ライフサイエンスコーパス: alkaloid

1 erivatives [buprenorphine] and natural opium alkaloids).

2 roergosine was identified as the major ergot alkaloid.

3 ighly strained and reduced fungal piperazine alkaloid.

4 eochemistry at the C2 position of the target alkaloid.

5 ise the molecular structure for this natural alkaloid.

6 hesis of complex epipolythiodiketopiperazine alkaloids.

7 substituted pyrrolidines, including oxindole alkaloids.

8 stereocenters of multiple monoterpene indole alkaloids.

9 embers of the oligocyclotryptamine family of alkaloids.

10 secondary metabolites, including the indole alkaloids.

11 ynones to furnish the hydrindane core of the alkaloids.

12 ) were obtained via modification of Cinchona alkaloids.

13 ing quaternary stereocenter of these dimeric alkaloids.

14 rmediate for the synthesis of related marine alkaloids.

15 large number of total syntheses of morphine alkaloids.

16 clic core structure of calyciphylline B-type alkaloids.

17 synthesis of naturally occurring pyrolidine alkaloids.

18 recursor for synthesis of these aspidosperma alkaloids.

19 the total synthesis of calyciphylline B-type alkaloids.

20 core shared among several prenylated indole alkaloids.

21 as major constituents, and several groups of alkaloids.

22 duction of antimicrobial benzophenanthridine alkaloids.

23 cacy of paclitaxel, docetaxel, and the vinca alkaloids.

24 ricyclic framework of the lepadiformine-type alkaloids.

25 c studies of reactions catalyzed by cinchona alkaloids.

26 preparation of C20, C19, and C18 diterpenoid alkaloids.

27 and (2) elicitor-triggered overproduction of alkaloids.

28 , C. roseus PLA2 only accommodates C. roseus alkaloids.

29 ic nitrogenous structures resembling natural alkaloids.

30 hrough the production of biologically active alkaloids.

31 ng that robbers were less tolerant of nectar alkaloids.

32 esis of sphingolipid HPA-12 and the sedamine alkaloids.

33 of all three known 10-oxygenated Lycopodium alkaloids: 10-hydroxylycopodine, paniculine, and deacety

34 proof of concept, a fluorinated isoquinoline alkaloid, (18) F-aspergillitine is prepared in 10 % isol

35 is1 and previous syntheses of this family of alkaloids,2,3 all of which employ dimerization of symmet

36 (+)-lasubine II, and substituted piperidine alkaloid (+)-241-D.

37 modification, (+/-)-2, of the tazettine-type alkaloid 3-O-demethylmacronine is described.

38 Monoterpene indole alkaloids, a class of specialized metabolites that inclu

39 synthesis of chiral nonracemic isoquinoline alkaloids, a family of natural products showing a wide r

40 yl group of SAM and the nitrogen atom of the alkaloid acceptor decreased enzyme activity without disr

41 Here, the optical, fluorescence, and alkaloid-accumulating properties of C. roseus leaf idiob

42 Alkaloid accumulation in plants is activated in response

43 ytotoxicity, we further profiled this unique alkaloid across panels of discrete molecular targets.

44 bserved chemical SAR, suggest that Mitragyna alkaloids adopt a binding pose at the mu-opioid receptor

45 e (l-hyoscyamine, scopolamine) and steroidal alkaloids (alpha-solanine, alpha-chaconine) in goji berr

46 Total syntheses of the monoterpenoid indole alkaloids (+/-)-alstoscholarisine B and C were accomplis

47 parable with those reported for the Cinchona alkaloid ammonium salts derivatives (83-96% ee), and wit

48 naturally occurring molecules, proteins and alkaloids, among others.

49 e is converted into akuammicine, a Strychnos alkaloid, an elusive biosynthetic transformation that ha

50 Steroidal alkaloid analysis employed silica gel-coated TLC plates,

51 he synthesis of the natural products, spruce alkaloid and (+)-241D.

