ライフサイエンスコーパス: aldose reductase

1 se related to metabolism of hexose sugars by aldose reductase.

2 the cavity sites and was especially true for aldose reductase.

3 ascular cell adhesion molecule (VCAM)-1, and aldose reductase.

4 undergoing apoptosis were immunoreactive for aldose reductase.

5 severe hyperglycemia and/or high activity of aldose reductase.

6 , sodium/chloride/betaine cotransporter, and aldose reductase.

7 e drug Alrestatin bound to a mutant of human aldose reductase.

8 cofactor binding characteristics observed in aldose reductase.

9 ion catalyzed in vitro by homogenous cardiac aldose reductase.

10 y suppressed the heat-induced aggregation of aldose reductase.

11 is most likely caused by S-nitrosylation of aldose reductase.

12 educe inflammatory responses downstream from aldose reductase.

13 including aquaporin-2, urea transporter, and aldose reductase.

14 e challenge were suppressed by inhibition of aldose reductase.

15 Aldose reductase, a member of the aldo-keto reductase fa

16 models, we report that hyperglycemia-induced aldose reductase activation and subsequent reactive oxyg

17 hyperactivation, mitochondrial dysfunction, aldose reductase activation, reactive oxygen species pro

18 Aldose reductase activity and polyols were below our lim

19 monstrate that ischemia increases myocardial aldose reductase activity and that these increases are,

20 Excess aldose reductase activity can be a mechanism for human d

21 The results support the role for increased aldose reductase activity in functional and structural c

22 Diabetic mice, known to have much lower aldose reductase activity in other tissues when compared

23 These data indicate that inhibition of aldose reductase activity preserves high-energy phosphat

24 Inhibition of aldose reductase activity substantially diminished myo-i

25 5); GAPDH activity was higher; and G-3-P and aldose reductase activity were lower.

26 ent, the hexose monophosphate shunt pathway, aldose reductase activity, and levels of sorbitol and ga

27 The increased aldose reductase activity, higher sorbitol content and l

28 Aldose reductase (AKR1B1) is a critical drug target beca

29 es involved in BH(4) biosynthesis, including aldose reductase (AKR1B1), carbonyl reductase (CBR1 and

30 lant, is a potent and selective inhibitor of aldose reductase (AKR1B1).

31 Aldose reductase (ALR2) is the first and rate-limiting e

32 Aldose reductase (ALR2), a NADPH-dependent aldo-keto red

33 e of FR-1 shows striking homology with human aldose reductase, an enzyme linked to the pathogenesis o

34 Two distinct peaks corresponding to aldose reductase and aldehyde reductase, the latter bein

35 ORE/TonE reporter activity, and induction of aldose reductase and betaine transporter mRNAs.

36 ic histidine residues in the key proteins in aldose reductase and heat-shock protein-70 within living

37 bitors that are able to discriminate between aldose reductase and other members of the aldo-keto redu

38 mice, glucose consumption is accompanied by aldose reductase and polyol pathway activation in steato

39 data also support the idea of activation of aldose reductase and polyol pathway as an important mech

40 The presence of aldose reductase and sorbitol dehydrogenase in these cel

41 To study aldose reductase and the sorbitol pathway in periodontit

42 reductase)-null, cardiospecific-akr1b4 (rat aldose reductase), and akr1b8 (FR-1)-transgenic mice.

43 probe vibration to the active site of human aldose reductase, and the response of the nitrile stretc

44 dehydrogenase flavoprotein [SDH Fp] subunit, aldose reductase, and TIM17 preprotein translocase); (4)

45 inhibitor (zopolrestat) or transfection with aldose reductase antisense oligonucleotide blocked the p

46 vas deferens protein (MVDP) (76%), and human aldose reductase (AR) (62%).

47 he sodium/myo-inositol cotransproter (SMIT), aldose reductase (AR) and heat shock protein 70 (HSP70)

48 that inhibition of the polyol pathway enzyme aldose reductase (AR) by two structurally unrelated inhi

49 -carboxylic acid, non-hydantoin inhibitor of aldose reductase (AR) capable of potently blocking the e

50 Aldose reductase (AR) catalyzes the reduction of several

51 and structural changes in recombinant human aldose reductase (AR) due to modification by S-nitrosogl

52 is study, the selectivity and specificity of aldose reductase (AR) for glutathionyl aldehydes was exa

