ライフサイエンスコーパス: aldosterone synthase

1 xycorticosterone, the immediate substrate of aldosterone synthase.

2 dogenesis factor-1-dependent upregulation of aldosterone synthase.

3 The -344C allele, associated with higher aldosterone synthase activity, has been linked to hypert

4 hesis involves three membrane-bound enzymes: aldosterone synthase, adrenodoxin, and adrenodoxin reduc

5 g classes, eg, inhibitors of vasopeptidases, aldosterone synthase and soluble epoxide hydrolase, agon

6 ), but the adjacent candidate genes Cyp11b2 (aldosterone synthase) and Cyp11b3 were ruled out.

7 CYP11B2, the aldosterone synthase, and CYP11B1, the cortisol synthase

8 Aldosterone synthase (AS) regulates blood volume by synt

9 Aldosterone synthase (AS, cytochrome P450 11B2, cyp11B2)

10 inoma cell line (H295R) overexpressing human aldosterone synthase cDNA was established.

11 ts to quantify the selectivity of LCI699 for aldosterone synthase compared with 11-beta-hydroxylase.

12 ing enzyme and steroid 11 beta-monooxygenase/aldosterone synthase complex depending on the steroidoge

13 hat the C-allele containing genotypes of the aldosterone synthase CYP11B2 T(-344)C gene polymorphism

14 Dual inhibitors of aromatase (CYP19) and aldosterone synthase (CYP11B2) are therefore proposed as

15 he adipokine leptin is a direct regulator of aldosterone synthase (CYP11B2) expression and aldosteron

16 The relationship between age and adrenal aldosterone synthase (CYP11B2) expression was evaluated

17 al studies conducted with LCI699 established aldosterone synthase (CYP11B2) inhibition as a promising

18 In PA, hypomethylation of aldosterone synthase (CYP11B2) is associated with aldost

19 The enzyme aldosterone synthase (CYP11B2) is responsible for the fi

20 The inhibition of aldosterone synthase (CYP11B2) to reduce aldosterone lev

21 in rat telemetry studies and no increase of aldosterone synthase (CYP11B2) was detected in H295R cel

22 ell clusters (APCCs) with high expression of aldosterone synthase (CYP11B2) were found in both normal

23 nhibitors proved to be able to interact with aldosterone synthase (CYP11B2), a cytochrome P450 enzyme

24 angiotensin II type 1 receptor (AGTR1), and aldosterone synthase (CYP11B2), including sex-SNP or SNP

25 Therefore, the inhibition of aldosterone synthase (CYP11B2), which is the pivotal enz

26 protein 1), as well as the gene encoding an aldosterone synthase (Cyp11b2).

27 Aldosterone synthase deficiency, salt-wasting forms of c

28 tochrome P-450 steroid 11 beta-monooxygenase/aldosterone synthase, EC 1.14.15.4).

29 twofold, including a three-fold increase in aldosterone synthase expression in adrenal gland, and a

30 J5MUT-induced induction of CYP11B2 (encoding aldosterone synthase) expression and aldosterone product

31 orphism exists in the promoter region of the aldosterone synthase gene (CYP11B2) at position -344 (T/

32 e polymorphism (SNP) at position -344 of the aldosterone synthase gene (CYP11B2).

33 tween single-nucleotide polymorphisms in the aldosterone synthase gene and plasma glucose levels in a

34 his study was to examine the extent to which aldosterone synthase genotype (CYP11B2) and genetic ance

35 the effects of increased expression of human aldosterone synthase (hAS) on blood pressure (BP), we es

36 pport additional research to evaluate use of aldosterone synthase inhibition in primary hypertension

37 Aldosterone synthase inhibition with LCI699 significantl

38 r losartan and by spironolactone, but not by aldosterone synthase inhibition.

39 We now report novel series of aldosterone synthase inhibitors with single-digit nanomo

40 C to T conversion at position -344) encoding aldosterone synthase is associated with hypertension, pa

41 eases, dual inhibition of CYP19 and CYP11B2 (aldosterone synthase) is a promising treatment for breas

42 ochrome P450 side chain cleavage enzyme) and aldosterone synthase, it did inhibit 3betaHSD2 expressio

43 We studied aldosterone synthase knockout (AS(-/-)) mice to define r

44 We show myocardial aldosterone and aldosterone synthase mRNA levels were elevated by 4- to

45 eart Failure Trial demonstrate the impact of aldosterone synthase polymorphism on left ventricle remo

46 ericans) substudy and were genotyped for the aldosterone synthase polymorphism.

47 The aldosterone synthase promoter -344C allele linked to hig

48 We sought to evaluate the effect of the aldosterone synthase promoter polymorphism on heart fail

49 Aldosterone synthase protein levels are increased in leu

50 LCI699, a novel inhibitor of aldosterone synthase, reduces serum aldosterone, and may

51 Fadrozole (an inhibitor of aldosterone synthase) treatment significantly reduced BP