ライフサイエンスコーパス: alkylate

1 phenol functionality, which was acylated and alkylated.

2 n-rich substituted benzenes are successfully alkylated.

3 diate catechol moiety that is subsequently O-alkylated.

4 utilizes 2-propargyloxypyridines to access N-alkylated 2-pyridone products derived from both 5-exo an

5 ure-dependent fluorescent studies on an N(5)-alkylated 4a-hydroxy flavin: the putative bacterial luci

6 The same technology was used to alkylate a K18C mutant of histone H3.

7 KR12 alkylates adenine N3 at the target sequence, causing str

8 ere treated with RT, and almost 40% received alkylating agent (AA) -containing chemotherapy (predomin

9 erapy with bortezomib, dexamethasone, and an alkylating agent (BDex+AA) is associated with improved b

10 rgeting of KRAS mutant DNA using a synthetic alkylating agent (pyrrole-imidazole polyamide indole-sec

11 from the corresponding N-alkyl imidazole, an alkylating agent (usually MeI), and sodium borohydride (

12 yes/no), radiation to the neck (yes/no), and alkylating agent (yes/no).

13 Compared with temozolomide, a clinical DNA-alkylating agent against glioma, 6OTD required lower con

14 at G4 targeting of this clinically important alkylating agent alters the overall mechanism of action.

15 Conditioning regimens consisted of an alkylating agent and fludarabine, and GVHD prophylaxis i

16 rate that ALX, through its dual action as an alkylating agent and topoisomerase inhibitor, represents

17 TH-302, a prodrug of the cytotoxic alkylating agent bromo-isophosphoramide mustard, is pref

18 10.5-41.6] since diagnosis) who had received alkylating agent chemotherapy but no radiation therapy.

19 increase in mutations and sensitivity to an alkylating agent compared with the WT hMPG.

20 Direct normoxic PARP1 activation by a DNA alkylating agent enhanced Bnip3 expression, and caused B

21 ta define the dose-specific relation between alkylating agent exposure and semen variables in adult s

22 Alkylating agent exposure was estimated using the cyclop

23 under basic conditions in the presence of an alkylating agent leads to atropselective O-alkylation wi

24 leotide resolution in yeast treated with the alkylating agent methyl methanesulfonate (MMS).

25 e was enhanced upon DNA damage caused by the alkylating agent methyl methanesulfonate and that the re

26 arly severe in mutant cells treated with the alkylating agent methyl methanesulfonate.

27 312 helps to prevent tumour induction by the alkylating agent MNU, which predominantly caused T cell

28 The trichloroacetimidate alkylating agent must be a stable cation precursor for t

29 o had not had a response to rituximab and an alkylating agent or had had a relapse within 6 months af

30 y the proteasome inhibitor bortezomib or the alkylating agent temozolomide.

31 increased invasiveness and resistance to the alkylating agent temozolomide.

32 s glioblastoma-resistant cancer cells to the alkylating agent temozolomide.

33 of the cobalt complex with 0.75 mol % of the alkylating agent to afford the desired products in up to

34 Temozolomide is a DNA-alkylating agent used to treat brain tumors, but resista

35 A adducts based on the reactivity of the DNA alkylating agent was demonstrated by inclusion of an ion

36 An isoxazole-based alkylating agent was developed to selectively alkylate c

37 le mice with melphalan (MLP), a bifunctional alkylating agent widely used in chemotherapy, induces DN

38 g with two alkylating agents (p=0.015 vs one alkylating agent) and last available pre-HSCT bilirubin

39 ly accelerated by treatment of mice with the alkylating agent, N-ethyl-N-nitrosourea (ENU), regardles

40 d after reduction of receptor reserve by the alkylating agent, phenoxybenzamine, as it reduced the ma

41 ent of polymers with methyl iodide (MeI), an alkylating agent, to convert polymer-bound tertiary amin

42 confirm the formation of PARP-1 DPCs during alkylating agent-induced base excision repair (BER) and

43 yl trifluoromethanesulfonate as a reversible alkylating agent.

