ライフサイエンスコーパス: allene

1 e reaction proceeds via acetoxylation of the allene.

2 xemplified by the reaction with an activated allene.

3 tion of the indole unit by reaction with the allene.

4 which an enamine forms between Pro-1 and the allene.

5 e that performs an alkyne walk to afford the allene.

6 ctive addition can be achieved from the same allene.

7 -cyclohexadiene, a rarely exploited strained allene.

8 l level of chirality transfer from a pendant allene.

9 ifferent from previously reported 1,3-DCs of allenes.

10 s to pi-allyls in the absence of intervening allenes.

11 inal alkynes provides di- and trisubstituted allenes.

12 ieved by intramolecular hydroalkoxylation of allenes.

13 es add to alkynyl imines to form 1,3-alkenyl allenes.

14 during the functionalization of alkynes and allenes.

15 hat are difficult to access via nonsilylated allenes.

16 the bonding situation and vast reactivity of allenes.

17 al methods to the wide and rich chemistry of allenes.

18 ghtened reactivity with thioester-containing allenes.

19 nspired in the chemistry developed in simple allenes.

20 derived from enol triflates to access chiral allenes.

21 hydride donor for the synthesis of terminal allenes.

22 l information was observed for disubstituted allenes.

23 ides, showcasing the first halo-arylation of allenes.

24 r CdI2 for the synthesis of 1,3-disubstitued allenes.

25 ynthesis of di-, tri-, and tetra-substituted allenes.

26 of propargylic sulfides to give substituted allenes.

27 Treatment of readily available allene 1 with Cy2BH followed by addition of an aldehyde

28 do-1,3-oxazoles to produce 1,1-disubstituted allenes (11).

29 zyme processes other substrates including an allene (2,3-butadienoate) to produce acetoacetate.

30 ntramolecular cyclization of the heteroenyne-allene, 2-((phenylimino)methyleneamino)-benzonitrile (1)

31 dem gold-catalyzed furan formation and furan-allene [4+3] cycloaddition to build the 5,7-fused ring s

32 The substitution pattern of the allene affected the transfer of chiral information.

33 More sterically encumbered allenes afford higher cycloadduct yields, and such effec

34 method is fairly general for a wide range of allenes affording the respective indolo[2,3-c]pyrane-1-o

35 ic mechanism involving ruthenium(0)-mediated allene-aldehyde oxidative coupling to form a transient o

36 putations suggests that the initially formed allene-aldehyde product assists in the transformation of

37 he conversion of propargyl vinyl ethers into allene aldehydes, proceeds under homogeneous conditions

38 The latter allenes also gave 4-methylenepyrrolidines on reacting wi

39 Although simple allene and acetylene have similar reaction barriers, int

40 r merging an N-H ketimine, a monosubstituted allene and B2(pin)2, affording products in up to 95% yie

41 based organic chiral magnetic molecules with allene and cumulene couplers have been theoretically des

42 s type intramolecular reaction leading to an allene and that Au also rapidly promoted a second intram

43 opargylic esters offers versatile entries to allene and vinyl carbene intermediates for various fasci

44 ctivated by gold(i), in an order of alkynes, allenes and alkenes.

45 intermolecular (4 + 2) cycloaddition between allenes and dienes is reported.

46 stereoselectivity in the (3+2) annulation of allenes and enones catalyzed by an amino acid derived ph

47 atalyze the CC coupling of 1,1-disubstituted allenes and fluorinated alcohols to form homoallylic alc

48 ivatives, such as dienynes, enediynes, enyne-allenes and hetero-analogues.

49 ith various 1,1-di- and 1,1,3-trisubstituted allenes and N-hydroxyaniline derivatives.

50 l [4 + 2]-cycloadditions between substituted allenes and N-hydroxyanilines are described.

51 oquinolines are synthesized in one step from allenes and phenylethylamines or benzylamines, respectiv

52 enhanced scope (the use of gamma-substituted allenes), and good ee.

53 complexes containing alkene, alkyne, diene, allene, and enol ether ligands have been documented.

54 colaldehyde imine to afford allylic hydroxyl allenes, and allyl boronates add to alkynyl imines to fo

55 re, couples readily available simple imines, allenes, and diboranes, and yields high-value homoallyli

56 cularly fragmentations that give alkynes and allenes, and such reactions have been applied to a range

57 nt- and oxidant-dependent transformations of allenes are described.

58 Allenes are important 2pi building blocks in organic syn

59 Cascade reactions involving nitrones and allenes are known to facilitate the rapid synthesis of s

60 droazidation and hydroamination reactions of allenes are presented herein.

