dehydrogenase levels; and 5) increased expressi

263 ine compounds, we propose that an additional aldehyde-dehydrogenase-mediated step is required to make

264 ted by genetic deletion of the mitochondrial aldehyde dehydrogenase (mtALDH).

265 in vivo, and we identify it as mitochondrial aldehyde dehydrogenase (mtALDH).

266 mutation (present in one-half of Asians) in aldehyde dehydrogenase (NAD + ) and NAD (in relation to

267 The 2.3-kb cDNA encodes an aldehyde dehydrogenase of 487 amino acid residues, about

268 al difference between this protein and other aldehyde dehydrogenases of the same enzyme superfamily;

269 creasing research interest, considering that aldehyde dehydrogenases overexpression is characteristic

270 The leaders of yeast aldehyde dehydrogenase (pALDH) and malate dehydrogenase

271 By using the Aldefluor assay, aldehyde dehydrogenase-positive (ALDH+) cells comprised

272 utputs are similarly distributed between the aldehyde dehydrogenase-positive and -negative subsets of

273 y showing that a BCL11A peptide can decrease aldehyde dehydrogenase-positive BCSCs and mammosphere fo

274 with a lack of CD38 expression and contained aldehyde dehydrogenase-positive cells as well as cells w

275 growth in BMSC-adherent myeloma cell lines, aldehyde dehydrogenase-positive MM cancer stem cells and

276 represents the first crystal structure of an aldehyde dehydrogenase-product complex.

277 action but is a combination of hydrolase and aldehyde dehydrogenase reactions.

278 te (GABA) aminotransferase and succinic semi-aldehyde dehydrogenase, respectively, and to form a GABA

279 ct of Mg2+ ions on human liver mitochondrial aldehyde dehydrogenase revealed that the bacterial enzym

280 er the native or a non-functioning leader of aldehyde dehydrogenase so that an internal leader sequen

281 h as the spinach (Spinacia oleracea) betaine aldehyde dehydrogenase (SoBADH), efficiently oxidize bet

282 Crystal structures of many enzymes in the aldehyde dehydrogenase superfamily determined in the pre

283 ization flap, which is unprecedented for the aldehyde dehydrogenase superfamily.

284 decarboxylases and screening for promiscuous aldehyde dehydrogenases, synthetic pathways were constru

285 zymatic (anchoring sequentially both ADH and aldehyde dehydrogenase) systems were tested.

286 rogenase (P5CDH; also known as ALDH4A1), the aldehyde dehydrogenase that catalyzes the oxidation of g

287 PuuC is a nonspecific aldehyde dehydrogenase that oxidizes all the aldehydes i

288 drogenase II is disordered, whereas in other aldehyde dehydrogenases this region forms a well defined

289 e alcohol, such as alcohol dehydrogenase and aldehyde dehydrogenase; those associated with disinhibit

290 f their relatively high levels of the enzyme aldehyde dehydrogenase; thus, high-dose cyclophosphamide

291 oblasts in serum-free medium did not restore aldehyde dehydrogenase to keratocyte levels but did rest

292 est, we tested a small-molecule activator of aldehyde dehydrogenase type 2, Alda-1, which reduced oxi

293 s that an equilibrium coupled to the enzyme, aldehyde dehydrogenase type 2, prevents the accumulation

294 Activation and inhibition of mitochondrial aldehyde dehydrogenase type-2 (ALDH2) also mimicked and

295 Aldehyde dehydrogenase typically performs oxidation of a

296 Metabolism of 3-AP to beta-alanine by aldehyde dehydrogenase was also evaluated in retinal gan

297 An aldehyde dehydrogenase was detected in crude cell extrac

298 ydrolase, the alcohol dehydrogenase, and the aldehyde dehydrogenase, was determined in Escherichia co

299 By contrast, inhibition of aldehyde dehydrogenase with phenethyl isothiocyanate inc

300 ion than the mRNA for retinaldehyde-specific aldehyde dehydrogenase (zRalDH), a retinoic acid-synthes