ライフサイエンスコーパス: aldo-keto reductase

1 ycin A catalyzed by Aln4, an NADPH-dependent aldo-keto reductase.

2 a dimeric aldo-keto reductase or a family 2 aldo-keto reductase.

3 ing pocket that is more polar than a typical aldo-keto reductase.

4 ient binding of glutathione conjugates to an aldo-keto reductase.

5 glutamate-cysteine ligase modifier subunit, aldo-keto reductases-1-C1 and -C2, and IL-8.

6 nt from bacteria to mammals, and we identify aldo-keto reductase 1A1 as the mammalian functional anal

7 Aldo-keto reductase 1B10 (AKR1B10) protein is a new tumo

8 show that FXR induces expression of Akr1b7 (aldo-keto reductase 1b7) in murine small intestine, colo

9 Human aldo-keto reductases 1C1-1C4 (AKR1C1-AKR1C4) function in

10 Type 5 17beta-hydroxysteroid dehydrogenase, aldo-keto reductase 1C3 (AKR1C3) converts Delta(4)-andro

11 Aldo-keto reductase 1C3 (AKR1C3) has been shown to media

12 Aldo-keto reductase 1C3 (AKR1C3; type 5 17beta-hydroxyst

13 cells, PR-104A is independently activated by aldo-keto-reductase 1C3 (AKR1C3).

14 Human aldo-keto reductase 1D1 (AKR1D1) and AKR1C enzymes are e

15 AKR1D1 (aldo-keto reductase 1D1) is the only known human enzyme

16 template for the homology modeling of other aldo/keto-reductase 4 family members, including the redu

17 d (2) it expresses alcohol dehydrogenase and aldo-keto reductase activity native to AdhD from Pyrococ

18 pe 3 3alpha-hydroxysteroid dehydrogenase, or aldo-keto reductase (AKR) 1C2, eliminates the androgen s

19 Aldo-keto reductase (AKR) family 1, member 7 (AKR1B7), a

20 Aldo-keto reductase (AKR) inhibitors blocked this effect

21 It is the only HSD of known structure in the aldo-keto reductase (AKR) superfamily and may provide a

22 Both enzymes are members of the aldo-keto reductase (AKR) superfamily and possess cataly

23 , E.C. 1.1.1.213, AKR1C9) is a member of the aldo-keto reductase (AKR) superfamily which inactivates

24 ase isoforms (AKR1C1-AKR1C4), members of the aldo-keto reductase (AKR) superfamily, activate trans-di

25 ydrogenase (3 alpha-HSD/DD), a member of the aldo-keto reductase (AKR) superfamily, oxidizes PAH tran

26 d potassium (Kv) channels are members of the aldo-keto reductase (AKR) superfamily.

27 hydroxysteroid dehydrogenases (HSDs) of the aldo-keto reductase (AKR) superfamily.

28 d with recombinant rat liver 3 alpha-HSD, an aldo-keto reductase (AKR) that plays critical roles in s

29 servation indicates that Kvbeta resembles an aldo-keto reductase (AKR), an enzyme that catalyzes a re

30 Aldose reductase (ALR2), a NADPH-dependent aldo-keto reductase (AKR), is widely distributed in mamm

31 Human aldo-keto reductase (AKR)1C isoforms have been shown to

32 Aldo-keto reductases (AKR) are monomeric oxidoreductases

33 e dehydrogenases, alcohol dehydrogenases and aldo-keto reductases (AKR).

34 Aldo-keto reductase (AKR1C) isoforms can regulate ligand

35 g carcinoma, differential display shows that aldo-keto reductase (AKR1C) transcripts are dramatically

36 The human aldo-keto reductase AKR1C1 (20alpha(3alpha)-hydroxystero

37 Four human cytosolic aldo-keto reductases (AKR1C1-AKR1C4) are known to act as

38 show that four homogeneous human recombinant aldo-keto reductases (AKR1C1-AKR1C4) are regioselective

39 for monitoring the activity of the inducible aldo-keto reductases AKR1C2 and AKR1C3 in living human c

40 d isoform-selective (1500-fold) inhibitor of aldo-keto reductase AKR1C3: a target of interest in both

41 Dihydrodiol dehydrogenases are a family of aldo-keto reductases (AKR1Cs) involved in the metabolism

42 Aldo-keto reductases (AKRs) are a large superfamily of N

43 Aldo-keto reductases (AKRs) are widely distributed in na

44 Aldo-keto reductases (AKRs) comprise a superfamily of pr

45 on of intermediate PAH trans-dihydrodiols by aldo-keto reductases (AKRs) leads to the formation of el

46 PAH-diols can be converted to o-quinones by aldo-keto reductases (AKRs) or to diol-epoxides by cytoc

47 Human aldo-keto reductases (AKRs) regulate nuclear receptors b

48 dihydrodiol dehydrogenase (DD) isoforms are aldo-keto reductases (AKRs) that activate polycyclic aro

49 rodiol proximate carcinogens are oxidized by aldo-keto reductases (AKRs) to their corresponding react

50 zo[a]pyrene (B[a]P-7,8-trans-dihydrodiol) by aldo-keto reductases (AKRs) to yield benzo[a]pyrene-7,8-

51 0 proteins possess conserved motifs found in aldo/keto reductases (AKRs) of yeast and fungi.

