ライフサイエンスコーパス: alkalinization

1 e endoplasmic reticulum (ER) and cytoplasmic alkalinization.

2 y, whereas cortical vesicles undergo a rapid alkalinization.

3 hat is strongly potentiated by intracellular alkalinization.

4 thological states associated with organellar alkalinization.

5 opropyl-amiloride-inhibitable, intracellular alkalinization.

6 lation of V-ATPase in response to luminal pH alkalinization.

7 ical plasma membrane, leading to cytoplasmic alkalinization.

8 rowth inhibition, and has no role in AtRALF1 alkalinization.

9 sion of a dominant negative kinase prevented alkalinization.

10 tion, whereas raising the external pH caused alkalinization.

11 ibution of endosomes, reflecting cytoplasmic alkalinization.

12 E1 at specific sites, inducing intracellular alkalinization.

13 sulfonic acid), at 10(-4) M eliminates lumen alkalinization.

14 st and after intracellular acidification and alkalinization.

15 on, whereas MEK-1 inhibition converted it to alkalinization.

16 arin did not inhibit systemin-induced medium alkalinization.

17 o stimulation of glycolysis by intracellular alkalinization.

18 c pigments and enduring severe cytoplasmatic alkalinization.

19 mpletely reversible with either chelation or alkalinization.

20 that it's concentration was not decreased by alkalinization.

21 r acidification and reduced by extracellular alkalinization.

22 lic acidification and inhibited by cytosolic alkalinization.

23 on channels and pumps to promote cytoplasmic alkalinization.

24 uct lumen was observed, followed by a marked alkalinization.

25 lso recover spontaneously from intracellular alkalinization.

26 the non-ionized form was titrated by luminal alkalinization.

27 om 2.5 to 50 mM resulted in an intracellular alkalinization.

28 gical processes associated with acidosis and alkalinization.

29 nting excessive cytoplasmic acidification or alkalinization.

30 acid secretion while preventing cytoplasmic alkalinization.

31 to reflect transient events of mitochondrial alkalinization.

32 calcium but is insensitive to intracellular alkalinization.

33 s necessary but not sufficient for lysosomal alkalinization.

34 acidic and decrease their polyP content upon alkalinization.

35 ) was reversed by NH(4)(+)-induced cytosolic alkalinization.

36 activated by both voltage and intracellular alkalinization.

37 ns alters mIPSCs in a manner consistent with alkalinization.

38 ge inhibitor, on the apical side produced an alkalinization (0.02 pH units) followed by acidification

39 e Ringer, apical H2DIDS produced a transient alkalinization (0.02 pH units), whereas basolateral expo

40 oval from the apical side caused a transient alkalinization (0.03 pH units) followed by a return to b

41 all acidification (0.01 pH unit) followed by alkalinization (0.05-0.1 pH unit), consistent with diffu

42 e of cell contraction or cause intracellular alkalinization (-0.01+/-0.02 U, NS).

43 The rate of alkalinization, 0.047 pH units/min, was reduced to 42% o

44 tive ATO1(G53D) allele results in a delay in alkalinization, a defect in hyphal formation, and a redu

45 nels of sperm proteins (CATSPERS1-4) form an alkalinization-activated Ca(2+)-selective channel requir

46 bly as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel.

47 equires Ca2+ entry into the sperm tail by an alkalinization-activated voltage-sensitive Ca2+-selectiv

48 Alkalinization activates the pH(i)-sensitive I(KSper), s

49 ished its proteinase inhibitor induction and alkalinization activities.

50 ding those for peptidase, decarboxylase, and alkalinization activity.

51 Thus, cellular alkalinization after Cl- removal is caused primarily by

52 EIPA inhibited alkalinization after lactate removal.

53 The rate of gradual alkalinization after the addition of HCO(3)(-)/CO(2) was

54 hese same treatments augmented the vesicular alkalinization already present in cells from ethanol-fed

55 Here, we show that alkalinization also has a dramatic effect on membrane po

56 Alkalinization also required the stress-activated p38 mi

57 lar mechanism for RALF-induced extracellular alkalinization and a signaling pathway that regulates ce

58 herefore dedicated to inducing intracellular alkalinization and activating spermatozoa.

