ライフサイエンスコーパス: alkenyl

1 lation with dialkylzinc reagents furnishes 1-alkenyl-1,1-borozinc heterobimetallic intermediates.

2 e esters with dicyclohexylborane generates 1-alkenyl-1,1-diboro species.

3 boration with dicyclohexylborane generates 1-alkenyl-1,1-diboro species.

4 forward method for generation of versatile 1-alkenyl-1,1-heterobimetallic intermediates and their app

5 The 1-alkenyl-1,1-heterobimetallic intermediates have also bee

6 duced herein is a practical application of 1-alkenyl-1,1-heterobimetallic intermediates in the synthe

7 Under optimized conditions, addition of 1-alkenyl-1,1-heterobimetallic intermediates to a variety

8 In situ treatment of 1-alkenyl-1,1-heterobimetallic intermediates with aldehyde

9 lation with dialkylzinc reagents furnishes 1-alkenyl-1,1-heterobimetallic intermediates.

10 1-Alkenyl-1,1-heterobimetallics are potentially very usefu

11 the in situ synthesis of (E)-3-substituted 6-alkenyl-1,2,4,5-tetrazine derivatives through an elimina

12 n includes a rhodium-catalyzed reaction of 4-alkenyl-1-sulfonyl-1,2,3-triazoles featuring an unusual

13 Vinyl-, E-, or Z-disubstituted alkenyl-, 1,1-disubstituted alkenyl-, acyclic, or hetero

14 rmation to the preparation of a variety of N-alkenyl 2-pyridonyl ether analogues, which have the pote

15 nal studies suggest that the desired 5-exo N-alkenyl 2-pyridonyl ethers are formed reversibly in the

16 tramolecular ring closures by inclusion of 2-alkenyl, 2-aryl, or 2-oximinyl functionality reacted rat

17 icantly increases the yield of the desired 4-alkenyl-3,4,5-trisubstituted isoxazoles.

18 These studies demonstrate that (2-alkenyl-3-pentene-1,5-diyl)iron complexes can serve as o

19 The reactivity of (2-alkenyl-3-pentene-1,5-diyl)iron complexes toward olefin

20 Disubstituted malonyl chlorides gave 2-alkenyl-4,4-dialkyl-3,5-isoxazolidinediones (8a-f) and 2

21 tereospecifically the E or Z isomer of the 5-alkenyl-4-iminohydantoin products from the corresponding

22 ne-complexed lithiated carbamates with trans-alkenyl-9-BBN derivatives followed by addition of aldehy

23 The alkenyl acetal and ketal substrates show dramatically fa

24 Z-disubstituted alkenyl-, 1,1-disubstituted alkenyl-, acyclic, or heterocyclic trisubstituted alkeny

25 Diacyl, alkyl-acyl, and alkenyl-acyl phospholipids with the same head group exhi

26 he three-component addition cascade, and the alkenyl addition product can readily be converted into d

27 ere a rhodium-catalyzed asymmetric conjugate alkenyl addition with subsequent silyl trapping and a Mu

28 id and more subtle electronic effects of the alkenyl alcohol.

29 n of highly substituted allylic alcohols and alkenyl alcohols by means of a single catalytic system.

30 An alkoxide-catalyzed directed diboration of alkenyl alcohols is described.

31 as it disengages during the isomerization of alkenyl alcohols when additional substituents are presen

32 lecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids.

33 (50), 230 microM), by endogenously occurring alkenyl aldehydes (EC(50): 4-hydroxynonenal 19.9 microM,

34 H(2)O(2) and the naturally occurring alkenyl aldehydes and 15d-PGJ(2) acted on a subset of is

35 The abilities of H(2)O(2), alkenyl aldehydes and 15d-PGJ(2) to raise [Ca(2+)](i) in

36 f disulfide bonds whereas the actions of the alkenyl aldehydes and 15d-PGJ(2) were not reversed, sugg

37 Alkenyl aldehydes did not react, but an alkynyl aldehyde

38 sses to provide aryl-aryl, alkenyl-aryl, and alkenyl-alkenyl coupled products by exploiting a common

39 The late-stage alkenyl-alkenyl silicon-based cross-coupling reaction un

40 ilylative iodination reaction, as well as an alkenyl-alkenyl silicon-based cross-coupling reaction.

41 ketone (aryl-alkyl, alkyl-alkyl, aryl-aryl, alkenyl-alkyl, alkynyl-alkyl) coupling partners.