53 Increased glucose utilization by aldose reductase (AR) has been implicated in the develop

54 Aldose reductase (AR) has been implicated in the etiolog

55 Aldose reductase (AR) has been implicated in the etiolog

56 ion of glucose via the polyol pathway enzyme aldose reductase (AR) has been linked to the development

57 The study addressed the role for aldose reductase (AR) in 1) retinal oxidative stress and

58 This study examined the functions of aldose reductase (AR) in mediating acute lung inflammati

59 cidate the role of the polyol pathway enzyme aldose reductase (AR) in the mediation of ocular inflamm

60 of this study was to evaluate the effect of aldose reductase (AR) inhibition on posterior capsular o

61 Sorbinil, an aldose reductase (AR) inhibitor, attenuated GS-DHN level

62 Our recent studies indicate that aldose reductase (AR) inhibitors such as fidarestat inhi

63 hibition of the aldehyde-metabolizing enzyme aldose reductase (AR) inhibits NF-kappa B activation dur

64 Aldose reductase (AR) is a member of the aldo-keto reduc

65 Aldose reductase (AR) is a multifunctional enzyme that c

66 Aldose reductase (AR) is a multifunctional enzyme that r

67 Aldose reductase (AR) is an aldo-keto reductase that has

68 e stress and an earlier study has shown that aldose reductase (AR) mediates oxidative stress signals,

69 Sustained increases in glucose flux via the aldose reductase (AR) pathway have been linked to diabet

70 The aldose reductase (AR) polyol pathway contributes to thes

71 y, the authors showed that the inhibition of aldose reductase (AR) prevents bacterial endotoxin-induc

72 that inhibition of the polyol pathway enzyme aldose reductase (AR) prevents the increase in ICAM-1 an

73 Aldose reductase (AR) reduces cytotoxic aldehydes and gl

74 rated that, in response to multiple stimuli, aldose reductase (AR) regulates the inflammatory signals

75 Aldose reductase (AR) was immunohistochemically localize

76 Induction of aldose reductase (AR) was observed in human cells treate

77 Aldose reductase (AR), a member of the aldo-keto reducta

78 Aldose reductase (AR), a member of the aldo-keto reducta

79 Aldose reductase (AR), a member of the aldo-keto reducta

80 e activity and on expression and activity of aldose reductase (AR), a primary enzyme of polyol metabo

81 We have recently shown that inhibition of aldose reductase (AR), an enzyme that catalyzes the redu

82 The gene encoding aldose reductase (AR), an enzyme that mediates the gener

83 ee enzymes: triosephosphate isomerase (TIM), aldose reductase (AR), and phosphomannose isomerase (PMI

84 glucose were more potent: Inhibiting NOS or aldose reductase (AR), scavenging superoxide or peroxyni

85 The enzyme aldose reductase (AR), which is implicated in the regula

86 e studies reported here, we examined whether aldose reductase (AR), which reduces hydrophobic aldehyd

87 rnosine-propanals is catalyzed by the enzyme aldose reductase (AR).

88 Sorbitol synthesis is catalyzed by aldose reductase (AR).

89 hibition of the aldehyde-metabolizing enzyme aldose reductase (AR; AKR1B3) modulates NF-kappaB-depend

90 inhibitors with the carboxy-terminal loop of aldose reductase are critical for the development of inh

91 eover, osmotic stress response genes such as aldose reductase are not induced upon T cell activation.

92 ihydroxyphenylethanol (DOPET) by aldehyde or aldose reductase (ARs).

93 transgenic mice broadly overexpressing human aldose reductase (ARTg) driven by the major histocompati

94 aracterize the kinetic properties of cardiac aldose reductase, as well as to study the impact of flux

95 ion of mRNA for hypertonicity-induced genes (aldose reductase, betaine/gamma-amino-n-butyric acid tra

96 enes of the aldo-keto reductase superfamily (aldose reductase, bile acid binder, and type I and type

97 ed NF-kappaB and increased the expression of aldose reductase but not ICAM-1 and VCAM-1.

98 Ablation of aldose reductase by small interference RNA (siRNA) preve

99 tudy show that pharmacological inhibition of aldose reductase by sorbinil or knockdown of the enzyme

100 Our data suggest that aldose reductase can compensate for the loss of GLO1.

101 Aldose reductase catalyzed the reduction of chemically s

102 Aldose reductase-catalyzed reduction is an important pat

103 The crystal structure of aldose reductase complexed with 13 revealed an interacti

104 tat, an acetic acid-type inhibitor, bound to aldose reductase complexed with either NADPH or NADP+.