59 ATO1(G53D) double mutant strain has additive alkalinization and ammonia release defects.

60 ated by both intracellular acidification and alkalinization and are regulated by the enzyme phospholi

61 mice with CGD due to defective DC endosomal alkalinization and autophagy.

62 e time point of Bax translocation (a similar alkalinization and Bax translocation was also observed a

63 (rapid alkalinization factor)(2,3) to induce alkalinization and cause disease in plants.

64 stimulation likewise elicited an apoplastic alkalinization and cytoplasmic acidification as well as

65 This synergy between alkalinization and GlcNAc to induce hyphal genes involve

66 on Factor 1 [RALF1]) that triggers cell wall alkalinization and growth arrest, possibly through the i

67 posure to phorbol ester caused intracellular alkalinization and it increased the rate of recovery fro

68 , strongly inhibited the UV-B-induced medium alkalinization and MAPK activity.

69 ther that ADK1 functions between cytoplasmic alkalinization and PIN3 relocalization in a linear pathw

70 bafilomycin) suppresses stimulation-induced alkalinization and reduces endocytotic uptake of FM1-43.

71 arium (F)-RALF peptide failed to induce host alkalinization and showed markedly reduced virulence in

72 ccharide specificity for induction of medium alkalinization and the generation of reactive oxygen in

73 ociated hyperuricemia consists of hydration, alkalinization, and allopurinol.

74 e relationship between 16K binding, endosome alkalinization, and altered EGFR signaling remains uncle

75 tants lacking AHR1 were defective in growth, alkalinization, and ammonia release on amino acid-rich m

76 treated with acetazolamide to cause urinary alkalinization, and Cerenkov images were compared with P

77 eatment includes fluid administration, urine alkalinization, and monitoring for signs of acute renal

78 ith increased NHE-1 phosphorylation and cell alkalinization, and plays a role in cell cycle progressi

79 DR) protein is associated with intracellular alkalinization, and several investigators have reported

80 on with vacuolar acidification and cytosolic alkalinization, and subsequent addition of K(+) ion incr

81 l and basolateral surfaces produced cellular alkalinization (apical side, 0.07 pH units; basolateral

82 increase in [H(+)]), followed by a prolonged alkalinization ( approximately 30 nM peak decrease in [H

83 raised in the presence of CNQX/APV, a second alkalinization arose, presumably due to direct activatio

84 inhibitor furosemide prevented intracellular alkalinization, Bax translocation, cytochrome c release,

85 plasma membrane H(+) V-ATPase energizes this alkalinization but the ion carriers involved are unknown

86 rize the basolateral membrane led to a small alkalinization but this was not mimicked by addition of

87 on ATPases, respectively, both induce medium alkalinization, but neither response was inhibited by su

88 TnaA may reverse alkalinization by metabolizing amino acids to produce ac

89 The inhibition of medium alkalinization by suramin was reversible in the presence

90 hetic NAEs inhibited elicitor-induced medium alkalinization by tobacco cells in a time- and concentra

91 honic acid (DIDS) partially inhibits luminal alkalinization caused by apical SCFA.

92 DIDS has no effect on luminal alkalinization caused by transepithelial CO2 gradients.

93 somal function as a consequence of lysosomal alkalinization, caused by failed maturation of the proto

94 hile the bicarbonate-dependent intracellular alkalinization could be related to chloride/bicarbonate

95 neural plate, suggesting that intracellular alkalinization could contribute to propagation of noggin

96 A) participates in a glutamate decarboxylase alkalinization cycle to protect E. coli from cytoplasmic

97 entiate force under these conditions nor did alkalinization decrease force.

98 in the amplitude of the Ca2+ transient, and alkalinization decreased its magnitude.

99 s rise in pH(i) was a depolarization-induced alkalinization (DIA).

