ライフサイエンスコーパス: alkyl

1 neral trend in porosity: alkynyl > alkenyl > alkyl.

2 oupling involving both primary and secondary alkyls.

3 N-substituted ortho-halobenzamides to form 2-alkyl-1,2-benzisoselenazol-3(2H)-ones containing a C-Se-

4 A library of 15 2-alkyl-1,2-benzisoselenazol-3(2H)-ones was prepared.

5 2-Alkyl-1,2-benzisoselenazol-3(2H)-ones, represented by eb

6 ously to a ruthenium catalyst, a 1-lithium-2-alkyl-1,2-dihydropyridine complex is shown to be a compe

7 nko products, the 1 and 3 n-alkylesters of 2-alkyl-1,3-diols, which is unprecedented in organocatalys

8 formation and intramolecular cyclization of alkyl 2-[(2-alkoxybuta-2,3-dienimidoyl)sulfanyl]acetates

9 iated alkoxyallenes with isothiocyanates and alkyl 2-bromoacetates has been discovered.

10 The reported alkyl 2-cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrah

11 A general six-step approach to alkyl 2-oxo-2,3,6,7-tetrahydro-1H-1,3-diazepine-5-carbox

12 N(2) -Alkyl-2'-deoxyguanosine triphosphate (N(2) -alkyl-dGTP)

13 c anionic ring-opening copolymerization of 2-alkyl-2-oxo-1,3,2-dioxaphospholanes provided functional

14 A copper-catalyzed cross-coupling of 2-alkyl-/2-arylaziridines with benzimidazoles is reported.

15 rovides a concise and scalable approach to 1-alkyl-3-methyleneindan-1-ols in high enantiomeric ratios

16 onalized multisubstituted thiophenes such as alkyl 4-alkoxy-5-amino-3-methylthiophene-2-carboxylates

17 5-Alkoxy, amino, and N,N-dialkylamino-3-aryl/alkyl-4-(2-R-vinyl)isoxazoles afford 2-aryl/alkyl-5-aryl

18 /alkyl-4-(2-R-vinyl)isoxazoles afford 2-aryl/alkyl-5-aryl/alkyl/methoxycarbonyl-1H-pyrrol-3-carboxyli

19 and decreased levels of phosphatidylcholine alkyl-acyl C42:5 and phosphatidylcholine alkyl-acyl C44:

20 ine alkyl-acyl C42:5 and phosphatidylcholine alkyl-acyl C44:4.

21 easurements of 8-oxoguanine DNA glycosylase, alkyl-adenine DNA glycosylase, MutY DNA glycosylase, ura

22 es is herein described for the reaction of n-alkyl aldehydes in the presence of methylvinylketone and

23 rnadiene (NBD) readily generate the bicyclic alkyl-/alkenyl-substituted stannylenes, ArSn(norbornyl)

24 catalyst can mediate doubly stereoconvergent alkyl-alkyl cross-coupling, specifically, reactions of a

25 ddition, and reductive elimination to enable alkyl-alkyl fragment coupling.

26 cteriochlorins bearing various substituents (alkyl/alkyl, aryl, and alkyl/ester) at positions 2 and 3

27 balt dihalide compounds, when activated with alkyl aluminum reagents, form highly active catalysts fo

28 of variation of the longer and shorter chain alkyl amides at the depth of the cultural transition may

29 We suggest that alkyl amides may have potential as new biomarkers in arc

30 A series of alkyl amides was detected and identified in the sediment

31 ontrolled synthesis of N-nitrosoamide from N-alkyl amides, (2) hydrolysis of N-methoxyamides to carbo

32 thylene C(sp(3) )-H bonds of nosyl-protected alkyl amines are developed using NBS as the brominating

33 We developed a strategy to harness alkyl amines as alkylating agents via C-N bond activatio

34 nt additions of cyclic and acyclic secondary alkyl amines to a wide range of alkyl olefins with compl

35 nic nitrogen, including low molecular weight alkyl-amines.