105 However, the crystal structure of aldose reductase complexed with inhibitor unambiguously

106 Aldose reductase contributes to diabetes-mediated mitoch

107 In this regard, we show that aldose reductase-deficient mice are protected against gl

108 affinity for cofactor than the related human aldose reductase does.

109 Aldose reductase (EC 1.1.1.21) catalyzes the NADPH-media

110 effects of reducing both the Km and Vmax of aldose reductase (EC 1.1.1.21), an enzyme whose function

111 hyde reductase (EC 1.1.1.2, Akr1a4 (GR)) and aldose reductase (EC 1.1.1.21, Akr1b3 (AR)) as the enzym

112 A new and essential cis-element AEE (aldose reductase enhancer element), necessary for the co

113 Two representative genes are the aldose reductase enzyme (AR, EC 1.1.1.21), which is resp

114 Transgenic mice overexpressing human aldose reductase exhibited increased JAK2 and STAT5 acti

115 romol/l zopolrestat, a specific inhibitor of aldose reductase, for 10 min, followed by 20 min of glob

116 The aldose reductase gene is controlled by a tonicity-respon

117 , using an ORE.AP-1 reporter from the target aldose reductase gene or the same reporter with a mutate

118 levels, we partially characterized the human aldose reductase gene promoter present in a 4.2-kb fragm

119 Recently, we cloned the rabbit aldose reductase gene, characterized its structure, and

120 rosmotic stress induces transcription of the aldose reductase gene.

121 drophobic region of the active site of human aldose reductase (hALR2).

122 are enriched in an "activated" form of human aldose reductase (hAR), a NADPH-dependent oxidoreductase

123 and in alcohol oxidation activities of human Aldose reductase (hAR).

124 In the spinal cord, aldose reductase immunoreactivity was present solely in

125 t and human retinal endothelial cells showed aldose reductase immunoreactivity, and human retinas exp

126 ase inhibitor, the presence and influence of aldose reductase in cardiac tissue remain unknown.

127 lic regulation due to increased flux through aldose reductase in diabetic hearts may influence the ab

128 safety; as a result, the pathogenic role of aldose reductase in diabetic retinopathy remains controv

129 Inhibition of aldose reductase in GLO1(-/-) cells is associated with a

130 d a western blot confirmed a higher level of aldose reductase in mutant mitochondria.

131 further test the possible pathogenic role of aldose reductase in the development of diabetic retinopa

132 means of osmotic stress induced by activated aldose reductase in the sorbitol pathway.

133 , a function of renal medullary genes, e.g., aldose reductase, in diabetes.

134 Inhibition of aldose reductase increased survival in mice injected wit

135 Even though inhibition of aldose reductase increases vascular oxidative stress, th

136 Aldose reductase inhibited hearts, when subjected to isc

137 nil Retinopathy Trial, a randomized trial of aldose reductase inhibition among patients aged 18-56 ye

138 The plant was evaluated for aldose reductase inhibition and anti-diabetic action.

139 INSIM, with the conclusion that all reported aldose reductase inhibition can be rationalized in terms

140 In conclusion, aldose reductase inhibition counteracts diabetes-induced

141 To determine if aldose reductase inhibition improves tolerance to ischem

142 tion cannot be regarded as an alternative to aldose reductase inhibition in eliminating antioxidant a

143 Aldose reductase inhibition increased glycolysis and glu

144 This study evaluated the effects of aldose reductase inhibition on diabetes-induced oxidativ

145 Aldose reductase inhibition with fidarestat (16 mg . kg(

146 pathway, and PKCbetaII were all sensitive to aldose reductase inhibition.

147 lected from commercial databases for testing aldose reductase inhibition.

148 (butylated hydroxytoluene; 1% by diet) or an aldose reductase inhibitor (ARI) (sorbinil; 25 mg/kg/day

149 abetic rats were treated with or without the aldose reductase inhibitor (ARI) fidarestat (16 mg . kg(

150 ARI-809 is a recently discovered aldose reductase inhibitor (ARI) of a new structural cla

151 trol and galactose-fed rats treated with the aldose reductase inhibitor (ARI) Ponalrestat.

152 onic treatment with insulin or ICI222155, an aldose reductase inhibitor (ARI) previously shown to pre

153 erous attempts over 16 years, the results of aldose reductase inhibitor (ARI) trials for the treatmen

154 containing 50% galactose with or without an aldose reductase inhibitor (ARI) were investigated.