42 n cross-coupling reactions between aromatic, alkenyl, alkynyl, and alkyl substrates in library or ind

43 Aryl-, heteroaryl-, alkenyl-, alkynyl- and alkyl-substituted allylic phospha

44 Aryl-, heteroaryl-, alkenyl-, alkynyl-, and alkyltrifluoroborates were conve

45 Alkyl-, alkenyl-, alkynyl-, aryl- or heteroaryl-substituted trif

46 boronates add to alkynyl imines to form 1,3-alkenyl allenes.

47 sigma-bond metathesis between the resultant alkenyl aluminum species and HBpin, which acts to drive

48 lyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines.

49 ates containing hindered alpha-methyl, alpha-alkenyl amino acids and (ii) the ring-closing olefin met

50 A new series of alkenyl amino alcohol (AAA) ionizable lipid nanoparticle

51 l group along with an aryl, a heteroaryl, an alkenyl, an alkynyl, or an alkyl substituent.

52 as performed under neutral conditions with 2-alkenyl and 2-cycloalkenyl acetates.

53 Here, we report the formation of new alkenyl and alkyl C-F bonds in the coordination sphere o

54 Reactions involving unsymmetrical alkenyl and alkynyl dienophiles proceed with good to exc

55 ed-anti-[2.2]metacyclophanedienes (CPD) with alkenyl and alkynyl internal (8,16) groups is described

56 cyclic ketones from the coupling reaction of alkenyl and allenyl cycloalkanols with aryl diazonium sa

57 zed to form radicals from unactivated alkyl, alkenyl and aryl iodides.

58 The Rh(I)-catalyzed addition of alkenyl and aryl MIDA boronates to N-tert-butanesulfinyl

59 played a striking longitudinal gradient with alkenyl and hydroxyalkenyl glucosinolates enriched in th

60 fers regiospecific access to acyl/aryl, acyl/alkenyl, and acyl/alkoxy gold carbenes by in situ expuls

61 he hydroacylation of vinylphenols with aryl, alkenyl, and alkyl aldehydes to form branched products w

62 oselective protocol can be extended to aryl, alkenyl, and alkyl aldehydes with up to 99:1 d.r.

63 s afforded three organic cages with alkynyl, alkenyl, and alkyl edges, respectively.

64 as amenable to a broad range of alkyl, aryl, alkenyl, and alkynyl organomagnesium, -zinc, -aluminum,

65 studies have shown compatibility with alkyl, alkenyl, and alkynyl, aromatic, and several heteroaromat

66 , that is, products bearing versatile amino, alkenyl, and borane functionality.

67 allylic amines that exhibit versatile amino, alkenyl, and boryl units.

68 hyde input; electron rich and poor aromatic, alkenyl, and branched and unbranched alkyl aldehydes all

69 Aryl-, alkenyl- and alkynylboronic acids and their derivatives

70 methods for C-C bond formation using aryl-, alkenyl- and alkynylboronic acids under transition-metal

71 is illustrated herein for the synthesis of o-alkenyl- and o-arylphenones, which have potential for th

72 Aryl-, heteroaryl-, alkenyl-, and alkyl-substituted aldehydes and enynes can

73 rant of a broad range of aryl-, heteroaryl-, alkenyl-, and alkyltrifluoroborates as well as structura

74 Starting from aryl-, heteroaryl-, alkynyl-, alkenyl-, and alkyltrifluoroborates, a library of highly

75 etals with widely available potassium aryl-, alkenyl-, and alkynyltrifluoroborates.

76 and tandem cyclizations of alpha-halo-ortho-alkenyl anilides bearing an additional substituent on th

77 Et(3)B/air, rt) of racemic alpha-halo-ortho-alkenyl anilides provide 3,4-dihydroquinolin-2-ones in h

78 e function of the tautomerization rate of an alkenyl anion intermediate.

79 counterintuitive Lewis base stabilization of alkenyl anions in anionic cyclization) and nanomaterials

80 Substituted alkenyl aryl tetrafluoro-lambda(6) -sulfanes have been p

81 stituted homoallylic alcohol derivatives and alkenyl(aryl) iodonium salts combine to form syn-1,3-car

82 al for many terminal epoxides bearing alkyl, alkenyl, aryl, alkoxy, chloromethyl, phthalimido, and ac

83 ry, secondary and tertiary alkyl, as well as alkenyl, aryl, allenyl and alkynyl groups.