36 The cyclic alkyl(amino) carbene (cAAC) stabilized monoanionic phosp

37 role derivative 2 was converted to a cyclic (alkyl) (amino)carbene (cAAC) via 1,2-hydrogen migration

38 lows for the synthesis of storable bicyclic (alkyl)(amino)carbenes (BICAACs), which feature enhanced

39 f alkynyl iminium salts derived from cyclic (alkyl)(amino)carbenes (CAACs) affords propargyl/allenyl

40 Discovered in 2005, cyclic (alkyl)(amino)carbenes (CAACs) are among the most nucleop

41 accepting properties compared to monocyclic (alkyl)(amino)carbenes (CAACs).

42 cationic ground states stabilized by cyclic (alkyl)(amino)carbenes (CAACs).

43 ical, we assign it to the corresponding 1,3,-alkyl-aminyl biradical.

44 de ring by the symmetric superposition of an alkyl ammonium bridge.

45 s reported where Cat=a secondary or tertiary alkyl ammonium ion, x=7, 8 or 9, and M=Fe(III) , Ga(III)

46 ethane as a suitable scaffold with optimized alkyl ammonium side chains.

47 enes through the hydroallylation of terminal alkyl and aryl alkynes with simple allyl phosphates and

48 escribes this novel and efficient method for alkyl and aryl carboxylic acid isotopic labeling using a

49 This transformation allows alkyl and aryl groups to serve for the first time as rem

50 n the donor olefins was initially limited to alkyl and aryl groups, additional efforts culminated in

51 ach has proven general for several different alkyl and aryl substituted alkynes.

52 hane products are highly activated magnesium alkyls and show unprecedented, uncatalyzed reactivity to

53 nstrated with 24 examples with various halo, alkyl, and alkoxy substituents on either of the aromatic

54 acils was developed by the dimerization of 3-alkyl- and 3-aryl-2-propynamides promoted by either Cs2C

55 A regioselective synthesis of 6-alkyl- and 6-aryluracils was developed by the dimerizati

56 cyclization was found to be general for both alkyl- and aryl-substituted enones, providing the corres

57 hese salts provides a variety of substituted alkyl- and arylthiazolines.

58 , di-, and trisubstituted olefins as well as alkyl- and arylthioamides with variations in electronics

59 ns are tolerable for dialkyl-, aryl(hetaryl) alkyl-, and cycloalkyl ketones.

60 catalysed oxidation to characterize their n-alkyl appendages attached to aromatic cores.

61 NH and methyl, alkyl, aralkyl, vinyl, cyano, aryl and N-heteroaryl, acy

62 pseudorotaxane, namely, endo-benzyl and endo-alkyl, are formed by a stereoselectivity controlled by t

63 ver current processes that produce saturated alkyl arenes.

64 ing electron-donating, electron-withdrawing, alkyl, aryl, halogen, and haloalkyl substituents were pr

65 e presence in their structure of an extended alkyl-aryl side chain, which establishes idiosyncratic i

66 EBX) to afford a wide variety of 3-alkynyl-3-alkyl/aryl 2-oxindole under transition-metal free condit

67 eport an efficient direct alkynylations of 3-alkyl/aryl 2-oxindoles employing ethynyl-1,2-benziodoxol

68 7-triazacyclononane (Me3tacn) and the cyclic alkyl/aryl C-donor ligand -CH2CMe2-o-C6H4- (cycloneophyl

69 alkene substrates provided the corresponding alkyl/aryl difunctionalized products in moderate to exce

70 diphosphacyclooctane diphosphine ligand with alkyl/aryl groups on N and P), have been developed for h

71 tion of sensitive functional groups, such as alkyl/aryl halides, azides, and esters.

72 both 3-iodo-1H-indenes (from beta-alkyl-beta-alkyl/aryl-o-(alkynyl)styrenes) and 3-iodobenzofulvenes

73 s distortion effect is however higher in the alkyl azide compounds than in phenyldiazomethane.

74 ature; the regioselectivity is complete with alkyl azides and phenyldiazomethane, but is inexistence

75 roups were subjected to CuAAC reaction using alkyl azides, and the resulting triazoles were quaterniz

76 talyzed direct and stereospecific N-H- and N-alkyl aziridination of olefins is reported that uses hyd

77 re converted into the corresponding N-H or N-alkyl aziridines in good to excellent yields.

78 :C{N(2,4,6-Me3 C6 H2 )CH2 }2 ]) with Group 1 alkyl bases suggest this destructive process is triggere

79 of common constituents of detergent (linear alkyl benzene sulphonate).

