ライフサイエンスコーパス: alkaline ceramidase

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1 ologue in S. cerevisiae that also encodes an alkaline ceramidase.

2 e been accordingly called acid, neutral, and alkaline ceramidases.

3 that Ca2+(o) markedly upregulates the human alkaline ceramidase 1 (haCER1) in HEKs; and its upregula

4 haCER1 is the human ortholog of mouse alkaline ceramidase 1 that we previously identified.

5 Human alkaline ceramidase 2 (ACER2) plays an important role in

6 Here we demonstrate that the human alkaline ceramidase 2 (ACER2), a Golgi enzyme, regulates

7 knockdown up-regulated the expression of the alkaline ceramidase 2 (ACER2), and the ACER2 up-regulati

8 demonstrate that our previously cloned human alkaline ceramidase 3 (ACER3) specifically controls the

9 ve been identified: 1 acid, 1 neutral, and 3 alkaline ceramidases (ACER1, ACER2, and ACER3).

10 Not only alkaline ceramidase activity but also the generation of

11 Instead, D-e-MAPP inhibited alkaline ceramidase activity in vitro with an IC50 of 1-

12 Here, we demonstrate that only alkaline ceramidase activity is expressed in erythrocyte

13 Alkaline ceramidase activity is highly expressed in mous

14 Collectively, these results suggest that alkaline ceramidase activity is important for the genera

15 onstrate that the yeast gene YPC1 encodes an alkaline ceramidase activity responsible for the breakdo

16 cloning of a cDNA encoding for a novel human alkaline ceramidase (aPHC) that hydrolyzes phytoceramide

17 ramidase inhibitor D-e-MAPP, suggesting that alkaline ceramidases have a role in the generation of SP

18 Brainwashing (Bwa) is the only putative alkaline ceramidase homologue present in Drosophila.

19 Several genes encode for variants of alkaline ceramidase in mammals.

20 e that D-e-MAPP functions as an inhibitor of alkaline ceramidase in vitro and in cells resulting in e

21 SPH and S1P increases were inhibited by the alkaline ceramidase inhibitor D-e-MAPP, suggesting that

22 loning and characterization of a novel mouse alkaline ceramidase (maCER1) with a highly restricted su

23 Similar to other alkaline ceramidases, maCER1 had an alkaline pH optimum

24 lkaline phytoceramidase, the first mammalian alkaline ceramidase to be identified as being specific f

25 and small interfering RNA knockdown of human alkaline ceramidase, which all increase endogenous ceram

26 accharomyces cerevisiae gene YPC1 encodes an alkaline ceramidase with a dual activity, catalyzing bot

27 r, these data suggest that maCER1 is a novel alkaline ceramidase with a stringent substrate specifici

28 Based on sequence homology to the yeast alkaline ceramidases YPC1p, we report the identification

29 s a 28 and 32% identity to the Saccharomyces alkaline ceramidases (YPC1p and YDC1p) and the human alk

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