ライフサイエンスコーパス: allorecognition

1 may engage both direct and indirect antigen allorecognition.

2 to both the direct and indirect pathways of allorecognition.

3 hyporesponsiveness in the direct pathway of allorecognition.

4 + direct allorecognition or by CD4+ indirect allorecognition.

5 e if autoreactivity was induced after direct allorecognition.

6 phocyte (CTL) precursors' priming via direct allorecognition.

7 d peptide-MHC complex in peptide-independent allorecognition.

8 pendent on CD4(+) T-cell help after indirect allorecognition.

9 ymphocytes primed by the indirect pathway of allorecognition.

10 t MHC-bound peptides play a critical role in allorecognition.

11 for the direct and the indirect pathways of allorecognition.

12 has important implications for understanding allorecognition.

13 molecules, i.e., via the indirect pathway of allorecognition.

14 ements are involved in the direct pathway of allorecognition.

15 for the exquisite specificity of Hydractinia allorecognition.

16 lish a platform for advancing the science of allorecognition.

17 ith the MHC, in directing the specificity of allorecognition.

18 propose a third, semidirect, pathway of MHC allorecognition.

19 fication, cell adhesion, innate immunity and allorecognition.

20 a model system for the study of invertebrate allorecognition.

21 ation on the direct and indirect pathways of allorecognition.

22 MHC mismatch through the indirect pathway of allorecognition.

23 raft survival by avoiding the aforementioned allorecognition.

24 ely propagated through the direct pathway of allorecognition.

25 ably an intact role of the direct pathway of allorecognition.

26 donor CD4 T cells by the indirect pathway of allorecognition, a phenomenon that requires DC-derived,

27 block T-cell responses generated by indirect allorecognition after lung transplantation may provide a

28 g evidence of a direct link between indirect allorecognition and acquired thymic tolerance.

29 As both indirect allorecognition and autoantigen recognition are self-res

30 reign peptides through the direct pathway of allorecognition and can additionally recognize allopepti

31 These results definitively link indirect allorecognition and cardiac allograft vasculopathy.

32 or class II antigens were used to study the allorecognition and effector pathways of islet allograft

33 Further understanding of innate allorecognition and its consequences would provide essen

34 othelium can act as an APC for CD8(+) direct allorecognition and may, therefore, play an important ro

35 make them specific for the direct pathway of allorecognition and more sensitive in the case of the HT

36 elineate the cellular mechanisms of indirect allorecognition and provide a potential strategy to stud

37 The concurrence of allorecognition and recurrence of autoimmunity might exp

38 esent a new clinically relevant mechanism of allorecognition and should be taken into consideration w

39 leukocyte removal during EVLP reduces direct allorecognition and T cell priming, diminishing recipien

40 ggest that CAV is dependent on CD4+ indirect allorecognition and that CD8+ direct allorecognition sti

41 finitive evidence of a link between indirect allorecognition and the development and progression of c

42 tigen to T cells via the indirect pathway of allorecognition and the generation of donor specific all

43 New insights into the mechanisms of allorecognition and the interactions of the TCR with the

44 ype APCs with those of recipient-type alters allorecognition and the pathogenesis of both acute and c

45 Understanding the events leading to allorecognition and the subsequent effector pathways eng

46 not play an important role in CD4(+) direct allorecognition and thus does not contribute to the vigo

47 n of chronic rejection, implicating indirect allorecognition as the predominant immunological driving

48 tory cytokine IL-17 enhances cytotoxicity in allorecognition assays.

