ライフサイエンスコーパス: alkynyl

1 ycals along with various nucleophiles (aryl, alkynyl).

2 via nucleophilic attack of the amide N(-) to alkynyl.

3 ochiral metallocycles with up to 38 6,6'-bis(alkynyl)-1,1'-binaphthalene bridging ligands (L) and 38

4 of a series of compounds belonging to the 5-alkynyl-1,2,3-triazole family that exhibits potent antil

5 ydes or ketones is shown to give access to 2-alkynyl-1,3-diols in a stereoselective manner.

6 Interestingly, N-Boc-2-alkynyl-1-amino-3-yn-2-ols 6, bearing an additional alky

7 Under the same conditions, N-Boc-2-alkynyl-1-amino-3-yn-2-ols were converted into the corre

8 Thus, hydroboration of 1-alkynyl-1-boronate esters with dicyclohexylborane genera

9 eginning with readily available air-stable 1-alkynyl-1-boronate esters, hydroboration with dicyclohex

10 The synthesis of novel (omega-alkynyl-1-hydroxy-1,1-diyl)bisphosphonic acid tetramethy

11 The formation of alkynyl 11-hydroxy-8,9-epoxy-eicosatrienoic acid compare

12 as alkynyl 11-hydroxy-eicosatetraenoic acid, alkynyl 11-hydroxy-8,9-epoxy-eicosatrienoic acid, and al

13 The products were identified as alkynyl 11-hydroxy-eicosatetraenoic acid, alkynyl 11-hyd

14 ion into the Rh(II)-catalyzed reactions of 2-alkynyl 2-diazo amido-substituted esters.

15 he electrophilic cyclization of various 1-(1-alkynyl)-2-(methylseleno)arenes by Br2, NBS, I2, ICl, Ph

16 the intramolecular heterocyclization of 2-(1-alkynyl)-2-alkene-1-ones and facilitates high levels of

17 sides, when starting from acetyl-protected 5-alkynyl-2'-deoxyuridines (85-86%).

18 The method gives access to 1-alkynyl-2-(hydroxymethyl)imidazoles which undergo 6-endo

19 had previously been found with a series of 2-alkynyl-2-diazo-3-oxobutanoates.

20 )-catalyzed cyclization of N-Boc-protected 6-alkynyl-3,4-dihydro-2H-pyridines, prepared by the Sonoga

21 (1H)-one (EBX) to afford a wide variety of 3-alkynyl-3-alkyl/aryl 2-oxindole under transition-metal f

22 3-Alkynyl-3-hydroxyisoindolinones react with hydrazine and

23 two novel transformations of 3-vinyl- and 3-alkynyl-3-hydroxyisoindolinones.

24 s the straightforward synthesis of various 2-alkynyl-3H-imidazo[4,5-b]pyridines, a valuable scaffold

25 o-(1,3-butadiynyl)phenyltriazene produced 3-alkynyl-4-bromocinnoline.

26 thesize a new metabolic chemical reporter, 6-Alkynyl-6-deoxy-GlcNAc (6AlkGlcNAc), for the identificat

27 ross-coupling of ortho-[2-(4-methoxylphenyl)-alkynyl]acetophenones with ortho-alkynylbenzaldehydes af

28 We demonstrate that two alkynyl-acetyl-CoA analogues, 4-pentynoyl-CoA and 5-hexy

29 ess provides practical access to chiral beta-alkynyl acids.

30 The rate law for alkynyl alcohol hydroalkoxylation/cyclization is first-o

31 first-order in [catalyst] and zero-order in [alkynyl alcohol], as observed in the intramolecular hydr

32 he hydroalkoxylation/cyclization of internal alkynyl alcohols affords excellent E-selectivity.

33 clization of the SiMe(3)-terminated internal alkynyl alcohols reveals interesting product profiles wh

34 ylation/cyclization of primary and secondary alkynyl alcohols to yield the corresponding exocyclic en

35 nificantly more rapid than those of internal alkynyl alcohols, arguing that steric demands dominate t

36 benzofuropyridines 8a-p by the reaction of o-alkynyl aldehyde 4a-t and 5a-p with tert-butylamine 6 un

37 Alkenyl aldehydes did not react, but an alkynyl aldehyde gave a 71% yield and 95% ee of an aziri

38 catalyzed aldol condensation reaction of an alkynyl aldehyde was also successfully achieved.

