ライフサイエンスコーパス: aldol

1 ction, Kumada coupling, and Crimmins acetate aldol.

2 lso allowed the determination of the product aldols' absolute configuration (S).

3 -azaallylic anions undergo a stereoselective aldol addition across aromatic aldehydes and subsequent

4 Extensive studies of asymmetric cross-aldol addition between enolizable aldehydes are describe

5 During the aldol addition catalyzed by BphI, the S-configured stere

6 he latter transformation is straightforward: aldol addition followed by Wittig olefination and dehydr

7 The in-ice nonenzymatic aldol addition leads to the continuous accumulation of f

8 ethylglutaryl synthase (HMGS), catalyzes the aldol addition of an acyl donor to a beta-keto-polyketid

9 catalyzes the reversible and stereospecific aldol addition of dihydroxyacetone phosphate (DHAP) and

10 1-phosphate aldolase F131A-variant-catalyzed aldol addition of dihydroxyacetone phosphate to aldehyde

11 n of an aldehyde or ketone substrate affords aldol addition products that are stereochemically homolo

12 landmark publications of the first directed aldol addition reaction in 1973, the site, diastereo-, a

13 ated the development of Lewis base catalyzed aldol addition reactions.

14 DFT calculations on the key aldol addition revealed the presence of a highly ordered

15 The key step is a bioinspired aldol addition to set the stereogenic center in an inter

16 An unusual intramolecular aldol addition was developed for the assembly of its cyc

17 n-Bu2BOTf) and trialkylamines and subsequent aldol addition was probed structurally and mechanistical

18 Rate studies show that the aldol addition with isobutyraldehyde occurs as proffered

19 nts of FBP aldolase stereospecificity during aldol addition, a key ternary complex formed by DHAP and

20 ioselective formaldehyde C-C coupling beyond aldol addition.

21 A catalytic asymmetric aldol addition/cyclization reaction of unactivated keton

22 ossible utility of lithium enolates in Evans aldol additions are discussed.

23 Aldol additions to isobutyraldehyde and cyclohexanone wi

24 and tested as organocatalysts in asymmetric aldol additions.

25 de a deeper insight into histidine-catalyzed aldol additions.

26 stidine followed by biotransformation of the aldol adduct by an alcohol dehydrogenase without the nee

27 The aldol adducts are obtained in excellent yield with high

28 oselectivity features the production of anti-aldol adducts from alpha,beta-unsaturated ketones and al

29 The absolute configuration of the imino-aldol adducts has been determined.

30 ination of the NMR data for the above set of aldol adducts revealed consistent trends that were explo

31 (methoxymethoxy)-4,6,8-trimethylnonan-5 -one aldol adducts were confirmed by NMR analysis of 12 aceto

32 The aldol adducts were obtained with moderate to high 1,5-an

33 ctions of ketone 1a (known to give 3,5-trans aldol adducts with high selectivity) with a series of ke

34 te and many (hetero)aromatic aldehydes yield aldol adducts without subsequent dehydration.

35 riethylsilyloxy)-4,6,8-trimethylnonan -5-one aldol adducts.

36 kinetically controlled products via a domino aldol-aldol reaction sequence with excellent diastereose

37 c control operating in this multistep domino-aldol-aldol-hemiacetal protocol was used for probing the

38 The domino-aldol-aldol-hemiacetal-reaction cascade of indium and ot

39 d for the synthesis of a chiral cyclopropane aldol and a gamma-lactone in a >95:5 diastereomeric rati

40 tereochemistry at the spiro-center via retro-aldol and aldol condensation of compound 20 failed.

41 h ee has been developed via asymmetric imino-aldol and aldol reactions, respectively, starting from p

42 ermit to modulate asymmetric quimioselective aldol and conjugate addition reactions.

43 This approach could produce a series of aldol and Mannich products from enol carbamate with exce

44 classical (Robinson annulation and Mukaiyama aldol) and two are newly devised.