80 Linear alkyl benzenes (LAB) are global chemicals that are produ

81 These reactions produce the n-alkyl benzenes with regeneration of the calcium hydride.

82 nthesis of both 3-iodo-1H-indenes (from beta-alkyl-beta-alkyl/aryl-o-(alkynyl)styrenes) and 3-iodoben

83 ses in the order: alpha,beta-dialkyl > alpha-alkyl-beta-aryl > alpha,beta-diaryl.

84 s covered comprise alpha,beta-dialkyl, alpha-alkyl-beta-aryl, and alpha,beta-diarylvinyl esters, the

85 ntial C-N bond formation followed by C(CO)-C(alkyl) bond cleavage.

86 hod to rapidly access densely functionalized alkyl boronate esters from abundant carboxylic substitue

87 ivity, thereby facilitating synthesis of the alkyl boronic acid drugs Velcade and Ninlaro as well as

88 The widespread use of alkyl boronic acids and esters is frequently hampered by

89 de range of alkyl boronic esters and aryl or alkyl boronic acids to react with electron-deficient ole

90 This system enabled a wide range of alkyl boronic esters and aryl or alkyl boronic acids to

91 elective synthesis of secondary and tertiary alkyl boronic esters have spanned over five decades and

92 s strategies for the asymmetric synthesis of alkyl boronic esters, from the seminal hydroboration met

93 i(carb)) can serve as photoreductants of the alkyl bromide.

94 rimary carbamates with unactivated secondary alkyl bromides at room temperature.

95 um-catalyzed carbocyclization of unactivated alkyl bromides with alkenes is described.

96 ally available aldehydes, along with aryl or alkyl bromides, into the corresponding ketones in excell

97 copper-catalyzed coupling of carbazole with alkyl bromides.

98 tly, as well as more functionalized aryl and alkyl bromides.

99 c esters, sulfonamides, alkyl tosylates, and alkyl bromides.

100 their homopolymerization mechanism: whereas alkyl-BTAs cooperatively self-assemble, oDMSi-BTAs self-

101 uch as N-phenylacetamide, N-alkylacetamide, (alkyl=butyl, hexyl and octyl group) in chloroform.

102 e abundance of carboxyl, aryl, alkyl, or O/N-alkyl C in forest floor, bulk mineral soil, or any soil

103 te alpha-conjugated C-H bonds over 3 degrees alkyl C(sp(3))-H bonds and apply these insights to react

104 des ago, i.e., hydrogen chalcogenide gas and alkyl cadmium.

105 All alkyl-carbo-benzenes were also found to be highly crysta

106 ersion of relative reactivities between aryl/alkyl carbonate and another leaving group of similar nuc

107 rG degrees for solvolysis of benzhydryl aryl/alkyl carbonates and benzhydryl carboxylates reveal that

108 A variety of aromatic, heteroaromatic, and alkyl carboxaldehydes were condensed with oxalyl boronat

109 ormation of primary, secondary, and tertiary alkyl carboxylic acids as well as a diverse range of nat

110 on chemistry has been developed for aryl and alkyl carboxylic acids respectively with two rationally

111 coupling of primary, secondary, and tertiary alkyl carboxylic acids with both aryl and heteroaryl org

112 and variegated building blocks of chemistry: alkyl carboxylic acids.

113 SBT core is completely planar, likely via S(alkyl)cdots, three dots, centeredS(thiophene) intramolec

114 cted a complex mixture of both odd- and even-alkyl chain alkylresorcinols (AR), branched-chain alkylr

115 ulation in rats showed that elongating the N-alkyl chain decreased abuse-related effects in vivo that

116 sumably facilitate the cleavage of saturated alkyl chain from quaternary N via N-dealkylation reactio

117 end is that the selectivity increases as the alkyl chain is lengthened far from the reactive centers.

118 The effects of alkyl chain length and charge density and the antimicrob

119 hannels to study the effects of increasing N-alkyl chain length of 4-MA on interactions at DAT, NET,

120 The effect of alkyl chain length on the anti-oxidative properties of t

121 hilic alpha-keto acids with differing linear alkyl chain lengths was investigated, demonstrating the

122 solution are robust and generalizable across alkyl chain lengths.

