ライフサイエンスコーパス: aldose

1 C(5) configuration (equivalent to (1)C(4) in aldoses).

2 of D-[1-(13)C]aldose and D-[1-(13)C; 1-(2)H]aldose.

3 nary center, starting from readily available aldoses.

4 ins all the conserved amino acids within the aldose 1-epimerase protein motif.

5 Aldose-1-epimerase (mutarotase) catalyzes the interconve

6 rases from bacteria, and no gene encoding an aldose-1-epimerase has been isolated previously from hig

7 rs and is effected by the enzyme mutarotase (aldose-1-epimerase).

8 y, gp40 has 28 to 34% amino acid identity to aldose-1-epimerases from bacteria, and no gene encoding

9 The greatest sequence similarity was with aldose-6-phosphate reductase (EC 1.1.1.200), a key enzym

10 Aldose, aldehyde, and glyceraldehyde reductases are pres

11 containing equimolar mixtures of D-[1-(13)C]aldose and D-[1-(13)C; 1-(2)H]aldose.

12 Hydrogen atom transfer reactions between the aldose and ketose are key mechanistic features in formos

13 C. 5.3.1.5) catalyzes the interconversion of aldose and ketose sugars and has an absolute requirement

14 nterconversion of alpha- and beta-anomers of aldoses and is a recently identified member of the gal o

15 ere a complex mixture of linear and branched aldoses and ketoses are produced.

16 distribution into isotopomers of 13C-labeled aldoses and ketoses, and the fragmentation pathways for

17 sphoenolpyruvate (PEP) and the corresponding aldose: arabinose 5-phosphate (A5P) and erythrose 4-phos

18 l anodes and biosensors capable of oxidizing aldoses as cellobiose as well as lactose and glucose and

19 ears to involve the anomeric position (C1 in aldoses, C2 in ketoses), which has a more acidic hydroxy

20 Specifically, a 5 wt% aldose (for example, glucose, xylose or arabinose) solut

21 onsible for ring opening of the sugar to the aldose form, an observation that has been difficult to e

22 first step in the assimilation of xylose, an aldose found to be a major constituent monosaccharide of

23 molecular carbon shift (1,2-CS) reactions of aldoses, i.e., various molybdenum oxide and molybdate sp

24 ate catalyses the selective epimerization of aldoses in aqueous media.

25 ecause PMP specifically reacts with reducing aldoses, interference from noncarbohydrate components pr

26 The enzymatic aldose ketose isomerisation of glucose and fructose suga

27 acceleration for enzymatic catalysis of the aldose-ketose isomerization of (R)-glyceraldehyde 3-phos

28 chment of dihydroxyacetone obtained from the aldose-ketose isomerization of D,L-glyceraldehyde in D(2

29 echanism involves an initial metal-catalyzed aldose-ketose isomerization reaction, which results in t

30 triosephosphate isomerase (TIM) catalyze the aldose-ketose isomerization reactions of D-xylose and d-

31 ng thermal treatment indicated a tripling of aldose-ketose transformation in the presence of l-pyrogl

32 t molecules including phenolics, low pH, and aldose monosaccharides to activate its pathogenic pathwa

33 on refers to the reversible reaction between aldoses (or ketoses) and amino groups yielding relativel

34 ing hyperglycemic and hypertonic stress, the aldose-reducing property of AR has been accepted as its

35 Aldose reductase (AKR1B1) is a critical drug target beca

36 es involved in BH(4) biosynthesis, including aldose reductase (AKR1B1), carbonyl reductase (CBR1 and

37 lant, is a potent and selective inhibitor of aldose reductase (AKR1B1).

38 Aldose reductase (ALR2) is the first and rate-limiting e

39 Aldose reductase (ALR2), a NADPH-dependent aldo-keto red

40 vas deferens protein (MVDP) (76%), and human aldose reductase (AR) (62%).

