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1 ategy-level reaction (the Mukaiyama directed aldol reaction).
2 the stereochemical outcome of the asymmetric aldol reaction.
3 pplications as a catalyst for the asymmetric aldol reaction.
4 gment utilized a chiral auxiliary based anti-aldol reaction.
5 gate to the traditional vinylogous Mukaiyama aldol reaction.
6 s, undergoing an N-selective nitrosocarbonyl aldol reaction.
7 rding the role of dimeric 2 in the Mukaiyama aldol reaction.
8 rted by mass spectrometry, is due to a retro-aldol reaction.
9 rols the absolute stereochemistry of the key aldol reaction.
10 diastereocontrol in a tandem chain-extension-aldol reaction.
11 sertion but is diverted by an intermolecular aldol reaction.
12 its use in the high-yielding aldehyde cross-aldol reaction.
13 for the divergent selectivity trends in the aldol reaction.
14 led to the development of a new tandem aldol-aldol reaction.
15 ation of the C-C bonds is a stepwise Michael-aldol reaction.
16 2) has been completed using a boron-mediated aldol reaction.
17 onal docking of the transition states of the aldol reaction.
18 chanism of the nornicotine-catalyzed aqueous aldol reaction.
19 electivity and represents a surrogate to the aldol reaction.
20 ences the selectivity of the lithium enolate aldol reaction.
21 icient norephedrine propionate boron enolate aldol reaction.
22 talysis, as demonstrated here for the chiral aldol reaction.
23 action, but is diverted by an intramolecular aldol reaction.
24 xylation, and a 1,3-anti-selective Mukaiyama aldol reaction.
25 active in ionic liquid/aqueous media for the aldol reaction.
26 hetic steps using a trifluoroacetate-release aldol reaction.
27 via a previously uncharacterized retro oxime-aldol reaction.
28 lectivity was observed in the intramolecular aldol reaction.
29 ences of the cyclic protecting groups on the aldol reactions.
30 ations have been tested as catalysts for the aldol reactions.
31 ly observed high syn diastereoselectivity of aldol reactions.
32 nprecedented mechanistic subtlety of aqueous aldol reactions.
33 (4R)-4-benzyl-2-oxazolidinone-mediated boron aldol reactions.
34 he use of two new asymmetric boron glycolate aldol reactions.
35 es as compared to secondary enamine-mediated aldol reactions.
36 hedrine were used in diastereoselective anti-aldol reactions.
37 by using antibody-catalyzed aldol and retro-aldol reactions.
38 ric allylation, ring closing metathesis, and aldol reactions.
39 additions, aza-Michael additions, and direct Aldol reactions.
40 ed as a substrate for divergent transannular aldol reactions.
41 electivity in Lewis-acid-catalyzed Mukaiyama aldol reactions.
42 through catalytic enantioselective reductive aldol reactions, a catalytic Negishi coupling, and a cat
43 or antibodies 84G3- and 93F3-catalyzed retro-aldol reactions, allowing the preparation of highly enan
44 d by a catalytic enantioselective vinylogous aldol reaction and a boron-mediated anti-aldol reaction
45 d excellent de by a zinc-ProPhenol-catalyzed aldol reaction and a palladium-catalyzed asymmetric ally
47 age is used to assign stereochemistry of the aldol reaction and as the final step in a short synthesi
50 ehydrogenation to the ketone, followed by an aldol reaction and hydrogenation of the resulting enone.