52 by the concise synthesis of isocryptolepine alkaloid and a series of its synthetic analogues with de

53 o unreveal potential role of steroidal glyco-alkaloids and phenylpropanoids during early blight resis

54 on independence, anthracnose resistance, low alkaloids and Phomopsis stem blight resistance, highligh

55 The successful synthesis of these alkaloids and the challenges that led to the development

56 e safe for feed consumption, since the ergot alkaloids and the regulated mycotoxins were below their

57 Cinchona alkaloids and their derivatives are widely used as organ

58 The biosynthesis of the N. fumigata ergot alkaloids and their relation to those produced by altern

59 opic affiliation between carbon atoms in the alkaloids and those in the precursors; (b) obtain inform

60 ent of the absolute (S)-configuration of the alkaloid, and together, these data engender the structur

61 re the structural motif of relevant cationic alkaloids, and they have a wide range of potential appli

62 embers of polyene macrocycles, pyrroloindole alkaloids, angucyclines, and leupeptins chemical familie

63 amine H, isodaphlongamine H, and a bioactive alkaloid, annotinolide A, which shows antiaggregation ac

64 are rich in bioactive phytochemicals such as alkaloids, anthocyanins, as well as monomeric and oligom

65 Indole alkaloids are a diverse class of natural products known

66 The akuammiline alkaloids are a family of natural products that have bee

67 Amaryllidaceae alkaloids are a large group of plant natural products wi

68 Benzylisoquinoline alkaloids are a large group of plant-specialized metabol

69 ry metabolites that comprise the diterpenoid alkaloids are categorized into C18, C19, and C20 familie

70 ticular, sulfonamide derivatives of cinchona alkaloids are highly enantioselective desymmetrization c

71 We have discovered that agelastatin alkaloids are potent modulators for cancer invasion and

72 Dimeric indole alkaloids are structurally diverse natural products that

73 KSP (ispinesib), and tubulin (taxanes, vinca alkaloids), are presented.

74 agents (MTA), such as the taxanes and vinca alkaloids, are used to treat a variety of cancers due to

75 The studied compounds include alkaloids, aromatic compounds, flavonoids, volatiles, se

76 Alkaloids as a compound class may have potential for dru

77 volved in the biogenesis of hapalindole-type alkaloids as a new family of calcium-dependent enzymes,

78 am-containing drugs, and naturally occurring alkaloids, as well as for the selective cyanation of the

79 of the perhydroquinoline core of the indole alkaloid aspidophytine (2), starting from commercially a

80 concise total syntheses of classical indole alkaloids (-)-aspidospermidine, (-)-tabersonine, and (-)

81 erization of mitragynine and related natural alkaloids at the human mu-, kappa-, and delta-opioid rec

82 frogs sequester lethal amounts of steroidal alkaloid batrachotoxin (BTX) in their skin as a defense

83 The synthesis of biologically active alkaloid benzosimuline, isolated from the shrub Zanthoxy

84 ated the binding mechanism of the anticancer alkaloid berberine to the human telomeric G4 (d[AG3(T2AG

85 Benzylisoquinoline alkaloids (BIAs) are a family of approximately 2500 alka

86 Benzylisoquinoline alkaloids (BIAs) are produced in a wide variety of plant

87 ulates the biosythesis of benzylisoquinoline alkaloids (BIAs).

88 nzyme duo in the context of hapalindole-type alkaloid biogenesis and implicate their promise for the

89 atic chlorination timing in ambiguine indole alkaloid biogenesis led to the discovery and characteriz

90 ment of class II CPRs for monoterpene indole alkaloid biosynthesis with a minimal or null role of cla

91 ions in the elicitor-initiated expression of alkaloid biosynthetic genes by recruiting the vacuolar p

92 ntrolled selective functionalizations of the alkaloid brucine.

93 production of carbocyclic amino ketones, key alkaloid building blocks.

94 ar concentrations of carbohydrates and toxic alkaloids, but A. lycoctonum was more likely to secrete

95 The pentacyclic alkaloid calothrixin B (1) has been synthesized in 5 ste

96 , has been identified as a derivative of the alkaloid camptothecin bound to phytosphingosine.

97 used in combination with bleomycin and vinca alkaloids, can lead to vascular events including acute c

98 ides, glycopeptides, terpenoids, macrolides, alkaloids, carbohydrates, and others.

99 harman along with two related beta-carboline alkaloids, carboline, and 5-carboline, which were report

100 ped and validated to measure tobacco-related alkaloids, carcinogens, and their metabolites in raw was

101 ing transition state (TS) model for cinchona alkaloid catalysis that we recently showed to be favored

102 erchlorate (1-2 equiv) as an additive to the alkaloid catalyst system was found to favor formation of

103 erg's report from 1977 that natural cinchona alkaloids catalyze the asymmetric conjugate addition of

104 l total syntheses of dimeric cyclotyrptamine alkaloids (+/-)-chimonanthine (3a), (+/-)-folicanthine (

105 scribe herein formal syntheses of the indole alkaloids cis-trikentrin A and herbindole B from a commo

106 Despite the fact that many members of this alkaloid class were discovered over 50 years ago, synthe

107 The denudatine-type diterpenoid alkaloids cochlearenine, N-ethyl-1alpha-hydroxy-17-verat

108 esis of magnoflorine, a quaternary aporphine alkaloid common in plants.