44 icrotubule toxin and a duocarmycin-class DNA-alkylating agent.

45 s as a topoisomerase inhibitor as well as an alkylating agent.

46 ng bromocrotonate as the activated methylene alkylating agent.

47 ine is a newly approved and better-tolerated alkylating agent.

48 verse nucleophiles using methylarenes as the alkylating agent.

49 The use of an alkene as the formal "alkylating" agent associated with the tolerance for nume

50 al tumors who did (and did not) benefit from alkylating-agent chemotherapy with RT.

51 %) or in association with rituximab (21.1%), alkylating agents (36.8%) or a combination of cyclophosp

52 ies), including proteasome inhibitors (91%), alkylating agents (91%), autologous stem cell transplant

53 multivariate analysis, conditioning with two alkylating agents (p=0.015 vs one alkylating agent) and

54 ive SCID suggest that minimizing exposure to alkylating agents and ionizing radiation is important fo

55 ne (1-MeA) is formed in DNA by reaction with alkylating agents and naturally occurring methyl halides

56 plausible cause-effect relationship between alkylating agents and PVOD.

57 ses and related quaternary ammonium salts as alkylating agents and singlet oxygen sensitizers.

58 compromise fertility, especially exposure to alkylating agents and whole body irradiation, which caus

59 ng adult (CAYA) cancer who were treated with alkylating agents and/or radiation, with potential expos

60 s in Diels-Alder reactions and electrophilic alkylating agents are described.

61 N) or CB-839, hypersensitize cancer cells to alkylating agents both in vitro and in vivo.

62 poxic microenvironment induces resistance to alkylating agents by activating targets in the mammalian

63 Alkylating agents can induce sustained drug-free remissi

64 ored by depletion of Top1, illustrating that alkylating agents can trigger cytotoxic Top1-breaks.

65 Trichloroacetimidates are useful alkylating agents for aromatic amines, requiring only a

66 nd their relationship to genotype and use of alkylating agents for conditioning.

67 pated and unknown DNA adducts induced by DNA alkylating agents in biological samples.

68 icancer cotherapies, used as enhancements of alkylating agents in chemotherapy.

69 erase (MGMT), a key enzyme for resistance to alkylating agents in glioblastoma patients.

70 Due to the abundant presence of alkylating agents in living cells and the environment, D

71 ht alcohols such as ethanol could be used as alkylating agents in this methodology.

72 Alkylating agents induce cytotoxic DNA base adducts.

73 However, use of preconditioning with alkylating agents is associated with a greater likelihoo

74 DNA alkylating agents like nitrogen mustard (NM) are easily

75 itivity was not observed upon treatment with alkylating agents or UV irradiation.

76 Oxazaphosphorines are alkylating agents used in routine clinical practices for

77 eloped a strategy to harness alkyl amines as alkylating agents via C-N bond activation.

78 on, corticosteroids, and chronic exposure to alkylating agents via distinct molecular routes involvin

79 Exposure to alkylating agents was observed in 83.8% of cases, mostly

80 re susceptible to bi- and tri-functional DNA alkylating agents with this phenotype readily complement

81 no optimal approach that uses standard dose-alkylating agents without significant late effects.

82 st the hypothesis that increased exposure to alkylating agents would be associated with decreased spe

83 s, a mild protocol using simple and abundant alkylating agents would have considerable use in the syn

84 an catalyze the hydrolysis of the potent DNA-alkylating agents yatakemycin (YTM) and CC-1065.

85 s-resistant drugs used for conditioning (eg, alkylating agents) could favor elimination of residual c

86 tients, is associated with prior exposure to alkylating agents, and a high frequency of TP53 loss or

87 r-stable and inexpensive nitroalkanes as the alkylating agents, and delivers synthetically versatile

88 trobenzofurazan-based scaffolds, maleimides, alkylating agents, and electrophilic aldehydes, toward c

89 repair kinetics and increases sensitivity to alkylating agents, but not other forms of DNA damage.