84 cessfully applied to the synthesis of alkyl, alkenyl, aryl, heteroaryl, and cyclopropyl ethers, mixed

85 oss-coupling processes to provide aryl-aryl, alkenyl-aryl, and alkenyl-alkenyl coupled products by ex

86 ted alpha-hydroxystannanes cross-couple with alkenyl/aryl/heteroaryl iodides in moderate to good yiel

87 vated carbon-carbon multiple bond to give an alkenyl Au intermediate, notwithstanding the fact that t

88 n metal catalyzed C-H functionalization of C-alkenyl azoles is disclosed.

89 e performed to afford structurally complex Z-alkenyl-B(pin) as well as Z-alkenyl iodide compounds rel

90 NHC-Cu-catalyzed EAS with alkenyl-B(pin) reagents containing a conjugated carboxyl

91 variety of robust alkenyl-(pinacolatoboron) [alkenyl-B(pin)] compounds that can be either purchased o

92 Here, we show that dienes containing an E-alkenyl-B(pinacolato) group, widely used in catalytic cr

93 y ring-closing metathesis of the resultant N-alkenyl beta-amino esters, reduction to the correspondin

94 mediated dihydroxylation of a range of beta-alkenyl-beta-hydroxy-N-acyloxazolidin-2-ones results in

95 tively high barriers to rotation round the N-alkenyl bond (DeltaG() rotation >20 kcal mol(-1)) were s

96 Barriers to rotation of the N-alkenyl bond in a series of N-cycloalkenyl-N-benzyl acet

97 Barriers to rotation of the N-alkenyl bond in a series of N-cycloalkenyl-N-benzyl alph

98 The barrier to rotation around the N-alkenyl bond of 38 N-alkenyl-N-alkylacetamide derivative

99 aster or slower than the estimated rate of N-alkenyl bond rotation in the derived radicals, depending

100 es with diethylborane to generate beta-amino alkenyl boranes.

101 This reaction employs nonsymmetric bis(alkenyl)borates as substrates and appears to occur by a

102 p(2)-C-B bond in 2-ammoniophenyl(aryl)- or -(alkenyl)borates.

103 variety of boronic esters, amides, and other alkenyl boron adducts.

104 se of 15 mol % of (S)-VAPOL as the catalyst, alkenyl boronates as nucleophiles, ethyl glyoxylate as t

105 yze the enantioselective Petasis reaction of alkenyl boronates, secondary amines, and ethyl glyoxylat

106 ynes couple with various substituted alkynyl/alkenyl boronates/boronic acids by this procedure to fur

107 enables the formal homologation of aryl and alkenyl boronic acid pinacol esters.

108 the Csp-Csp2 coupling of alkynyl bromide and alkenyl boronic acid to provide conjugated 1,3-enynes.

109 o-step process involves etherification of an alkenyl boronic acid with N-hydroxyphthalimide followed

110 Two in two: Dioxygenation of alkenyl boronic acids has been achieved with N-hydroxyph

111 e with aryl, pi-electron-rich heteroaryl, or alkenyl boronic acids in the presence of stoichiometric

112 atalyzed conversion of aryl, heteroaryl, and alkenyl boronic acids into sulfinate intermediates, and

113 The cyclic alkenyl boronic acids participate in Suzuki-Miyaura coup

114 the conversion of terminal alkenes to trans-alkenyl boronic esters using commercially available cate

115 The synthesis of cyclic alkenyl boronic half acids from vinyl and propenyl boron

116 s-coupling of the vinylic stannane 4 and the alkenyl bromide 5 to produce a highly functionalized die

117 tuted ethanolamine derivative and an aryl or alkenyl bromide.

118 3-enyl)hydroxylamine derivatives and aryl or alkenyl bromides afford cis-3,5- and trans-4,5-disubstit

119 The reaction affords terminal E-alkenyl bromides in high yield and with excellent regio-

120 e involves treating a NH-indole with various alkenyl bromides using a combination of 10 mol % of copp

121 The aminomethylation of alkenyl bromides was also examined.

122 phenyl and benzyl Grignards are coupled with alkenyl bromides.

123 Both aromatic and alkenyl C(sp(2) )-H bonds undergo the three-component ad

124 w access to desirable functionality, such as alkenyl C(sp(2))-F or chiral C(sp(3))-F centers.