39 and naphthyridines 6a-v by the reaction of o-alkynyl aldehydes 3a-aa with amines having embedded nucl

40 s a facile conversion of easily accessible o-alkynyl aldehydes into medicinally useful heterocycles i

41 ifications afforded three organic cages with alkynyl, alkenyl, and alkyl edges, respectively.

42 Starting from aryl-, heteroaryl-, alkynyl-, alkenyl-, and alkyltrifluoroborates, a library

43 atic alkynes couple with various substituted alkynyl/alkenyl boronates/boronic acids by this procedur

44 In particular, alkynyl alkyl ketones resolve the long-standing problem

45 studies is applied to iron-SciOPP catalyzed alkynyl-alkyl cross-couplings, providing the first detai

46 lkyl, alkyl-alkyl, aryl-aryl, alkenyl-alkyl, alkynyl-alkyl) coupling partners.

47 oxidation of aryl-, silyl-, and alkyl-capped alkynyl alpha-cyano alkanone systems to the correspondin

48 eacts with terminal alkynes to give the [Zr]-alkynyl/ammonium systems 19.

49 itions for (i) metabolic incorporation of an alkynyl analog of palmitic acid into cellular proteins c

50 quantify the cellular targets labeled by the alkynyl analogue of HNE (aHNE).

51 The C2-alkynyl analogue was found to have double- to single-dig

52 s and the steric encumbrance of the terminal alkynyl and allenyl subsituents.

53 The mu-alkynyl and mu-triazolide complexes undergo reversible r

54 affinities agreed with predicted binding of alkynyl and triazole analogues.

55 14R computationally, two alternatives, i.e., alkynyl and triazolyl derivatives, were identified.

56 oupling reactions between aromatic, alkenyl, alkynyl, and alkyl substrates in library or individual f

57 n of alpha-quaternary centers bearing allyl, alkynyl, and heteroaryl groups in an umpolung fashion.

58 means of Sonogashira reaction, a series of 2-alkynyl- and 2,7-dialkynyl derivatives of 1,8-bis(dimeth

59 in D analogues, we identified a new class of alkynyl- and alkenyl-substituted macrolides with activit

60 bon bond forming methodology using potassium alkynyl- and alkenyltrifluoroborate salts has been devel

61 Aryl-, heteroaryl-, alkenyl-, alkynyl- and alkyl-substituted allylic phosphates may th

62 Aryl-, heteroaryl-, alkenyl-, alkynyl-, and alkyltrifluoroborates were converted into

63 yclization of the resulting N,N-dialkyl-o-(1-alkynyl)anilines using I2 in CH2Cl2.

64 zation of the resulting N,N-dialkyl-ortho-(1-alkynyl)anilines with arylsulfenyl chlorides or arylsele

65 erall, omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid appear to be metabolically comp

66 of arachidonic acid may limit the utility of alkynyl arachidonic acid in the tracking of cyclooxygena

67 ons of omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid were compared to that of linole

68 d when omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid were reacted with lipoxygenase

69 ze alkynyl linoleic but efficiently oxidized alkynyl arachidonic acid.

70 nopyridines can be prepared by allowing o-(1-alkynyl)arenecarboxaldehydes and ketones to react with I

71 lso readily prepared by the reaction of 2-(1-alkynyl)arenecarboxaldehydes with I2 and simple olefins

72 shown compatibility with alkyl, alkenyl, and alkynyl, aromatic, and several heteroaromatic substituen

73 The reaction of alkyl sulfinates with alkynyl(aryl)iodonium salts provides a facile access int

74 ganometallic reagents includes alkyl, allyl, alkynyl, aryl, and heteroaryl compounds including those

75 Alkyl-, alkenyl-, alkynyl-, aryl- or heteroaryl-substituted trifluoromethy

76 spherical fullerene wheels, freely rotating alkynyl axles, and a molecular chassis.

77 use of those with large bite angles leads to alkynyl azacycles, with high stereoselectivity.