90 ed necrotic cell death, induced by cytotoxic alkylating agents, hyperactivation of poly-ADP-ribose po

91 sm may not augment some regionally delivered alkylating agents, leading to a net increase in tumor si

92 Using thiol-alkylating agents, mass spectrometry, and an assay for a

93 a (WM) and closely related disorders include alkylating agents, purine analogs, and monoclonal antibo

94 agents in WM include monoclonal antibodies, alkylating agents, purine analogs, proteasome inhibitors

95 Alkylating agents, such as cyclophosphamide, set up the

96 changes color upon the exposure to dangerous alkylating agents, such as iodomethane vapor, without th

97 proaches with alkyl halides or sulfonates as alkylating agents, the use of unactivated olefins for al

98 oma cells to apoptosis following exposure to alkylating agents, while not affecting primary melanocyt

99 ator compound for many types of carcinogenic alkylating agents.

100 and can detect both gas- and solution-phase alkylating agents.

101 t severe, pulmonary vascular complication of alkylating agents.

102 s makes them significantly more sensitive to alkylating agents.

103 nd intrastrand cross-linking agents, but not alkylating agents.

104 h antimetabolites, T-cell inhibitors, and/or alkylating agents.

105 SCC foci formation and are hypersensitive to alkylating agents.

106 ylation strategy using simple olefins as the alkylating agents.

107 ersus-host disease regardless of exposure to alkylating agents.

108 poor growth in ARTEMIS deficiency and use of alkylating agents.

109 reactive methyl donor, and by reaction with alkylating agents.

110 ed upon exposure to endogenous and exogenous alkylating agents.

111 ation of ketones using simple alkenes as the alkylating agents.

112 foci specifically upon exposure of cells to alkylating agents.

113 nse of malignant melanoma cells treated with alkylating agents.

114 protects cells from carcinogenic effects of alkylating agents; however, MGMT is silenced by promoter

115 asymmetric induction in the resulting alpha-alkylated aldehydes.

116 n air and odor qualities of guaiacol and its alkylated, alkenylated, and methoxylated derivatives wer

117 array of structurally complex free and mono-alkylated alpha-amino ketones in excellent yields.

118 leophilic addition to the N-C(O) moiety of N-alkylated amides, indicating the lack of n(N) to pi*(C=O

119 n this 100% atom-economic synthesis of alpha-alkylated amines.

120 Compared with alkylated analogs of the same backbone, the triethylene

121 ligand-free Tdp2 and Tdp2-DNA complexes with alkylated and abasic DNA that unveil a dynamic Tdp2 acti

122 rt in such transformations, with mixtures of alkylated and acylated products often being obtained, th

123 Commercially available pyrazoles were alkylated and formylated in a regiocontrolled manner to

124 e/all-cis hydrogenation of a large series of alkylated and fused arene derivatives to the correspondi

125 AlkD induces flipping of the alkylated and opposing base accompanied by DNA stack com

126 silylmethyl-1,2-dihydropyridines can also be alkylated and subsequently desilylated to give endocycli

127 linked with increased susceptibility to DNA alkylating and inter-strand cross-linking agents.

128 We extracted doses of 14 alkylating and similar DNA interstrand crosslinking drug

129 Purified ADAMTS13 was reduced, alkylated, and processed into peptides with either tryps

130 Maleimide-based, alkylating, and aldehydic thiol labeling reagents provid

131 Thereby, meta-alkylated anilines could be accessed, which are difficul

132 ion of the iodo groups of the resulting di-O-alkylated anti-1,3-diiodides provides access to the anti

133 reported correlation between sensitivity to alkylating anticancer agents and topoisomerase inhibitor

134 be superior in the colorimetric assay of the alkylating anticancer drug cyclophosphamide.

