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1 and the cessation of TCRbeta rearrangements (allelic exclusion).
2 es VH-DJH rearrangement at the other allele (allelic exclusion).
3 egments (spatial segregation-based model for allelic exclusion).
4 ells, where Trbv recombination is squelched (allelic exclusion).
5 unrearranged Trbvs, which may contribute to allelic exclusion.
6 eripheral IgH rearrangements occurred beyond allelic exclusion.
7 en receptor, a restriction contributed to by allelic exclusion.
8 to suppress aberrant V beta cleavages during allelic exclusion.
9 th a unique specificity via a process termed allelic exclusion.
10 This phenomenon is referred to as allelic exclusion.
11 ttranslational regulation of the alpha-chain allelic exclusion.
12 ombination, a phenomenon also referred to as allelic exclusion.
13 ansgenic model of immunoglobulin heavy-chain allelic exclusion.
14 d TCR up-regulation leads to this phenotypic allelic exclusion.
15 ogous chromosomes is critical for Ig and TCR allelic exclusion.
16 -region genes is regulated in the context of allelic exclusion.
17 l expansion, RAG downregulation, and TCRbeta allelic exclusion.
18 s that had normal immunoglobulin heavy-chain allelic exclusion.
19 nous TCR chains is then less likely owing to allelic exclusion.
20 ry elements are required for mediating Vbeta allelic exclusion.
21 d at a different frequency and is subject to allelic exclusion.
22 -to-Jkappa rearrangements to enforce Igkappa allelic exclusion.
23 ve selection, was shown to lead to effective allelic exclusion.
24 eceptor gene rearrangement in lymphocytes on allelic exclusion.
25 However, the same Raf signal did not mediate allelic exclusion.
26 ive selection, is shown to lead to effective allelic exclusion.
27 hain or TCRbeta chain loci, thereby ensuring allelic exclusion.
28 gh protective activity escape TCR-beta chain allelic exclusion.
29 three hypersensitive sites in the control of allelic exclusion.
30 e alternate allele, a process referred to as allelic exclusion.
31 ion, are involved in the control of TCR-beta allelic exclusion.
32 regions genes is regulated in the context of allelic exclusion.
33 ible locus associated with the occurrence of allelic exclusion.
34 ll cycle is not essential for enforcement of allelic exclusion.
35 er Igkappa rearrangements to control Igkappa allelic exclusion.
36 Zealand White F1 mice exhibit nearly perfect allelic exclusion.
37 lineage specific, ordered rearrangement and allelic exclusion.
38 ient for the establishment or maintenance of allelic exclusion.
39 ng, drives a "winner-takes-all" mechanism of allelic exclusion.
40 tent to which Ig and TCR loci are subject to allelic exclusion.
41 sly normal thymocyte development and TCRbeta allelic exclusion.
42 ombination events and the phenomenon of Tcrb allelic exclusion.
43 receptor loci is thought to be important for allelic exclusion.
44 Such interactions may be essential for Tcrb allelic exclusion.
45 lted in fewer such interactions and impaired allelic exclusion.
46 hromatin to the initiation or maintenance of allelic exclusion.
47 eta14 accessibility per se is not subject to allelic exclusion.
48 asis for T cell antigen receptor-beta (Tcrb) allelic exclusion.
49 arising B cells and a second checkpoint for allelic exclusion.
50 tulated to provide an instructive signal for allelic exclusion.
51 ore V-DJ recombination, a process subject to allelic exclusion.
52 recombination, is not sufficient to instruct allelic exclusion.
53 romatin correlates with the establishment of allelic exclusion.
54 ; this process has been proposed to underlie allelic exclusion.
55 of IL-7R/STAT5 signaling is not required for allelic exclusion.
56 ificity, intra- and interlocus ordering, and allelic exclusion.
57 ion of IL-7R signaling should interfere with allelic exclusion.
58 alterations in chromatin are a key factor in allelic exclusion.
59 e allele is critical to the establishment of allelic exclusion, a key question is whether or not germ
60 fects in mechanisms that control Ag receptor allelic exclusion and a reappraisal of the physiologic r
61 g rescuing cells from programmed cell death, allelic exclusion and alphabeta versus gammadelta T-cell
62 (pre-TCR) regulates survival, proliferation, allelic exclusion and differentiation of thymocytes.
63 mature thymocytes (TCRhigh) show phenotypic allelic exclusion and express only a single alpha-chain.
65 ry cooperate to help enforce IgH and TCRbeta allelic exclusion and indicate that control of V-to-DJ r
67 he ability of these domains to signal B cell allelic exclusion and maturation in transgenic mice.