125 le of Co(III)-catalyzed functionalization of alkenyl C-H bonds.

126 5-Endo cyclizations of N-alkenyl carbamoylmethyl radicals provide gamma-lactam ra

127 1]nonane and syn-diboration of the resultant alkenyl carbocycle.

128 Synthetically useful (E)-alkenyl-CF3 building blocks and 1,1-bis(trifluoromethyl)

129 at sn-1 of an ether bond to an alkyl or a 1Z alkenyl chain and that of a sn-2-esterified n-3 fatty ac

130 in which a borane prepared from the pendent alkenyl chain of the cyclohexene domain was reacted with

131 Triacsin C, with an alkenyl chain resembling but not identical to either acy

132 of aromatic residues making contact with the alkenyl chain.

133 ned to generate thermodynamically disfavored alkenyl chlorides and fluorides in high yield and with e

134 vides access to a broad array of substituted alkenyl chlorides in excellent yields and with high regi

135 Many isomerically pure E-alkenyl chlorides, applicable to catalytic cross-couplin

136 We obtain many alkenyl chlorides, bromides and fluorides in up to 91 pe

137 SalG has broad substrate tolerance toward 2-alkenyl-CoAs that give rise to the salinosporamide C-2 s

138 ytically active chiral NHC-Cu-aryl or NHC-Cu-alkenyl complex can be accessed from reaction of a Cu-ha

139 HMBPP, a pi/sigma "metallacycle" or eta (2)-alkenyl complex.

140 sopropoxy substituents (>99:1), whereas most alkenyl complexes give high selectivity with both substi

141 n all cases examined including both aryl and alkenyl complexes.

142 res dinuclear (NHCCu)2(mu-H)(OTf) (X = F, H, alkenyl) complexes as key catalytic intermediates.

143 hat NHCCuOTf rapidly traps NHCCuX (X = F, H, alkenyl) complexes to produce (NHCCu)2(mu-X)(OTf) (X = F

144 es to produce (NHCCu)2(mu-X)(OTf) (X = F, H, alkenyl) complexes.

145 ethod was developed for the hydroboration of alkenyl-containing organotrifluoroborates to generate di

146 cupration of an alkyne, and alkylation of an alkenyl copper intermediate.

147 n alkyne, followed by the bromination of the alkenyl copper intermediate.

148 the structure, stability, and reactivity of alkenyl copper intermediates, as well as insight into th

149 kylation of tertiary allylic carbonates with alkenyl cyanohydrin pronucleophiles is described.

150 rectly couple di-, tri- and tetrasubstituted alkenyl cyanohydrin pronucleophiles to prepare the corre

151 Fe-mediated cyclocarbonylation of a derived alkenyl cyclopropane gave a bicyclic enone that then was

152 ion in the presence of Fe(CO)5 converted the alkenyl cyclopropanes to the 2-substituted cyclohexenone

153 sphonium bromide delivered the corresponding alkenyl cyclopropanes.

154 Using SnCl4 as the catalyst, alkenyl cyclopropyl ketones undergo ring-opening cycliza

155 l group on the nitrogen atom of the tethered alkenyl diazo amido indolo ester seemingly provides bett

156 They are also linked by the A rings by an alkenyl diester bridge to restrict the conformational fl

157 s-coupling processes had used either aryl or alkenyl electrophiles as one of the coupling partners.

158 ables the stereoselective formation of O-(Z)-alkenyl ether as precursors for the synthesis of plasmen

159 Similarly, E-alkenyl fluorides can be synthesized from simpler compou

160 es that bind substrates containing alkyl and alkenyl functional groups.

161 new method affords stable luminescent alkyl/alkenyl-functionalized SiNCs.

162 11 days (X = CHO) to 36 years (X = CN), with alkenyl functions being from 56 days to 10 years.

163 (RCM) was employed to join carboxy-terminal alkenyl glycine side chains together with vinyl- and all

164 followed by cross-coupling of the resulting alkenyl Grignard reagent with aryl halide to give tetras

165 -99% when cyclopropanes with a 2-substituted alkenyl group as a donor underwent isomerization.

166 For cyclopropanes bearing a trisubstituted alkenyl group either the corresponding cyclopent-3-enes

167 The insertion of an alkenyl group into aromatic and heteroaromatic rings by

168 dehyde, an epoxide, a carboxylic acid, or an alkenyl group may be used.

169 f chromium with a propargyl ether bearing an alkenyl group on the propargylic carbon.