135 s can directly react with NHP esters to form alkylated arenes.

136 is demonstrated that by using a library of N-alkylated aromatic oligoamide helix mimetics, potent hel

137 nines are sulfoxides (aS4ox); a fully lysine-alkylated aS (acetyl-aS); and aS fibrils, testing their

138 mo-3-methoxycyclohex-2-en-1-ones are readily alkylated at C-6 with reactive halides, and then treatme

139 thesis of a library of kanamycin B analogues alkylated at various hydroxyl groups.

140 Since this strategy leaves the alkylated base solvent exposed, the means to achieve enz

141 y a backbone phosphate group proximal to the alkylated base.

142 cial nucleotides that specifically pair with alkylated bases offer a possible strategy for recognitio

143 nzyme that initiates base excision repair of alkylated bases, the flipped-out nucleotide is stabilize

144 1 in response to interstrand cross links and alkylated bases, whereas it acts independently of the AT

145 ous DNA damage including N(2)-dG adducts and alkylated bases.

146 the fuel-amended incubations confirmed that alkylated benzene hydrocarbons were metabolized via know

147 the synthesis of 46 tertiary amine-bearing N-alkylated benzo[d]imidazol-2(3H)-ones, imidazo[4,5-b]pyr

148 p-free method that delivers C3-arylated and -alkylated benzothiophenes with complete regioselectivity

149 , a known metabolite of diallyl monosulfide, alkylates both amines and thiols under physiologically r

150 dues strongly affect their probability to be alkylated by ethyl methanesulfonate.

151 primary aliphatic amines can be cleanly mono-alkylated by unactivated secondary alkyl iodides in the

152 For each additional alkylated carbon, log KPEw increased by an average of 0.

153 tary COMT mutants and can be used to prepare alkylated catechols, including ethyl vanillin.

154 lated with the number of carbons in the PFCA alkylated chain.

155 ratinocytes upon exposure to UVB and the DNA-alkylating chemicals such as methyl methanesulphonate (M

156 '-nitro-nitrosoguanidine (MNNG, a common DNA-alkylating chemotherapeutic agent).

157 that clinically relevant dosages of standard alkylating chemotherapies, such as temozolomide and cycl

158 ey show that in ARTEMIS patients, the use of alkylating chemotherapy agents is associated with a high

159 Resistance toward alkylating chemotherapy but not radiotherapy was depende

160 ssue was not more predictive for response to alkylating chemotherapy in patients who received concomi

161 erapy for malignancies that are treated with alkylating chemotherapy, and the contribution of standar

162 1) as a key determinant of resistance toward alkylating chemotherapy, driven by hypoxia but also by t

163 als are often conducted after treatment with alkylating chemotherapy, given either as standard therap

164 s induced and predictive of poor response to alkylating chemotherapy.

165 d to avoid exposing responder lymphocytes to alkylating chemotherapy.

166 ablish that TsrM and a triple-alanine mutant alkylate cob(II)alamin efficiently leading to the synthe

167 Alkylating commercial 2-pyridinesulfonylacetonitrile wit

168 intramolecular aldol-type condensation of S-alkylated compounds affords substituted thiophenes in ex

169 HMW, highly aromatic, alkylated compounds decreased in relative abundance conc

170 Nitrogen mustards (NMs) are DNA-alkylating compounds that represent the earliest antican

171 of peracetylated 2(I)-O-, 3(I)-O- and 6(I)-O-alkylated cyclodextrins in up to 19% yields.

172 g-resistant EGFR-L858R/T790M, and covalently alkylate Cys797.

173 ntage of increased residence time at EGFR by alkylating Cys797 and thereby preventing toxic effects.

174 lkylating agent was developed to selectively alkylate cysteine residues in situ.