61 Allenes are useful functional groups in synthesis as a r

62 ent of new domino methodologies in which the allenes are valuable intermediates in route to a wide ra

63 Unsymmetrically substituted allenes are well tolerated with nickel catalysis and aff

64 ation of two new and rare examples of a bent allene as well as the isolation of the first carbene-car

65 C-C activation of cyclobutanones and employs allenes as a one-carbon unit.

66 metalation process enables the use of simple allenes as allylmetal nucleophile surrogates in imine al

67 only confronted the great challenge in using allenes as dipolarophiles of 1,3-DCs, but also provided

68 but also provided a unique strategy of using allenes as equivalents of alkynes to construct spiro[ind

69 es, which add to aldehydes to give the title allenes as single diastereomers (see scheme; Ts=4-toluen

70 search contents of 1,3-DCs, the chemistry of allenes as well as the synthetic methods of spirooxindol

71 catalytic [4+2] and [4+3] cycloadditions of allenes, as efficient and practical methodologies for as

72 A tandem allene aziridination/[4+3]/reduction sequence converts s

73 In contrast, with (1H-tetrazol-5-yl)-allenes bearing bulkier substituents at C-3, such as i-p

74 rearrangement of an enantiopure chiral enyne-allene (bearing one stereogenic center) selected as a mo

75 with beta addition of the phosphepine to the allene being the turnover-limiting step of the catalytic

76 Selected examples involving allenes, biaryls, arylamides and transient axially chira

77 copper-catalyzed three-component coupling of allenes, bis(pinacolato)diboron, and imines allows regio

78 allene formation (af) and rotamerization of allene-bound gold complex (ra) are found to be quite fac

79 dependencies reveal that the dynamics of the allene buildup are controlled by the structural changes,

80 hirality was obtained for all trisubstituted allenes, but loss of chiral information was observed for

81 gement followed by trapping of the resulting allenes by an adjacent pyrrole ring.

82 ation of propargylic alcohols into transient allenes by means of a strategic [2,3]-sigmatropic rearra

83 A one-pot synthesis of allenes by the 2-nitrobenzenesulfonylhydrazide-mediated

84 d for the synthesis of imidazole-substituted allenes by the reaction of 1,1,3-triphenylprop-2-yn-1-ol

85 ed (4+2) coupling between cyclobutanones and allenes, by C-C cleavage, is reported.

86 six-membered transition state of the Zn-ene-allene carbocyclization found by DFT calculations.

87 ective 5-exo aminocyclization to the central allene carbon followed by aromatization.

88 ddition of amino functionality to the distal allene carbon to yield enantiopure 2,5-dihydro-1H-pyrrol

89 p toward either the internal or the terminal allene carbon, respectively, being favored.

90 eteroatom bond at each of the three original allene carbons.

91 Allene carboxylates, scarcely used as Michael acceptors,

92 the carbodicarbene-type ligand "cyclic bent allene" (CBA) have been synthesized from the common prec

93 The allene character of the spacer implies an orthogonal ori

94 of chemical bonding renders 1,3-substituted allenes chiral, making them attractive targets for asymm

95 In the presence of NaBH4 and the allene, cis-CaaD is completely inactivated after one tur

96 Allenes constitute an important subclass among these.

97 k rearrangement and Zn-ene-allene (or Zn-yne-allene) cyclization reaction.

98 The unusual intramolecular arene/allene cycloaddition described 30 years ago by Himbert p

99 The fascinating intramolecular arene/allene cycloaddition discovered by Himbert affords dearo

100 ng-rearrangement metathesis of Himbert arene/allene cycloadducts to form fused polycylic lactams led

101 ted to steric interactions and the degree of allene deformation as significant factors in determining

102 udy of complex reaction mechanisms involving allene derivatives in organic and organometallic chemist

103 from cinchona alkaloids, provided nonracemic allene derivatives.

104 yclization/ring-opening route via a bicyclic allene described in previous reports.

105 chanism of the Diels-Alder reactions with an allene dienophile.

106 tuted allenes is associated with a competing allene dimerization that irreversibly sequesters rhodium

107 vel of theory support long-held beliefs that allene dimerization to 1,2-dimethylenecyclobutane procee

108 uents significantly increases the barrier of allene dimerization while the barrier of the (5 + 2) cyc

109 The connected continuous process of allene dissolution, lithiation, Li-Zn transmetallation,

110 red that methyl substituents on the terminal allene double bond counterintuitively change the reactiv

111 This leads to the greater reactivity of the allene double bond relative to the alkynyl group in alle

112 llene-ynes occur exclusively at the terminal allene double bond.