49 We here evaded natural allorecognition barriers by generating well mixed embryo

50 studies have uncovered a mechanism of innate allorecognition based on detection of the polymorphic mo

51 a conformational epitope for direct-pathway allorecognition, because B6 DCs isolated from cocultures

52 Finally, it has been suggested that indirect allorecognition by CD4+ T cells mediate graft rejection

53 fully allogeneic grafts (direct and indirect allorecognition by CD4+ T cells) compared to MHC-class I

54 histocompatibility Ag, with implications in allorecognition by cytolytic T cells in solid organ and

55 iously described how graft-versus-host (GVH) allorecognition by passenger CD4 T cells within MHC clas

56 t lacks bone marrow-derived dendritic cells, allorecognition by recipient T cells must occur by way o

57 ses of anti-PBMC T cell clones but inhibited allorecognition by T cell clones raised against DR+Ii-DM

58 dicate that specific suppression of indirect allorecognition can be achieved by using structural vari

59 These studies show that indirect allorecognition can cause strain-dependent chronic rejec

60 To further define the role of indirect allorecognition, cardiac allografts from HLA-A2-transgen

61 d to the same chromosomal region, called the allorecognition complex (ARC).

62 The allorecognition complex of Hydractinia symbiolongicarpus

63 6) with recombination breakpoints within the allorecognition complex.

64 indings, which suggested peptide-independent allorecognition, CTL-mediated cytolysis was reduced or a

65 appears that the secreted form may be major allorecognition determinant.

66 ul assay to study the occurrence of indirect allorecognition during chronic rejection in humans.

67 of the NKR machinery, potentially promoting allorecognition either through T cell receptor (TCR) cro

68 ografts are acutely rejected via CD8+ direct allorecognition even if the alloantigen is not presented

69 ution of the direct and indirect pathways of allorecognition following tissue transplantation is esse

70 ife history that links several components of allorecognition from disparate fields that are experimen

71 We positionally cloned an allorecognition gene by using inbred strains of the cnid

72 ies share some, but not all, loci within the allorecognition gene complex (ARC).

73 ontrolled by at least two highly polymorphic allorecognition genes, Alr1 and Alr2 [3, 5, 9-12].

74 Indirect allorecognition has been implicated in the initiation of

75 Genetic models for the study of allorecognition have been developed in the jawed vertebr

76 After decades of study, genes controlling allorecognition have been identified in two model system

77 hat only CD4+ T cells activated via indirect allorecognition have the ability to reject allogeneic co

78 To examine the role of indirect allorecognition in a clinically relevant large animal mo

79 involvement of nTregs in the two pathways of allorecognition in a murine adoptive transfer model in w

80 To address the question of indirect allorecognition in acquired thymic tolerance, we examine

81 ally been considered the dominant pathway of allorecognition in acute transplant rejection.

82 estigate the role and mechanisms of indirect allorecognition in allograft rejection, we studied wheth

83 a biologically significant role of indirect allorecognition in allograft rejection.

84 eview examines adaptive immune responses and allorecognition in animals with very different immune re

85 These findings suggest that allorecognition in Botryllus consists of independent pat

86 Previous studies have demonstrated that allorecognition in Botryllus is principally controlled b

87 nd discusses some of the puzzling aspects of allorecognition in Botryllus that might contribute to un

88 Despite the ubiquity of allorecognition in colonial phyla, however, its molecula

89 results show that the molecules that mediate allorecognition in D. discoideum also control the integr

90 refute the potential importance of indirect allorecognition in graft rejection.

91 Allorecognition in Hydractinia, a cnidarian, is governed

92 The role of allorecognition in initiating lung graft rejection is no

93 Sequence variation at each gene predicts allorecognition in laboratory strains such that colonies

94 bution of the direct and indirect pathway of allorecognition in the evolution of transplant arteriosc

95 dendritic cells via the indirect pathway of allorecognition in the thymus induces T cell tolerance.

96 ic tolerance suggests an indirect pathway of allorecognition in the thymus.

97 nce or initiation of the indirect pathway of allorecognition in transplantation.