155 Rats treated with the aldose reductase inhibitor AL01576 for the duration of t

156 se transporter inhibitor cytochalasin B, the aldose reductase inhibitor alrestatin, and the advanced

157 Normal chow containing the aldose reductase inhibitor fidarestat (16 mg x kg(-1) x

158 The aldose reductase inhibitor sorbinil (2.5 mg/ml) when add

159 We then tested whether the aldose reductase inhibitor sorbinil and aspirin, which h

160 lglyoxal-treated HUVECs was prevented by the aldose reductase inhibitor sorbinil.

161 ecedented non-hydantoin, non-carboxylic acid aldose reductase inhibitor, 24, which shows remarkably p

162 abetic rats treated with a p38 inhibitor, an aldose reductase inhibitor, and insulin.

163 ly prevented by 12 weeks' treatment with the aldose reductase inhibitor, fidarestat.

164 on by sorbinil, a classic negatively charged aldose reductase inhibitor, results from binding to the

165 The coadministration of the aldose reductase inhibitor, sorbinil, with 40 mM galacto

166 strating protection of ischemic hearts by an aldose reductase inhibitor, the presence and influence o

167 Aldose reductase inhibitors (ARIs) prevent peripheral ne

168 11A mutant by several commercially available aldose reductase inhibitors (ARIs) was variable, with to

169 were treated with three structurally diverse aldose reductase inhibitors (ARIs).

170 Aldose reductase inhibitors (tolrestat or sorbinil) or a

171 es have demonstrated that negatively charged aldose reductase inhibitors act primarily by binding to

172 Insulin and aldose reductase inhibitors can prevent excess polyol pa

173 se results are confirmed in patient tissues, aldose reductase inhibitors could have some therapeutic

174 dependent manner by treating these dogs with aldose reductase inhibitors from the onset of galactosem

175 Aldose reductase inhibitors have shown promise in animal

176 group suggests an efficacious application of aldose reductase inhibitors in treating diabetic retinop

177 een nonsteroidal anti-inflammatory drugs and aldose reductase inhibitors like zopolrestat.

178 Treatment with aldose reductase inhibitors or aldose reductase siRNA di

179 ent of vascular smooth muscle cells with the aldose reductase inhibitors tolrestat and sorbinil preve

180 ion of extant literature findings with other aldose reductase inhibitors, including zopolrestat, resu

181 ol in pericytes that was markedly reduced by aldose reductase inhibitors.

182 rugs but had little effect on the binding of aldose reductase inhibitors.

183 furoxane derivatives, 5a-k,m, synthesized as aldose reductase inhibitors.

184 zothiazol-2-yl)methyl]indole-N-alkanoic acid aldose reductase inhibitors.

185 the bioactive constituent possessing potent aldose reductase inhibitory action, with an IC50 value o

186 studies of the novel compounds clarified the aldose reductase inhibitory profile observed, thus ratio

187 These findings indicate that aldose reductase is a component of ischemic injury and t

188 Recently, we demonstrated that aldose reductase is a component of myocardial ischemic i

189 Aldose reductase is also overexpressed in diabetic retin

190 Aldose reductase is an NADPH-dependent oxidoreductase th

191 One product of aldose reductase is sorbitol, which has been linked to o

192 ctase, these results support the notion that aldose reductase is the key relay that converts hypergly

193 Sorbitol, synthesized through aldose reductase, is a predominant osmolyte induced unde

194 The kinetic parameter of cardiac aldose reductase (Kcat) was significantly higher in isch

195 ially docked to the expanded conformation of aldose reductase, known to bind larger ligands.

196 viously, to explore the mechanism regulating aldose reductase levels, we partially characterized the

197 metabolism of the GS-HNE conjugate involves aldose reductase-mediated reduction, a reaction catalyze

198 determine whether the polyol pathway enzyme aldose reductase mediates diabetes abnormalities in vasc

199 The present demonstration that aldose reductase mediates endotoxin-induced inflammation

200 of inducible NO synthase, cyclooxygenase-2, aldose reductase, Mn superoxide dismutase, and probably

201 GT1) and sodium-myo-inositol transporter and aldose reductase mRNA expression under hypertonic condit

202 s we report that the hypertonic induction of aldose reductase mRNA in HepG2 cells as well as the osmo

203 ibitors (tolrestat or sorbinil) or antisense aldose reductase mRNA prevented hyperproliferation of cu