78 An alkynyl azide analogue of 1, which may be useful as a gl

79 kyl aziridines display similar reactivity to alkynyl aziridines, giving insight into mechanistic poss

80 Multidimensional reaction screening of ortho-alkynyl benzaldehydes with a variety of catalysts and re

81 The electrophilic cyclization of 2-(1-alkynyl)benzamides affords high yields of cyclic imidate

82 ves formation of the (E)-1-(2-nitrovinyl)-2-(alkynyl)benzene species 2 via condensation of synthon 1

83 lective 5-exo- and 6-endo-cyclizations of an alkynyl benzothioamide have been achieved.

84 organocatalytic asymmetric approach to beta-alkynyl-beta-amino acids with high efficiency and practi

85 yzed exclusive 5-exo-dig hydroarylation of o-alkynyl biaryls has been demonstrated.

86 III)-catalyzed intramolecular coupling of 2'-alkynyl-biphenyl-2-carbaldehydes.

87 cts the bicyclic guanidinium ion core from a alkynyl bisguanidine.

88 The strain on the alkynyl bonds enabled a copper-free, three-fold azide-al

89 Simple as ABC: Alkynyl borane cycloadditions can be substrate-directed

90 tioselective approaches have been developed; alkynyl boronates add to glycolaldehyde imine to afford

91 ling of alkynyl bromide and pinacol ester of alkynyl boronic acid catalyzed by CuFe2O4 nanoparticles

92 s also extended for the Csp-Csp2 coupling of alkynyl bromide and alkenyl boronic acid to provide conj

93 An efficient Csp-Csp cross-coupling of alkynyl bromide and pinacol ester of alkynyl boronic aci

94 vated aryl chloride, alkenyl halides, and an alkynyl bromide) serve as suitable partners.

95 the coupling of a wide range of amides with alkynyl bromides is described here.

96 (i) The product of alkynyl C-H addition, (PCP)Ir(CCPh)(H) (3), has been iso

97 sted acids will catalyze the addition of the alkynyl C-H bond of phenylacetylene to the pincer comple

98 [Tp'Rh(PMe3)] was also able to activate the alkynyl C-H bond of terminal alkynes to give activation

99 eed through three steps: (i) addition of the alkynyl C-H bond to iridium, (ii) insertion of a second

100 ut the need for an additive to deprotect the alkynyl carbon as endstanding anchor group.

101 C-N bond formation on the more electrophilic alkynyl carbon resulting in the formation of 6-endo-dig

102 C-N bond formation on the more electrophilic alkynyl carbon through 6-endo-dig cyclization.

103 N-C bond formation on the more electrophilic alkynyl carbon, resulting in the regioselective 6-endo-d

104 strategy allows direct access to chiral beta-alkynyl carbonyl compounds employing allylic alcohol sub

105 unds with alkynylstannanes to form secondary alkynyl carbonyl compounds via palladium catalysis emplo

106 l-lambda(3)-iodanes have been established as alkynyl cation equivalents for the alkynylation of carbo

107 e inhibition varied, and introduction of a 2-alkynyl chain greatly reduced affinity.

108 uronamides derivatives with functionalized 2-alkynyl chains of varying length terminating in a reacti

109 of this unique modification, we developed an alkynyl chemical reporter for detection and identificati

110 e reaction between non-heteroatom-stabilized alkynyl chromium carbene complexes prepared in situ and

111 gen atom directed to the alkylidyne leads to alkynyl-cis-hydride-alkylidyne intermediates, which rapi

112 moieties has been realized using the Huisgen alkynyl click reaction, resulting in altered optical and

113 We report a homoleptic Au-Cu alkynyl cluster that represents an unexplored class of l

114 Studies of the mixed-valence mu-alkynyl complex's reactivity suggest that a mixed-valenc

115 A discrete, dicopper mu-alkynyl complex, [Cu2(mu-eta(1):eta(1)-C identical withC

116 gation of the gold-carbon bonding in gold(I)-alkynyl complexes using photoelectron spectroscopy and t

117 c material is the first example of a gold(I) alkynyl compound demonstrating vapochromic behavior.

118 pyrazole units by the reaction of alpha,beta-alkynyl compounds with hydrazine monohydrate, (iv) gold-

119 yclic species) synthetic routes to two novel alkynyl-conjugated multiple ferrocene- and biferrocene-c

120 e, diazoacetonitrile (DAN), and an activated alkynyl coupling partner to form substituted 1,2-diarylp

121 e present work investigates this strategy in alkynyl crown ethers, where propargylic C-O bonds contai

122 The metabolic labeling of cells with an alkynyl derivative of 20(S)-hydroxycholesterol has allow

123 actions with rhodium carbenoids derived from alkynyl diazo acetates.