98 The indirect pathway of allorecognition, in which cells of the adaptive immune s

99 Although indirect allorecognition is considered to be a single entity, our

100 s and confirmed earlier results showing that allorecognition is controlled by a single chromosomal re

101 the cnidarian Hydractinia symbiolongicarpus, allorecognition is controlled by at least two highly pol

102 In every taxon studied to date, allorecognition is controlled by one or more highly poly

103 Indirect allorecognition is important in the development of humor

104 To determine whether indirect allorecognition is involved in heart allograft rejection

105 T-cell receptor (TCR) allorecognition is often presumed to be relatively nonsp

106 These findings provide evidence that not all allorecognition is peptide dependent.

107 These results indicate that CTL allorecognition is peptide-specific whether the allogene

108 but which of the two pathways of CD4 T cell allorecognition is responsible for generating allospecif

109 Allorecognition is ubiquitous, or nearly so, amongst col

110 or (TCR) beta chain in the direct pathway of allorecognition, it is not clear whether a particular HL

111 somatic stage, the role of [Het-s]/HET-S in allorecognition leads to frequency-dependent selection f

112 Allorecognition loci are the most diverse ever described

113 cnidarian Hydractinia, one of the two known allorecognition loci, alr2, has been isolated, and a sec

114 on of extensive polymorphism at invertebrate allorecognition loci.

115 t T cells primed via the indirect pathway of allorecognition may be important mediators of chronic re

116 experimental evidence suggests that indirect allorecognition may promote the development of chronic r

117 y complex antigen (the "indirect" pathway of allorecognition) may be responsible for mediating chroni

118 -presenting cells (the "indirect pathway" of allorecognition) may play a key role in the initiation o

119 This ability, called allorecognition, mediates spatial competition and can pr

120 T cell allorecognition occurs through direct contact with donor

121 We examined allorecognition of an HLA-A2-restricted Hodgkin's lympho

122 In particular, there was increased allorecognition of CBA miHA by B10.BR CD4+ T cells, as d

123 These results suggest that indirect allorecognition of donor MHC class I molecules leads to

124 idence of a definitive link between indirect allorecognition of donor-derived MHC class II peptides a

125 Allorecognition of fetal placental cells by uNK cells is

126 f systemic lupus erythematosus is induced by allorecognition of foreign MHC class II determinants.

127 rum as to why SLT is required for CD8 T-cell allorecognition of graft parenchymal cells and suggest a

128 this study was to determine whether indirect allorecognition of HLA class I-derived peptides occurred

129 , the p2Ca peptide that is immunodominant in allorecognition of Ld also lacks the P2 proline anchor a

130 ferences in signaling processes that lead to allorecognition of major and minor histocompatibility Ag

131 Allorecognition of minor histocompatibility Ags was high

132 Indirect CD4 T-cell allorecognition of mismatched donor MHC class I and II,

133 d to MHC-class I mismatched grafts (indirect allorecognition only by CD4+ T cells) (day 7: 6+/-7 vs.

134 that CAV is triggered either by CD8+ direct allorecognition or by CD4+ indirect allorecognition.

135 he first 6 months is dominated by the direct allorecognition pathway driven by HLA-DR mismatch.

136 Although the indirect allorecognition pathway has the strongest influence on r

137 The role of the indirect allorecognition pathway in acute allograft rejection has

138 de to the developing T cells by the indirect allorecognition pathway in the induction of acquired thy

139 ting that T cells activated via the indirect allorecognition pathway participate actively in acute al

140 This reliance on a relatively minor allorecognition pathway removes a major threat to fetal

141 To determine the allorecognition pathway responsible for CAV in this mode

142 alloreactive CD4+ T cells involved in direct allorecognition pathway.

143 tion and strong suppressors of defects in an allorecognition pathway.

144 timulates chronic rejection via the indirect allorecognition pathway.

145 ses is provided exclusively via the indirect-allorecognition pathway.

146 lls activated via the direct and/or indirect allorecognition pathway.

147 we consider current understanding of T-cell allorecognition pathways and discuss the most likely mec

148 ill require an intimate understanding of the allorecognition pathways and effector mechanisms that ar

149 the contributions of the indirect and direct allorecognition pathways in chronic airway rejection.

150 everal studies examining the contribution of allorecognition pathways to acute and chronic rejection

151 relative contribution of direct and indirect allorecognition pathways to chronic rejection of allogen

152 t (recipient MHC and donor-derived peptides) allorecognition pathways.