109 the super-relaxed state, piperine (the main alkaloid component of black pepper).

110 fied for the first time as significant ergot alkaloid components within the C. africana sclerotia, th

111 Monoterpene indole alkaloids comprise a diverse family of over 2000 plant-p

112 kly mutagenic aromatic amines, and the known alkaloid comutagen norharman along with two related beta

113 but visits correlated negatively with nectar alkaloid concentration and declined sharply between 200

114 However, alkaloid concentrations of >20 ppm were deterrent to B.

115 This fungus produced indole alkaloids containing an anti-bicyclo[2.2.2]diazaoctane c

116 ns have been performed into the synthesis of alkaloids containing this structure.

117 its, namely, vernalization requirement, seed alkaloid content, and resistance to anthracnose and Phom

118 e, as well as a single locus regulating seed alkaloid content.

119 The data indicate that ergot alkaloids contribute to virulence of N. fumigata in this

120 he biologically active pyridoacridine marine alkaloids demethyldeoxyamphimedine, deoxyamphimedine, an

121 nt and concise access to the pyrroloindoline alkaloids (+/-)-deoxyeseroline (1a), (+/-)-esermethole (

122 lytic system was determined to be a cinchona alkaloid derivative (TMS-quinine or Me-quinidine).

123 The synthesis of new agelastatin alkaloid derivatives and their anticancer evaluation in

124 ective C-H oxidation of complex aspidosperma alkaloid derivatives.

125 of cryptolepine, a pharmacologically active alkaloid derived from the roots of Cryptolepis sanguinol

126 ion in aldol reactions catalyzed by cinchona alkaloid-derived amines, and chiral vicinal diamines in

127 g effect between the chirality of a cinchona alkaloid-derived aminophosphine ligand for the silver(I)

128 A cinchona-alkaloid-derived chiral primary-amine-catalyzed enantios

129 A series of Cinchona alkaloid-derived dimers were obtained in high yields in

130 Cinchona alkaloid-derived organocatalysts as Bronsted bases have

131 enones under the catalysis of a new cinchona alkaloid-derived phase-transfer catalyst.

132 n, disclosed by List et al. using a cinchona alkaloid-derived primary amine (cinchona amine) organoca

133 The cinchona alkaloid-derived urea-catalyzed asymmetric conjugate add

134 pair of compounds, 4, assigned to the marine alkaloid discoipyrrole D is reported.

135 The evolution of proteases was conserved, alkaloid diversity has escalated across the studied spec

136 response of breast cancer patients to Vinca alkaloid drug treatment.

137 Berberine is an ancient multipotent alkaloid drug which derived from Coptis chinensis plants

138 ed in the biosynthesis of monoterpene indole alkaloids either through multiple isomers of strictosidi

139 These results demonstrate that alkaloids enhance pollinator flower constancy, opening n

140 Novel heterocyclic alkaloids eudistidines A (1) and B (2) were isolated fro

141 the more complex congeners of this class of alkaloids exploiting the diastereoselective addition of

142 f congeners in the reverse-prenylated indole alkaloid family related to stephacidin A by taking advan

143 rocyclization reaction, generates the marine alkaloids (-)-fasicularin 2 and a pro-forma synthesis of

144 ed access to hexacyclic C19-hemiaminal ether alkaloids (+)-fendleridine, (+)-acetylaspidoalbidine, an

145 Papaverine is a non-narcotic alkaloid found endemically and uniquely in the latex of

146 , a compound that embodies the haemanthidine alkaloid framework.

147 emistry facilitates rapid access to multiple alkaloid frameworks in an enantioselective fashion.

148 Morphine is an alkaloid from the opium poppy used to treat pain.

149 icyclic core of several aspidospermatan-type alkaloids from a linear, densely functionalized substrat

150 membrane transport leading to the anticancer alkaloids from C. roseus.

151 Morphinan alkaloids from the opium poppy are used for pain relief.

152 inations may also be due to an uptake of the alkaloids from the soil, previously being leached out fr

153 h the (-)- and (+)-enantiomeric forms of the alkaloid galanthamine [(-)-1] are reported.

154 originally proposed structure of the Hancock alkaloid (-)-galipeine, do not match those of the natura

155 e racemic modification of the unusual uleine alkaloid gilbertine.