124 functionalized bridged bicyclic systems from alkynyl diazoesters is presented.

125 and characterization of the mixed-valence mu-alkynyl dicopper complex, [Cu2(mu-eta(1):eta(1)-C identi

126 ular Diels-Alder reaction with an alkenyl or alkynyl dienophile.

127 les by heteroatom substitution and utilizing alkynyl dienophiles enhances the reaction rates up to 10

128 e effects of tether length, heteroatoms, and alkynyl dienophiles on reactivity were analyzed.

129 eactions involving unsymmetrical alkenyl and alkynyl dienophiles proceed with good to excellent regio

130 In the case of alkynyl dienophiles, [4 + 2] cycloaddition initially gen

131 The most active species was an alkynyl diphosphate having IC(50) = 0.45 microM (K(i) ap

132 loisomerization reaction of boron-containing alkynyl epoxides toward C2- and C3-borylated furans has

133 ed for the efficient one-step preparation of alkynyl epoxides, important organic building blocks, fro

134 te addition of alkyl groups to an alpha,beta-alkynyl ester intermediate, and differential activation

135 ters to generate conjugated and deconjugated alkynyl esters and conjugated allenyl esters.

136 hus allows for rapid elaboration of the beta-alkynyl esters into a variety of chiral, substituted het

137 ew strategy for the synthesis of chiral beta-alkynyl esters which relies on sequential Pd and Cu cata

138 curs with high 1,4-selectivity yielding beta-alkynyl esters with excellent levels of enantioselectivi

139 In particular, use of alkynyl ether-tethered substrates led to (3 + 2) cycload

140 erated in situ via the retro-ene reaction of alkynyl ethers provides amides in good yield, in many ca

141 ible toward a wide range of aryl-substituted alkynyl ethers with electron-donating and electron-withd

142 Substituted benzyl alkynyl ethers, prepared from the corresponding alpha-al

143 Here we report the development of alkynyl-fatty acid chemical reporters and improved bioor

144 In addition, alkynyl-fatty acid chemical reporters enable the visuali

145 ormal [8 + 2] cycloaddition reaction between alkynyl Fischer carbene complexes and tropothione leads

146 th an azide and the polypeptide with pendant alkynyl functionality.

147 cid (LNA) monomers, i.e. conventional and C5-alkynyl-functionalized LNA and alpha-L-LNA pyrimidine mo

148 ition of side chains modified with azido and alkynyl functions and explore alternative synthetic rout

149 mplexes for the facile formation of terminal alkynyl-gold intermediates and activation of the carbon-

150 y, the effects of steric substitution of the alkynyl Grignard reagent on catalytic performance were i

151 e mechanism of ESI ionization of alkenyl and alkynyl group 6 Fischer carbene complexes.

152 ons and regioselective water addition to the alkynyl group at C-3 of the corresponding pyrrole-3-carb

153 ty of the allene double bond relative to the alkynyl group in allene-ynes.

154 We found that the alkynyl group not only enhances the oxidation stability

155 Utility is showcased by conversion of the alkynyl group to other useful functional units (e.g., ho

156 a reactions replace the Br-substituent by an alkynyl group, placed on the azaacene core.

157 s and their conjugate bases suggest that the alkynyl groups are interacting through space.

158 high regioselectivities, placing alkenyl or alkynyl groups distal to the forming C-C bond.

159 The chemoselectivity of diazo and alkynyl groups enables dual labeling of cells that is no

160 0) at a high molar ratio of linear chains to alkynyl groups in the backbone, the brush copolymers wit

161 host maximizes the number of interactions of alkynyl groups with the cation at an ideal distance.

162 ing/withdrawing aryl groups, silyl-protected alkynyl groups, as well as ferrocenyl and azulenyl group

163 e Me, Ph, and (phenyl-substituted) vinyl and alkynyl groups.

164 the initial molar ratio of linear chains to alkynyl groups.

165 alkyl, as well as alkenyl, aryl, allenyl and alkynyl groups.

166 of cells that is not possible with azido and alkynyl groups.

167 ids illustrated a general trend in porosity: alkynyl > alkenyl > alkyl.