170 hich undergo intramolecular migration of the alkenyl group to the carbanionic center.

171 The metathesis step serves to remove a beta-alkenyl group, which facilitated the aldol step.

172 k of the lithionitrile derivatives on the N'-alkenyl group.

173 of the initial structural identities of the alkenyl groups are attributable to the formation of ally

174 tions permit installation of a wide range of alkenyl groups at positions beta, gamma, or delta to a c

175 Substrates having gem-hydrogen, -alkyl, or -alkenyl groups give products with stereochemical retenti

176 yl-, acyclic, or heterocyclic trisubstituted alkenyl groups may be added in up to >98% yield, >98:2 S

177 tho-alkylation of aromatic imines containing alkenyl groups tethered at the meta position relative to

178 the first solution to the problem of ECA of alkenyl groups to acyclic trisubstituted enones, an adva

179 ion of ethyl, 2-silylethyl, 2-phenethyl, and alkenyl groups.

180 rated a general trend in porosity: alkynyl > alkenyl > alkyl.

181 ds, alkynes, and halogenating agents to give alkenyl halides is reported.

182 nd Pd-catalyzed cross-coupling with aryl and alkenyl halides proceeded smoothly with essentially comp

183 ziridinyl stannatrane 8 couples with aryl or alkenyl halides RX under modified Stille conditions to a

184 al method for the selective hydrogenation of alkenyl halides to alkyl halides is described.

185 an aryl bromide, an activated aryl chloride, alkenyl halides, and an alkynyl bromide) serve as suitab

186 place of alkynes to furnish tetrasubstituted alkenyl halides, showcasing the first halo-arylation of

187 with a number of functional groups including alkenyl halides, sulfides, triflates, and phosphonates a

188 cross-couplings between boronic acids and Z-alkenyl halides.

189 ions that afford acyclic 1,2-disubstituted Z-alkenyl halides.

190 ocesses that can be used to generate acyclic alkenyl halides.

191 sequently the Markovnikov vinyl sulfides via alkenyl-hydride reductive elimination.

192 )2 in the oxidation of a series of alkyl and alkenyl hydrocarbons as well as of an aromatic sulfide w

193 Several reactions are applied to alkenyl imidazoles, pyrazoles, and triazoles to provide

194 N-Alkenyl iminium ions serve as conduits to three-componen

195 The initially formed 5-alkenyl iminohydantoins may be hydrolyzed and oxidativel

196 urally complex Z-alkenyl-B(pin) as well as Z-alkenyl iodide compounds reliably, efficiently, and with

197 For disubstituted (Z)-alkenyl iodide D, 2c was identified as an acceptable Ni

198 ng process between either an (hetero)aryl or alkenyl iodide with ethenesulfonyl fluoride (ESF).

199 cular cross-coupling reaction with a pendant alkenyl iodide.

200 For three types of alkenyl iodides A-C, a satisfactory Ni catalyst(s) was f

201 2) complexes 1a-c and 2a-c and five types of alkenyl iodides A-E were chosen for the study, thereby d

202 sed cross-coupling reaction uniting the core alkenyl iodides and the side-chain alkenylsilanol was ac

203 s described, in which ortho-acylanilines and alkenyl iodides converted to multisubstituted quinolines

204 zed synthesis of acyl pyrroles from aryl and alkenyl iodides is reported.

205 pyrroles in good to excellent yields, while alkenyl iodides provide the corresponding acyl pyrroles

206 ws the direct conjugate addition of aryl and alkenyl iodides, bromides, and to a lesser extent, chlor

207 ert the cyclization product to both E- and Z-alkenyl iodides, which would eventually lead to isodomoi

208 aromatic halogenated ketones or imines, and alkenyl iodides.

209 2 + 2] cycloaddition of terminal alkynes and alkenyl isocyanates leading to the formation of indolizi

210 The first conjugate addition/alkylation to alkenyl isocyanides is described, which addresses this d

211 ta- and beta,beta-disubstituted arylsulfonyl alkenyl isocyanides to rapidly assemble diverse isocyani

212 is bonded to the osmium atom and a bridging alkenyl ligand that is pi-bonded to the osmium atom.

213 Compounds 12 and 13 are isomers containing alkenyl ligands formed by the insertion of the PhC2H mol

214 3T cells significantly decreased LPEAT and 1-alkenyl-LPEAT activities but did not affect other lysoph

215 ependent acyltransferase activity toward 1-O-alkenyl-lysophosphatidylethanolamine, lysophosphatidylgl

216 yntheses of natural and unnatural conjugated alkenyl(methyl)maleic anhydrides have been described.