175 To model endogenous alkylating damage, we determined the mutation spectrum c

176 en a densely packed and a porous phase of an alkylated dehydrobenzo[12]annulene (DBA) derivative phys

177 work details the evaluation of a number of N-alkylated deoxynojirimycin derivatives on their merits a

178 s), alkylated PAHs, dibenzothiophene and its alkylated derivatives (DBTs).

179 ibuted in eight homologous series, including alkylated derivatives and two hitherto unknown series.

180 The ortho-alkylated derivatives of phenoxy products possessing the

181 ehydes with diazo compounds leading to alpha-alkylated derivatives.

182 subjected to pronase treatment yielding the alkylated dipeptide hydroxyethylthioethyl-CysPro (HETE-C

183 The resultant alkylated disaccharides are quantifiable by LC-MS/MS.

184 hat colibactins form unsaturated imines that alkylate DNA by cyclopropane ring opening (2 --> 3).

185 corresponding pyridone derivatives, potently alkylate DNA.

186 egulating MGMT homeostasis and DNA repair of alkylated DNA adducts in cells.

187 otide and amino acid biosynthesis, repair of alkylated DNA and the synthesis of mechanosensitive ion

188 nd that it plays a crucial role in reverting alkylated DNA base lesions and cytotoxicity.

189 rovide new important insights into how these alkylated DNA lesions compromise the flow of genetic inf

190 Among the alkylated DNA lesions, O(4)-alkylthymidine (O(4)-alkyldT

191 milar episulfonium ion intermediate, thereby alkylating DNA and leading to eventual cell death.

192 Mechanistically, upon oxidative stress or alkylating DNA damage, PARP1 interacts with and attaches

193 rast, inhibition of PARP by PARPi attenuates alkylating DNA damage-induced EZH2 downregulation, there

194 an episulfonium ion intermediate capable of alkylating DNA.

195 wise, N-alkyl aziridines are prepared from N-alkylated DPH derivatives.

196 sphate (BCIPP), diphenyl phosphate (DPHP), 2 alkylated DPHPs, and TBBA in urine collected in 2013 fro

197 Greater doses of contemporary alkylating drugs and cisplatin were associated with a de

198 g Rnf4 are hypersensitive to hyroxyurea, DNA alkylating drugs and DNA crosslinking agents, but this s

199 ression and restores chemosensitivity of DNA-alkylating drugs in mouse models.

200 melanoma therapy with temozolomide and other alkylating drugs suggests a combination approach where c

201 contribute to resistance of melanomas to the alkylating drugs temozolomide, dacarbazine, and fotemust

202 gammaglobulinemia, conventional therapy with alkylating drugs, and recently, purine analogs and mAb-a

203 d with the sensitivity toward venetoclax and alkylating drugs.

204 Thus, these specialized alkylating enzymes have dramatic and fully opposed effec

205 bons (PAHs) were predominantly present in an alkylated form, and the composition of the aromatic orga

206 s of their small molecule precursors such as alkylated FOSAs or FBSAs were not detectable (<LODs) in

207 at alternatives, such as cyclophosphamide or alkylating-free combinations, should be considered inste

208 nd solvophilic segments of fully hydrophobic alkylated fullerene molecules.

209 We demonstrated that PDS-Chl alkylates G4 structures at low muM concentrations, witho

210 tives characterized by variously substituted alkylating groups on the nitrogen atom of the quinolinon

211 goes bioactivation to a nitrenium ion, which alkylates guanines at both the C8-dG and N2-dG positions

212 omer and multiple fragmentation patterns per alkylated homologue (MFPPH) is used to quantify target c

213 ameliorating the efficacy of the most common alkylating immunomodulatory compound.

214 ar complex under mild conditions to afford N-alkylated indole derivatives in good yield (up to 86 %)

215 andomization", a small set of differentially-alkylated indolocarbazole analogues was generated by usi

216 not the presence of vcMMAE or mcMMAF on the alkylated interchain cysteine residues.

217 Doubly alkylated ketones can be prepared from methyl ketones an

218 a chiral auxiliary protocol involving alpha-alkylated malonate imidazolidinones.