41 he sodium/myo-inositol cotransproter (SMIT), aldose reductase (AR) and heat shock protein 70 (HSP70)

42 that inhibition of the polyol pathway enzyme aldose reductase (AR) by two structurally unrelated inhi

43 -carboxylic acid, non-hydantoin inhibitor of aldose reductase (AR) capable of potently blocking the e

44 Aldose reductase (AR) catalyzes the reduction of several

45 and structural changes in recombinant human aldose reductase (AR) due to modification by S-nitrosogl

46 is study, the selectivity and specificity of aldose reductase (AR) for glutathionyl aldehydes was exa

47 Increased glucose utilization by aldose reductase (AR) has been implicated in the develop

48 Aldose reductase (AR) has been implicated in the etiolog

49 Aldose reductase (AR) has been implicated in the etiolog

50 ion of glucose via the polyol pathway enzyme aldose reductase (AR) has been linked to the development

51 The study addressed the role for aldose reductase (AR) in 1) retinal oxidative stress and

52 This study examined the functions of aldose reductase (AR) in mediating acute lung inflammati

53 cidate the role of the polyol pathway enzyme aldose reductase (AR) in the mediation of ocular inflamm

54 of this study was to evaluate the effect of aldose reductase (AR) inhibition on posterior capsular o

55 Sorbinil, an aldose reductase (AR) inhibitor, attenuated GS-DHN level

56 Our recent studies indicate that aldose reductase (AR) inhibitors such as fidarestat inhi

57 hibition of the aldehyde-metabolizing enzyme aldose reductase (AR) inhibits NF-kappa B activation dur

58 Aldose reductase (AR) is a member of the aldo-keto reduc

59 Aldose reductase (AR) is a multifunctional enzyme that c

60 Aldose reductase (AR) is a multifunctional enzyme that r

61 Aldose reductase (AR) is an aldo-keto reductase that has

62 e stress and an earlier study has shown that aldose reductase (AR) mediates oxidative stress signals,

63 Sustained increases in glucose flux via the aldose reductase (AR) pathway have been linked to diabet

64 The aldose reductase (AR) polyol pathway contributes to thes

65 y, the authors showed that the inhibition of aldose reductase (AR) prevents bacterial endotoxin-induc

66 that inhibition of the polyol pathway enzyme aldose reductase (AR) prevents the increase in ICAM-1 an

67 Aldose reductase (AR) reduces cytotoxic aldehydes and gl

68 rated that, in response to multiple stimuli, aldose reductase (AR) regulates the inflammatory signals

69 Aldose reductase (AR) was immunohistochemically localize

70 Induction of aldose reductase (AR) was observed in human cells treate

71 Aldose reductase (AR), a member of the aldo-keto reducta

72 Aldose reductase (AR), a member of the aldo-keto reducta

73 Aldose reductase (AR), a member of the aldo-keto reducta

74 e activity and on expression and activity of aldose reductase (AR), a primary enzyme of polyol metabo

75 We have recently shown that inhibition of aldose reductase (AR), an enzyme that catalyzes the redu

76 The gene encoding aldose reductase (AR), an enzyme that mediates the gener

77 ee enzymes: triosephosphate isomerase (TIM), aldose reductase (AR), and phosphomannose isomerase (PMI

78 glucose were more potent: Inhibiting NOS or aldose reductase (AR), scavenging superoxide or peroxyni

79 The enzyme aldose reductase (AR), which is implicated in the regula

80 e studies reported here, we examined whether aldose reductase (AR), which reduces hydrophobic aldehyd

81 Sorbitol synthesis is catalyzed by aldose reductase (AR).

82 rnosine-propanals is catalyzed by the enzyme aldose reductase (AR).

83 hibition of the aldehyde-metabolizing enzyme aldose reductase (AR; AKR1B3) modulates NF-kappaB-depend

84 ihydroxyphenylethanol (DOPET) by aldehyde or aldose reductase (ARs).

85 transgenic mice broadly overexpressing human aldose reductase (ARTg) driven by the major histocompati

86 Aldose reductase (EC 1.1.1.21) catalyzes the NADPH-media

87 effects of reducing both the Km and Vmax of aldose reductase (EC 1.1.1.21), an enzyme whose function

88 hyde reductase (EC 1.1.1.2, Akr1a4 (GR)) and aldose reductase (EC 1.1.1.21, Akr1b3 (AR)) as the enzym

89 drophobic region of the active site of human aldose reductase (hALR2).

90 are enriched in an "activated" form of human aldose reductase (hAR), a NADPH-dependent oxidoreductase

91 and in alcohol oxidation activities of human Aldose reductase (hAR).

92 The kinetic parameter of cardiac aldose reductase (Kcat) was significantly higher in isch

93 e sodium/chloride/betaine cotransporter, and aldose reductase (synthesis of sorbitol).