168 It was demonstrated that alkynyl halides could serve as a source of Br+ and acety

169 ta-C(sp(3))-H bonds in aliphatic amides with alkynyl halides has been enabled using Pd(0)/N-heterocyc

170 In the first step, a multicomponent alkynyl halo-Prins reaction joins an enyne, a carbonyl d

171 The combination of a bis-alkynyl-helicene moiety with two iron centers leads to n

172 grees C) is required for aryl-heteroaryl and alkynyl-heteroaryl couplings.

173 This protocol allows an access to novel N-(1-alkynyl)imidazoles in moderate to good yields.

174 ion of in situ generated challenging N-Boc C-alkynyl imines from previously unreported C-alkynyl N-Bo

175 le the phosphatyloxy migration in conjugated alkynyl imines in their cycloisomerization to N-fused py

176 e catalytic asymmetric Mannich reaction of C-alkynyl imines that provide syn-configured propargylamin

177 hydroxyl allenes, and allyl boronates add to alkynyl imines to form 1,3-alkenyl allenes.

178 mmetric addition of carbon nucleophiles to C-alkynyl imines, culminating in a highly syn-selective ca

179 Reduction of alkynyl iminium salts derived from cyclic (alkyl)(amino)

180 has been demonstrated by using a series of 2-alkynyl indoles and arylacetylenes.

181 ne-pot reaction involving the treatment of 2-alkynyl indoles with arylacetylenes in the presence of a

182 ism involving an organometallic aryl-Co(III)-alkynyl intermediate species is preferred for terminal a

183 ]metacyclophanedienes (CPD) with alkenyl and alkynyl internal (8,16) groups is described together wit

184 observed for a variety of enantioenriched 1-alkynyl isochromans.

185 A set of cycloisomerization methodologies of alkynyl ketones and imines with concurrent acyloxy, phos

186 Alkynyl ketones are attractive but challenging nucleophi

187 e mechanism of cycloisomerization of skipped alkynyl ketones containing an acyloxy group was found to

188 s of the 1,2-acyloxy migration of conjugated alkynyl ketones en route to furans demonstrated the invo

189 the analogous cycloisomerization of skipped alkynyl ketones proceeds through two consecutive 1,2-mig

190 riments in the cycloisomerization of skipped alkynyl ketones under transition metal catalysis reveale

191 (i) synthesis of pyrrole-derived alpha,beta-alkynyl ketones, (ii) introduction of various substituen

192 Alkynyl-lambda(3)-iodanes have been established as alkyn

193 ism of the Cp* complexes, while topology and alkynyl ligand electronics combine more subtly to drive

194 nylated iron(II)-SciOPP species due to rapid alkynyl ligand redistribution.

195 or nitrile groups extending tetragonally via alkynyl linkages from the para positions is described.

196 tified the optimal combinations of azido and alkynyl linkers necessary for stapling BCL9 helices.

197 atural product was replaced with alkenyl and alkynyl linkers to probe the influence of structural rig

198 Overall, omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid

199 y fatty acid products were formed when omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid

200 nenzymatic and enzymatic oxidations of omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid

201 Cyclooxygenase-1 and -2 did not oxidize alkynyl linoleic but efficiently oxidized alkynyl arachi

202 T1, T3, and T4 have been completed using an alkynyl macrolactone as a common late-stage intermediate

203 lexes 1 are described in their reaction with alkynyl malonates.

204 provides access to highly useful chiral beta-alkynyl Meldrum's acid building blocks as demonstrated b

205 tment of three different isotopically edited alkynyl metabolic reporters.

206 Herein we describe the development of an alkynyl-modified GlcNAc analog (GlcNAlk) as a new chemic

207 ols for efficiently and selectively labeling alkynyl-modified glycans.

208 attractive approach for the incorporation of alkynyl moieties into organic molecules.

209 o, notably, to the silicon atoms of the four alkynyl moieties.

210 ran, whose substituents are derived from the alkynyl moiety (2-position), the imine (3- and 4-positio

211 The hydration of the alkynyl moiety (22 and 900 M(-1) s(-1)for QM-1 and QM-2,

212 -alkynyl imines from previously unreported C-alkynyl N-Boc-N,O-acetals, with alpha-substituted beta-k

213 eries of pyridinium skipped aza-enediynes (2-alkynyl-N-propargyl pyridinium salts).