217 ic alcohols were transformed into conjugated alkenyl(methyl)maleic anhydrides via oxidation followed

218 veloped for the sigmatropic rearrangement of alkenyl-methylenecyclopropanes.

219 xtradiol catechol dioxygenases: a direct 1,2-alkenyl migration for extradiol cleavage and an O-O homo

220 ansion product, consistent with a direct 1,2-alkenyl migration for extradiol cleavage.

221 titution of hydroxyl groups by stereodefined alkenyl moieties using alkenylboron dihalides.

222 bile molecule of water and an iridium-bonded alkenyl moiety (-C(R) horizontal lineC(R)-(R=CO2Me)) as

223 donor-acceptor cyclopropanes, containing an alkenyl moiety and diverse electron-withdrawing group(s)

224 the cleavage of the terminal C-H bond of the alkenyl moiety and the dearomatization of the phenol rin

225 ct is determined by the configuration of the alkenyl moiety of the substrate.

226 (SuFEx) click chemistry, in which either the alkenyl moiety or the sulfonyl fluoride group can be the

227 the cleavage of the terminal C-H bond of the alkenyl moiety, generates highly valuable benzoxepine sk

228 d to proceed with the assistance of an ortho-alkenyl moiety, which is formed by the initial alkyne co

229 er of (hetero)aromatic group attached to the alkenyl moiety.

230 h binding of the acyl moiety of atRE via the alkenyl moiety.

231 Both aromatic and aliphatic gamma- and delta-alkenyl N-arylsulfonamides undergo the oxidative cycliza

232 Alkenyl N-pivaloylhydroxamates undergo an Ir(III)-cataly

233 o rotation around the N-alkenyl bond of 38 N-alkenyl-N-alkylacetamide derivatives was measured (Delta

234 The radical cyclizations of a subset of N-alkenyl-N-benzyl-alpha-haloacetamides exhibiting relativ

235 or the [4+2] anionic annulation to give 3-(2-alkenyl)naphthoates in regiospecific manner.

236 h (Z)-alkenyl pinacol boronic esters and (E)-alkenyl neopentyl boronic esters gave (E)-syn- and (E)-a

237 of the dimers, byproducts formed through the alkenyl Ni species, are observed; (3) the coupling goes

238 ype reactions generate valuable (hetero)aryl/alkenyl nitriles, iodides, and bromides as well as allyl

239 of terminal alkynes to furnish E-configured alkenyl nitriles.

240 tterns, along with a wide range of boron and alkenyl nucleophiles that couple under palladium catalys

241 intramolecular Diels-Alder reaction with an alkenyl or alkynyl dienophile.

242 ty and very high regioselectivities, placing alkenyl or alkynyl groups distal to the forming C-C bond

243 cts with up to 94% ee from readily available alkenyl or aryl bromides and N-boc-pent-4-enylamines.

244 and effectively replacing it with an alkyl, alkenyl or aryl group.

245 ts, the ring contraction and then a hydride, alkenyl, or aryl shift.

246 ocks for the preparation of functionalized 3-alkenyl-oxindoles through a Suzuki-Miyaura reaction.

247 tem, presumably via the in situ formation of alkenyl-oxocarbenium intermediates, which eliminates the

248 this method is expanded by the generation of alkenyl-oxocarbenium species as highly activated alkene

249 IPP levels, whereas the alcohol of HMBPP and alkenyl phosphonates are directly recognized.

250 pounds-mevalonate, the alcohol of HMBPP, and alkenyl phosphonates-likely stimulate differently.

251 tive with other methods for the synthesis of alkenyl phosphorus compounds, and in the case of trisubs

252 e in which the HMBPP product forms an eta(2)-alkenyl pi- (or pi/sigma) complex with the 4th Fe in the

253 eine-complexed lithiated carbamates with (Z)-alkenyl pinacol boronic esters and (E)-alkenyl neopentyl

254 Reactions can involve a variety of robust alkenyl-(pinacolatoboron) [alkenyl-B(pin)] compounds tha

255 re then stereoselectively reduced to the cis-alkenyl pinacolboronates via hydroboration with dicycloh

256 , and leading to cyclic ketones featuring an alkenyl side chain with complete diastereoselectivity.

