ライフサイエンスコーパス: allele

1 MFN2 mutations and at least one p.Arg707Trp allele.

2 for the first time, to be a loss of function allele.

3 ") in a way that is harmless for a wild-type allele.

4 IgG3 compared to those without the IgG3-H435 allele.

5 ed reduced expression from the mutant MYBPHL allele.

6 racterization of mice harboring a null Upf3b allele.

7 nly when the mutations occur on the maternal allele.

8 f the gene, generating the {for(BAC)} rescue allele.

9 ene segment corresponding to the IGHV4-61*02 allele.

10 factor apolipoprotein E (APOE) varepsilon3/4 allele.

11 odds ratio multiplied by the number of risk alleles.

12 sitivity to AMA1 alleles and 42%-52% to MSP2 alleles.

13 nses were more common in RA patients with SE alleles.

14 hypo-competition phenotype for four of these alleles.

15 shown in C. albicans using conditional TOR1 alleles.

16 uppression, indicating they function as null alleles.

17 in of SIV in animals with TRIM5a restrictive alleles.

18 thylated or unmethylated minority-epigenetic-alleles.

19 ting both conditional and targeted insertion alleles.

20 presented in existing repositories of immune alleles.

21 th specific major histocompatibility complex alleles.

22 database containing all currently known fimH alleles.

23 geny from a backcross segregating MRL and B6 alleles.

24 ctional tumor suppressor genes by the mutant alleles.

25 city when individuals did not carry epsilon4 alleles.

26 s that modulates the effects of target-locus alleles.

27 e, which is caused by mutations in both GALC alleles.

28 4) generates both null and other informative alleles.

29 d group, had a higher frequency of two APOL1 alleles (1.0% versus 0.1%) and the HBB variant (2.0% ver

30 Mosquitoes carrying the more-susceptible allele (2L+(a)) are also behaviorally less likely to be

31 ulation-based Rotterdam study (N=1604, betaT-allele=3.60, P-value=3 x 10(-2)).

32 Of 130 KIR alleles, 55 are Bornean specific, 65 are Sumatran specif

33 Homozygotes for the PSC disease risk allele (AA) showed significantly lower CD28 mRNA express

34 ling the recurrence of 301 unique resistance alleles across 1934 drug-resistant tumours.

35 a)pyrene exposure of skin shows that SNP309G allele actually protects against squamous cell carcinoma

36 wever, it is largely unknown which genes and alleles adjust plant growth in Fe limited environments.

37 Building on the divergent allele advantage hypothesis, we show that functional asp

38 As transgenic flies with either allele aged, nephrocyte function declined, cell size inc

39 seven F2:3 families homozygous for the pss1 allele and (2) the pen1-1 mutant with Columbia-0.

40 ct against re-targeting the 'knockout-first' allele and identify essential genes in ES cells, includi

41 r results were obtained with the weak vip3-6 allele and in vip6, a mutant for another Paf1c subunit.

42 y deletion of the maternally inherited UBE3A allele and is characterized by developmental delay, inte

43 dren maintained their seropositivity to AMA1 alleles and 42%-52% to MSP2 alleles.

44 eotide polymorphisms, as well as imputed HLA alleles and amino acids.

45 ween classical human leukocyte antigen (HLA) alleles and common immune-mediated diseases (IMDs).

46 auxin response, we screened mpk insertional alleles and identified mpk1-1 as a mutant that displays

47 lysis of two independent L. japonicus mutant alleles and investigated the regulation of ERN1 via tran

48 omprehensively studied by imputing classical alleles and polymorphic amino acid positions.

49 We used chc1 alleles and the related chc2 mutant as tools to investig

50 tions to build up between haploid-beneficial alleles and the sex that experiences haploid selection m

51 control strain, diet, presence of the misty allele, and parity as potential contributors to the lost

52 delete foraging, generating the for(0) null allele, and used recombineering to reintegrate a full co

53 gent allele frequencies and the most private alleles, and observed heterozygosity indicates outcrossi

54 n of mutants) are candidate hypo-competition alleles, and we confirmed the hypo-competition phenotype

55 ismatches between donor and patient in these alleles are associated with an increased risk of graft-v

56 rican ancestry carrying certain APOL1 mutant alleles are at elevated risk of developing renal disease

57 milarly, some individuals that carry disease alleles are nevertheless healthy despite affected family

58 evidence demonstrating that these APOL1 risk alleles are pathogenic is still lacking because the APOL

59 henotypic selection, we show that eYHB-based alleles are robust substitutes for antibiotic/herbicide-

60 ly among patients carrying APOBEC3B-deletion alleles, as examined in a second cohort (n = 188; p = 0.