219 Forty-four non-native S/Se-alkylated Met analogues were synthesized and applied to

220 cromolecules (CAMs) containing a hydrophobic alkylated mucic acid segment and a hydrophilic poly(ethy

221 adducts in DNA that are generated by various alkylating mutagens and drugs.

222 lls treated with PR104A, an experimental DNA alkylating nitrogen mustard prodrug currently under inve

223 in the case of AlkB, slowly hydroxylates an alkylated nucleobase.

224 rial AlkC and AlkD are specific for cationic alkylated nucleobases and have a distinctive HEAT-like r

225 These foci associate with alkylated nucleotides, and coincide spatially with elong

226 (phenylselanyl)methyl]pyrrolidine, which was alkylated on nitrogen with 2-bromo-1-(4-methoxyphenyl)et

227 on of primary amines into their respective N-alkylated or N-arylated pyridinium salts.

228 articularly at purines and various oxidized, alkylated, or otherwise damaged nucleobases.

229 discriminate sources of naturally occurring alkylated PAHs (fossil and modern biomass).

230 ignificant exponential declines were for the alkylated PAHs and DBTs and attributed to their associat

231 Relative to parent PAHs, alkylated PAHs and DBTs are enriched in bitumen and ther

232 Alkylated PAHs and DBTs were not elevated during the for

233 source (93% petrogenic, 7% forest fire) for alkylated PAHs during the past approximately 50 years.

234 for polycyclic aromatic hydrocarbons (PAHs), alkylated PAHs, dibenzothiophene and its alkylated deriv

235 s) within lake sediments, particularly C1-C4-alkylated PAHs, increased significantly after developmen

236 homologue group are within 0.2 log units for alkylated-PAHs but span up to an order of magnitude for

237 yclic aromatic hydrocarbons (PAHs) including alkylated-PAHs in petroleum-impacted sediments.

238 E) values in deionized water for parent- and alkylated-PAHs show a good correlation with a regression

239 .e., chlorines for PCBs and alkyl groups for alkylated-PAHs) to the molecular structure.

240 f freely dissolved aqueous concentrations of alkylated-PAHs, which comprise a significant fraction of

241 ar efficiency for parent-PAHs and a suite of alkylated-PAHs, which predominate over parent-PAHs in pe

242 phase combined with sequencing of the fully alkylated peptide by tandem mass spectrometry.

243 ckbone with helicoidal conformation, and its alkylated peptide side chains are structurally identical

244 s in Ugi and Passerini reactions to afford N-alkylated peptides and depsipeptides, respectively, foll

245 The ortho-alkylated phenoxypyridine possessing ester functionality

246 , respectively, to investigate the effect of alkylated pi-spacer on dye aggregation on the TiO2 surfa

247 Finally, we demonstrate that the synthetic alkylated piperazine-azole hybrids do not function by fu

248 activity of novel alkylated piperazines and alkylated piperazine-azole hybrids, their time-kill stud

249 e synthesis and antifungal activity of novel alkylated piperazines and alkylated piperazine-azole hyb

250 Although concentrations of alkylated polycyclic aromatic hydrocarbons (alkyl-PAHs)

251 cruises and were measured for 50 parent and alkylated polycyclic aromatic hydrocarbons (PAHs).

252 Commonly monitored aromatics (parent and alkylated-polycyclic aromatic hydrocarbons and dibenzoth

253 ers are within a factor of 2 for parent- and alkylated-polycyclic aromatic hydrocarbons in petroleum-

254 ona alkaloid derivatives affording the final alkylated products in good yields and excellent enantios

255 th potent antimalarial activity were able to alkylate protein target(s) within the asexual erythrocyt

256 inyl ketone and ends with the formation of O-alkylated pyridine oxime ether.