156 A synthesis route to the pentacyclic alkaloid (-)-gilbertine, which features a cyclization ca

157 ward one of these-the complex amaryllidaceae alkaloid gracilamine-affording the shortest route to dat

158 everse prenylation of the tetracyclic indole alkaloid hapalindole U at its C-2 position.

159 derivatives, including the antiproliferative alkaloid (+)-haplocidine.

160 i.e., fumitremorgin C (FTC), Ko143, and the alkaloid harmine, which contain a tetrahydro-beta-carbol

161 The alkaloid has profound effects on learning in a dose-depe

162 In more recent times, these alkaloids have been discovered to span a wide range of c

163 A revised structure for the Lycopodium alkaloid huperzine N is proposed and confirmed by synthe

164 has been demonstrated by the analysis of the alkaloid in human serum and urine samples.

165 logues with the ring system of this class of alkaloids in 11 steps overall.

166 We conclude that alkaloids in Aconitum spp. nectar affect rates of both p

167 aracterised, but the potential role of these alkaloids in animal pathogenesis has not been studied ex

168 dition/reduction to access aspidosperma-type alkaloids in excellent diastereoselectivities.

169 ur synthesis of this hexacyclic aspidosperma alkaloid includes an efficient molybdenum-catalyzed enan

170 Several groups of Amaryllidaceae alkaloids including the hemanthamine- and crinine-type a

171 We identified several alkaloids, including the beta-carboline harmine and the

172 source of several medicinal terpenoid indole alkaloids, including the low-level anticancer vinblastin

173 lar isotope distribution patterns in the two alkaloids independent of plant species, whereas the rema

174 pyridines, and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yield

175 ntly higher levels of numerous pyrrolizidine alkaloids involved in plant defence.

176 A short convergent route to the racemic alkaloid is described which comprises only eight linear

177 The prodiginine family of bacterial alkaloids is a diverse set of heterocyclic natural produ

178 sadine and related dimeric pyrrole-imidazole alkaloids is a synthetic challenge.

179 ese prenylated and reverse-prenylated indole alkaloids is bioinspired, and may also inform the as-yet

180 trahydrocarbazole (ABE) core of Aspidosperma alkaloids is described.

181 employed by bacteria to produce prodiginine alkaloids is summarized.

182 Berberine, an isoquinoline alkaloid, is a traditional oriental medicine used to tre

183 rancheamide is a dichlorinated fungal indole alkaloid isolated from both Malbranchea aurantiaca and M

184 Mattogrossine is an indole alkaloid isolated from Strychnos mattogrossensis that co

185 ]oxy-6-(hydroxymethyl)oxane-3,4,5-triol], an alkaloid isolated from the root of Panax ginseng, slows

186 The okaramines are a class of complex indole alkaloids isolated from Penicillium and Aspergillus spec

187 onalized ABC ring system of the Aspidosperma alkaloid jerantinine E is reported.

188 ise route to a small family of exotic marine alkaloids known as the araiosamines has been developed,

189 h a recently reported total synthesis of the alkaloid kopsihainanine A (1).

190 ing isolation of pharmacologically important alkaloids: magnoflorine and berberine.

191 ed chemical synthesis of the natural product alkaloids mahanimbine and koenidine.

192 ly unique NMT involved in benzylisoquinoline alkaloid metabolism will facilitate the establishment of

193 Camptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic antitumor d

194 pharmaceutically valuable monoterpene indole alkaloids (MIAs) in Catharanthus roseus are derived from

195 oduce a large number of monoterpenoid indole alkaloids (MIAs) with different substitution patterns th

196 ctural expansion in the monoterpenoid indole alkaloids (MIAs) yielding thousands of unique molecules

197 than a hundred different monoterpene indole alkaloids (MIAs).

198 alyl linker offering rapid access to complex alkaloid mimics in very few experimentally simple steps:

199 oethanocarbazole core structure found in the alkaloid minfiensine (2).

200 The total synthesis of the Strychnos alkaloid (+/-)-minfiensine was achieved via an intramole

201 tive rearrangement product of the corynanthe alkaloid mitragynine.

202 method to determine the content of six opium alkaloids (morphine, codeine, thebaine, noscapine, papav

203 ins of N. fumigata and three different ergot alkaloid mutants derived by previous gene knockouts and

204 ly efficient 12-step synthesis of the marine alkaloid (-)-nakadomarin A has been accomplished.