51 th aldol donor and acceptor molecules in the aldol reaction and is, therefore, of particular interest
52 mploying an intramolecular iodo halo-Michael aldol reaction and its merger with an ABCD ring fragment
53 New insight into the synthetically important aldol reaction and state-of-the-art methodology is prese
54 d mechanism of nornicotine-catalyzed aqueous aldol reactions and also provide the basis for future st
56 g Wittig, conjugate addition, and asymmetric aldol reactions and found to be reversible competitive i
58 displayed a higher k(cat) value in the retro-aldol reaction, and a linear relationship was observed i
60 thioester cleavage, sulfa-Michael addition, aldol reaction, and elimination reaction sequences to pr
61 oups that are known to undergo 1,2-addition, aldol reaction, and O-, N-, enolate-alpha-, and C(sp(2))
64 ts and the origins of the selectivity of the aldol reaction are discussed on the basis of the results
70 mediated TMAL process versus other Mukaiyama aldol reactions based on our experimental evidence to da
71 by nature for biological chemistry including aldol reactions being essential for glycolysis, gluconeo
72 ed organocatalytic asymmetric domino Michael-aldol reaction between 3-substituted oxindoles and methy
73 eveloped that relies on a diastereoselective aldol reaction between a suitably protected hydantoin an
74 y of various organocatalysts to catalyze the aldol reaction between acetone and 2,2,2-trifluoromethyl
75 m, and its catalytic potential in the direct aldol reaction between acetone and 4-nitrobenzaldehyde w
78 ide (16S,17S)-adduct 51 and a boron-mediated aldol reaction between enone 10 and aldehyde 9, exploiti
79 A zinc-ProPhenol-catalyzed direct asymmetric aldol reaction between glycine Schiff bases and aldehyde
80 orresponding seco acid 32 originated from an aldol reaction between methyl ketone 6 and methyl (E)-3-
81 lphenoxide) (ATNP), in the doubly vinylogous aldol reaction between methyl-5-methyl-2-furoate and ald
83 F fragments followed by a diastereoselective aldol reaction between the CDEF ketone and an AB aldehyd
84 in of diastereo- and enantioselectivities of aldol reactions between aldehydes catalyzed by histidine
85 d catalyst affords asymmetric intermolecular aldol reactions between unmodified ketones and various a
86 tive and proline that can eliminate the self-aldol reactions by suppressing an irreversible aldol con
89 tudies on several key steps, namely a direct aldol reaction catalyzed by the dinuclear zinc ProPhenol
92 nti-allylic alcohols using a catalytic Evans aldol reaction conjoined with a relay-type ring-closing
93 reaction of the enolate to the other enone, aldol reaction, dehydration, and enamine formation will
94 chiral auxiliary mediated asymmetric acetate aldol reaction, dianion addition, and base mediated cycl
95 The influence of resident stereocenters on aldol reaction diastereoselection has been examined in d
98 ls-Alder reactions, conjugate additions, and aldol reactions employing these auxiliaries are now repo
99 lecular Suzuki reaction and stereocontrolled aldol reactions establishing the C19/C20 and C22/C23 ste
100 le starting materials and coupled through an aldol reaction followed by dehydration to afford stereos
101 termediate titanium enolate could undergo an aldol reaction followed by the intramolecular Schmidt re
102 s include a series of highly stereoselective aldol reactions followed by directed reductions to build
103 our propionate diastereoisomers combining an aldol reaction, followed by a stereoselective radical-ba
104 ough application of a tandem chain extension-aldol reaction, followed by CAN-mediated oxidative cleav
107 , lanthanide-catalyzed, asymmetric Mukaiyama aldol reactions for the synthesis of chiral beta-hydroxy
109 loyed as an asymmetric catalyst in Mukaiyama aldol reactions, generating enantioselectivities of up t
110 boron-mediated syn- and anti-stereoselective aldol reaction giving rise to various beta-hydroxyenones
111 , the site, diastereo-, and enantioselective aldol reaction has been elevated to the rarefied status
115 merisation, transfer-hydrogenation and retro-aldol reactions have emerged as relevant transformations
116 velopments in the area of aqueous asymmetric aldol reactions highlighting two fundamental directions-
118 ficient methods for the asymmetric Mukaiyama aldol reaction in aqueous solution has received great at
120 oline catalysts carry out the intermolecular aldol reaction in water and provide high diastereoselect
121 e single transition state model observed for aldol reactions in organic solvent, the nornicotine-cata
123 ng an organocatalytic cascade of Michael and aldol reactions in the presence of a chiral thiourea cat
124 , artificial catalysts designed and used for aldol reactions in water can be promising for the synthe
125 exible chiral catalysts for enantioselective aldol reactions in water, on water, and in the presence
126 a a highly diastereoselective boron-mediated aldol reaction/in situ reduction between ketone (S)-8 an
129 izing the 1,4-syn stereoselectivity of boron aldol reactions involving certain alpha-chiral methyl ke
130 es, and stereochemistries of amine-catalyzed aldol reactions involving enamine intermediates have bee
132 iastereoselective solid-supported Evans' syn-aldol reactions is described, with aldol products being
135 Transition states for the intramolecular aldol reactions leading to the formation of hydrindanone
136 yde 22 was employed for formaldehyde in this aldol reaction, leading to the beta-hydroxy aldehyde 20
137 ave been shown to be effective in catalysing aldol reactions, Morita-Baylis-Hillman reactions, conjug
138 ay for the base-catalyzed reverse vinylogous aldol reaction of (-)-(4abeta,5beta)-4,4a,5,6,7,8-hexahy
143 was shown to promote enantioselective direct aldol reaction of 7-iodoisatin and 2,2-dimethyl-1,3-diox
144 tic system for the asymmetric direct crossed-aldol reaction of acetaldehyde in aqueous media using br
145 2 and 94 were (i) a Nagao asymmetric acetate aldol reaction of aldehyde 77 with thionothiazolidine 78
148 ons were a lithium-mediated, anti-selective, aldol reaction of aryl ester 8 (under Felkin-Anh inducti
151 led 1,5-syn and -anti stereoinduction in the aldol reaction of beta-tris(trialkylsilyl)siloxy methyl
154 had significantly increased activity for the aldol reaction of erythrose with pyruvate compared with
155 ons were achieved by a lithium-mediated anti aldol reaction of ester 40 and aldehyde 13 under Felkin-
156 C(24)), was established via a boron-mediated aldol reaction of ethyl ketone 15 and formaldehyde, foll
157 The E ring was assembled via the Mukaiyama aldol reaction of F-ring methyl ketone 3 and the 2,3-syn
158 esigned serine-based organocatalyst promoted aldol reaction of hydroxyacetone leading to syn-diols.