61 nns (frequency 1.1%), with the low-frequency allele associated with an increase in fasting plasma ins

62 d by dietary fat composition, with the APOE4 allele associated with greater LDL-cholesterol elevation

63 Moreover, the SNP rs12815313-T allele associated with increased susceptibility to CD an

64 and specificity in predicting the number of alleles associated with complex traits in each locus.

65 APOL1 risk alleles' association with blood pressure-related traits

66 The protective T allele at rs7178051 was also associated with reduced ADA

67 Finally, we show that risk alleles at rs11203203 and rs80054410, two T1D-associated

68 Because of the large number of genes and alleles attributed to DCM, comprehensive genetic testing

69 role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio)

70 election most often (e.g., pollen beneficial alleles become strongly associated with the male determi

71 elative reduction of the KIT D816V expressed allele burden (EAB) at month 6, patients were classified

72 Here, we measured 2-HG, mIDH2 allele burden, and co-occurring somatic mutations in seq

73 and ruxolitinib showed reduction of mutated allele burden, and ruxolitinib might extend survival of

74 RHGAP29 in vivo, we generated a novel murine allele by inserting a point mutation identified in a pat

75 2 transcriptional activity relative to the T allele by reducing the binding affinity of PAX2.

76 inant ZSD in whom a heterozygous mutant PEX6 allele (c.2578C>T [p.Arg860Trp]) was overrepresented due

77 -nucleotide polymorphism: rs149133391, minor allele [C] frequency = 0.01, P = 7.9 x 10(-9)) and 4 mor

78 binding in promoter-binding assays, and risk allele carriage diminished transcriptional correlations

79 a gene-by-environment interaction for minor allele carrier status at the TLR4 haplotype defined by r

80 In addition, the C allele carriers of rs2270112 demonstrated significantly

81 x uptake in apolipoprotein E (APOE) epsilon4 allele carriers than in noncarriers in participants (mea

82 itors escitalopram and sertraline than did A allele carriers.

83 ignificantly higher DHEA-S levels than the G allele carriers.

84 ombination of eol1 with the curly leaf (clf) allele, carrying a mutation in the catalytic core of PRC

85 This allele causes a single nucleotide change in the promoter

86 The domesticated allele causes later flowering than the wild allele under

87 ts are regulatory variants for which the two alleles confer different regulatory activities.

88 as particularly strong; each copy of the Thr allele conferred 42% lower triglycerides (beta=-0.92+/-0

89 nse, has resulted in elevated frequencies of alleles conferring survival advantages for infectious di

90 Characterization of a second strong allele confirms the function of PPR78 in nad5 mRNA accum

91 gene replacement (e.g., conditional knockout alleles containing exons flanked by LoxP sites).

92 To what extent the wild-type allele contributes to leukemogenesis is unclear.

93 eotide polymorphisms on stroke risk per risk allele, corresponding to a one allele increase in the my

94 CRTC2 knockout mice that express one CRTC3 allele (CRTC2/3m mice) develop neutrophilia and splenome

95 The C (minor) allele decreased EPHA2 transcriptional activity relative

96 The total number of different alleles detected per gene in the population varied over

97 n, but infants carrying the alternative OXTR allele did not exhibit as great a separation response.

98 une receptors and that the addition of novel alleles discovered from genome sequence data are likely

99 Moreover, these same mutant alleles disrupted hp53 foci and inhibited biosensor acti

100 how how genetic transfer of host segregating alleles, distributed as predicted for niche specifying g

101 ability may result in the spatial sorting of alleles during range expansion.

102 owed a primary association with HLA class II alleles encoding for the HLA DQ2.5 molecule.

103 a harmful wild-type allele with a gene drive allele engineered to have desired functionalities.

104 , abstinent smokers with the withdrawal risk allele experienced greater alleviation of their urges to

105 recombination generates a Notch2(DeltaPEST) allele expressing a Notch2 mutant lacking the PEST domai

106 6156 genes) that contrasted the preferential allele expression of between 2180 and 3502 and 3367 and

107 Preferential allele expression was significantly associated with evol

108 ondary structure of the paRNA, with the risk allele facilitating the assembly of the microRNA-guided

109 is metacyclic promastigotes lacking one SODA allele failed to replicate in macrophages and were sever

110 Using a conditional allele for Braf(V600E) , a mutation observed in clinical

111 xperimental proof of causality of these risk alleles for renal disease.