100 IL-7) or IL-3 produced a rapid intracellular alkalinization, disrupting mitochondrial metabolism and

101 However, releasing stored Ca2+ via alkalinization does not appear to trigger significant Ca

102 Thus, recovery from alkalinization does not utilize specific, ion-dependent

103 we demonstrate that astrocytes undergo rapid alkalinization during periods of seizure-like activity,

104 bsent in uninduced ectoderm, indicating that alkalinization elicits alterations in tyrosine phosphory

105 ence tags revealed that genes encoding Rapid ALkalinization Factor (RALF) preproproteins were present

106 TE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plan

107 34 genes encoding proteins related to rapid alkalinization factor (RALF), a peptide growth factor.

108 Arabidopsis thaliana rapid alkalinization factor 1 (AtRALF1) is a small secreted pe

109 is a receptor for a signaling peptide (Rapid Alkalinization Factor 1 [RALF1]) that triggers cell wall

110 9-amino acid polypeptide, AtRALF1 (the rapid alkalinization factor protein family).

111 of the plant regulatory peptide RALF (rapid alkalinization factor)(2,3) to induce alkalinization and

112 e found that a secreted peptide, RALF (rapid alkalinization factor), suppresses cell elongation of th

113 RAPID ALKALINIZATION FACTOR-LIKE8 (AtRALFL8) was induced in ro

114 Rapid Alkalinization Factors (RALFs) are plant peptides that r

115 (2)/HCO(3)(-) with HEPES buffer caused rapid alkalinization followed by a gradual decrease in pH(i).

116 (-) in the presence of HCO(3)(-) produced an alkalinization followed by a resumption of the slow acid

117 tracellular bicarbonate, glycine produced an alkalinization followed by an acidification while, in th

118 des of depolarization coinciding with matrix alkalinization, followed by uncoupling.

119 Intracellular alkalinization following bath perfusion of quinine mimic

120 plication of NPPB and ACh accelerated the re-alkalinization following the initial acidification, indi

121 application of H2DIDS and ACh slowed the re-alkalinization following the initial acidification, indi

122 Increased river alkalinization has major environmental implications incl

123 AA induced rapid and transient extracellular alkalinization; however, the characteristics of the OGA

124 se as crucial components of the steady-state alkalinization in anterior midgut of mosquito larvae.

125 Cytoplasmic alkalinization in breast cancer cells occurs as a result

126 The intracellular alkalinization in Cl(-)-free, HCO(3)(-)-containing mediu

127 a positive inotropic effect or intracellular alkalinization in control cells.

128 Synthetic SnHypSys I was capable of inducing alkalinization in other Solanaceae cell types (or specie

129 the biliary epithelium reduces bile flow and alkalinization in patients with cystic fibrosis (CF).

130 rated that Xenopus ectoderm cells undergo an alkalinization in response to planar inductive signals d

131 lamide had no effect on the NH(4)(+)-induced alkalinization in the AE3 knock-out neurons.

132 We have examined the role of intracellular alkalinization in the establishment of anterior neural f

133 investigating the requirement for phagosomal alkalinization in the host defense against pulmonary asp

134 antiporter is the mechanism responsible for alkalinization in the isolated hippocampal brain slice i

135 increase (n = 11; approximately 0.4 pH unit alkalinization) in HPTS fluorescence in the lamellipodia

136 Extracellular alkalinization increased the magnitude of the rise of [C

137 In a manner consistent with alkalinization, increasing the buffering capacity from 3

138 NF 007, a suramin derivative, induced medium alkalinization, indicating that neither NF 007 nor hepar

139 Transient matrix alkalinization induced by NH4Cl only minimally influence

140 Experimental alkalinization inhibited the development of priming.

141 nt Ca2+ entry, perhaps because intracellular alkalinization inhibits either the Ca2+ entry pathway or

142 The cortical vesicle alkalinization is independent of exocytosis and cytosoli

143 pH increase of <0.1), indicating that matrix alkalinization is minimal during an mt-cpYFP flash.