123 between the tert-butyl groups of 1c and the alkyl chain of the cationic axle are likely responsible

124 nt ligands screened, those with the shortest alkyl chain, -(CH2)2-, and a hydrophilic carboxylic acid

125 was well implemented on alkynes bearing long alkyl chain, an alicyclic ring, hydroxy, ether, and este

126 molecules with low energy LUMO and terminal alkyl chain.

127 e result of subtle structural changes in the alkyl chains and produces a second minor thermal hystere

128 with a unique correlation to the position of alkyl chains on the perenosins.

129 We show that conjugating dendritic alkyl chains to DNA creates amphiphiles that exhibit hig

130 artition coefficients and miscibility of the alkyl chains.

131 affinity to lipids with unsaturation on both alkyl chains.

132 halogen-pi interaction between the ligand's alkyl chloride and a guanine residue.

133 installation of the sterically congested C13 alkyl chloride and control of the wayward reactivity of

134 aryl, but oxidation of 2H-pyrans also gives alkyl cleavage products.

135 Open-shell iron and cobalt alkyl complexes have been synthesized that serve as sing

136 alkene, followed by capture of the generated alkyl-copper intermediate with an acid chloride.

137 With the right proportion of the flexible alkyl corona to the rigid core, mesomorphic behavior of

138 is applied to iron-SciOPP catalyzed alkynyl-alkyl cross-couplings, providing the first detailed insi

139 N.2LiCl or CuCN.2LiCl to afford 5-alkyl or 4-alkyl cyclopentenone regioisomers: the former conditions

140 eno[3,2-b]thiophene) co-crystallized with an alkyl derivative of bisphenol A.

141 Calcium n-alkyl derivatives-synthesized by reaction of ethene, but

142 -Alkyl-2'-deoxyguanosine triphosphate (N(2) -alkyl-dGTP) derivatives with methyl, butyl, benzyl, or 4

143 ough a new methodology for synthesis of aryl-alkyl diazenes using electronically attenuated hydrazine

144 Incorporating alkyl diazoacetates and, important for high ee's, ortho-

145 Complex 6 represents the first alkyl disulfide thorium species and illustrates the abil

146 ree organic cages with alkynyl, alkenyl, and alkyl edges, respectively.

147 te nucleophile with an unactivated secondary alkyl electrophile to generate a substituted carbamate,

148 yzed cross-coupling reactions of unactivated alkyl electrophiles are emerging as a powerful tool in o

149 The ability to couple alkyl electrophiles opens the door to a stereochemical d

150 reactions between nitrogen nucleophiles and alkyl electrophiles, many such substitution reactions re

151 d that effect cross-couplings of an array of alkyl electrophiles, thereby greatly expanding the diver

152 various substituents (alkyl/alkyl, aryl, and alkyl/ester) at positions 2 and 3 (beta-pyrrole sites, r

153 f organoleptic defects for samples with high alkyl esters content.

154 s selected for the synthesis of four other n-alkyl esters with different chain-lengths.

155 used nonionic polyglycol ether surfactants (alkyl ethoxylates (AEOs), nonylphenol ethoxylates (NPEOs

156 (PEGs), polypropylene glycols (PPG), linear alkyl-ethoxylates, and triisopropanolamine (TIPA).

157 mechanism to generate highly enantioenriched alkyl fluoride compounds.

158 ith bipyrimidine (bipym) and a palladium bis-alkyl fragment, PdMe2, allows the rapid formation and st

159 Alkyl Grignard reagents (Et, (n)Bu, (i)Pr, cyclohexyl),

160 to a radical or radical-like pathway for the alkyl Grignard reagents and possibly a carbanion pathway

161 lfur diimide reagent, a copper catalyst, and alkyl Grignard reagents.

162 n of imide and amide bonds with a long-chain alkyl group is an attractive feature of this protocol.

163 The alkyl group is the most common component of organic mole

164 ing of the epoxy bridge with transfer of one alkyl group to the intermediate cycloadduct.

165 primary amide group from a chemically inert alkyl group.

166 d activation of an amine with an unactivated alkyl group.

167 osphate and monophosphonate groups by simple alkyl groups and evolved into the sophisticated ProTide

168 Primary and secondary alkyl groups can be installed.

169 e closely related area of dehydrogenation of alkyl groups of substrates containing heteroatoms.

170 elopment of catalysts for dehydrogenation of alkyl groups to give the corresponding olefins could ope

171 d substrates, such as those bearing tertiary alkyl groups, were additions slower.