257 avoring formation of 2,2-disubstituted metal-alkenyl species and subsequently the Markovnikov vinyl s

258 Tertiary enamides with four alkenyl substituents exhibited half-lives for rotation b

259 s, carbamates, and thiocarbamates bearing N'-alkenyl substituents generates carbanions which undergo

260 tiomerically pure 2-pyrones, or converted to alkenyl-substituted 2-pyrones such as naturally occurrin

261 Twenty-seven alkenyl-substituted azaborines have been synthesized thr

262 promoting the [2+2] photocycloaddition of 4-alkenyl-substituted coumarins, which led to the correspo

263 unctionalization at the C(2)-position of a N-alkenyl-substituted indole derivative that was also stud

264 cross-coupling reaction to access several N-alkenyl-substituted indoles has been developed.

265 cids to furnish C(3) aryl-, heteroaryl-, and alkenyl-substituted isoindolinones.

266 s, we identified a new class of alkynyl- and alkenyl-substituted macrolides with activities comparabl

267 Alkenyl-substituted N-heterocycles react in superacidic

268 Similar reactions were accomplished with an alkenyl-substituted pyrimidine, pyrazine, thiazole, quin

269 e (NBD) readily generate the bicyclic alkyl-/alkenyl-substituted stannylenes, ArSn(norbornyl) (2a or

270 corresponding aryl-, heteroaryl-, alkyl-, or alkenyl-substituted terminal alkynes with diisobutylalum

271 to a family of 2,1-borazaronaphthalenes with alkenyl substitution at the C3 position.

272 Alkenyl substrates and amides have been successfully uti

273 of tetrahydroquinoline derivatives employing alkenyl substrates in good to excellent yields.

274 Studies with geometrically pure E- and Z-alkenyl sulfide isomers reveal a likely dichotomy of rea

275 The utility of the alkenyl sulfide products is also demonstrated in simple

276 ed by either (a) a cyclization cascade of an alkenyl sulfide tethered to a 2-azido-1-allenylbenzene c

277 re or (b) cationic cyclization of a tethered alkenyl sulfide with a putative 2-indolidenium cation.

278 p, a methyl sulfide, into the products as an alkenyl sulfide.

279 uning the stereoelectronic properties of the alkenyl sulfides intermediates in order to improve the d

280 The corresponding sugar-derived alkenyl sulfides were submitted to a 6-endo [I(+)]-induc

281 intramolecular cyclocondensation of tethered alkenyl sulfides with either indolidene or indolidenium

282 ifluoroborates with a variety of substituted alkenyl sulfones through an alpha-aminomethyl radical ad

283 proteins and small molecules yielding stable alkenyl sulfoxide products at rates more than 100x great

284 -alkyl, N-allyl-, and N-benzyl-substituted S-alkenyl sulfoximines under appropriate conditions result

285 e of the alkoxy-surface groups with alkyl or alkenyl-surface groups in the presence of BH3.THF.

286 inimally affected by the substituents on the alkenyl tether.

287 Alkenyl-to-allyl 1,4-rhodium(I) migration enables the ge

288 the generation of allylrhodium(I) species by alkenyl-to-allyl 1,4-rhodium(I) migration.

289 ed mechanism of these reactions involves the alkenyl-to-allyl 1,4-rhodium(III) migration.

290 e reaction is general for a broad range of 4-alkenyl triazoles and dienes, enabling the stereoselecti

291 The alkenyl triflate products can be elaborated through cros

292 tioselective intermolecular Heck reaction of alkenyl triflates and acyclic primary or racemic seconda

293 utilize a redox-relay Heck reaction between alkenyl triflates and acyclic trisubstituted alkenols of

294 A wide array of terminal (E)-alkenyl triflates are suitable for this process.

295 The new process forms highly substituted alkenyl triflates from a range of alkynes via a pathway

296 ttributed to the use of electron-withdrawing alkenyl triflates, which offer selective beta-hydride el

297 (EAS) reactions that allow for additions of alkenyl units to readily accessible allylic electrophile

298 s from the corresponding starting E- or Z-N'-alkenyl urea, each of which may be formed from the same

299 ations of a number of terminally unsaturated alkenyl zinc iodides to cyclopentylmethylzinc iodides, f

300 Treatment of a [(trimethylsilylethynyl)alkenyl]ZrCp2 complex with Piers' borane [HB(C6F5)2] res