214 The enantioselective conjugate addition of alkynyl nucleophiles has been a long-standing challenge

215 ght into iron speciation and reactivity with alkynyl nucleophiles reported herein provides an essenti

216 ron-catalyzed cross-coupling reactions using alkynyl nucleophiles represent an attractive approach fo

217 ps--propargylamine, 4-pentynoic acid, and an alkynyl-oligoethyleneoxide.

218 wed the labeled substrates to be probed with alkynyl or azido-tagged fluorescent reporters by the cop

219 method is reported for the preparation of N-alkynyl or N-bromoalkenyl heteroarenes from bromoalkynes

220 ic acid while reagents bearing, for example, alkynyl or nitrophenyl moieties, hydrolyze extremely slo

221 For an alkynyl -OR substituent, the results strongly suggest a

222 etrasubstituted chrysenes bearing four aryl, alkynyl, or amino groups by means of the Suzuki, Sonogas

223 g with an aryl, a heteroaryl, an alkenyl, an alkynyl, or an alkyl substituent.

224 rms another pi/sigma metallacycle, an eta(2)-alkynyl, or ferracyclopropene.

225 o a broad range of alkyl, aryl, alkenyl, and alkynyl organomagnesium, -zinc, -aluminum, or -boron rea

226 s to afford single geometric isomers of aryl alkynyl oxime ethers has also been developed.

227 e the regioselective epoxide ring-opening of alkynyl oxiranes and a stereoselective aza-Cope-Mannich

228 ce of a Cu(I) catalyst and a pyridine oxide, alkynyl oxiranes and oxetanes can be converted into func

229 spectroscopy to demonstrate that sulfonyl 3-alkynyl pantetheinamide is fully sequestered by the ACP,

230 o cyclization of the resulting 2-nitro-1-(2-(alkynyl)phenyl)ethanol (6) to furnish iodo isochromene d

231 developed a new phosphoramidite synthon--the alkynyl phosphinoamidite, which is compatible with conve

232 ohydrazides 17a-17g rather than the expected alkynyl phthalazinones.

233 A number of alkynyl pinacolboronates bearing various functional grou

234 pproach are an asymmetric synthesis of the 2-alkynyl piperazine core via a base-promoted isomerizatio

235 -yl)-di-tert-butylphosphine) and the acetate alkynyl position from an aryl to vinyl substituent in th

236 tes with a pendant aryl group at the acetate alkynyl position were found to undergo preferential 1,3-

237 From the alkynyl precursor, the final helical compounds are obtai

238 ly to our previous results with an azido Fuc/alkynyl probe system, we demonstrated that click-activat

239 inally unlabeled ((12)C identical with(12)C) alkynyl probe.

240 xy-8,9-epoxy-eicosatrienoic acid compared to alkynyl prostaglandins suggests that the omega-alkyne gr

241 1-hydroxy-8,9-epoxy-eicosatrienoic acid, and alkynyl prostaglandins.

242 An alkynyl-protected gold nanocluster [Au24(C identical wit

243 especially on (1) effective use of a series alkynyl protecting groups, (2) Sonogashira cross-couplin

244 indium reagents (R3In, R = aryl, heteroaryl, alkynyl) react selectively under palladium catalysis wit

245 nalization of AMPylation substrates with the alkynyl reporter in lieu of adenylyl 5'-monophosphate (A

246 d the regioselective introduction of various alkynyl residues at the C-2 position of pyrroles.

247 isolation and structural characterization of alkynyl Ru-alkylidene species has been elusive owing to

248 s provides the platform to form a variety of alkynyl Ru-alkylidene species possessing a sterically an

249 ging and visualization of glycoconjugates in alkynyl-saccharide-treated cells at extremely low concen

250 y means of 1,2-Zr/B FLP addition followed by alkynyl shift from boron to zirconium and reductive coup

251 chosen as the target amino acid because its alkynyl side chain can be selectively and efficiently co

252 Bisbenzimidazoles with alkynyl side chains display excellent E. coli DNA topois

253 droxyl side groups, polymeric backbones with alkynyl side groups on essentially every monomer unit (P

254 transformations provided easy access to the alkynyl side-chain containing (2S,3R)-AHBAs.

255 e report the stereoselective synthesis of an alkynyl side-chain containing (2S,3R)-alpha-hydroxy-beta

256 The synthesis features a base-catalyzed alkynyl silane alcoholysis/ring-closing enyne metathesis

257 leads to the scrambling of labels over both alkynyl (sp) carbons.