172 in sp(3) C-H bonds are replaced with sp(3) C-alkyl groups.

173 action is undiminished by sterically bulky N-alkyl groups.

174 of a silyl (pseudo)halide, R3 Si-X (R=aryl, alkyl, H; X=Cl, Br, I, OTf, SPh), cleanly affords (R3 Si

175 abstraction (enabled by polarity matching), alkyl halide oxidative addition, and reductive eliminati

176 Using readily available alkyl halide precursors and simple borohydride salts, al

177 th the Dha 'acceptor', the solubility of the alkyl halide precursors in aqueous solution and the kine

178 Although the alkylation of an amine by an alkyl halide serves as a "textbook example" of a nucleop

179 pyrrolidine-derived nucleophile with cyclic alkyl halides (as mixtures of stereoisomers) to produce

180 nt treatment with a stoichiometric amount of alkyl halides (X = Cl, Br, I) enables a rapid access to

181 ng the course of the reaction with bases and alkyl halides 3 are discussed.

182 ctions to take place with nitrogen bases and alkyl halides 3 to give alpha-alkyl ketones 1(R) after a

183 The analogous union between alkyl halides and metallated aryl systems has not been a

184 the quaternary ammonium salts, derived from alkyl halides and tertiary amines, were the intermediate

185 ve recently emerged as useful surrogates for alkyl halides in cross-coupling chemistry.

186 coupling of benzyltriboronates, enoates, and alkyl halides is described.

187 In addition to conventional approaches with alkyl halides or sulfonates as alkylating agents, the us

188 atalyzes the efficient reduction of aryl and alkyl halides under relatively mild conditions by using

189 s, dehydrogenation of alkanes, conversion of alkyl halides, and oxidation of hydrogen halides, with e

190 I) species undergoes oxidative addition with alkyl halides, as well as rapid oxidation by O2, to gene

191 and oxonium ion intermediates from activated alkyl halides.

192 fides/peroxides or halide-atom transfer from alkyl halides.

193 ng the initiation by a photo-BHAS process on alkyl halides.

194 rs this reaction a broadly useful method for alkyl-(hetero)aryl coupling involving both primary and s

195 Individual parent and C1-5 alkyl homologues were easily separated (GC x GC/MS), all

196 ion of trifluoromethylated ynones with aryl (alkyl) hydrazines in the presence of acidic catalysts le

197 of trifluoroacetylated acetylenes and aryl (alkyl) hydrazines was performed, aimed to the regioselec

198 h B(C6 F5 )3 to produce the zwitterionic bis(alkyl) hydridoborato Ce{C(SiHMe2 )3 }2 HB(C6 F5 )3 (2).

199 ted to oxidative stress, suggesting that the alkyl hydroperoxide reductase is an important regulator

200 cteria, a dedicated peroxiredoxin reductase, alkyl hydroperoxide reductase subunit F (AhpF), catalyze

201 Finally, the alkyl hydroperoxide reductase, a primary scavenger of en

202 The respective aryl/alkyl imido/iminyl pairs (3, 2; 5, 6) have been characte

203 N-aryl and N-alkyl imines readily undergo formal [4+2] cycloaddition

204 uble dagger)) approximately 5 kcal/mol]; the alkyl iminyl 6 has a reduced enthalpic barrier (1.84 kca

205 water-soluble phenylethanoid and hydrophobic alkyl into one molecule thus are endowed with dual funct

206 Herein, a new reaction of an alkyl iodide (R-I) with an azide anion (N3(-)) to revers

207 iting step is the iodine abstraction from an alkyl iodide by (.) Mn(CO)5 .

208 an alkenylcopper intermediate activates the alkyl iodide by single electron transfer to enable a rad

209 y electron transfer with another molecule of alkyl iodide, continuing the chain, and triggering a 1,2

210 carbonylative coupling of the alkyne and the alkyl iodide, followed by reduction of the intermediate

211 th an organolithium reagent derived from the alkyl iodides (R)- or (S)-30, which contain the C11-C13

212 eck reaction of alpha-heteroatom substituted alkyl iodides and -bromides with vinyl arenes/heteroaren

213 oupling of terminal alkynes with unactivated alkyl iodides has been developed, enabling highly chemo-

214 Mn2 (CO)10 , to generate alkyl radicals from alkyl iodides has been developed.

215 anly mono-alkylated by unactivated secondary alkyl iodides in the presence of visible light and a cop

216 inyl boronates react with electron-deficient alkyl iodides in the presence of visible light to give b

217 -alkylation of nitroalkanes with unactivated alkyl iodides is described.