113 type hydride transfer to an in situ prepared allene enables the synthesis of ortho-fused 4-substitute

114 h enantioselectivity, allow access of either allene enantiomer, and are readily synthesized.

115 suggests that this reaction proceeds via an allene-enyne intermediate generated by an Alder-ene reac

116 the substituent of the alkyne moiety on the allene-enyne intermediate, the subsequent transformation

117 ts from the involvement of two regioisomeric allene-enyne intermediates.

118 eroxy-eicosatetraenoic acid (8R-HPETE) to an allene epoxide, a reaction activated by the ferric heme,

119 virtue of an in situ base-promoted alkyne to allene equilibration which takes place prior to the sily

120 scribes their use in various versions of the allene ether Nazarov cyclization.

121 izations of 4-allen-1-ols into one prochiral allene face.

122 nt and most importantly maintained excellent allene facial selectivities regardless of the substrate

123 In contrast, silylated allenes favor the formation of propargylic cation interm

124 rylation of the substituted pi-system of the allene followed by hydroboration of the remaining pi-com

125 ell as activation of an unsaturated aldehyde-allene for a [2 + 2] cycloaddition reaction.

126 and indicate the participation of mainly the allene form in the reaction.

127 atory steps of the catalytic process such as allene formation (af) and rotamerization of allene-bound

128 he regioselectivity results from a selective allene formation that is governed by allylic strain.

129 preparation of a trisubstituted iodoalkene, allene formation using the Myers-Movassaghi protocol, st

130 o directly synthesize enantioenriched chiral allenes from achiral precursors.

131 nantioselective methods to synthesize chiral allenes from chiral starting materials, fewer methods ex

132 e furan ring and addition of a proton to the allene function, leading to a conjugated and violet tert

133 ated substrates possessing olefin, alkyne or allene functions.

134 aldehydes, nucleophiles, and monosubstituted allenes furnishes functionalized non-C2-symmetric naphth

135 ompound in a free or bound state to the gold-allene (GA) complex, were investigated.

136 process for asymmetric propargylation using allene gas as a reagent is reported.

137 alpha-(1'-fluoro)vinyl trigger, a potential allene-generating functionality originally proposed by A

138 in which substituents on the termini of the allenes had rotated away from the vinyl moieties, and th

139 -unsaturated nitrones and electron-deficient allenes has been discovered that allows single-step acce

140 om the interaction of a Rh-carbenoid with an allene have been applied to the synthesis of substituted

141 is tutorial review highlights the value that allenes have as reagents in [2+2+2] cycloaddition and th

142 vergent hydrosilylation of 1,3-disubstituted allenes have been developed.

143 DCs) of isatin-derived azomethine ylide with allenes have been established, which efficiently assembl

144 (1H-Tetrazol-5-yl)-allenes have been prepared for the first time, and their

145 Regioselective methods for allene hydrosilylation have been developed, with regiose

146 tals that serve as chiral auxiliaries on the allene in highly enantioselective Nazarov cyclizations i

147 reaction proceeds rapidly, generating chiral allenes in 10-20 minutes with high enantioselectivity (8

148 ed to the corresponding trisubstitued chiral allenes in 71-89% yields with up to 99% ee upon reaction

149 this enigmatic reactivity and selectivity of allenes in [Rh(CO)2Cl]2-catalyzed intermolecular (5 + 2)

150 ounterintuitively change the reactivities of allenes in [Rh(CO)2Cl]2-catalyzed intermolecular (5 + 2)

151 y chiral biphenols to access enantioenriched allenes in a traceless Petasis reaction.

152 onent transformation is also compatible with allenes in place of alkynes to furnish tetrasubstituted

153 eported for the syn-insertion of alkynes and allenes in the Au-Si bonds of complexes (R3P)Au-SiR'Ph2

154 ldehydes were reacted with 1,3-disubstituted allenes in the presence of PPh2Et, naphthalene derivativ

155 ted to the corresponding disubstitued chiral allenes in up to 81% yield and 99% ee upon reaction with

156 preparation of eight-membered rings from bis(allenes) in the absence of metals have been achieved by

157 onal group adds to the central carbon of the allene, initiating a sequence of bond-forming reactions,

158 terest in the study of the reactivity of bis(allenes) inspired in the chemistry developed in simple a

159 Mechanistic studies suggest formation of an allene intermediate, which undergoes hydroamination to g

160 mposition at physiological pH, likely via an allene intermediate.