144 e in P(o) for the subconductance channels by alkalinization is not associated with an increase in PIP

145 also suggest that IAA-induced extracellular alkalinization is not sufficient to account for the mech

146 e expression in planar explants in which the alkalinization is prevented by treatment with 4,4'-dihyd

147 The alkalinization is selectively eliminated by blocking ves

148 The astrocytic alkalinization is shown to be highly correlated with ast

149 gulating NHE1 expression, suggesting that SC alkalinization is the major stimulus for increased NHE1

150 Extracellular alkalinization is thought to contribute to fungal pathog

151 ted cortical granule exocytosis, cytoplasmic alkalinization, MAP kinase dephosphorylation, DNA synthe

152 ior neural-specific gene expression and that alkalinization may act by regulating the activity of a t

153 is and suggest that the protective effect of alkalinization may be attributed to inhibition of myoglo

154 The resulting cytosolic alkalinization may facilitate vesicular endocytosis.

155 Resistance is not observed when the alkalinization mediated by reverse Cl-/HCO3- exchange up

156 erved in intact animal caps, indicating that alkalinization-mediated changes in gene expression do no

157 The most rapid rates of river alkalinization occurred at sites with highest inputs of

158 mPTP-dependent alkalinization occurred in procoagulant platelets, sugge

159 Pulse-perfusion alkalinization occurred with or without flow reversal an

160 IAA-induced alkalinization occurs primarily in the growing apical re

161 free and total carbonate is demonstrated by alkalinization of a thin layer sample ( approximately 10

162 Tunicamycin treatment and alkalinization of acidic cell compartments with NH4Cl di

163 omol/L colchicine also brought about a rapid alkalinization of acidic vesicles in a manner that resem

164 roximately 40 min superfusion resulted in an alkalinization of approximately 0.35 pH units and an acc

165 latter would enhance depolarization-induced alkalinization of astrocytes, and extracellular acidific

166 Perioperative alkalinization of blood and urine using an infusion of s

167 Alkalinization of CF airway cultures prevented CF ASL hy

168 as increasing endolysosomal P2X4 activity by alkalinization of endolysosome lumen, promoted vacuole e

169 eceptor, the results indicate that sustained alkalinization of endosomes could have important functio

170 at increased CD36 translocation is caused by alkalinization of endosomes resulting from inhibition of

171 onic anhydrase is vital for NaCl resorption, alkalinization of gut contents, and absorption of short-

172 nol administration also caused a significant alkalinization of hepatic endosomes, and this increased

173 esponsible for acidification of endosome and alkalinization of intracellular pH.

174 ease (usually delayed 3 to 7 days), citrate, alkalinization of litmus milk, oxidization of glycerol (

175 In vitro alkalinization of luminal fluid led to reversal of defec

176 ves of young tomato plants and induces rapid alkalinization of media containing suspension-cultured L

177 Alkalinization of normally acidic intracellular compartm

178 se of other Al-chelating ligands, Al-induced alkalinization of rhizosphere pH, changes in internal le

179 The cytosolic alkalinization of root cap columella cells that normally

180 ing experimental observations were made: (i) alkalinization of slices mimicked the effect of D3 agoni

181 This process is known to require alkalinization of sperm cytoplasm, but the mechanism res

182 The three new peptides cause an alkalinization of suspension-cultured cells and induce t

183 aureus-associated endosomes with lysosomes, alkalinization of the acidic environment with chloroquin

184 In contrast, insulin causes an alkalinization of the cell, consistent with its main fun

185 nit within 55 s of gravistimulation, whereas alkalinization of the cells on the upper side was slower

186 Blocking the gravity-induced alkalinization of the columella cytoplasm with caged pro

187 n of the wall around the columella cells, an alkalinization of the columella cytoplasm, and the devel

188 ella but did not inhibit the gravity-induced alkalinization of the columella cytoplasm.

