ライフサイエンスコーパス: allosteric activation

1 many PDZ proteases use a common mechanism of allosteric activation.

2 active-site pairs, providing a mechanism for allosteric activation.

3 h transmission of intrasteric inhibition and allosteric activation.

4 ing movement of the beta1 strand even during allosteric activation.

5 HR) were involved in methylated DNA-mediated allosteric activation.

6 one, corroborating the proposed mechanism of allosteric activation.

7 d an increase in V(max), suggesting positive allosteric activation.

8 l occupancy of the enzyme catalytic site via allosteric activation.

9 ng to the anionic interface and a consequent allosteric activation.

10 ondrial mRNA correlates with the property of allosteric activation.

11 G binds TDG on Arg275 providing an enzymatic allosteric activation.

12 affinity and suggest a role for the loop in allosteric activation.

13 previously been implicated in mediating the allosteric activation.

14 his noncatalytic site facilitates homotropic allosteric activation.

15 hrough dephosphorylation and, more potently, allosteric activation.

16 ctivation depends on SOS1 expression but not allosteric activation.

17 le mechanistic link between the two types of allosteric activation.

18 nderstood, namely, sequential metabolism and allosteric activation.

19 hosphorylation, although it does not lead to allosteric activation.

20 gainst dephosphorylation, as well as causing allosteric activation.

21 into the regulation of SAMHD1 with regard to allosteric activation and active site specificity.

22 fasting) and when 2) AAs provide leucine for allosteric activation and glutamate from transaminations

23 as the synthetic activator A-769662 to cause allosteric activation and inhibition of dephosphorylatio

24 Allosteric activation and inhibition of PFK1 by over ten

25 ct residues support different mechanisms for allosteric activation and inhibition.

26 t potentially plays an important role in the allosteric activation and modulation of the Cys loop fam

27 the S-loop is critical for cofactor binding, allosteric activation and oligomerization.

28 ion occurs by a dual mechanism that involves allosteric activation and phosphorylation by upstream ki

29 were inconsistent with a two-state model of allosteric activation and suggested multiple activated s

30 e apoptosome, ruling out the requirement for allosteric activation and supporting an induced proximit

31 in the N-terminal 17-residue linker mediates allosteric activation, and its mutation to alanine leads

32 With no exceptions, signature residues of allosteric activation appear in bacterial sequences alon

33 nges in the repressor monomer that accompany allosteric activation are not known.

34 at 2.9 A and provide a structural model for allosteric activation based on comparisons with other in

35 tent with the Monod-Wyman-Changeux model for allosteric activation but also suggest that rigidificati

36 to the feedback inhibitor UTP, and decreased allosteric activation by 5-phosphoribosyl-1-pyrophosphat

37 insulin was enhanced 4-fold, in part due to allosteric activation by a glucosamine metabolite.

38 that betaY137 is involved in NAD binding and allosteric activation by ADP.

39 respective kinetic defects in catalysis and allosteric activation by AMP.

40 ate binding by IDH1 being a prerequisite for allosteric activation by AMP.

41 cooperativity with respect to isocitrate and allosteric activation by AMP.

42 mers provides a mechanistic understanding of allosteric activation by cAMP.

43 guanylyltransferase, which does not require allosteric activation by Cet1.

44 ion, but has no effect on the equilibrium of allosteric activation by deoxynucleotides.

45 psilon null mice were also supersensitive to allosteric activation by ethanol and flunitrazepam.

46 idue in bacterial PFK, prevented binding and allosteric activation by fructose 2,6-bisphosphate.

47 bits positively cooperative (ultrasensitive) allosteric activation by fructose-1,6-bisphosphate (FBP)

48 aling is generally thought to be mediated by allosteric activation by G proteins and Ca(2+).

49 inase demonstrated that it is the subject of allosteric activation by GlcNAc-6-P.

50 on of GSase, which alters the sensitivity to allosteric activation by glucose 6-phosphate (G6P), is a

51 Following allosteric activation by high phenylalanine levels, the

52 glutamine as a nitrogen donor, and required allosteric activation by N-acetylglutamate (AGA), a sens

53 This allosteric activation by PA could involve a conformation

54 ivity of Fe(III)-CBS, and still responded to allosteric activation by S-adenosyl-L-methionine.

55 after this protein, suggests a mechanism for allosteric activation by S-adenosylmethionine.

56 is subject to complex regulation, including allosteric activation by the methyl donor, S-adenosylmet

57 cooperativity of AdoMet binding mediated by allosteric activation by the methylated CG steps.