161 In general, reactions of nonsilylated allenes involve an allylic cation intermediate by formin

162 In this allene-involved 1,3-DC, an unexpected spirooxindole fram

163 selectivity observed experimentally with the allene is shown to result from the insertion of the term

164 tion-metal catalysed nucleophile addition to allenes is a very powerful tool for the synthesis of fun

165 ent hydroformylation of 1,1,3-trisubstituted allenes is accomplished with low loadings of a Rh cataly

166 The chemistry of allenes is an appealing topic which fascinates chemists

167 t low reactivity of terminally unsubstituted allenes is associated with a competing allene dimerizati

168 nickel-catalyzed [2+2] cycloaddition of ene-allenes is reported.

169 ative addition of beta-ketoacids to terminal allenes is reported.

170 ntermediates from nonsilylated and silylated allenes is strongly supported by DFT calculations.

171 l C(2)-C(6) (Schmittel) cyclization of enyne-allenes is studied computationally and experimentally ev

172 of examples of cyclization reactions of bis(allenes) is presented as well as the future perspectives

173 Two different coordination modes of the allene isomer of triphenylphosphoniumpropargylide to gol

174 The alkyne-allene isomerization involves not only a torsional motio

175 eal the occurrence of an efficient alkyne to allene isomerization of the spacer with a time constant

176 +2] annulation process was devised employing allene ketones as C2 synthons and beta,gamma-unsaturated

177 substrates could be extended to substituted allenes, leading to the development of the first catalyt

178 hemistry becomes conrotatory en route to the allene-LiBr complex.

179 its structural nature (propargyl-like versus allene-like geometry) were also characterized using theo

180 Pr), which features a mu-oxo ligand along an allene-like molecular core.

181 he Pd-catalysed formation of a C-O bond from allenes mainly occurs via the inter- or intramolecular r

182 allenyl-boron compound or a monosubstituted allene may be used.

183 rst catalytic asymmetric cyclopropanation of allene, mediated by the dirhodium catalyst Rh2 (S-TBPTTL

184 uents on the amine, the phosphonate, and the allene moieties.

185 at the allylic and terminal positions of the allene moiety has a crucial effect on the regioselectivi

186 roarylation across the central carbon of the allene moiety has not been detected.

187 e addition of a 1-trimethylsilyl-substituted allene moiety to phosphinoylimines is presented.

188 The product allene of the aryldiazoacetates undergoes rearrangement

189 of nonconjugated 2-azetidinone-tethered bis(allenes) on application of microwave irradiation.

190 pact of different substrates (alkynes versus allenes) on the reaction mechanism has been discussed in

191 erse transformations of alkenes, alkynes and allenes, opening new opportunities for chemical synthesi

192 whether cyclization reactions of conjugated allenes or ketenes follow a pericyclic or a pseudopericy

193 an allenyl-Zn-Brook rearrangement and Zn-ene-allene (or Zn-yne-allene) cyclization reaction.

194 njugate addition vs reaction with an alkyne, allene, or aldehyde).

195 highly chemo-, regio-, and stereocontrolled allene oxidation that can install a new carbon-heteroato

196 nnot form cyclopropanone 10b or the isomeric allene oxide 13b; instead, it is eventually trapped by w

197 n protein transforms arachidonic acid to the allene oxide 8R,9-epoxy-5,9,11,14-eicosatetraenoic acid

198 pentanone class of oxylipins is catalyzed by allene oxide cyclase (AOC) that forms cis(+)-12-oxo-phyt

199 c accumulation of the JA biosynthesis enzyme allene oxide cyclase (AOC), which correlates with elevat

200 is sustained by further increases in LOX and allene oxide cyclase mRNA and protein levels.

201 one, provide insights into the mechanisms of allene oxide cyclization, and define the double bond geo

202 lated the initial products and separated two allene oxide isomers by HPLC at -15 degrees C.