205 in the total synthesis of the quinolizidine alkaloid natural products (-)-lasubine I, (+)-lasubine I

206 titive inhibitors, exemplified by the marine alkaloid neoamphimedine (neo), block TCF activity in vit

207 ory settings, we examined the effects of the alkaloid nicotine on bumblebee foraging performance.

208 ective total synthesis of the norditerpenoid alkaloid nigelladine A is described.

209 een used in the synthesis of other strychnos alkaloids, no investigations have been performed into th

210 nthetic pathway of noscapine from the simple alkaloid norlaudanosoline by engineering a yeast strain

211 e to the construction of quadrigemine H-type alkaloids not isolated previously from natural sources.

212 Cycloclavine is a clavine-type Ergot alkaloid noteworthy for its unique pentacyclic skeleton

213 otected bidentate chelating ligand, xanthine alkaloids, nucleosides, and related antiviral drug molec

214 inked to defensive mutualism attributable to alkaloids of fungal-origin.

215 inding pocket that specifically accommodates alkaloids of the class produced by the same plant, but n

216 The alkaloids of the Southeast Asian plant Mitragyna specios

217 alidated biosynthetic precursor to ambiguine alkaloids, of which biogenetic origin remains unknown.

218 The first cinchona-alkaloid-organocatalyzed enantioselective synthesis of c

219 toward chemical synthesis of the prodiginine alkaloids over the last several decades is extensively r

220 Awareness about pyrrolizidine alkaloids (PAs) and tropane alkaloids (TAs) in food was

221 Pyrrolizidine alkaloids (PAs) are toxic secondary metabolites that are

222 dities contain traces of toxic pyrrolizidine alkaloids (PAs).

223 ntrol mechanism for the bifurcation of these alkaloid pathway branches.

224 including products of a branch of the ergot alkaloid pathway called fumigaclavines.

225 In plant-derived ajmalan alkaloid pathways, the biosynthetic intermediate vomilen

226 The synthesis of the piperidine alkaloid (-)-pelletierine was successfully undertaken in

227 ep convergent synthesis of the semisynthetic alkaloid (-)-perhydrohistrionicotoxin is described.

228 l-known stimulant caffeine, and its xanthine alkaloid precursors, has evolved multiple times in flowe

229 rahydroharmine and harmaline, the three main alkaloids present in B. caapi, and the harmine metabolit

230 osynthetic pathways driving the diversity of alkaloids produced by the endophyte.

231 ify the ergot species by molecular and ergot alkaloid profile analysis, to determine the ergot alkalo

232 oid profile analysis, to determine the ergot alkaloid profile in pure honeydew and in infected sorghu

233 evious gene knockouts and differing in ergot alkaloid profiles.

234 ually every natural product class: terpenes, alkaloids, prostaglandins, macrolides, and tetracyclines

235 We also demonstrate that the cinchona alkaloids quinidine and quinine give rise to products (s

236 (-)-N-Methylguattescidine (3) is an alkaloid recently isolated from Fissistigma latifolium a

237 ess, is limited in distribution and specific alkaloid repertoires are variable across taxa.

238 sis of hybrubin A, a bipyrrole tetramic acid alkaloid representing a new carbon framework derived fro

239 Our concise synthesis of these alkaloids required the development of a late-stage and h

240 subunits present in Aspidosperma and Kopsia alkaloids, respectively, en route to highly efficient sy

241 ionally, highly specialised Asota moths used alkaloid rich plants.

242 uted 7-deazahypoxanthine analogues of marine alkaloid rigidins led to the design and synthesis of com

243 The solanaceous alkaloids S-(-)-nicotine and hyoscyamine (atropine) are

244 pful to annotate specific compounds, such as alkaloids, saponins, flavonoids, and terpenoids, which a

245 sful construction of a polycyclic Lycopodium alkaloid scaffold has been explored.

246 of a chiral quaternary carbon center in the alkaloid scaffold is introduced.

247 Therefore, the Mitragyna alkaloid scaffold represents a novel framework for the d

248 This route allowed the alkaloid serralongamine A to be synthesized for the firs

249 ic changes were active from steroidal glycol-alkaloid (SGA), lignin and flavonoid biosynthetic pathwa

250 ly, the stereoisomers of the heteroyohimbine alkaloids show diverse pharmacological activities.

251 including the hemanthamine- and crinine-type alkaloids show promise as anticancer agents.