45 ied to the enantioselective alpha-amination, aldol, and alpha-aminoxylation/alpha-hydroxyamination re

46 was achieved using a sequential Diels-Alder/aldol approach in a highly diastereoselective manner.

47 Condensation reactions such as Guerbet and aldol are important since they allow for C-C bond format

48 roup results in an unanticipated aza-Michael/aldol/aromatization cascade to give polysubstituted quin

49 protocol entails a highly diastereoselective aldol/Brook rearrangement/cyclization cascade.

50 The enantioselective vinylogous Michael/aldol cascade is an underdeveloped approach to cyclohexe

51 e of a divergent organocatalytic aza-Michael/aldol cascade process toward quinolines and 1,4-dihydroq

52 tly undergo base-promoted diastereoselective aldol cascade reactions resulting in the natural or unna

53 by using either tertiary amines or a dizinc aldol catalyst constitute two parallel routes to the de

54 The combination of a distinct retro-aldol catalyst with a 1,2-HS catalyst enables lactic aci

55 Due to a lack of efficient retro-aldol catalysts, most previous investigations of catalyt

56 be compatible with the aforementioned retro-aldol catalysts.

57 substituted conjugated diene, non-Evans syn aldol, CBS reduction, Hantzsch's thiazole synthesis, Hor

58 This role is corroborated by loss of aldol cleavage ability and pyruvate C3 proton exchange a

59 d via hydroxylation of C1' followed by retro-aldol cleavage and acetal formation.

60 condensation, and the pyruvate enolate upon aldol cleavage as well as support proton exchange at C3.

61 The enzyme-catalyzed retro-aldol cleavage of 2-VIC unmasks a Michael substrate, 2-v

62 ass I aldolase that catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) from

63 ound that the overall rate-limiting step for aldol cleavage shifted from C-C bond scission (or an ear

64 d/base catalysis that facilitates reversible aldol cleavage.

65 de intermediate by stereodirected vinylogous aldol condensation (SVAC), (ii) installation of the amin

66 Subsequent intramolecular aldol condensation afforded the indenones.

67 ce alkylresorcinols and alkylpyrones through aldol condensation and lactonization of the same polyket

68 anding challenge because of competitive self-aldol condensation and multiple arylations.

69 d to investigate the cooperatively catalyzed aldol condensation between acetone and 4-nitrobenzaldehy

70 nyldiazines has been efficiently prepared by aldol condensation between the appropriate methyldiazine

71 yclization specificity from lactonization to aldol condensation for a type III PKS.

72 ith hemiacetal formation less important, and aldol condensation insignificant.

73 Although aldol condensation is one of the most important organic

74 The cascade reaction proceeds via a cross-aldol condensation of 2-(1H-imidazol-1-yl/benzimidazolyl

75 The intramolecular aldol condensation of 4-substituted heptane-2,6-diones l

76 ino reactions, namely a domino sulfa-Michael/aldol condensation of alpha,beta-unsaturated aldehydes w

77 Sn-, and Zr-Beta zeolites catalyze the cross-aldol condensation of aromatic aldehydes with acetone un

78 the rate-limiting step in the base-catalyzed aldol condensation of benzaldehydes with acetophenones,

79 stry at the spiro-center via retro-aldol and aldol condensation of compound 20 failed.

80 process to form active gold species for the aldol condensation of isocyanides and aldehydes to form

81 on of arylvinylquinazolines was performed by aldol condensation of the appropriate methylquinazoline

82 C12-C13 of providencin using intermolecular aldol condensation of the enolate from the selenyl lacto

83 osphoramidite binaphthol ligand, followed by aldol condensation of the resulting aluminum enolate wit

84 carbon bonds as cleaved in glycolysis in an aldol condensation of the unstable catabolites glycerald

85 carboxaldehyde shows that MppR catalyzes the aldol condensation of these compounds and subsequent deh

86 An efficient proline-mediated direct cross-aldol condensation of two advanced aldehyde intermediate

87 mediate can be folded to a suitable form for aldol condensation only in such a relatively narrow cavi

88 ion and characterization of the intermediate Aldol condensation product.