189 he polypeptide wound signal systemin are the alkalinization of the culture medium and the activation

190 ted from tobacco leaves that induced a rapid alkalinization of the culture medium of tobacco suspensi

191 transport into the cytoplasmic space, while alkalinization of the cytoplasm significantly enhanced t

192 To prevent alkalinization of the cytoplasm, a basolateral bicarbona

193 ocampal neurons, we studied NH(4)(+)-induced alkalinization of the cytosol, which is mitigated by Cl(

194 increase in auxin levels induces a transient alkalinization of the extracellular matrix, reducing cel

195 Alkalinization of the extracellular space occurred conco

196 These data demonstrate that Ca2+ evokes alkalinization of the inside of secretory vesicles befor

197 Interior alkalinization of the inside-out proteoliposomes due to

198 of hydrolases within lysosomes together with alkalinization of the intralysosomal compartment would r

199 We conclude that the transient alkalinization of the leaf apoplast is related to salini

200 a selective block in endocytosis, and (3) if alkalinization of the luminal fluid reverses this defect

201 methylamine, and bacitracin is not due to an alkalinization of the lysosome.

202 were coincident with a pronounced transient alkalinization of the matrix and are therefore not cause

203 Alkalinization of the medium exacerbated the protein syn

204 48-kDa mitogen-activated protein kinase and alkalinization of the medium of suspension-cultured cell

205 magnitude could be increased 3,000-fold upon alkalinization of the milieu (pK(a) = 7.1).

206 ne, blocked oxidase-induced 86Rb+ fluxes and alkalinization of the phagocytic vacuole, whereas NS1619

207 he ability of S. aureus to survive following alkalinization of the phagolysosomes by chloroquine.

208 does not affect gravity-induced cytoplasmic alkalinization of the root statocytes, suggesting either

209 TSLP production and dermatitis induced by alkalinization of the skin could be blocked by the PAR2

210 poietin production and dermatitis induced by alkalinization of the skin could be blocked by the prote

211 Alkalinization of the skin of asymptomatic NC/Tnd mice h

212 Alkalinization of the skin of asymptomatic NC/Tnd mice h

213 Alkalinization of the urine is a controversial treatment

214 ard therapies include intravenous hydration, alkalinization of the urine to increase the solubility o

215 idic organelles and was more effective after alkalinization of this compartment by the previous addit

216 Alkalinization of uninduced ectoderm at stage 10.5 led t

217 CA-I-induced alkalinization of vitreous increased kallikrein activity

218 The class C ash causes rapid alkalinization of water that is neutralized over time by

219 Alkalinizations of approximately 0.2-0.4 pH units of Hel

220 Finally, the effects of intracellular alkalinization on protein tyrosine phosphorylation were

221 zed SCFA (N-butyrate) augments crypt luminal alkalinization only slightly (0.08 pH units) versus a po

222 The concerted effects of depolarization and alkalinization open voltage-sensitive Ca2+ channels.

223 pHi 7.0 and were inhibited by intracellular alkalinization or acidification.

224 tion of the pathway was reversed by enforced alkalinization or overexpression of NHE-1, leading to a

225 centrations of OGA did not block IAA-induced alkalinization or the initial IAA-induced inhibition of

226 We now observe that this novel alkalinization pathway is mediated by the pH regulator N

227 On alkalinization (pH >12), signals from the pigment moiety

228 ne (P < 0.05), associated with intracellular alkalinization (pH(i) + 0.08+/-0.02 U, P < 0.05) and a s

229 n, increased ROI production, and cytoplasmic alkalinization play crucial roles in altered IL-10 respo

230 Our results indicate that intracellular alkalinization plays a critical role in the activation o

231 vity, thus permitting PTH secretion, whereas alkalinization potentiates CaR activity to suppress PTH

232 cium channel, and suggest that intracellular alkalinization potentiates CatSper current to increase i

233 f mosquito larvae maintains a specific lumen alkalinization profile with large longitudinal gradients

234 The strongest predictor of river alkalinization rates was carbonate lithology.

235 River alkalinization rates were significantly related to water

236 riables explained ~40% of variation in river alkalinization rates.