112 Major alleles for seed dormancy and flowering time are well st

113 r, all humanized strains representing common alleles found in cancer patients failed to complement in

114 nes known, well-supported alleles with novel alleles found in the 1000 Genomes Project data.

115 eveloped for this purpose assume that marker allele freque218 in a population are known without error

116 Finally, we considered the transition of allele frequencies across geographic space and suggest t

117 However, higher risk allele frequencies and population-attributable risk perc

118 ion with low nucleotide diversity, divergent allele frequencies and the most private alleles, and obs

119 ls, there were no significant differences in allele frequencies between affecteds and controls (C/TTC

120 le maintaining the ability to correctly call allele frequencies of known single nucleotide variants.

121 Cellular or population allele frequencies of L1s were assessed by droplet digit

122 provide only summary statistics or aggregate allele frequencies.

123 SNV and indel detection at very low variant allele frequencies.

124 heterozygote frequencies among populations (allele frequencies: African = 0.0016; East Asian = 0.004

125 One SNV with a minor allele frequency <0.01, (rs3025380 at DBH) was genome-wi

126 s common among full-heritage Pima Indians (A allele frequency =0.54) but is monomorphic in the 1000 G

127 sociation with diabetes risk (combined minor allele frequency [MAF] 0.22%; odds ratio [OR] 2.02; 95%

128 etic architecture of complex traits, such as allele frequency and effect size.

129 For the allele frequency calculation, the implementation in the

130 iant-specific prior information derived from allele frequency databases, consequence prediction algor

131 eutral demographic events can create similar allele frequency differences between populations.

132 ), and TT in 85 patients (10%), with a minor allele frequency of 30%.

133 s study, the consistency of increase in 132L allele frequency suggests pathogen-mediated selection ha

134 cancer cell lines with increased KRAS mutant allele frequency were more sensitive to MAP kinase inhib

135 We enumerated 49,138 rare (<1% minor allele frequency) pLoF mutations.

136 lift, loci can exhibit conspicuous seasonal allele-frequency fluctuations, but often fluctuations ma

137 8 epitope in mice expressing the MHC class I allele H-2D(b).

138 Women with the IgG3-H435 allele had a 78% (95% CI 17%, 170%, p = 0.007) increased

139 d cardiomyocytes mutated to carry the effect allele had diminished contractile activity when compared

140 a functional configuration, while the second allele has recombined only the DJ sequences; the other 4

141 individuals with more diabetes genetic risk alleles have a higher risk of developing DR.

142 Furthermore, independently of the MICA*008 allele, higher levels of soluble MICA proteins were dete

143 l genetic backgrounds, and of two additional alleles, HttQ92 and HttQ50, on the C57BL/6J background.

144 etic risk factors and potentially pathogenic alleles identified in future studies.

145 iorated the defects of only a subset of pex6 alleles, implying that decreased PEX5 is not the sole mo

146 cell receptor beta (TCRbeta) V-to-DJ-joined allele in a functional configuration, while the second a

147 ise a mouse line carrying a loss of function allele in Katnal1.

148 olecular marker for detecting the SfABCC2mut allele in resistant fall armyworm.

149 ncluding reduced expression of the drl2-Mo17 allele in the Mo17 inbred.

150 We identified leafy (lfy) and apetala1 (ap1) alleles in a mutant screen for floral regulators in C. h

151 ion of functionality between galE1 and galE2 alleles in meningococcal isolates was retained for all s

152 ut three are depleted of the life-shortening alleles in older Biobank participants.

153 order as well as the persistence of its risk alleles in the modern human genome.

154 Several common alleles in the oxytocin receptor gene (OXTR) are associa

155 e, enabling the establishment of conditional alleles in zebrafish by generating intronic insertions v

156 risk per risk allele, corresponding to a one allele increase in the myeloperoxidase increasing geneti

157 However, sets of alleles increasing body mass index (P=2.2x10(-5)) and th

158 RNA-lipid complexes targeting the Tmc1(Bth) allele into the cochlea of neonatal Tmc1(Bth/+) mice sub

159 usly identified as a hotspot of shape-tuning alleles involved in wing mimicry.