94 ological inhibition or antisense ablation of aldose reductase (which catalyzes the reduction of GS-HN

95 models, we report that hyperglycemia-induced aldose reductase activation and subsequent reactive oxyg

96 hyperactivation, mitochondrial dysfunction, aldose reductase activation, reactive oxygen species pro

97 Aldose reductase activity and polyols were below our lim

98 monstrate that ischemia increases myocardial aldose reductase activity and that these increases are,

99 Excess aldose reductase activity can be a mechanism for human d

100 The results support the role for increased aldose reductase activity in functional and structural c

101 Diabetic mice, known to have much lower aldose reductase activity in other tissues when compared

102 These data indicate that inhibition of aldose reductase activity preserves high-energy phosphat

103 Inhibition of aldose reductase activity substantially diminished myo-i

104 5); GAPDH activity was higher; and G-3-P and aldose reductase activity were lower.

105 ent, the hexose monophosphate shunt pathway, aldose reductase activity, and levels of sorbitol and ga

106 The increased aldose reductase activity, higher sorbitol content and l

107 Two distinct peaks corresponding to aldose reductase and aldehyde reductase, the latter bein

108 ORE/TonE reporter activity, and induction of aldose reductase and betaine transporter mRNAs.

109 ic histidine residues in the key proteins in aldose reductase and heat-shock protein-70 within living

110 bitors that are able to discriminate between aldose reductase and other members of the aldo-keto redu

111 mice, glucose consumption is accompanied by aldose reductase and polyol pathway activation in steato

112 data also support the idea of activation of aldose reductase and polyol pathway as an important mech

113 The presence of aldose reductase and sorbitol dehydrogenase in these cel

114 To study aldose reductase and the sorbitol pathway in periodontit

115 inhibitor (zopolrestat) or transfection with aldose reductase antisense oligonucleotide blocked the p

116 inhibitors with the carboxy-terminal loop of aldose reductase are critical for the development of inh

117 eover, osmotic stress response genes such as aldose reductase are not induced upon T cell activation.

118 ed NF-kappaB and increased the expression of aldose reductase but not ICAM-1 and VCAM-1.

119 Ablation of aldose reductase by small interference RNA (siRNA) preve

120 tudy show that pharmacological inhibition of aldose reductase by sorbinil or knockdown of the enzyme

121 Our data suggest that aldose reductase can compensate for the loss of GLO1.

122 Aldose reductase catalyzed the reduction of chemically s

123 The crystal structure of aldose reductase complexed with 13 revealed an interacti

124 tat, an acetic acid-type inhibitor, bound to aldose reductase complexed with either NADPH or NADP+.

125 However, the crystal structure of aldose reductase complexed with inhibitor unambiguously

126 Aldose reductase contributes to diabetes-mediated mitoch

127 affinity for cofactor than the related human aldose reductase does.

128 A new and essential cis-element AEE (aldose reductase enhancer element), necessary for the co

129 Two representative genes are the aldose reductase enzyme (AR, EC 1.1.1.21), which is resp

130 Transgenic mice overexpressing human aldose reductase exhibited increased JAK2 and STAT5 acti

131 The aldose reductase gene is controlled by a tonicity-respon

132 , using an ORE.AP-1 reporter from the target aldose reductase gene or the same reporter with a mutate

133 levels, we partially characterized the human aldose reductase gene promoter present in a 4.2-kb fragm

134 Recently, we cloned the rabbit aldose reductase gene, characterized its structure, and

135 rosmotic stress induces transcription of the aldose reductase gene.

136 In the spinal cord, aldose reductase immunoreactivity was present solely in

137 t and human retinal endothelial cells showed aldose reductase immunoreactivity, and human retinas exp

138 ase inhibitor, the presence and influence of aldose reductase in cardiac tissue remain unknown.

139 lic regulation due to increased flux through aldose reductase in diabetic hearts may influence the ab

140 safety; as a result, the pathogenic role of aldose reductase in diabetic retinopathy remains controv

141 Inhibition of aldose reductase in GLO1(-/-) cells is associated with a

142 d a western blot confirmed a higher level of aldose reductase in mutant mitochondria.

143 further test the possible pathogenic role of aldose reductase in the development of diabetic retinopa

144 means of osmotic stress induced by activated aldose reductase in the sorbitol pathway.