89 The Ho crossed aldol condensation provides access to a series of carbon

90 In particular, the observation of direct aldol condensation reactions enabled by hydrophobic zeol

91 action to set up the whole carbon framework, aldol condensation to construct the highly substituted c

92 tion/ring-opening followed by intramolecular aldol condensation under microwave irradiation is descri

93 reaction of 2-pyridylacetate followed by the Aldol condensation under mild reaction conditions has be

94 one-step procedure including a base-mediated aldol condensation using microwave irradiation.

95 OAC), which catalyzes a C2-C7 intramolecular aldol condensation with carboxylate retention to form OA

96 s a domino reaction sequence that employs an aldol condensation, alkene isomerization, and intramolec

97 roton abstraction, the aldehyde alignment in aldol condensation, and the pyruvate enolate upon aldol

98 include reduction of ketones to alcohols and aldol condensation, both reactions that are common in ex

99 oluene using Dean-Stark apparatus, where the aldol condensation, cyclopropyl ring opening followed by

100 (PT) domain of PhnA catalyzes only the C4-C9 aldol condensation, which is unprecedented among known P

101 -opening and successive intramolecular cross-aldol condensation.

102 ization and a subsequent base-mediated retro-aldol condensation.

103 hienyl ether derivatives via a well-designed aldol condensation/regioselective intramolecular cycliza

104 el structural contributions to regiospecific aldol condensations and show that reshaping the cyclizat

105 High-temperature, TiCl4-catalyzed, triple aldol condensations of aceanthrenone 5 and acenaphthacen

106 he beneficial amine-silanol cooperativity in aldol condensations, resulting in lower catalytic rates

107 The use of common aldol conditions resulted in predominant syn-addition vi

108 A subsequent Mukaiyama aldol coupling allows for the incorporation of a wide ar

109 This synthesis featured a diastereoselective aldol coupling between the aryl fragment and a central t

110 Asymmetric anti-aldol coupling of a norephedrine-derived ester with an a

111 ickel and copper hydroxides catalyze the key aldol coupling reaction of acetaldehyde to exclusively y

112 hesis include Evans alkylation, Crimmins syn-aldol, Crimmins acetate aldol, Wittig olefination, and S

113 rom native molecules that had intramolecular aldol cross-links at each end.

114 The success of the key imine aldol cyclization is acutely sensitive to substrate stru

115 o the activated alkynes and subsequent rapid aldol cyclization led to the formation of labile N-tosyl

116 uently reduced to initiate an intramolecular aldol cyclization to [3.2.1], [3.3.1], and [4.3.1] bicyc

117 of malonyl-CoA and catalyzes decarboxylative aldol cyclization to yield the pentaketide 2'-oxoalkylre

118 2) cycloaddition involving Michael addition, aldol cyclization, and lactonization.

119 x, tandem conjugate reduction/intramolecular aldol cyclization, and oxidative dearomatization.

120 uires oxidation, enolization, intramolecular aldol cyclization, and reduction, are not fully known.

121 NR-PKSs) are responsible for controlling the aldol cyclizations of poly-beta-ketone intermediates ass

122 nzymes in bacteria, regiospecific first-ring aldol cyclizations result in characteristically differen

123 e Cu(OTf)2-catalyzed Michael reaction/tandem aldol cyclizations, and one-pot reduction/transposition

124 ive and silver nanoparticle-mediated bridged aldol/dehydration to construct the [3.3.1] ring system.

125 scalable protocol involving a one-pot cross-Aldol direct arylation reaction protocol for the rapid c

126 e amino acids, such as glycine or serine, as aldol donors, and acetaldehyde is a coproduct.