203 resses linoleate 9R-dioxygenase (9R-DOX) and allene oxide synthase (AOS) activities in membrane fract

204 of the plant defensive response pathway, the allene oxide synthase (AOS) and hydroperoxide lyase (HPL

205 Catalase-related allene oxide synthase (cAOS) from the coral Plexaura hom

206 ants altered in JA synthesis and perception, allene oxide synthase and coi1-16B (for coronatine insen

207 he coral Capnella imbricata, form a being an allene oxide synthase and form b giving uncharacterized

208 indicating differing gene regulation of the allene oxide synthase and the newly identified catalase-

209 ombined, promote stomatal closure of ABA and allene oxide synthase biosynthetic mutants, albeit most

210 ly alter oxylipin profiles, particularly the allene oxide synthase branch of the oxylipin pathway, re

211 tion of 9S-hydroperoxylinoleic acid with the allene oxide synthase CYP74C3, a reported reaction that

212 The coronative insensitive1 dgd1 and allene oxide synthase dgd1 double mutants no longer exhi

213 EG_02036 transformed 9R-HPODE to an unstable allene oxide, 9(R),10-epoxy-10,12(Z)-octadecadienoic aci

214 orted reaction that unexpectedly produces an allene oxide-derived cyclopentenone.

215 actions of the epoxy proton at C9 in the two allene oxides (and the equivalent NOE experiment in 12,1

216 One matched previously described allene oxides in its UV spectrum (lambdamax 236 nm) and

217 The transformation of vinyl allene oxides into cyclopentenones is key to the biosynt

218 The stereochemistry of the natural allene oxides is incompletely defined, as are the struct

219 the equivalent NOE experiment in 12,13-epoxy allene oxides) allowed assignment at the isomeric C10 ep

220 teins transform fatty acid hydroperoxides to allene oxides, highly reactive epoxides leading to cyclo

221 onfiguration in all previously characterized allene oxides.

222 double bond geometry in naturally occurring allene oxides.

223 esis and reactivity of methylene aziridines, allene oxides/spirodiepoxides, methylene silacyclopropan

224 tion of a Rh-allyl intermediate.Reduction of allenes poses several challenges in terms of chemo-, reg

225 cient regioselective hydrostannylation of an allene precursor, and the construction of the triene fra

226 A cascade cyanation/diborylation of terminal allenes proceeds efficiently with copper catalysis using

227 f paraformaldehyde with dienes, alkynes, and allenes provide access to products of hydrohydroxymethyl

228 be extended to the reaction of aldehydes and allenes, providing silyl-protected allylic alcohol deriv

229 yl-3-phenylaziridine, whereas with the other allenes, pyrroles were obtained as major products togeth

230 iridium catalyst modified by PhanePhos, CF3-allenes react with methanol to form branched products of

231 All the studied (1H-tetrazol-5-yl)-allenes reacted with N-benzyl-cis-3-phenylaziridine-2-ca

232 ne-catalyzed isomerization to trisubstituted allenes (see picture; NHC = N-heterocyclic carbene).

233 With terminally substituted allenes, steric repulsion between the terminal substitue

234 tivity of allenes, the subtle differences in allene structures are manifested in the formation of div

235 nsformation encompasses a broad range of ene-allene substrates, thus providing efficient access to fu

236 f an enyne-allene with two aryl rings at the allene terminus experimentally leads to three formal Die

237 e-allenes with an aryl group as probe at the allene terminus follow a dynamic non-IRC Diels-Alder cyc

238 lyzed [4 + 1] annulation of an amine with an allene that furnished an achiral dihydropyrrole in 22% y

239 m with 1-phenyl-1,2-dien-1-yl diazoacetate - allenes that are rapidly formed at room temperature thro

240 reaction of acetone addition to propyne and allene, the addition of acetone and acetophenone to meth

241 f the cis-CaaD-catalyzed reaction using this allene, the enzyme was unexpectedly inactivated in the p

242 are example of a Type I DyKAT reaction of an allene, the first example of DyKAT in a cyclocarbonylati

243 For the synthesis of 1,3-disubstituted allenes, the propyne derivatives containing either a all

244 ence of the substituent on the reactivity of allenes, the subtle differences in allene structures are

245 All-catalytic route to trisubstituted allenes: The first examples of catalytic enantioselectiv

246 e copper-boron addition to a monosubstituted allene; the resulting boron-substituted organocopper int

247 he formation of a palladacycle into which an allene then undergoes insertion.

248 affording the enantioselective reduction of allenes, thereby yielding access to motifs commonly used

249 hich undergo low-temperature ring opening to allenes; this is known as the Doering-Moore-Skattebol re

250 wn protocol to gain access to functionalized allenes through the [3,3]-sigmatropic transformation of

251 vely transferring the axial chirality of the allene to central chirality in the products.

252 d(I)-catalyzed cyclization of a beta-hydroxy allene to construct the dihydropyran ring.