218 re tolerated, and both primary and secondary alkyl iodides react well.

219 entally benign method for the deuteration of alkyl iodides via radical pathway using D2O as source of

220 atible with primary, secondary, and tertiary alkyl iodides; and tolerant of a wide range of functiona

221 In fact, RSSH are excellent H-atom donors to alkyl (k approximately 5 x 10(8) M(-1) s(-1)), alkoxyl (

222 ogen bases and alkyl halides 3 to give alpha-alkyl ketones 1(R) after acidic hydrolysis.

223 ynthesis of hydroxyl-functionalized aryl and alkyl ketones from simple phenols and phenylacetylene vi

224 nt method for the synthesis of unsymmetrical alkyl ketones.

225 romatic and aliphatic tertiary amides, and N-alkyl lactams is reported.

226 and X-ray crystallography indicate that each alkyl ligand contains two bridging Celeft harpoon-up H-S

227 n peripheral positions octa-substituted with alkyl linked carbazole has been prepared by cyclomerizat

228 o form N-H bonds, or 3) C-H amination of the alkyl linker of the (n) PDI2 ligand.

229 reaction using the dianion derived from an N-alkyl methanesulfonamide proceeded in much lower yield.

230 od to excellent yield by treating N-allyl, N-alkyl methanesulfonamides with n-BuLi, followed by react

231 -vinyl)isoxazoles afford 2-aryl/alkyl-5-aryl/alkyl/methoxycarbonyl-1H-pyrrol-3-carboxylic acid deriva

232 )Pd catalysts to allylate C3 concurrent with alkyl migration from B to C2 of the indole.

233 In addition, alkyl migration processes available to the BIM framework

234 trophilic alkene arylation, triggering a 1,2-alkyl migration to afford a range of nonracemic spirocyc

235 B(C6 F5 )3 can be used to effect formal 1,5-alkyl migrations from the ester functional groups to uns

236 formation and stabilization of a Pd(IV) tris-alkyl moiety after oxidative addition with MeI.

237 2N(CH3)2 group in the aerobic oxidation of 4-alkyl-N,N-dimethylbenzylamines catalyzed by N-hydroxypht

238 The radicals are easily generated from alkyl nitriles in the presence of the mild oxidant di-te

239 ic secondary alkyl amines to a wide range of alkyl olefins with complete anti-Markovnikov regioselect

240 f Et2Zn/CuCN.2LiCl or CuCN.2LiCl to afford 5-alkyl or 4-alkyl cyclopentenone regioisomers: the former

241 a less radical stabilizing group such as an alkyl or amide group at the C3-position of indole furnis

242 furan and non-racemic secondary and tertiary alkyl or aryl boronic esters undergo deborylative three-

243 uently captured by a nucleophile, such as an alkyl or aryl lithium compound.

244 route toward the asymmetric synthesis of 7-(alkyl or aryl)-6-oxa-2-azabicyclo[3.2.1]octane derivativ

245 roduce 4-piperidones in good yields when R = alkyl or aryl, but oxidation of 2H-pyrans also gives alk

246 a range of 1,2-azaborines readily exchange B-alkyl or B-aryl moieties for B-alkoxide fragments.

247 less reactive phenolic unit substituted with alkyl or halide groups.

248 eactions reported in the literature invoke N-alkyl or N-carbonyl-protected sulfamidates.

249 ssessing two or three binding stations, long alkyl or oligoethylene glycol spacers or bulky barriers

250 not altered the abundance of carboxyl, aryl, alkyl, or O/N-alkyl C in forest floor, bulk mineral soil

251 Acyclic 1,4-diene products bearing either alkyl- or aryl-substituted benzylic stereocenters are af

252 emonstrate the use of bench-stable N-H and N-alkyl oxaziridines derived from readily available terpen

253 The alkyl oxoacids under study here can undergo a Norrish Ty

254 and thermodynamically disfavored 6-membered alkyl palladacycle intermediates.