164 equence is a transition metal/base-catalyzed aldol reaction of methyl isocyanoacetate and difluoroace
165 s a highly stereoselective fragment assembly aldol reaction of methyl ketone 4 and aldehyde 5 to esta
166 (+)-diisopinocampheylboron chloride-mediated aldol reaction of methyl ketone 7 (overturning the inher
167 ynthesis features the highly stereoselective aldol reaction of methyl ketone 8b and aldehyde 60c and
168 r, has been achieved by employing Evans' syn-aldol reaction of N-acyl-(4R)-benzyl oxazolidin-2-one 3
170 een reduced to practice for catalysis of the aldol reaction of silyl ketene acetals and silyl dienol
171 he stereoselective intramolecular vinylogous aldol reaction of the furoic ester 25a to give 30 or its
173 e diastereoselectivity of the intramolecular aldol reaction of two differently sized monocyclic 1,3-d
174 o develop an efficient asymmetric vinylogous aldol reaction of unprecedented scope with respect to bo
178 lectivity in Lewis acid-promoted (Mukaiyama) aldol reactions of achiral unsubstituted enolsilanes and
180 c is a very efficient catalyst for Mukaiyama aldol reactions of aldehydes with trimethylsilyl enolate
181 stereocontrol can be realized for enolsilane aldol reactions of beta-alkoxy and beta-silyloxy aldehyd
183 on the levels of 1,5-stereoselectivities of aldol reactions of boron enolates generated from beta-al
186 eloped by routes involving fragment assembly aldol reactions of chiral aldehyde 6a and the chiral met
187 range of beta-hydroxy ketones deriving from aldol reactions of chiral aldehydes with a variety of ch
188 beta-alkoxy ketones were derived from nitro-aldol reactions of chiral alkoxy aldehydes with a series
189 h diastereoselectivity relying on asymmetric aldol reactions of chlorotitanium enolates of N-propiony
190 ted from two complex reactions involving the aldol reactions of cyclohexanone with benzaldehyde or wi
191 the highest ee's obtained to date in direct aldol reactions of glycine equivalents catalyzed by inex
192 laldehyde, but cannot readily catalyze retro-aldol reactions of hexoses and pentoses at these moderat
193 ed by determining the stereoselectivities of aldol reactions of ketone 1a (known to give 3,5-trans al
194 or Horner-Emmons olefinations, and directed aldol reactions of lithium enolates), the one-pot proces
196 rs that involves tandem Wittig rearrangement/aldol reactions of O-benzyl- or O-allylglycolate esters
197 gh trans- and syn-diastereoselectivities for aldol reactions of SF5-acetates with aldehydes in the pr
200 ed via substrate-controlled, boron-mediated, aldol reactions of the chiral ethyl ketones 10, 11, and
203 ate-temperature (around 100 degrees C) retro-aldol reactions of various hexoses in aqueous and alcoho
204 ach involving asymmetric Mannich-type (imino-aldol) reactions of methyl phenylacetate with N-tert-but
205 imental observation that the activity of the aldol reaction on mesoporous silica depends on the lengt
207 rded aldehydes that underwent intramolecular aldol reactions on treatment with a NaOH solution to yie
209 hetic utility of this chemistry, the racemic aldol reaction product was converted in five steps to a
214 een developed via asymmetric imino-aldol and aldol reactions, respectively, starting from protected a
215 ion of ketones and a tandem radical addition-aldol reaction sequence to access vicinal quaternary ste
216 cally controlled products via a domino aldol-aldol reaction sequence with excellent diastereoselectiv
217 feature a double diastereoselective acetate aldol reaction solely controlled by the chirality of the
219 fully intramolecular variant of the Sakurai-aldol reaction that creates four stereocenters, two new
220 ompounds was assembled via a stereoselective aldol reaction that unifies the C(1)-C(12) ketone fragme
221 erives from employment of diastereoselective aldol reactions that emanate from an 11 carbon piece.