58 variant, which has been shown to be inert to allosteric activation by the natural activator TF, sugge

59 on and multimerization properties respond to allosteric activation by the substrate phenylalanine (Ph

60 centrosomes in the early stages of mitosis, allosteric activation by TPX2 of dephosphorylated Aurora

61 We then address the allosteric activation by TPX2 through activity assays an

62 tion of the loop and suggest a mechanism for allosteric activation: calcium binding results in partia

63 This demonstrates that allosteric activation can be recapitulated throughout a

64 f1 and Nef thus play interconnected roles in allosteric activation, cargo recruitment, and coat assem

65 ites responsible for feedback inhibition and allosteric activation control filament length, implying

66 model through which membrane recruitment and allosteric activation could be structurally integrated.

67 ce very effective channel activation (direct allosteric activation (DAA)) by operating at two distinc

68 nd thus displayed the expected phenotype for allosteric activation-deficient PrfA mutations.

69 0 amino acids, indicating the presence of an allosteric activation determinant between amino acids 12

70 ing seen as switches with fixed responses to allosteric activation, ensembles can evolve to be "funct

71 ansitions can decouple regions important for allosteric activation from receptor binding specificity.

72 Arachidonic acid-induced allosteric activation has not been directly observed wit

73 n the fully activated state, and the bulk of allosteric activation has occurred in the intermediate.

74 studied, structural changes associated with allosteric activation in mammalian PheH have been elusiv

75 affinity and leads us to propose a model for allosteric activation in nuclear receptor dimers, in whi

76 nd T3, highlighting a dominant role of M2PYK allosteric activation in the regulation of cancer prolif

77 nus domain, has been signaled as pivotal for allosteric activation in TRP channels.

78 Our data are consistent with a model for allosteric activation in which sGC undergoes a simple sw

79 dings support a minimal three-state model of allosteric activation in which the P14 mutations perturb

80 can be interpreted in terms of differential allosteric activation, including DNA binding in the abse

81 CARF domain mutations that abolish allosteric activation inhibit Csm6 activity in vivo, and

82 (DTW) and NOD("DR2")) demonstrates that this allosteric activation is critical for the function of NO

83 nd to be unable to bind AMP, suggesting that allosteric activation is dependent both upon binding of

84 Classic allosteric activation is in play where either activation

85 They also indicate that PrfA allosteric activation is not required for early intracel

86 The Y355F mutant exhibited allosteric activation kinetics in the presence of arachi

87 our study provides a compelling and unifying allosteric activation mechanism in STKR1 kinases that re

88 xyl-terminal domain so that the endothermic, allosteric activation mechanism of CRP by cAMP is restor

89 arged residues of the GH disaccharide in the allosteric activation mechanism was investigated with va

90 results are discussed in light of a proposed allosteric activation mechanism.

91 em diversified rapidly, while conserving the allosteric activation mechanism.

92 rally attributed to lipid cofactor-dependent allosteric activation mechanisms at membranes.

93 This allosteric activation occurred if the sequence was attac

94 enzymes are exquisitely tuned to ensure that allosteric activation occurs only when concentrations of

95 Allosteric activation of 5(')-AMP-activated protein kina

96 Accumulation of citrate could lead to allosteric activation of ACC, further augmenting malonyl

97 Our data show that both orthosteric and allosteric activation of alpha7 nAChR require cooperativ

98 Compound 6 represents a chemotype for allosteric activation of alpha7 nAChRs, with therapeutic

99 t is shown to derive from three sources: (i) allosteric activation of antithrombin by a sequence-spec

100 A revised model for the mechanism of the allosteric activation of antithrombin is proposed.

101 ons of the NBS and the inferred mechanism of allosteric activation of ArsA provide a useful model for

102 charide, is mediated exclusively through the allosteric activation of AT towards efficient inhibition

103 eet A, which is known to be critical for the allosteric activation of AT.

104 parin-responsive molecular switch during the allosteric activation of ATIII anticoagulant activity.

105 An allosteric activation of auto(poly-ADP-ribosylation) by

106 Activated tBID results in an allosteric activation of BAK, inducing its intramembrano

107 to act as a redox switch that precludes the allosteric activation of bGP by AMP.

108 Kunitz inhibitors based on current ideas for allosteric activation of BK(Ca) channels by voltage and

109 The molecular events in the cAMP-induced allosteric activation of cAMP receptor protein (CRP) inv

110 lfuration pathway depending on the extent of allosteric activation of CBS by S-adenosylmethionine.

111 erol and fatty acid correlated with enhanced allosteric activation of CCTalpha by the membrane lipids

112 Allosteric activation of CD11b via pretreatment with the

113 face plays a critical modulatory role in the allosteric activation of CfaE.

114 he nuclear localization of ChREBP through an allosteric activation of ChREBP/14-3-3 interactions and

115 The results are interpreted in terms of the allosteric activation of CRP by cAMP by a conformational

116 Allosteric activation of DAT via the Zn(2+)-binding site

117 ing conformation of DAT, which allows for an allosteric activation of DAT, in both, the forward trans

118 provide a compelling molecular mechanism for allosteric activation of DegS by OMP-peptide binding.