258 More broadly, clickable alkynyl sterols may represent useful tools for sterol ce

259 -indenes (from beta-alkyl-beta-alkyl/aryl-o-(alkynyl)styrenes) and 3-iodobenzofulvenes (from beta,bet

260 -iodobenzofulvenes (from beta,beta-diaryl-o-(alkynyl)styrenes) in good yields under mild reaction con

261 on the 5-endo iodocyclization reaction of o-(alkynyl)styrenes, represents one of the scarce examples

262 -1-amino-3-yn-2-ols 6, bearing an additional alkynyl substituent alpha to the hydroxyl group, spontan

263 2-dialkynyl-1,2-diols, bearing an additional alkynyl substituent at C-2, a cascade process, correspon

264 cal, generated from spiroepoxide 14, onto an alkynyl substituent generating tetracyclic compound 13 w

265 eful clues for predicting the effects of the alkynyl substituent on the nature of the key intermediat

266 solated yield depending on the nature of the alkynyl substituent.

267 nic and steric properties for three types of alkynyl substituents along the reaction paths and the im

268 ine monomers that are conjugated to small C5-alkynyl substituents induce significant improvements in

269 We describe here three alkynyl substituted naphthalenes that display promising

270 aryl-substituted acenes, photooxygenation of alkynyl-substituted acenes proceeds most likely by a con

271 Aryl- and alkynyl-substituted o-thiomethyl-p-methoxyaniline-derive

272 anel of glycoproteins by click reaction with alkynyl sugar analogs in plasma cells coupled with mass

273 Alkynyl sugar monomers, based on fucose (Fuc) and N-acet

274 ACP dehydratase (DH) domains by means of a 3-alkynyl sulfone warhead.

275 s from ynoate-enoate, ynoate-enenitrile, and alkynyl sulfone-enenitrile substrates.

276 ess into otherwise difficult to obtain alkyl alkynyl sulfones and cyclic vinyl sulfones via 1,2-rearr

277 By using alkynyl sulfones or sulfonates as substrates, the oxidat

278 w methodology affords formation of alkyl and alkynyl surface monolayers of varied chain lengths (i.e.

279 Using alkynyl surrogates of O3-derived oxysterols, our data de

280 ly, supplementation of epithelial cells with alkynyl-tagged cholesterol followed by O3 exposure cause

281 An unstable, alkynyl-tagged curcumin analog yielded abundant adducts

282 st probable conductance value of a family of alkynyl terminated oligophenylenes (OPA(n)) connected to

283 nethiol, DNA) were successfully "clicked" to alkynyl-terminated BDD by irradiating the interface at 3

284 These alkynyl-terminated compounds permit the rapid and facile

285 in a functional-group tolerant manner using alkynyl thioethers.

286 drogen atom directed to the halide gives the alkynyl-trans-hydride-alkylidyne derivatives OsH(C ident

287 ic acid derivatives of para-substituted aryl-alkynyl triazacyclononane complexes are described.

288 eaction of azide with a hypervalent iodonium alkynyl triflate and reacted in situ with 21 different c

289 coupling of hydroxyaldehydes or ketones with alkynyl trifluoroborate salts is reported.

290 tion of a sulfonylhydrazone that reacts with alkynyl trifluoroborates to generate a transient proparg

291 ble with substrates containing more than one alkynyl unit, cleanly affording compounds containing mul

292 The insertion of alkynyl units into the C-C bonds of polyhedranes results

293 e dual role of Cu both in transmetalation of alkynyl units to Pd(II) and in assisting reoxidation of

294 njugates utilizing protein expressed with an alkynyl unnatural amino acid.

295 ycles by copper(II)-catalyzed cyclization of alkynyl ureas and secondary amides has been developed.

296 Alkynyl-vinyl bond formation in the C-C elimination tran

297 which the latter were previously limited in alkynyl zinc additions.

298 ions formed in situ followed by addition of alkynyl zinc complex to produce the propargylamine that

299 alladium catalyzed cross-coupling of methoxy alkynyl zinc reagents allows for the protecting-group-fr

300 2-promoted in situ formation of oxazolidine, alkynyl zinc, and propargylamine intermediates from 1-al