257 iazolo[5,4-d]thiazole heterocycle allows the alkylated pyridinium groups to remain planar, strongly a

258 ate scope encompasses a variety of N-H and N-alkylated pyridobenzazepine variants with yields up to 9

259 ated intermediates provides a variety of C-2 alkylated pyrrolidines.

260 Addition of two equivalents of an alkylating reagent to UO2 X2 (L)2 (X=Cl, Br, I, OTf; L=t

261 The alkylating reagent, N-(phenylseleno)phthalimide (NPSP),

262 s polymerization (ROMP) for use as efficient alkylating reagents is reported.

263 suggests a kinetic anionic activation of the alkylating reagents occurs, favoring nucleophilic additi

264 icable use of unactivated alcohols as latent alkylating reagents, achieved via the successful merger

265 y available uranyl salts, silyl halides, and alkylating reagents.

266 strategy for replacing toxic, electrophilic alkylating reagents.

267 tion of heteroarenes, using alcohols as mild alkylating reagents.

268 ass, such as lignocellulose, are employed as alkylating reagents.

269 pecific quantitative approach integrating an alkylating resin-assisted capture and mass spectrometry-

270 N-Alkylated (S)-7-halogen-5-[1-(2-methoxymethylpyrrolidiny

271 he rapid construction of a broad spectrum of alkylated scaffolds from alkyl zinc reagents generated i

272 organic acid as cocatalyst, a broad range of alkylated secondary and tertiary amines are obtained in

273 itions and allows obtaining a broad range of alkylated secondary and tertiary amines, including fluor

274 tives are more stable than the corresponding alkylated selenocysteine.

275 thesis and electrical properties of nine new alkylated silane self-assembled monolayers (SAMs) - (EtO

276 alogues might be exploited to activate a DNA-alkylating species selectively in hypoxic tissue.

277 nt with increased relative abundance of less alkylated stable aromatic structures.

278 Perfluorinated alkylate substances (PFASs) are widely used and have res

279 Postnatal exposure to perfluorinated alkylate substances (PFASs) is associated with lower ser

280 Perfluorinated alkylated substances (PFASs) are today considered persis

281 a pyrrolochromene derivative accompanied the alkylated succinimide.

282 probes, we define an ART proteome that shows alkylated targets in the glycolytic, hemoglobin degradat

283 Alkylated terpyridine ligands are an increasingly import

284 Upon Birch reduction of unprotected, C4-alkylated tetrahydroindanols and electrophilic trapping

285 t diazo compounds can be used to selectively alkylate the 5'-phosphate of ribo(oligo)nucleotides to g

286 e designed to retain biological activity and alkylate the molecular target(s) of Plasmodium falciparu

287 ream inhibitor of NF-kappaB degradation, (b) alkylated the NF-kappaB RelA protein to prevent DNA bind

288 dification is removed through catalysis; and alkylating the cysteine blocks activity.

289 rise to alkylation of DNA, and the resulting alkylated thymidine (alkyldT) lesions were found to be p

290 us studies showed that the minor-groove O(2)-alkylated thymidine (O(2)-alkyldT) lesions are poorly re

291 enzamide substrates can be selectively ortho-alkylated to give either mono- or dialkylated products b

292 e the first structural characterization of N-alkylated twisted amides prepared directly by N-alkylati

293 ic oligoureas containing multiple adjacent N-alkylated units derived from proline (i.e., Pro(u)) are

294 Both mutants are hexa-alkylated upon addition of iodoacetamide, demonstrating

295 RNA can also be alkylated upon exposure to endogenous and exogenous alky

296 Here we quantify interactions of urea, alkylated ureas, and other amides by osmometry and amide

297 ach the nitrogen of the starting pyrrole was alkylated with a special Michael acceptor having an ally

298 Diverse ketones could be alkylated with diarylmethanols, cinnamyl alcohols, and p

299 aniline derivative 1t, which was reductively alkylated with hexanal and coupled to l-proline.

300 cyclic and acyclic ketones can be mono-alpha-alkylated with simple terminal olefins, such as ethylene