160 nuclear protein interactions, where the risk allele is associated with increased SLC4A7 expression le

161 In conclusion, the MBOAT7 rs641738 T allele is associated with reduced MBOAT7 expression and

162 approaches, we show that the white recessive allele is due to a splice donor site mutation in the sca

163 The remaining wild-type allele is most commonly, but not always, retained.

164 This suggests that the remaining normal allele is required for the phenotype.

165 w ratio (0.05 to 0.7) of mutant to wild-type alleles (ITD [high] and ITD [low], respectively).

166 CRISPR-Cas9 genome editing to make a single allele knock-in of the most commonly mutated amino acid

167 CRC that harbors an inducible oncogenic Kras allele (Kras(mut) ) and conditional null alleles of Apc

168 tor ZEB1 binds preferentially to the nonrisk allele, leading to an increase in GUCY1A3 expression, hi

169 olution) HLA typing for HLA-A and HLA-B, and allele-level for HLA-DRB1.

170 d 1199 paediatric donor-recipient pairs with allele-level HLA matching who received a single unit umb

171 Using function-separating alleles, live-cell spindle assays, and in vitro biochemi

172 The disparate phenotypes of these pex alleles may reflect unanticipated functions of the perox

173 promoting the overrepresentation of a mutant allele might also play a role in other autosomal-recessi

174 ized that human genes and disease-associated alleles might be systematically functionally annotated u

175 s study, we generated an inducible Drd2 null-allele mouse strain that circumvented developmental comp

176 The fasting glucose-raising allele near PDX1, a known key insulin transcription fact

177 y, we report the identification of a natural allele of a C2H2-type transcription factor in rice that

178 (P > 0.05) in AAs, AA women who carried the allele of a functional single nucleotide polymorphism rs

179 produced only in individuals who carry a dG allele of a genetic variant rs368234815-dG/TT.

180 Expression of the wild-type or edited allele of AMD1 but not un-editable allele rescued the de

181 SOD1(G37R) mice expressing a conditional allele of an ALS-linked SOD1 mutation were crossed with

182 The epsilon4 allele of apolipoprotein E (apoE) gene is the strongest

183 The previously characterized L407F mutant allele of Arabidopsis cry1 is biologically hyperactive a

184 method can be used to silence the endogenous allele of ataxin 7 and replace it with an exogenous copy

185 Conversely, inducible deletion of one allele of Dkk1 in Osx-expressing cells in adult mice inh

186 auses embryonic lethality, and that a single allele of either CRTC2 or CRTC3 is sufficient for viabil

187 b10-sgb13) identified, sgb11 is a new mutant allele of ESKIMO1 (ESK1), which encodes a plant-specific

188 abidopsis mutant line harbouring a different allele of gene GRIK1 (grik1-2 grik2-1) that grows simila

189 A progerin allele of lamin-A is regulated in the same manner in iPS

190 Furthermore, mice heterozygous for a null allele of Nrip1 showed a CAKUT-spectrum phenotype.

191 We further demonstrate that loss of one allele of PTEN is sufficient to shift isoform dependency

192 The minor allele of rs1057233 (G), within the previously reported

193 The A allele of rs12669187 was significantly correlated with i

194 Furthermore, we show that the minor allele of rs322931 predicts expression of microRNAs miR-

195 efficiently after inactivation of the sec7-1 allele of Sec7, which controls transit through the Golgi

196 The low activity allele of the maternal polymorphism, 5HTTLPR, in the ser

197 n and 45 control) carried at least one short allele of the serotonin transporter gene.

198 The G allele of the TCN2 c.776G>C (rs1801198) polymorphism has

199 We also found that loss of one allele of TSC2 in human fibroblasts is sufficient to inc

200 In contrast, expression of the wildtype allele of wag31 in APYS1-resistant M. tuberculosis was d

201 ras allele (Kras(mut) ) and conditional null alleles of Apc and Trp53 (iKAP).

202 pes resulting from specific, patient-derived alleles of candidate disease genes.