127 For the product aldols, even weak acids (such as ammonium chloride) or p

128 gly correlated to the enolate geometry: anti aldols from (E)-enolates and syn aldols from (Z)-enolate

129 metry: anti aldols from (E)-enolates and syn aldols from (Z)-enolates.

130 The domino aldol/hetero-Diels-Alder synthesis of some new tricyclic

131 on time, is crucial for the isolation of the aldols in high (and stable) enantiomeric purity.

132 plication in various methodologies including aldol-lactonisations, Michael-lactonisations/lactamisati

133 ty of the nucleophile-catalyzed (Lewis base) aldol lactonization (NCAL) process for the diastereo- an

134 The ZnCl(2)-mediated tandem Mukaiyama aldol lactonization (TMAL) reaction of aldehydes and thi

135 hanistic extremes of [2+2] cycloaddition and aldol lactonization mechanisms, investigations of the TM

136 yclic carbene (NHC)-catalyzed intramolecular aldol lactonization of readily available ketoacids leadi

137 An improved, tandem acid activation/aldol-lactonization process is described.

138 elective intramolecular nucleophile-assisted aldol-lactonization was employed, leading to a beta-lact

139 An aldol-like cyclocondensation has been used to prepare he

140 y the hydroxylated intermediate undergoes an aldol-like phenoxide-ketone cyclization to yield the phe

141 alytically degrades via an unexpected 'retro-aldol-like' cleavage mechanism to a C18 aldehyde which i

142 ergistic catalyst for the List-Lerner-Barbas aldol (LLB-A) reaction of less reactive 2-azidobenzaldeh

143 nerally been successful in proline-catalyzed aldol, Mannich, alpha-amination, and alpha-aminoxylation

144 eaction and supports the proposed retroaldol-aldol mechanism of catalysis.

145 product B does not occur via an aldol/retro-aldol/Michael sequence.

146 hed anti,anti-dipropionate stereotriad 4 via aldol or crotylmetal chemistry represents a historical c

147 olates and enones to afford either glycolate aldol or Michael adducts.

148 procedure, some NHC-catalyzed sulfa-Michael/aldol organocascades were also investigated.

149 radical cyclization, and a tandem oxidation-aldol-oxidation are the key features of our methodology.

150 , we report excellent isolated yields of the aldol product (up to 99%), as well as modest to excellen

151 Deprotonation of the aldol product A with LDA induces equilibration to form t

152 hol moiety instead derived its preferred (R)-aldol product from an interplay between sterics and elec

153 zation was responsible for the exclusive (S)-aldol product in the antibody, the organocatalyst featur

154 vans' syn-aldol reactions is described, with aldol products being cleaved from the polymer by either

155 , and consequently, the R/S configuration of aldol products can be tuned by the use of either commerc

156 Single-crystal X-ray studies reveal that the aldol products can self-assemble to form supramolecular

157 The configuration of the aldol products is controlled by the proline chirality, a

158 r hydration, various beta-alkylation or beta-aldol products of the ketones are obtained with broad fu

159 The corresponding aldol products were obtained in high yields and good to

160 th unexpectedly resulted in the formation of aldol products with 6/7/5/5-fused molecular skeleton via

161 able and economical entry into syn- and anti-aldol products.

162 tion rate and the enantiomeric excess of the aldol products.

163 d excellent de by a zinc-ProPhenol-catalyzed aldol reaction and a palladium-catalyzed asymmetric ally

164 ehydrogenation to the ketone, followed by an aldol reaction and hydrogenation of the resulting enone.

165 New insight into the synthetically important aldol reaction and state-of-the-art methodology is prese

166 and an aqueous acid-catalyzed intramolecular aldol reaction are the key synthetic steps.