68 ion are part of the mechanism of kappa locus allelic exclusion and may be a general mechanism contrib
69 o samples lacking immunoglobulin heavy-chain allelic exclusion and most likely reflect genetic polymo
70 s VbetaDJbetaCbeta genes can enforce TCRbeta allelic exclusion and reveal another mechanism that cont
71 imeric IgM/G receptors triggered heavy chain allelic exclusion and supported development of mature CD
72 MDC1 is required for ATM to enforce Igkappa allelic exclusion and suppress Igkappa rearrangements.
74 onsible for the developmental transition and allelic exclusion and thus allows for separate examinati
76 We demonstrate that ATM enforces Igkappa allelic exclusion, and that RAG DSBs induced during Igka
77 Mammalian X inactivation, imprinting, and allelic exclusion are classic examples of monoallelic ge
78 iferation and survival, differentiation, and allelic exclusion are differently sensitive to subtle mu
80 We now provide evidence that the breach in allelic exclusion associated with Emu deletion results f
81 hromatin is diminished as thymocytes undergo allelic exclusion at the CD4(-)CD8(-) (double-negative)
83 cus-specific recombinase activity results in allelic exclusion at the immunoglobulin heavy chain locu
88 investigate the role of the pTalpha chain in allelic exclusion at the TCRbeta locus, a functionally r
93 the surrogate L chain complex that promotes allelic exclusion but not other aspects of pre-B cell de
94 ole for TCR signaling in causing alpha-chain allelic exclusion, but differential ubiquitination by c-
95 Ag receptor loci are regulated to promote allelic exclusion, but the mechanisms are not well under
96 ounterparts and appeared to be responsive to allelic exclusion, but were differentially sensitive to
97 development may be important for permitting allelic exclusion by ordering rearrangement of the two a
98 n signal through the TCR leads to phenotypic allelic exclusion by specifically maintaining cell surfa
101 mice was not preferential for cells escaping allelic exclusion by the TCR transgene, but was suppress
103 a TCRbeta transgene, suggesting that TCRbeta allelic exclusion can also be achieved by blocking the t
104 e inserted Vbeta segment was no longer under allelic exclusion control as it recombined at a similar
105 oallelic recruitment during establishment of allelic exclusion correlates with transcriptional silenc
107 on and that in CD4+ CD8+ thymocytes TCR beta allelic exclusion does not result from inaccessibility o
108 CR mediates signals resulting in heavy chain allelic exclusion, down-regulation of the recombination
114 ition and impairs immunoglobulin heavy chain allelic exclusion, hallmarks of defective pre-BCR signal
118 ly the four most proximal V(H) genes escaped allelic exclusion in immature mu-transgenic B lymphocyte
123 To elucidate mechanisms that enforce TCRbeta allelic exclusion in such cells, we analyzed Vbeta expre
125 of autoreactive T-cells in NOD mice through allelic exclusion induced by transgenic expression of an
126 BCR, which are thought to be responsible for allelic exclusion, induced L chain gene rearrangement, a
139 Here, we describe a system in which TCRbeta allelic exclusion is overcome as a result of V(D)J recom
140 ide evidence to support the proposition that allelic exclusion is the consequence of terminating sign
143 rearrangements on both H chain alleles, yet allelic exclusion is tightly maintained in mature 56R B
144 ntigen can induce receptor editing, in which allelic exclusion is transiently prevented or reversed t
148 Although the promoter is dispensable for allelic exclusion, it appears to suppress aberrant V bet
149 continue, which raises the question: how is allelic exclusion maintained, if at all, in the face of
151 with DbetaJbeta targets in DP cells revises allelic exclusion models from their current conformation
154 ergoing rearrangement, thereby bypassing the allelic exclusion normally associated with expression of
156 indicate the likely functional importance of allelic exclusion of genes disrupted by chromosomal tran
162 is also required for feedback regulation and allelic exclusion of proximal V(H)-to-DJ(H) recombinatio
163 We have previously shown that phenotypic allelic exclusion of TCR alpha-chain is functional only
166 nd humans express two TCRs due to incomplete allelic exclusion of TCRalpha, and we hypothesized they
171 model in which the developmentally regulated allelic exclusion of the TCR alpha-chain is caused by co
172 d by accelerated cellular proliferation upon allelic exclusion of the unrearranged copy of that gene.
177 e effects of both the JJAZ1/SUZ12 fusion and allelic exclusion on functions related to cell growth, w
178 ating that an additional level of control of allelic exclusion operates during the maturation of peri
180 In addition, the evolution often follows an allelic exclusion pattern, where only 1 of 2 rearranged
181 These cells are not the result of failure in allelic exclusion per se, but arise through receptor edi
182 erentiation, in which it plays a key role in allelic exclusion, positive selection, receptor editing,
183 transgenic T cells produced in vivo undergo allelic exclusion, preventing co-expression of an endoge
192 We previously described a checkpoint for allelic exclusion that occurs at the pre-B cell to immat
193 mature B cell transition strongly influences allelic exclusion, the breadth of the mature BCR reperto
194 Since the identification of Ag receptor allelic exclusion, the importance of this process and th
195 ed gene rearrangement is thought to underlie allelic exclusion, the observation that an individual B
202 omatin control of TCR beta rearrangement and allelic exclusion, we analyzed TCR beta chromatin struct
203 e putative chromatin changes associated with allelic exclusion, we assayed for DNase I hypersensitivi
204 promote DP differentiation in the absence of allelic exclusion, we characterized the properties of Vb
205 n regulating variable gene rearrangement and allelic exclusion, we constructed mutant mice in which a
206 e effects of constitutively active STAT5b on allelic exclusion, we crossed STAT5b-CA mice (which expr
207 -beta (CD79b) is required for immunoglobulin allelic exclusion, we examined the CD79b expressed by fo
208 n vivo, as well as in B cell development and allelic exclusion, we have created transgenic mice in wh
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