153 fts is independent of CD4(+) T cell-mediated allorecognition pathways.

154 Here we review allorecognition phenomena in both systems, summarizing r

155 These allorecognition phenomena mediate intraspecific competit

156 Transitory fusion is an allorecognition phenotype displayed by the colonial hydr

157 t T cells primed via the indirect pathway of allorecognition play an important role in allograft reje

158 enting cells through the indirect pathway of allorecognition plays a critical role in the development

159 Recent evidence indicates that indirect allorecognition plays a key role in initiating and susta

160 -derived APC by host T cells (direct pathway allorecognition) plays an important role in acute reject

161 lection cannot be a strong force maintaining allorecognition polymorphism in two colonial marine inve

162 t is counteracted by balancing selection for allorecognition polymorphism.

163 These allorecognition polymorphisms may regulate somatic inter

164 ckade of ICAM-1/LFA-1 binding at the time of allorecognition potently blocks initial T cell effector

165 g through the direct or indirect pathways of allorecognition provide help for the induction of antido

166 toring of the direct and indirect pathway of allorecognition provides a reliable method for predictio

167 1 and alr2 contributed differentially to the allorecognition response.

168 tion that is highly polymorphic and predicts allorecognition responses in laboratory and field-derive

169 de insight into basal processes conserved in allorecognition responses throughout the metazoa.

170 In colonial marine invertebrates, allorecognition restricts somatic fusion and thus, chime

171 In both species, allorecognition specificity is determined by highly poly

172 ndirect allorecognition and that CD8+ direct allorecognition stimulated by nonprofessional APCs plays

173 nd suggest the existence of mammalian innate allorecognition strategies distinct from detection of mi

174 ll responses through the indirect pathway of allorecognition, such as tolerance induction to the domi

175 C) class I expression, subtle features of NK allorecognition suggest that NK cells possess receptors

176 These results establish the hydroid allorecognition system as a novel model for the study of

177 Cooperation between cells depends on an allorecognition system comprising the polymorphic adhesi

178 n Botryllus schlosseri, a highly polymorphic allorecognition system limits the potential for vascular

179 nd evidence of the role of the [Het-s]/het-S allorecognition system on the incidence of infection by

180 nocytes and macrophages are equipped with an allorecognition system that allows them to respond direc

181 two antagonistic alleles that constitute an allorecognition system: the het-s allele encoding the pr

182 ulence) of pathogenic fungi is restricted by allorecognition systems operating in their fungal hosts.

183 cognition that is unique among characterized allorecognition systems within and outside invertebrates

184 s that shape the evolution of these distinct allorecognition systems, and highlighting questions that

185 receptor expressed in all tissues capable of allorecognition that is highly polymorphic and predicts

186 omozygote, suggested highly peptide-specific allorecognition that was energetically focused on antige

187 Allorecognition, the ability to discriminate between sel

188 Allorecognition--the ability of an individual to disting

189 colonial marine invertebrates are capable of allorecognition--the ability to distinguish between self

190 Direct allorecognition therefore appears unlikely to be respons

191 mediate acute rejection by triggering direct allorecognition, they may also act in an immunomodulator

192 the intrinsic process in which developmental allorecognition through the activating receptor regulate

193 To study the contribution of indirect allorecognition to chronic rejection, naive Lewis (RT1(1

194 ts demonstrate the feasibility of modulating allorecognition to engineer pathogenic fungi for more ef

195 ributions of direct and indirect pathways of allorecognition to graft rejection remain controversial.

196 Direct T cell allorecognition underlies the development of a vigorous

197 Four of five diallelic virus-restricting allorecognition [vegetative incompatibility (vic)] loci

198 These findings indicated that CTL allorecognition was peptide specific.

199 Indirect allorecognition was restricted by a single HLA-DR antige

200 A single form of allorecognition was shown to occur in some rejection epi

201 lls primed to P5 via the indirect pathway of allorecognition were harvested 7 days later and administ

202 4 completely blocked the indirect pathway of allorecognition, while anti-CD154 mAb blocked the indire