167 eveloped that relies on a diastereoselective aldol reaction between a suitably protected hydantoin an

168 y of various organocatalysts to catalyze the aldol reaction between acetone and 2,2,2-trifluoromethyl

169 The aldol reaction between benzaldehyde and acetone has been

170 A zinc-ProPhenol-catalyzed direct asymmetric aldol reaction between glycine Schiff bases and aldehyde

171 orresponding seco acid 32 originated from an aldol reaction between methyl ketone 6 and methyl (E)-3-

172 lphenoxide) (ATNP), in the doubly vinylogous aldol reaction between methyl-5-methyl-2-furoate and ald

173 Stereoselective direct aldol reaction between optically pure d- or l-glyceralde

174 This process consists of an initial aldol reaction catalyzed by readily available l-histidin

175 nti-allylic alcohols using a catalytic Evans aldol reaction conjoined with a relay-type ring-closing

176 The unexpected retroaldol-aldol reaction during O-alkylation of a beta-hydroxy lac

177 le starting materials and coupled through an aldol reaction followed by dehydration to afford stereos

178 , the site, diastereo-, and enantioselective aldol reaction has been elevated to the rarefied status

179 The directed aldol reaction has served as a fertile proving ground fo

180 By performing the aldol reaction in [Bmim]NTf(2) as a solvent, we report e

181 ficient methods for the asymmetric Mukaiyama aldol reaction in aqueous solution has received great at

182 in what can be considered an N-selective HNO-aldol reaction in up to quantitative yields.

183 oline catalysts carry out the intermolecular aldol reaction in water and provide high diastereoselect

184 was shown to promote enantioselective direct aldol reaction of 7-iodoisatin and 2,2-dimethyl-1,3-diox

185 tic system for the asymmetric direct crossed-aldol reaction of acetaldehyde in aqueous media using br

186 had significantly increased activity for the aldol reaction of erythrose with pyruvate compared with

187 esigned serine-based organocatalyst promoted aldol reaction of hydroxyacetone leading to syn-diols.

188 equence is a transition metal/base-catalyzed aldol reaction of methyl isocyanoacetate and difluoroace

189 An uncatalyzed aldol reaction of N-substituted thiazolidinediones with

190 imental observation that the activity of the aldol reaction on mesoporous silica depends on the lengt

191 oes a catalyst-free stereoselective transfer aldol reaction on water.

192 hetic utility of this chemistry, the racemic aldol reaction product was converted in five steps to a

193 Alternatively, an aldol reaction provided access to the same analogue in a

194 ion of ketones and a tandem radical addition-aldol reaction sequence to access vicinal quaternary ste

195 preparation are: (i) a stereoselective boron-aldol reaction to afford the acyclic carbon skeleton of

196 Synthetic highlights include a Crimmins aldol reaction to construct the C-1' and C-14 centers, a

197 C5-C11 polyol fragment, a diastereoselective aldol reaction to control the stereogenic center at C13,

198 alpha-ketol rearrangement, and a late stage aldol reaction to furnish the complex cage-like framewor

199 he C-1' and C-14 centers, a Crimmins acetate aldol reaction to generate the hydroxy group at the C-13

200 hexene inhibitor that features an asymmetric aldol reaction using a titanium enolate, diastereoselect

201 An organocatalytic enantioselective aldol reaction using paraformaldehyde as C1-unit has bee

202 Moreover, a related aldol reaction was also developed.

203 An intramolecular L-proline-mediated aldol reaction was employed to generate the cis-configur

204 combination of an asymmetric organocatalytic aldol reaction with a subsequent biotransformation towar

205 to an alkynone followed by an intramolecular aldol reaction with a tethered aldehyde to afford a cycl

206 th subsequent silyl trapping and a Mukaiyama aldol reaction with aqueous formaldehyde.

207 an organocatalytic one-pot Michael addition-aldol reaction with cheap 2-cyclohexenone and phenylacet

208 egy is based on two key reactions: first, an aldol reaction with formaldehyde in order to introduce s

209 The resulting enzyme catalyses a reversible aldol reaction with high stereoselectivity and tolerates

210 ategy-level reaction (the Mukaiyama directed aldol reaction).

211 an cyclization, a chiral Lewis acid mediated aldol reaction, and a facile amide union.