237 Podocyte alkalinization reduces cytosolic cathepsin L protease ac

238 CO(3)(-)-free) bath buffer resulted in lumen alkalinization reflecting HCO(3)(-) transport into the l

239 g pancreatic acinar cells, whereas cytosolic alkalinization released Ca2+ from intracellular stores.

240 However, the duration of the alkalinization response during continuous gravistimulati

241 ng tomato plants and nearly as active in the alkalinization response in Lycopersicon esculentum suspe

242 Additionally, systemin induced an alkalinization response in the transgenic tobacco cells

243 olymerization of 10 to 13, induced a maximal alkalinization response of 0.48 pH unit, but OGA treatme

244 IAA (1 microM) induced a saturating alkalinization response of approximately 0.2 pH unit and

245 nal mutants and by a gain in function of the alkalinization response to AtPep1 by tobacco suspension-

246 e FERONIA, which mediates the RALF-triggered alkalinization response(6), displayed enhanced resistanc

247 not to have an effect on the AtRALF1-induced alkalinization response.

248 with other approaches revealed that vacuolar alkalinization resulting from loss of Vma-dependent vacu

249 iminished mIPSCs in a manner consistent with alkalinization, resulting in faster rise time, a 39% red

250 ntial transducer revealed that the transient alkalinization rigidified (i.e. stiffened) the cell wall

251 reased the magnitude of SCFA-induced luminal alkalinization, roughly in the same proportion to the in

252 ation and amplitude being increased, whereas alkalinization shortened the action potential and reduce

253 fication was accompanied by an extracellular alkalinization, showing that it results from proton move

254 nt between WT and KO, and BZ amplified these alkalinizations similarly.

255 w here that the addition of an acidification/alkalinization step is essential in order to cancel any

256 the analysis, triggered by the acidification/alkalinization step, was behind the signal magnification

257 lated by barrier status per se, or by the SC alkalinization that accompanies barrier perturbation.

258 Loss of VPH1 results in vacuolar alkalinization that is even more rapid and pronounced th

259 ransmembrane conductance regulator-dependent alkalinization to abnormal CF ASL.

260 approximate 6.19), whereas neither external alkalinization to pH 8.4 nor internal acidification to p

261 nnels can then be increased by intracellular alkalinization to supra-physiological pH.

262 Interestingly, lysosomal alkalinization was accompanied by a rise in lipid oxidat

263 Intracellular alkalinization was accompanied by translocation of Bax t

264 The NH(4)(+)-induced alkalinization was also increased with inhibition of ani

265 ic response to the transient leaf apoplastic alkalinization was analyzed via ultra-high performance l

266 The K(+)-evoked alkalinization was Cl(-)-independent and was not substan

267 ream signaling of C5a-mediated intracellular alkalinization was dependent on C5aR1, intracellular cal

268 The NH(4)(+)-induced alkalinization was enhanced when the extracellular CAs w

269 ted from AE3-null mice, the NH(4)(+)-induced alkalinization was much larger than that seen in neurons

270 Endosomal alkalinization was observed in hearts from rats fed a la

271 was prevented by blocking a proton pump, re-alkalinization was prevented by blocking proton-permeant

272 ceptor outer segments increased by lysosomal alkalinization was restored 73% by a P2X7R antagonist.

273 Crypt luminal alkalinization was saturable by apical SCFA (substrate c

274 The intracellular alkalinization was the result of an alkaline shift in th

275 mitogen-activated protein kinases and medium alkalinization, were neither increased in BRI1-FLAG-over

276 rpolarizes horizontal cells, causes synaptic alkalinization, whereas activating an exogenously expres

277 ining HCO(3)(-) caused a rapid intracellular alkalinization, whereas the intracellular pH increase fo

278 y aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces

279 Alkalinization with weak bases or by removal of CO2 inhi

280 The resulting intracellular alkalinization would be expected to increase channel act