203 d to 86% when individuals carried one or two alleles of epsilon4, and to 72% sensitivity and 77% spec

204 ein overexpressing model harboring wild-type alleles of GBA, A53T-SNCA mouse model) were exposed to a

205 erved genes suggesting selection of specific alleles of genes responsible for biological processes co

206 By repairing the deletion, we resurrected 11 alleles of KIR2DP1(F) , the functional antecedent of KIR

207 s failed to identify any large-effect coding alleles of lower frequency influencing the risk of diabe

208 ldren, antibodies to different AMA1 and MSP2 alleles of merozoites, IE surface antigens, and antibody

209 The G alleles of rs4293393 was associated with higher serum CO

210 the transcription start site of ARID5B, that alleles of rs7090445 have differential enhancer activity

211 Here we show that alleles of the 2La inversion are associated with natural

212 tations that were represented in >20% of the alleles of the tumor biopsy with >90% sensitivity and ap

213 We studied the effects of the HttQ111 allele on the C57BL/6J, CD-1, FVB/NCr1, and 129S2/SvPasC

214 nt strategy has been to reawaken the healthy allele on the inactive X (Xi).

215 trate the overall enrichment of disease risk alleles on gene regulatory regions, they are not designe

216 HI) cells had uniformly recombined both Tcrb alleles (one predicting a functional and the other predi

217 ation was limited to children with 2 FLG LOF alleles or TSLPrs1898671 homozygotes, with no significan

218 onfidence interval, 0.32-0.54] kg/m(2) per A-allele, P<0.001; BMI gene score: 1.05 [95% confidence in

219 F (FTO, hazard ratio, 1.07 [1.02-1.11] per A-allele, P=0.004; BMI gene score, hazard ratio, 1.11 [1.0

220 n several existing methods when there is one allele per species, although STELLS2 is slower than thes

221 cells expressing Jun, at least two of three alleles per cell were induced, a sign of high expression

222 rast, the PKC pancreata bearing a Grp78(f/+) allele (PKC78(f/+) mice) expressing about 50% of GRP78 m

223 ts on both alleles, with only one of the two alleles predicting a functional TCRbeta protein.

224 We document significant allele-preferential expression of functional variants in

225 , and we show that a pair of highly diverged alleles preferentially form homo-multimers.

226 copies (homeologs, paralogs, and segregating alleles) present in each of three sets of 50 mostly poly

227 is tool uses a model-based method to compare allele read fractions at known single-nucleotide polymor

228 We found a high number of new alleles, representing increased nucleotide diversity, on

229 or edited allele of AMD1 but not un-editable allele rescued the defects of amd1 in ascospore discharg

230 Patients homozygous for the G allele responded significantly better to the selective s

231 d in IO IBD patients with two mutated ANKZF1 alleles result in dysfunctional ANKZF1, as shown by an i

232 ssays with constructs containing splice site alleles revealed errors in splicing.

233 d analysis of lines carrying rock2 and rock3 alleles revealed how plants respond to locally enhanced

234 ice with catalytic inactivation of one SHIP2 allele selectively in ECs (ECSHIP2(Delta/+)).

235 ediated replacement of WT KRAS with a mutant allele sensitized heterozygous mutant HCT116 cells to tr

236 These two alleles share three mutations with the large-library all

237 g empirical estimates of identity-by-descent allele sharing may be useful for studies of complex trai

238 tory elements in diploid organisms may cause allele specific expression (ASE) - unequal expression of

239 ere, we propose SCALE to analyze genome-wide allele-specific bursting, with adjustment of technical v

240 IA-PET2 can use phased genotype data to call allele-specific chromatin interactions.

241 a mouse model with nonrandom XCI to examine allele-specific DNA methylation in frontal cortex.

242 f expression quantitative trait loci, and by allele-specific enhancer loops in patient-derived primar

243 le Bayesian statistical approach to quantify allele-specific expression (ASE) in complex RNA-seq data

244 pression quantitative trait loci (eQTLs) and allele-specific expression (ASE).

245 ng a causal variant and causal mechanism for allele-specific expression and disease association at th

246 esults show that gene isoform expression and allele-specific expression cooperate to provide high div

247 Allele-specific expression is traditionally studied by b

248 ulation of transcription, isoform usage, and allele-specific expression.