212 e cyclization, a selective 1,2-syn Mukaiyama aldol reaction, and a Noyori reduction.

213 thioester cleavage, sulfa-Michael addition, aldol reaction, and elimination reaction sequences to pr

214 oups that are known to undergo 1,2-addition, aldol reaction, and O-, N-, enolate-alpha-, and C(sp(2))

215 but-2-ene-1,4-dione surrogate, Nagao acetate aldol reaction, and Shiina lactonization.

216 chiral auxiliary mediated asymmetric acetate aldol reaction, dianion addition, and base mediated cycl

217 our propionate diastereoisomers combining an aldol reaction, followed by a stereoselective radical-ba

218 action, but is diverted by an intramolecular aldol reaction.

219 xylation, and a 1,3-anti-selective Mukaiyama aldol reaction.

220 active in ionic liquid/aqueous media for the aldol reaction.

221 hetic steps using a trifluoroacetate-release aldol reaction.

222 via a previously uncharacterized retro oxime-aldol reaction.

223 lectivity was observed in the intramolecular aldol reaction.

224 the stereochemical outcome of the asymmetric aldol reaction.

225 s, undergoing an N-selective nitrosocarbonyl aldol reaction.

226 sertion but is diverted by an intermolecular aldol reaction.

227 talysis, as demonstrated here for the chiral aldol reaction.

228 mediated TMAL process versus other Mukaiyama aldol reactions based on our experimental evidence to da

229 by nature for biological chemistry including aldol reactions being essential for glycolysis, gluconeo

230 in of diastereo- and enantioselectivities of aldol reactions between aldehydes catalyzed by histidine

231 The sources of asymmetric induction in aldol reactions catalyzed by cinchona alkaloid-derived a

232 The transition states of aldol reactions catalyzed by vicinal diamines are charac

233 s include a series of highly stereoselective aldol reactions followed by directed reductions to build

234 Retro-aldol reactions have been implicated as the limiting ste

235 merisation, transfer-hydrogenation and retro-aldol reactions have emerged as relevant transformations

236 velopments in the area of aqueous asymmetric aldol reactions highlighting two fundamental directions-

237 ng an organocatalytic cascade of Michael and aldol reactions in the presence of a chiral thiourea cat

238 , artificial catalysts designed and used for aldol reactions in water can be promising for the synthe

239 exible chiral catalysts for enantioselective aldol reactions in water, on water, and in the presence

240 iastereoselective solid-supported Evans' syn-aldol reactions is described, with aldol products being

241 The enantioselectivity in the aldol reactions is reversed if the reactions are carried

242 The diastereoselectivities of aldol reactions of 2-methylpropanal with various enolate

243 nt of diastereo- and enantioselective direct aldol reactions of a broad range of substrates.

244 Enantioselective aldol reactions of acetophenone with beta,gamma-unsatura

245 A study of the aldol reactions of boron enolates from methylketones tha

246 on the levels of 1,5-stereoselectivities of aldol reactions of boron enolates generated from beta-al

247 laldehyde, but cannot readily catalyze retro-aldol reactions of hexoses and pentoses at these moderat

248 ed by determining the stereoselectivities of aldol reactions of ketone 1a (known to give 3,5-trans al

249 or Horner-Emmons olefinations, and directed aldol reactions of lithium enolates), the one-pot proces

250 We also demonstrate aldol reactions of more demanding substrates with high a

251 gh trans- and syn-diastereoselectivities for aldol reactions of SF5-acetates with aldehydes in the pr

252 ate-temperature (around 100 degrees C) retro-aldol reactions of various hexoses in aqueous and alcoho

253 syn-Selective aldol reactions realized by using either tertiary amines

254 This strategy relies on two aldol reactions to install the chiral centers at C3/C4 a

255 lyst has been developed for asymmetric cross-aldol reactions under neat conditions in ketone-ketone,

256 Four vicinal diamine-catalyzed aldol reactions were examined.

257 Three boron aldol reactions were used to assemble the linear carbon

258 Boron-mediated aldol reactions were used to configure the three key fra

259 CBS reduction, and proline-catalyzed crossed-aldol reactions were utilized as key steps for the gener

260 e (1) and characterization of representative aldol reactions with aldehydes and ketones.