145 Inhibition of aldose reductase increased survival in mice injected wit

146 Even though inhibition of aldose reductase increases vascular oxidative stress, th

147 Aldose reductase inhibited hearts, when subjected to isc

148 nil Retinopathy Trial, a randomized trial of aldose reductase inhibition among patients aged 18-56 ye

149 The plant was evaluated for aldose reductase inhibition and anti-diabetic action.

150 INSIM, with the conclusion that all reported aldose reductase inhibition can be rationalized in terms

151 In conclusion, aldose reductase inhibition counteracts diabetes-induced

152 To determine if aldose reductase inhibition improves tolerance to ischem

153 tion cannot be regarded as an alternative to aldose reductase inhibition in eliminating antioxidant a

154 Aldose reductase inhibition increased glycolysis and glu

155 This study evaluated the effects of aldose reductase inhibition on diabetes-induced oxidativ

156 Aldose reductase inhibition with fidarestat (16 mg . kg(

157 pathway, and PKCbetaII were all sensitive to aldose reductase inhibition.

158 lected from commercial databases for testing aldose reductase inhibition.

159 (butylated hydroxytoluene; 1% by diet) or an aldose reductase inhibitor (ARI) (sorbinil; 25 mg/kg/day

160 abetic rats were treated with or without the aldose reductase inhibitor (ARI) fidarestat (16 mg . kg(

161 ARI-809 is a recently discovered aldose reductase inhibitor (ARI) of a new structural cla

162 trol and galactose-fed rats treated with the aldose reductase inhibitor (ARI) Ponalrestat.

163 onic treatment with insulin or ICI222155, an aldose reductase inhibitor (ARI) previously shown to pre

164 erous attempts over 16 years, the results of aldose reductase inhibitor (ARI) trials for the treatmen

165 containing 50% galactose with or without an aldose reductase inhibitor (ARI) were investigated.

166 Rats treated with the aldose reductase inhibitor AL01576 for the duration of t

167 se transporter inhibitor cytochalasin B, the aldose reductase inhibitor alrestatin, and the advanced

168 Normal chow containing the aldose reductase inhibitor fidarestat (16 mg x kg(-1) x

169 The aldose reductase inhibitor sorbinil (2.5 mg/ml) when add

170 We then tested whether the aldose reductase inhibitor sorbinil and aspirin, which h

171 lglyoxal-treated HUVECs was prevented by the aldose reductase inhibitor sorbinil.

172 ecedented non-hydantoin, non-carboxylic acid aldose reductase inhibitor, 24, which shows remarkably p

173 abetic rats treated with a p38 inhibitor, an aldose reductase inhibitor, and insulin.

174 ly prevented by 12 weeks' treatment with the aldose reductase inhibitor, fidarestat.

175 on by sorbinil, a classic negatively charged aldose reductase inhibitor, results from binding to the

176 The coadministration of the aldose reductase inhibitor, sorbinil, with 40 mM galacto

177 strating protection of ischemic hearts by an aldose reductase inhibitor, the presence and influence o

178 Aldose reductase inhibitors (ARIs) prevent peripheral ne

179 11A mutant by several commercially available aldose reductase inhibitors (ARIs) was variable, with to

180 were treated with three structurally diverse aldose reductase inhibitors (ARIs).

181 Aldose reductase inhibitors (tolrestat or sorbinil) or a

182 es have demonstrated that negatively charged aldose reductase inhibitors act primarily by binding to

183 Insulin and aldose reductase inhibitors can prevent excess polyol pa

184 se results are confirmed in patient tissues, aldose reductase inhibitors could have some therapeutic

185 dependent manner by treating these dogs with aldose reductase inhibitors from the onset of galactosem

186 Aldose reductase inhibitors have shown promise in animal

187 group suggests an efficacious application of aldose reductase inhibitors in treating diabetic retinop

188 een nonsteroidal anti-inflammatory drugs and aldose reductase inhibitors like zopolrestat.

189 Treatment with aldose reductase inhibitors or aldose reductase siRNA di

190 ent of vascular smooth muscle cells with the aldose reductase inhibitors tolrestat and sorbinil preve

191 ion of extant literature findings with other aldose reductase inhibitors, including zopolrestat, resu

192 zothiazol-2-yl)methyl]indole-N-alkanoic acid aldose reductase inhibitors.

193 ol in pericytes that was markedly reduced by aldose reductase inhibitors.

194 rugs but had little effect on the binding of aldose reductase inhibitors.

195 furoxane derivatives, 5a-k,m, synthesized as aldose reductase inhibitors.