249 Placentas retained monoallelic allele-specific gene expression of IGF2, but 32.4% of co

250 Studies have linked allele-specific genetic changes to gene expression, DNA

251 rt the identification of 337 high-stringency allele-specific H3K4me3 and H3K36me3 peaks in maize endo

252 igh differentiation-induced variability, our allele-specific method detected thousands of quantitativ

253 the capabilities of the method by inferring allele-specific methylation and nucleosome occupancy in

254 emergence of real-time PCR assays utilizing allele-specific molecular detection technology that is h

255 and quantified by 4-color flow cytometry or allele-specific oligonucleotide real-time quantitative p

256 otyping pipeline utilizing KASP (Kompetitive Allele-Specific PCR) genotyping technology to create sca

257 In this study, BRAF(V600E) allele-specific polymerase chain reaction was used to ma

258 98 using HepG2 cell line demonstrated strong allele-specific promoter and enhancer activity and diffe

259 Using in vivo single-cell approaches (allele-specific RNAseq, nascent RNA-fluorescent in situ

260 By evaluating allele-specific transcript abundance in the F1 hybrids,

261 recessive and functionally null I/LnJ H2-Ob allele supported the production of virus-neutralizing an

262 Consistent with bottlenecks and allele surfing during northward expansion, we document a

263 such requirements, we used a V(D)J passenger allele system to assay, in mouse GC B cells, sequence-in

264 A common variant (rs1619661; coded allele: T) significantly modified the QT-PM10 associatio

265 nables parallel, independent manipulation of alleles targeted by Cas9 and traditional recombinase wit

266 elanoma incorporating a fluorescent reporter allele (tdTomatoLSL).

267 -11 isolates were positive for the five gene alleles tested by PCR; however, 5 to 36% of field isolat

268 s were also positive for at least one of the alleles tested.

269 at c.254-649T > G CLRN1 represents a founder allele that may significantly contribute to deafblindnes

270 uited for studies on the clinical effects of alleles that are rare in general populations but occur a

271 eated Lym1K, a collection of immune receptor alleles that combines known, well-supported alleles with

272 Alleles that confer multiple disease resistance (MDR) ar

273 within and across independent loci, T2D risk alleles that overlap with RFX footprints uniformly disru

274 f promoters generates diverse cis-regulatory alleles that provide beneficial quantitative variation f

275 nsight into spanin function, pseudorevertant alleles that restored plaque formation for lysis-defecti

276 erotype-matched invasive strain, the carrier allele (the gene encoding the LiaS protein with an argin

277 create expression variation of homoeologous alleles through protein-protein and protein-DNA interact

278 allele causes later flowering than the wild allele under short day and exhibits a signature of selec

279 of the proximal versus distal PAS, with some alleles using only the proximal PAS, and others using bo

280 ription assays demonstrated that the minor T allele variation at rs604723 increased the activity of t

281 Specific HLA-A alleles varied in the usage of the proximal versus dista

282 The effect size of one risk allele was 1.4 +/- 0.3 vs. 2.2 +/- 0.44 kg/m(2) in perso

283 The rs10995 G-allele was associated with better BP response to hydroch

284 Wag31 target demonstrated that the wild-type allele was dominant and showed no synergy with the inhib

285 The risk allele was found to have decreased IRF3 binding and incr

286 7B(K832R) Alzheimer's disease susceptibility allele was found, for the first time, to be a loss of fu

287 s with 0, 1, or 2 FLG loss of function (LOF) alleles was compared as well as those that were wildtype

288 These divergent alleles were differentially expressed across environment

289 Patients with 2 FLG LOF alleles were less likely to report skin clearance (odds

290 -DR molecules encoded by shared-epitope (SE) alleles were predicted to bind these self- and microbial

291 s-infected PHHs from individuals with the dG allele, where it was poorly secreted but highly function

292 e 3' untranslated region (UTR) of the mutant allele, which disrupts the most distal of two polyadenyl

293 e patients were found to possess an expanded allele, which was associated with a reduction in the qua

294 share three mutations with the large-library alleles, which are known from previous work, but also ha

295 ample, some hypertension and type 2 diabetes alleles will be associated with BMI in sample sizes of >

296 ntial to rapidly replace a harmful wild-type allele with a gene drive allele engineered to have desir

297 evated in carriers of the GABRA6 rs3219151 T allele with several independent markers and predictors o

298 alleles that combines known, well-supported alleles with novel alleles found in the 1000 Genomes Pro

299 ind that the Tianyuan individual shares more alleles with some Native American groups in South Americ

300 recombined the V to the DJ segments on both alleles, with only one of the two alleles predicting a f

301 t, under realistic scenarios, common disease alleles would become associated at P < 5 x 10- 8 with di