253 catalysts enables the conversion of racemic allene to enantiopure cyclopentenone product in a dynami

254 ctive transfer of the axial chirality of the allene to point chirality in the stereotriad.

255 of a transfer of chiral information from an allene to the 5-position of a cyclopentenone using a cyc

256 r in cis-CaaD versus direct hydration of the allene to yield acetoacetate in the case of Cg10062.

257 ly diverted to the distal double bond of the allene to yield endocyclic bicyclic methyleneaziridines

258 sequence comprises initial isomerizations of allenes to butadienes under N2 and subsequent oxidations

259 alytic system that reduces a variety of aryl allenes to chiral benzylic compounds with excellent sele

260 catalyzed isomerization of alkyl-substituted allenes to conjugated dienes in the presence of a nitros

261 oarenes, isomerizations of alkyl-substituted allenes to dienes, and final nitroso/butadiene [4 + 2] c

262 n the equilibrium structure and chirality of allenes to recent advances in the study of complex react

263 This article reviews methods for converting allenes to strained, three-membered methylene heterocycl

264 l (Ag(+)) or exclusive (Fe(3+)) formation of allene-type rearrangement products.

265 were subsequently transformed to the desired allenes under CdI2 or ZnI2 catalysis.

266 c method for enantioselective addition of an allene unit to aldimines is disclosed.

267 catalytic method for the hydroalkylation of allenes using alkyl triflates as electrophiles and silan

268 of indole-2-caboxylic acid derivatives with allenes via direct C-H functionalization to afford the c

269 ates from N-heterocyclic phosphine (NHP) and allenes via phospha-Michael/intramolecular nucleophilic

270 resence of triethylamine afforded the target allenes via Wittig reaction of the in situ generated pho

271 roducts are obtained in up to 91% yield, 98% allene (vs propargyl) selectivity, and 98:2 enantiomeric

272 regioselective 1:2 coupling of aldehydes and allenes was investigated by means of density functional

273 Tetrasubstituted allenes were achieved with up to 42:1 diastereomeric rat

274 he respective terminal and 1,3-disubstituted allenes were studied.

275 hanisms of gold-catalysed transformations of allenes which are based on computational studies, labell

276 first cyclization leading to a stereodefined allene, which could then be cyclized to the correspondin

277 ructure confirmed the stereochemistry of the allene, which is bent significantly from linearity (164

278 on of allyl oxides to phosphorus-substituted allenes, which are obtained in one step from simple star

279 (4+1) cyclization between cyclobutanones and allenes, which provides a distinct [4.2.1]-bicyclic skel

280 s initiated by oxidative coupling of the two allenes, which was found to be the rate-determining step

281 alytic asymmetric ketone-involved 1,3-DCs of allenes, which will also greatly enrich the research con

282 to investigate the (4 + 2) cycloadditions of allene with butadiene and with benzene.

283 (2)-C(6) (Schmittel) cyclization of an enyne-allene with two aryl rings at the allene terminus experi

284 he Pd-catalyzed regioselective annulation of allenes with 3-iodo-1-alkylindole-2-carboxylic acids is

285 alyzed regioselective alkoxycarbonylation of allenes with aliphatic alcohols allows to produce synthe

286 catalyzed intermolecular [3+2] annulation of allenes with alkenes; however, there have not been corre

287 ional (DFT) investigations reveal that enyne-allenes with an aryl group as probe at the allene termin

288 A library of tetrasubstituted allenes with broad functionalities have been prepared wi

289 ed cyclopropanation of alkenes, alkynes, and allenes with diacceptor diazo compounds is reported.

290 ates reductive coupling of 1,1-disubstituted allenes with formaldimines with complete branch-regiosel

291 cent examples of electrophilic activation of allenes with particular focus on analogies and differenc

292 opargylamines, which in turn give the chiral allenes with very high enantioselectivity via an intramo

293 e observation that racemic 1,3-disubstituted allenes, with access to an orthogonal transition state w

294 ups, can be transformed to the corresponding allenes without loss of enantiopurity.

295 amolecular para cycloaddition of arenes with allenes, yielding attractive rigid scaffolds bearing sev

296 insertion of the internal double bond of an allene-yne has a higher barrier as it would break pi con

297 rs, intermolecular (5 + 2) cycloadditions of allene-ynes occur exclusively at the terminal allene dou

298 has been achieved by treating benzene-linked allene-ynes with aryldiazonium tetrafluoroborates and DA

299 moselectivity in (5 + 2) cycloadditions with allene-ynes.

300 double bond relative to the alkynyl group in allene-ynes.