196 the bioactive constituent possessing potent aldose reductase inhibitory action, with an IC50 value o

197 studies of the novel compounds clarified the aldose reductase inhibitory profile observed, thus ratio

198 These findings indicate that aldose reductase is a component of ischemic injury and t

199 Recently, we demonstrated that aldose reductase is a component of myocardial ischemic i

200 Aldose reductase is also overexpressed in diabetic retin

201 Aldose reductase is an NADPH-dependent oxidoreductase th

202 One product of aldose reductase is sorbitol, which has been linked to o

203 ctase, these results support the notion that aldose reductase is the key relay that converts hypergly

204 viously, to explore the mechanism regulating aldose reductase levels, we partially characterized the

205 determine whether the polyol pathway enzyme aldose reductase mediates diabetes abnormalities in vasc

206 The present demonstration that aldose reductase mediates endotoxin-induced inflammation

207 GT1) and sodium-myo-inositol transporter and aldose reductase mRNA expression under hypertonic condit

208 s we report that the hypertonic induction of aldose reductase mRNA in HepG2 cells as well as the osmo

209 ibitors (tolrestat or sorbinil) or antisense aldose reductase mRNA prevented hyperproliferation of cu

210 in inhibition of the hypertonic induction of aldose reductase mRNA, ORE-driven reporter gene expressi

211 To rigorously test the effect of aldose reductase on myocardial ischemia-reperfusion inju

212 Pharmacological inhibition of aldose reductase or sorbitol dehydrogenase blocked JAK2

213 Specifically, the influence of the aldose reductase pathway flux on JAK-STAT signaling was

214 The aldose reductase pathway has been demonstrated to be a k

215 time, demonstrate JAK-STAT signaling by the aldose reductase pathway in ischemic hearts and is, in p

216 ctional recovery similar to that observed in aldose reductase pathway inhibited mice hearts.

217 cytosolic NADH/NAD+ ratio independent of the aldose reductase pathway inhibition, also blocked JAK2 a

218 vestigated signaling mechanisms by which the aldose reductase pathway mediates myocardial ischemic in

219 ucts; and increased glucose flux through the aldose reductase pathway.

220 tion of neutral endopeptidase, inhibition of aldose reductase plus lipoic acid supplementation, and i

221 njury and that pharmacological inhibitors of aldose reductase present a novel adjunctive approach for

222 ly, these results suggest that inhibition of aldose reductase prevents glucose-induced stimulation of

223 uciferase reporter gene construct containing aldose reductase promoter sequence from -1,094 base pair

224 and D-xylose), and a mutation in recombinant aldose reductase protein (C298A).

225 response to ischemia and that inhibition of aldose reductase reduces myocardial ischemic injury.

226 Pharmacological inhibition of aldose reductase significantly reduced ischemic injury a

227 reatment with aldose reductase inhibitors or aldose reductase siRNA did not affect mannitol-induced N

228 Both the aldose reductase specific inhibitor (zopolrestat) or tra

229 In human platelets, aldose reductase synergistically modulated platelet resp

230 thione conjugate, which has to be reduced by aldose reductase to stimulate cell growth.

231 chieved by increased catalytic efficiency of aldose reductase toward hemithioacetal (product of gluta

232 Notably, the aldose reductase transcript was overexpressed in LHON cy

233 normoglycemic levels via rapid increases in aldose reductase transcription and expression, which hav

234 The induction of aldose reductase transcription and the accumulation of s

235 ivity and the osmotic stress response of rat aldose reductase transcription in a rat liver cell line,

236 However, the introduction of a human aldose reductase transgene into a GK-deficient backgroun

237 petitive to mixed type of inhibition of lens aldose reductase using Lineweaver Burk plot.

238 With northern blot analysis, aldose reductase was detected in pericytes but not in en

239 Previously studied inhibitors of aldose reductase were largely from two chemical classes,

240 ndole-N-acetic acid (lidorestat, 9) inhibits aldose reductase with an IC(50) of 5 nM, while being 540

241 reductase)-null, cardiospecific-akr1b4 (rat aldose reductase), and akr1b8 (FR-1)-transgenic mice.