204 in inhibition of the hypertonic induction of aldose reductase mRNA, ORE-driven reporter gene expressi

205 moprotective genes, including those encoding aldose reductase, Na+/Cl--coupled betaine/gamma-aminobut

206 When exposed to sorbinil, an inhibitor of aldose reductase, no GS-DHN was recovered in the coronar

207 al cells (HUVECs) and C57 wild-type, akr1b3 (aldose reductase)-null, cardiospecific-akr1b4 (rat aldos

208 To rigorously test the effect of aldose reductase on myocardial ischemia-reperfusion inju

209 Pharmacological inhibition of aldose reductase or sorbitol dehydrogenase blocked JAK2

210 Specifically, the influence of the aldose reductase pathway flux on JAK-STAT signaling was

211 The aldose reductase pathway has been demonstrated to be a k

212 time, demonstrate JAK-STAT signaling by the aldose reductase pathway in ischemic hearts and is, in p

213 ctional recovery similar to that observed in aldose reductase pathway inhibited mice hearts.

214 cytosolic NADH/NAD+ ratio independent of the aldose reductase pathway inhibition, also blocked JAK2 a

215 vestigated signaling mechanisms by which the aldose reductase pathway mediates myocardial ischemic in

216 ucts; and increased glucose flux through the aldose reductase pathway.

217 tion of neutral endopeptidase, inhibition of aldose reductase plus lipoic acid supplementation, and i

218 njury and that pharmacological inhibitors of aldose reductase present a novel adjunctive approach for

219 Sorbinil, an inhibitor of aldose reductase, prevented all abnormalities.

220 ly, these results suggest that inhibition of aldose reductase prevents glucose-induced stimulation of

221 uciferase reporter gene construct containing aldose reductase promoter sequence from -1,094 base pair

222 and D-xylose), and a mutation in recombinant aldose reductase protein (C298A).

223 through hyperglycemia-induced activation of aldose reductase, reactive oxygen species, and c-Myc.

224 response to ischemia and that inhibition of aldose reductase reduces myocardial ischemic injury.

225 Pharmacological inhibition of aldose reductase significantly reduced ischemic injury a

226 reatment with aldose reductase inhibitors or aldose reductase siRNA did not affect mannitol-induced N

227 idney cortex characterized by high levels of aldose reductase, sorbitol and endogenous fructose.

228 Both the aldose reductase specific inhibitor (zopolrestat) or tra

229 In human platelets, aldose reductase synergistically modulated platelet resp

230 e sodium/chloride/betaine cotransporter, and aldose reductase (synthesis of sorbitol).

231 ction for the introduction of specificity to aldose reductase-targeted drugs.

232 studies have demonstrated that activation of aldose reductase, the first enzyme of the polyol pathway

233 An inhibitor of aldose reductase, the rate-limiting enzyme in the pathwa

234 Aldose reductase, the rate-limiting enzyme of the polyol

235 09 is a novel chemotype highly selective for aldose reductase, these results support the notion that

236 Three genes-aldose reductase, thioredoxin reductase 1, and glucose-6

237 thione conjugate, which has to be reduced by aldose reductase to stimulate cell growth.

238 chieved by increased catalytic efficiency of aldose reductase toward hemithioacetal (product of gluta

239 Notably, the aldose reductase transcript was overexpressed in LHON cy

240 normoglycemic levels via rapid increases in aldose reductase transcription and expression, which hav

241 The induction of aldose reductase transcription and the accumulation of s

242 ivity and the osmotic stress response of rat aldose reductase transcription in a rat liver cell line,

243 However, the introduction of a human aldose reductase transgene into a GK-deficient backgroun

244 petitive to mixed type of inhibition of lens aldose reductase using Lineweaver Burk plot.

245 With northern blot analysis, aldose reductase was detected in pericytes but not in en

246 Previously studied inhibitors of aldose reductase were largely from two chemical classes,

247 ological inhibition or antisense ablation of aldose reductase (which catalyzes the reduction of GS-HN

248 CD was also screened against the drug target aldose reductase, which can undergo large conformational

249 s pathway, we examined whether inhibition of aldose reductase, which catalyzes the first step of the

250 sepsis depend on the activity of the enzyme aldose reductase, which catalyzes the reduction of lipid

251 ly, these results suggest that inhibition of aldose reductase, which prevents PKC-dependent nonosmoti

252 ndole-N-acetic acid (lidorestat, 9) inhibits aldose reductase with an IC(50) of 5 nM, while being 540