252 Elimination of all ergot alkaloids significantly reduced virulence of N. fumigata

253 fforts toward the synthesis of Daphniphyllum alkaloids spanning the period from 2005 to the beginning

254 el addition reaction catalyzed by a cinchona alkaloid-squaramide bifunctional organocatalyst was stud

255 we show how the combination of trace cocaine alkaloids, stable isotopes, and multivariate statistical

256 s used in the total synthesis of the Stemona alkaloid (-)-stemaphylline in just 11 steps (longest lin

257 ms that are widely useful building blocks in alkaloid synthesis.

258 r more quaternary stereocenters render these alkaloids synthetically challenging.

259 mmetric syntheses of all eight tetraponerine alkaloids (T1-T8) were achieved using the diastereoselec

260 A closer monitoring of tropane alkaloids (TA) in foods is now recommended by the Europe

261 Seven new prenylated indole alkaloids, taichunamides A-G, were isolated from the fun

262 ut pyrrolizidine alkaloids (PAs) and tropane alkaloids (TAs) in food was recently raised by the Europ

263 chemical features in common with the complex alkaloid tetrodotoxin.

264 ionally, we identified a benzophenanthridine alkaloid that dissipates the hairpin species and destabi

265 Millingtonine is a glycosidic alkaloid that exists as a pair of pseudo-enantiomeric di

266 nd liriodenine are plant-derived aporphinoid alkaloids that exhibit potent inhibitory activity agains

267 oad-spectrum antibacterial pyrrole-imidazole alkaloids that have a complex polycyclic skeleton.

268 on frogs have a diverse arsenal of defensive alkaloids that target the nervous system.

269 rom both enantiomers of proline and cinchona alkaloid thiourea derivatives.

270 es offers the first solution to access these alkaloids through completely stereoselective union of mo

271 s, through dearomatizing ortho-substitution; alkaloids, through Hofmann-type elimination; tropolone a

272 polone and furan, through cycloaddition; and alkaloids, through three-component fragmentation-couplin

273 s roseus produces bioactive terpenoid indole alkaloids (TIAs), including the chemotherapeutics, vincr

274 tically valuable, bioactive terpenoid indole alkaloids (TIAs).

275 expand the potential application of B. caapi alkaloids to other brain disorders that may benefit from

276 terpenoids to the periderm and sesquiterpene alkaloids to the cortex layer of Tripterygium roots.

277 We investigated the contribution of ergot alkaloids to virulence of N. fumigata by measuring morta

278 l total synthesis of the famous arrow poison alkaloid tubocurarine.

279 the first successful entry toward the curare alkaloids (+/-)-tubocurine and (+/-)-curine.

280 aborated to the racemic modifications of the alkaloids uleine, dasycarpidone, noruleine, and nordasyc

281 el, which works for cinchonidine or cinchona alkaloid-urea catalyzed sulfa-Michael addition reactions

282 uch of the functionality associated with the alkaloid vindoline (3).

283 The synthesis of the Securinega alkaloid virosaine A by Hughes and Gleason is a perfect

284 In addition, a novel uncharacterized alkaloid was observed only in CRISPR/Cas9 edited plants.

285 modular synthesis of phenanthroindolizidine alkaloids was achieved by combining iodoaminocylization

286 Additionally, fractionation of alkaloids was achieved resulting isolation of pharmacolo

287 Rs in the biosynthesis of monoterpene indole alkaloids, we provide compelling evidence of an operatio

288 of eight dimeric and three monomeric nuphar alkaloids were achieved, along with the construction of

289 y (LC-DAD-ESI-MS/MS), whereby the two purine alkaloids were detected using positive ESI, and the othe

290 Jerantinine A (JA) is a novel indole alkaloid which displays potent anti-proliferative activi

291 We report an asymmetric approach to these alkaloids, which has culminated in the first total synth

292 . provided eudistidine C (1), a heterocyclic alkaloid with a novel molecular framework.

293 natively, can isomerize to form perakine, an alkaloid with a structurally distinct scaffold.

294 l-Vasicine is a quinazoline alkaloid with an electron dense ring and additional func

295 communesin F are structurally related indole alkaloids with an intriguing polycyclic core containing

296 Thus, comutagenicity of beta-carboline alkaloids with aromatic amines is shown to occur in surf

297 ds (BIAs) are a family of approximately 2500 alkaloids with both potential and realized pharmaceutica

298 nct ambiguine, fischerindole and hapalindole alkaloids with chlorine via late-stage aliphatic C-H gro

299 lied leading to a phenolic fraction, free of alkaloids, with higher antioxidant capacity (IC50=25 mug

300 o tricyclic analogues of the bis(piperidine) alkaloid xestoproxamine C are presented.