242 al cells (HUVECs) and C57 wild-type, akr1b3 (aldose reductase)-null, cardiospecific-akr1b4 (rat aldos

243 Aldose reductase, a member of the aldo-keto reductase fa

244 e of FR-1 shows striking homology with human aldose reductase, an enzyme linked to the pathogenesis o

245 probe vibration to the active site of human aldose reductase, and the response of the nitrile stretc

246 dehydrogenase flavoprotein [SDH Fp] subunit, aldose reductase, and TIM17 preprotein translocase); (4)

247 aracterize the kinetic properties of cardiac aldose reductase, as well as to study the impact of flux

248 ion of mRNA for hypertonicity-induced genes (aldose reductase, betaine/gamma-amino-n-butyric acid tra

249 enes of the aldo-keto reductase superfamily (aldose reductase, bile acid binder, and type I and type

250 romol/l zopolrestat, a specific inhibitor of aldose reductase, for 10 min, followed by 20 min of glob

251 , a function of renal medullary genes, e.g., aldose reductase, in diabetes.

252 Sorbitol, synthesized through aldose reductase, is a predominant osmolyte induced unde

253 ially docked to the expanded conformation of aldose reductase, known to bind larger ligands.

254 of inducible NO synthase, cyclooxygenase-2, aldose reductase, Mn superoxide dismutase, and probably

255 moprotective genes, including those encoding aldose reductase, Na+/Cl--coupled betaine/gamma-aminobut

256 When exposed to sorbinil, an inhibitor of aldose reductase, no GS-DHN was recovered in the coronar

257 Sorbinil, an inhibitor of aldose reductase, prevented all abnormalities.

258 through hyperglycemia-induced activation of aldose reductase, reactive oxygen species, and c-Myc.

259 idney cortex characterized by high levels of aldose reductase, sorbitol and endogenous fructose.

260 studies have demonstrated that activation of aldose reductase, the first enzyme of the polyol pathway

261 An inhibitor of aldose reductase, the rate-limiting enzyme in the pathwa

262 Aldose reductase, the rate-limiting enzyme of the polyol

263 09 is a novel chemotype highly selective for aldose reductase, these results support the notion that

264 Three genes-aldose reductase, thioredoxin reductase 1, and glucose-6

265 CD was also screened against the drug target aldose reductase, which can undergo large conformational

266 s pathway, we examined whether inhibition of aldose reductase, which catalyzes the first step of the

267 sepsis depend on the activity of the enzyme aldose reductase, which catalyzes the reduction of lipid

268 ly, these results suggest that inhibition of aldose reductase, which prevents PKC-dependent nonosmoti

269 Aldose reductase-catalyzed reduction is an important pat

270 In this regard, we show that aldose reductase-deficient mice are protected against gl

271 metabolism of the GS-HNE conjugate involves aldose reductase-mediated reduction, a reaction catalyze

272 ction for the introduction of specificity to aldose reductase-targeted drugs.

273 e challenge were suppressed by inhibition of aldose reductase.

274 se related to metabolism of hexose sugars by aldose reductase.

275 the cavity sites and was especially true for aldose reductase.

276 ascular cell adhesion molecule (VCAM)-1, and aldose reductase.

277 undergoing apoptosis were immunoreactive for aldose reductase.

278 severe hyperglycemia and/or high activity of aldose reductase.

279 , sodium/chloride/betaine cotransporter, and aldose reductase.

280 e drug Alrestatin bound to a mutant of human aldose reductase.

281 cofactor binding characteristics observed in aldose reductase.

282 ion catalyzed in vitro by homogenous cardiac aldose reductase.

283 y suppressed the heat-induced aggregation of aldose reductase.

284 is most likely caused by S-nitrosylation of aldose reductase.

285 educe inflammatory responses downstream from aldose reductase.

286 including aquaporin-2, urea transporter, and aldose reductase.

287 se, xylose or arabinose) solution with a 4:1 aldose:sodium tetraborate molar ratio reacted with catal

288 e reactions, with no detectable admixture of aldoses, stands in stark contrast to the formose reactio

289 ediate required for the attack of the second aldose substrate, changing the chemistry from aldolase t

290 A water-soluble aldose sugar dehydrogenase (Asd) has been purified for t

291 t into the characteristic anomeric carbon of aldose sugars and will facilitate the global analysis of

292 enzyme is able to act upon a broad range of aldose sugars, encompassing hexoses, pentoses, disacchar

293 but generic broad substrate specificity for aldose sugars.

294 reacts spontaneoulsy with ribose (and other aldoses) to give a mixture of four ribosides: alpha and

295 lysts are revealed: Bronsted acidity retards aldose-to-ketose isomerization by decreasing the equilib

296 pyridazinones, and has high selectivity for aldose versus aldehyde reductase.

297 g peracetylated furanoses directly from free aldoses was implemented.