222 e is a general lack of asymmetric vinylogous aldol reactions that tolerate variations of both the sil
223 rchetypical proline-catalyzed intramolecular aldol reaction, the Hajos-Parrish-Eder-Sauer-Wiechert re
224 models for diastereoselective methyl ketone aldol reactions, the discovery of a spontaneous Horner-W
225 line esters are efficient organocatalysts of aldol reactions, these results permit to modulate asymme
226 metric induction usually observed in acetate aldol reactions, this is of great synthetic utility and
227 hat is useful for monitoring the progress of aldol reactions through an increase in fluorescence.
228 preparation are: (i) a stereoselective boron-aldol reaction to afford the acyclic carbon skeleton of
229 Synthetic highlights include a Crimmins aldol reaction to construct the C-1' and C-14 centers, a
230 construction of C13-C14 (Z)-olefin, acetate aldol reaction to construct the C6-C7 bond and install t
231 g to form the C15-C16 carbon-carbon bond, an aldol reaction to construct the C6-C7 carbon-carbon bond
232 C5-C11 polyol fragment, a diastereoselective aldol reaction to control the stereogenic center at C13,
234 These two species are then reunited by an aldol reaction to form a new C-C bond, yielding an aldeh
235 alpha-ketol rearrangement, and a late stage aldol reaction to furnish the complex cage-like framewor
236 he C-1' and C-14 centers, a Crimmins acetate aldol reaction to generate the hydroxy group at the C-13
238 ed in a stereoselective MgBr2-catalyzed anti-aldol reaction to install the required stereochemistry o
239 dinuclear Zn-catalyzed asymmetric glycolate aldol reaction to prepare the syn 1,2-diol, and an intra
240 lyst provides an optimum environment for the aldol reaction to proceed selectively in water, and the
241 pro-adapter undergoes a 38C2-catalyzed retro-aldol reaction to produce the vinylketone linker, which
242 sulfonimide, which undergoes Sn(II)-mediated aldol reactions to diastereoselectively afford the anti,
244 reoselective, dialkylboron chloride-mediated aldol reactions to produce the anti,anti-aldol adduct.
247 minor nicotine metabolite, can catalyze the aldol reaction under physiologically relevant conditions
250 lyst has been developed for asymmetric cross-aldol reactions under neat conditions in ketone-ketone,
251 hexene inhibitor that features an asymmetric aldol reaction using a titanium enolate, diastereoselect
254 ploying asymmetric alkylation and asymmetric aldol reactions using chiral oxazolidinones as the key s
255 ctive lysine, 38C2 catalyzes aldol and retro-aldol reactions using the enamine mechanism of natural a
256 see text] Double diastereoselective acetate aldol reactions using the N-acetyl thiazolidinethione-ba
257 glyceraldehyde in situ from glycerol for the aldol reaction, using galactose oxidase catalyzed oxidat
259 reoselectivity of the tandem chain-extension-aldol reaction was determined through application of a C
263 sis of the transition states involving these aldol reactions was performed utilizing DFT (density fun
264 electivity in Lewis-acid-catalyzed Mukaiyama aldol reactions was studied using density functional the
266 (cat) values of the antibody-catalyzed retro-aldol reactions were correlated with the K(d) values, i.
271 CBS reduction, and proline-catalyzed crossed-aldol reactions were utilized as key steps for the gener
272 re catalytically competent toward asymmetric aldol reactions, were selected as the catalytic unit.
273 zyme optimized to perform a multistep retrol-aldol reaction when engineered into a TIM barrel protein
274 mproved stereoselectivity was observed in an aldol reaction when using a Boc-protected amino aldehyde
275 is-tetrahydro-4-hydroxy-6-methyl-2-pyrone by aldol reaction with 2,4-hexadienal, epoxidation followed
276 combination of an asymmetric organocatalytic aldol reaction with a subsequent biotransformation towar
277 to an alkynone followed by an intramolecular aldol reaction with a tethered aldehyde to afford a cycl
280 an organocatalytic one-pot Michael addition-aldol reaction with cheap 2-cyclohexenone and phenylacet
282 egy is based on two key reactions: first, an aldol reaction with formaldehyde in order to introduce s
283 The resulting enzyme catalyses a reversible aldol reaction with high stereoselectivity and tolerates
285 reochemical features of the titanium enolate aldol reaction with several 3-azidoaldehyde substrates d
286 rated by reactive immunization, catalyze the aldol reaction with the efficiency of natural enzymes, b
287 HB were accepted as donors in FSA-catalyzed aldol reactions with a variety of azido- and Cbz-amino a
289 tetrasubstituted enolborinates which undergo aldol reactions with aldehydes to form products with all
290 f aldolase antibodies that catalyze the same aldol reactions with antipodal selectivity were analyzed
291 ol-type reactions is the suppression of self-aldol reactions with enolizable aldehydes in reactions s
292 lyze both Mukaiyama-Mannich and oxocarbenium aldol reactions with high efficiency and enantioselectiv
295 e been explored as donors in organocatalytic aldol reactions with various aldehyde and ketone accepto
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