255 therapeutic potential of the clinical-grade alkyl-phospholipid ether analog CLR1404, 18-(p-iodopheny

256 ct on chemical shift has been observed for N-alkyl pyrazole analogues.

257 d beta-fragmentation of the initially formed alkyl radical (8b) to form dA* and acetone.

258 -)) to reversibly generate the corresponding alkyl radical (R(*)) is reported.

259 dicates that 6-exo radical cyclization of an alkyl radical to a phenyl ring is faster than the respec

260 by radical addition of an electron-deficient alkyl radical to the vinyl boronate followed by electron

261 (carb), generating a carbazyl radical and an alkyl radical.

262 ide precursors and simple borohydride salts, alkyl radicals can be generated in aqueous solution.

263 carbonyldimanganese Mn2 (CO)10 , to generate alkyl radicals from alkyl iodides has been developed.

264 These alkyl radicals react rapidly with protein-bound Dha resi

265 ability to transfer the isocyanate moiety to alkyl radicals.

266 when generating unstable phenyl and primary alkyl radicals.

267 ereoisomer in agreement with the known "endo-alkyl rule".

268 y a stereoselectivity controlled by the endo-alkyl rule.

269 e and a Weinreb amide to complete the C1-C13 alkyl scaffold, and a Yamaguchi esterification to set th

270 with either oligodimethylsiloxane (oDMSi) or alkyl side chains is unraveled by combining experimental

271 -catalyzed process provides direct access to alkyl silanes.

272 aluated for main types of protecting groups (alkyl, silyl, and acyl) usually used in carbohydrate che

273 mize the deleterious influence of achiral Cu-alkyl species, resulting in improved enantiomeric ratios

274 ide elimination is faster with an achiral Cu-alkyl species.

275 ysts form by beta-F elimination of Pd(beta-F-alkyl) species, VF or E insertion of the resulting (PO)P

276 imination from the bicyclic substituted aryl/alkyl stannylenes 2a or 2b and 3a or 3b.

277 nds to zinc porphyrins with thioester-linked alkyl straps is investigated in solution by NMR spectros

278 eanic transport for poly- and perfluorinated alkyl substances (PFASs) reaching the Arctic Ocean is no

279 Per- and poly fluorinated alkyl substances (PFASs), notably perfluorooctanoic acid

280 g toxicokinetics of per- and polyfluorinated alkyl substances in humans.

281 ines of evidence show that lengthening the N-alkyl substituent of 4-MA reduces potency to inhibit tra

282 a heteroaryl, an alkenyl, an alkynyl, or an alkyl substituent.

283 The steric demand of the alkyl substituents in the BODIPY subunit defines the sit

284 While bulky alkyl substituents inhibit the switching behavior, pi-co

285 E- and Z-alkenes with both aryl and alkyl substituents were compatible with this chemistry.

286 regioisomers: the former conditions afford 5-alkyl substituted cyclopentenones via beta-carbon elimin

287 mination, whereas the latter result in the 4-alkyl substituted regioisomers with concomitant oxidatio

288 Interestingly, aryl-substituted and alkyl-substituted alpha-diketones produced different pro

289 l offers a direct route for the synthesis of alkyl-substituted chiral aziridines from achiral startin

290 ized thioamides with aryl-, heteroaryl-, and alkyl-substituted dioxazolones under the Cp*Co(III) -cat

291 naphthalenediimide motifs thus far, branched alkyl-substituted PIID[2F]T polymers are particularly pr

292 relationship of this series with small N(6)-alkyl substitution, 5'-esters, deaza modifications of ad

293 e achieved in negative ion mode using sodium alkyl sulfates (C8, C12, C16, and C18).

294 ryl silyl ethers and aryl fluorosulfates (or alkyl sulfonyl fluorides).

295 d is effective for a broad range of aryl and alkyl terminal alkynes.

296 tuted alkenes, including the challenging all-alkyl tetrasubstituted alkenes, undergo CAH with enantio

297 t a stereospecific carbonylative coupling of alkyl tosylates and dienes producing enantioenriched die

298 halides, aryl boronic esters, sulfonamides, alkyl tosylates, and alkyl bromides.

299 protocol, based on single-electron-mediated alkyl transfer, circumvents the restriction of using rea

300 hod for the hydroalkylation of allenes using alkyl triflates as electrophiles and silane as a hydride