52 hydroxy-7,8-dihydroB[a]P by the mediation of aldo-keto reductases and its role in the genotoxicity an

53 ining substrate and inhibitor specificity of aldo-keto reductases and specifically identifies Arg311

54 rgeted for deletion: three genes that encode aldo-keto reductases and three genes that encode alcohol

55 tic hydrocarbon (PAH) o-quinones produced by aldo-keto reductases are ligands for the aryl hydrocarbo

56 d role for the metabolic enzymes enolase and aldo-keto reductase as positive and negative regulators

57 ydroxysteroid dehydrogenase (3alpha-HSD), an aldo-keto reductase, binds NADP(+) in an extended anti-c

58 Human aldo-keto reductases catalyze the metabolic activation o

59 We previously reported that Akr1b7, an aldo-keto reductase enriched in adipose stromal vascular

60 Identification of the aldo-keto reductase enzyme AKR1B10 as highly up-regulate

61 The aldo-keto reductase enzymes comprise a functionally dive

62 Recent studies have demonstrated that aldo-keto reductase family 1 B10 (AKR1B10), a novel prot

63 Aldo-keto reductase family 1 member B10 (AKR1B10) is ove

64 Aldo-keto reductase family 1 member B10 (AKR1B10) is pri

65 hesis of androgens (5alpha-reductase/SRD5A1, aldo-keto reductase family 1 member C3/AKR1C3), b) estab

66 ce of marker proteins for renin cells (e.g., aldo-keto reductase family 1, member 7 and connexin 40)

67 The increase in aldo-keto reductase family 1, member C3 (AKR1C3), the pr

68 sponding gene revealed that a protein of the aldo-keto reductase family carries out this reaction in

69 s high sequence identity with the genes from aldo-keto reductase family of proteins including the mou

70 Aldose reductase (AR), a member of the aldo-keto reductase family, has been implicated in the d

71 Aldose reductase, a member of the aldo-keto reductase family, has been implicated in the d

72 ductase modules, the latter belonging to the aldo-keto reductase family.

73 The aldo/keto reductase fold is structurally distinct from a

74 press the 3-ketosteroid reductase AKR1C9, an aldo-keto reductase gene family member.

75 xylose-pathway gene, a novel homolog of the aldo-keto reductase gene GRE3, while a second locus cont

76 sine residue found in the active site of all aldo-keto reductases have wild-type trafficking characte

77 rprisingly, AKR11B, the most closely related aldo-keto reductase in sequence.

78 molecular rationale to explore the status of aldo-keto reductases in dysregulations of adipose tissue

79 revealed surprising structural homology with aldo-keto reductases, including a triosephosphate isomer

80 The aldo-keto reductases make up a superfamily of enzymes wh

81 The latter involves aldo-keto reductase mediated oxidation of PAH dihydrodio

82 determined for a xylose reductase, a dimeric aldo-keto reductase or a family 2 aldo-keto reductase.

83 t throughout the remainder of the oligomeric aldo-keto reductases, predicting alternate modes of olig

84 ein has highest sequence similarity to other aldo-keto reductases, such as chalcone reductase, an enz

85 a mammalian HSD using rat 3alpha-HSD of the aldo-keto reductase superfamily (AKR1C9) with the substr

86 o all other characterized human genes of the aldo-keto reductase superfamily (aldose reductase, bile

87 n 3alpha-HSDs and 20alpha-HSDs belong to the aldo-keto reductase superfamily and share 67% amino acid

88 The ALDRXV4 belongs to the aldo-keto reductase superfamily of enzymes that catalyze

89 or NADH and belongs to the largely monomeric aldo-keto reductase superfamily of proteins.

90 esidues as are found in other members of the aldo-keto reductase superfamily that are naturally able

91 Thus, HSDs in the aldo-keto reductase superfamily thermodynamically favor

92 It belongs to the NADPH-dependent aldo-keto reductase superfamily whose members are in par

93 ensitive K(+) (K(v)) channels belongs to the aldo-keto reductase superfamily, and the crystal structu

94 id reductase A (2,5-DKGR A), a member of the aldo-keto reductase superfamily, has been determined by

95 Aldose reductase (AR), a member of the aldo-keto reductase superfamily, has been implicated in

96 Aldose reductase (AR), a member of the aldo-keto reductase superfamily, has been shown to metab

97 hydrogenase (3alpha-HSD/DD), a member of the aldo-keto reductase superfamily, inactivates circulating

98 e analyses showed M6PR to be a member of the aldo-keto reductase superfamily, which includes both ani

99 been solved for a prokaryotic example of the aldo-keto reductase superfamily.

100 approximately 36 kDa protein related to the aldo-keto reductase superfamily.

101 ide-binding beta-subunits that belong to the aldo-keto reductase superfamily.

102 lected yghZ, a gene encoding a member of the aldo-keto reductase superfamily.

103 ow been solved for a human HSD member of the aldo-keto reductase superfamily.

104 Aldose reductase (AR) is a member of the aldo-keto reductase superfamily.

105 en aldose reductase and other members of the aldo-keto reductase superfamily.

106 dopts the three-dimensional structure of the aldo/keto reductase superfamily.

107 , previously shown to be a broad specificity aldo-keto reductase that converts MG to acetol.

108 Aldose reductase (AR) is an aldo-keto reductase that has been widely investigated as

109 reated a fusion consisting of a thermostable aldo-keto reductase, two alpha-helical leucine zipper do

110 these reactions (fatty acid synthase, Fasp; aldo-keto reductase, Ypr1p; alpha-acetoxy ketone reducta