261 tetrasubstituted enolborinates which undergo aldol reactions with aldehydes to form products with all

262 lyze both Mukaiyama-Mannich and oxocarbenium aldol reactions with high efficiency and enantioselectiv

263 Aldol reactions with trifluoroacetophenones as acceptors

264 This opens a new route to iterative aldol reactions, and it has been used for the synthesis

265 loyed as an asymmetric catalyst in Mukaiyama aldol reactions, generating enantioselectivities of up t

266 ave been shown to be effective in catalysing aldol reactions, Morita-Baylis-Hillman reactions, conjug

267 een developed via asymmetric imino-aldol and aldol reactions, respectively, starting from protected a

268 models for diastereoselective methyl ketone aldol reactions, the discovery of a spontaneous Horner-W

269 line esters are efficient organocatalysts of aldol reactions, these results permit to modulate asymme

270 re catalytically competent toward asymmetric aldol reactions, were selected as the catalytic unit.

271 ric allylation, ring closing metathesis, and aldol reactions.

272 additions, aza-Michael additions, and direct Aldol reactions.

273 ed as a substrate for divergent transannular aldol reactions.

274 electivity in Lewis-acid-catalyzed Mukaiyama aldol reactions.

275 ences of the cyclic protecting groups on the aldol reactions.

276 ach involving asymmetric Mannich-type (imino-aldol) reactions of methyl phenylacetate with N-tert-but

277 ationale for, the observed patterns of imine aldol reactivity.

278 DMF, O-alkylation is faster than retroaldol-aldol rearrangement giving exclusively products with ret

279 Aldol relative topicity (simple diastereoselectivity) wa

280 r of Michael product B does not occur via an aldol/retro-aldol/Michael sequence.

281 Furthermore, a Michael/aldol sequence was developed for the construction of the

282 a beta-alkenyl group, which facilitated the aldol step.

283 F-5 topologies, the reaction is selective to Aldol-Tishchenko products, the 1 and 3 n-alkylesters of

284 amework, it becomes an electrophile yielding Aldol-Tishchenko selectivity.

285 s a masked OH at C6, (iii) an oxymercurative aldol to synthesize the tricyclo[5.3.2.0(1,6)]decene moi

286 eferences of a hydrogen-bonded nine-membered aldol transition state containing eight heavy atoms.

287 ps and the influence of E/Z isomerism on the aldol transition state were investigated.

288 Mukaiyama-aldol type reactions of acetals derived from enolizable

289 Aldol-type addition of alpha-triethylsilyl-alpha-diazoac

290 rocedure to the low-temperature LDA-promoted aldol-type addition of diazoacetone.

291 ell-defined precursors for a wide variety of aldol-type compounds.

292 lene compounds and concurrent intramolecular aldol-type condensation of S-alkylated compounds affords

293 roposal that this shared enzyme catalyzes an aldol-type condensation with glycine and uridine-5'-alde

294 rization, imine formation, ammonia addition, aldol-type condensation, cyclization, and aromatization,

295 The mechanistic insight toward the aldol-type cyanomethylation of N-tritylisatin with benzy

296 onvergent strategy comprise a boron-mediated aldol union to set the C(15)-C(17) syn-syn triad, reagen

297 ting materials, leading to the corresponding aldols with lower yields, but efficiently.

298 lation, Crimmins syn-aldol, Crimmins acetate aldol, Wittig olefination, and Shiina macrolactonization

299 ism of the former is a tandem gamma-umpolung/aldol/Wittig/dehydration process, as established by prep

300 synthetic strategy include modified Crimmins aldols, Yamaguchi esterification, and Grubbs ring-closin