119 with a conformational change accompanying an allosteric activation of DNA-binding.

120 RING/U-Box E3/E2 pairs, as the linchpin for allosteric activation of E2~Ub.

121 Understanding the allosteric activation of EcPFK by MgADP has been complic

122 Understanding of the structural basis of allosteric activation of EcPFK by MgADP is complicated b

123 The mechanism for this requirement is not allosteric activation of Epac2 by Ras but the compartmen

124 se data implicate a dual role for FAS in the allosteric activation of ExoS, involving both substrate

125 heparin pentasaccharide (300-500-fold), (ii) allosteric activation of factor IXa by calcium ions (4-8

126 r VIIa with high affinity and supported full allosteric activation of factor VIIa toward tripeptidyl-

127 Allosteric activation of fructose-1,6-bisphosphatase (FB

128 In the case of allosteric activation of G protein-coupled receptors (GP

129 metabolism by oxidative decarboxylation and allosteric activation of glutamate dehydrogenase (GDH).

130 egulatory arm of the HBP that involves rapid allosteric activation of glycogen synthase (GS) and stim

131 inis muscle reach levels sufficient to cause allosteric activation of glycogen synthase and inhibitio

132 that the absence of Epm2aip1 in mice impairs allosteric activation of GS by glucose 6-phosphate, decr

133 ion promotes muscle glycogen accumulation by allosteric activation of GS through an increase in gluco

134 GlcN-6-P levels within minutes, resulting in allosteric activation of GS, stimulation of GBS, and a r

135 migration--to promote cell motility, through allosteric activation of guanylyl cyclases by autophosph

136 suggests an important physiological role for allosteric activation of IDH during changes in environme

137 at of 3beta-HSD2 isomerase and abolishes the allosteric activation of isomerase by NADH.

138 Tyr-1 is also essential for binding and allosteric activation of mammalian guanylyltransferase b

139 -alpha(1L14)-alpha(2L14)), are essential for allosteric activation of MKP3 and formation of a product

140 One of these postulates an allosteric activation of monomeric caspase-9; the other

141 ieved through physical tethering rather than allosteric activation of Munc18-1.

142 Allosteric activation of NCX by [Ca]i was comparable in

143 ytic activity of EGFR is switched on through allosteric activation of one kinase domain by another, a

144 o form an asymmetric dimer that supports the allosteric activation of one kinase.

145 rease in surface AMPAR levels because of the allosteric activation of PDE2.

146 er describe the domain movements involved in allosteric activation of PheH in solution and present th

147 bradyphylaxis is mediated by cGMP-dependent allosteric activation of phosphodiesterase 5, which shap

148 lytic cleavage by caspase-3, suggesting that allosteric activation of PKCdelta is sufficient to trigg

149 e Eed core component of PRC2 and triggers an allosteric activation of PRC2's enzymatic activity.

150 f BH3-only proteins ultimately culminates in allosteric activation of pro-apoptotic BAX and BAK, the

151 region of Hook3 specifically required for an allosteric activation of processive motility.

152 o glucose through greater hepatic acetyl-CoA allosteric activation of pyruvate carboxylase flux.

153 hese modifications are the consequence of an allosteric activation of pyruvate kinase via cytosolic N

154 ysteine affect Ras membrane localization and allosteric activation of Raf kinase.

155 In this study, we investigate allosteric activation of SAMHD1 by deoxynucleotide-depen

156 Apart from the lack of direct allosteric activation of SNF1 by AMP, the regulation of

157 of Sos bound to two Ras molecules show that allosteric activation of Sos by Ras occurs through a rot

158 The expected allosteric activation of SOS by Ras-guanosine triphospha

159 We suggest that there might be allosteric activation of substrate binding.

160 lone (AP), regulate neuronal excitability by allosteric activation of synaptic and extrasynaptic GABA

161 at a key feature of the mechanism of heparin allosteric activation of the anticoagulant serpin, antit

162 erminal cyclic nucleotide binding domain and allosteric activation of the C-terminal acyltransferase

163 The second step involves the allosteric activation of the catalytic site through dist

164 These results suggest that the normal allosteric activation of the chemotaxis receptor has bee

165 the pores of MP-SiO(2), and particularly the allosteric activation of the DNAzymes through cooperativ

166 Binding of AMP causes allosteric activation of the enzyme and binding of eithe

167 nd acts as a redox switch that precludes the allosteric activation of the enzyme by AMP without affec

168 st the catalytic domain where it could drive allosteric activation of the enzyme.

169 dies reveal determinants for the binding and allosteric activation of the Fe-S assembly complex and p

170 Allosteric activation of the hexameric arginine represso

171 structure of a HslUV complex, a mechanism of allosteric activation of the HslV protease, wherein bind

172 unctions, such as DNA repair, to augment the allosteric activation of the main protective system, Kef

173 chromatin marks, and that this leads to the allosteric activation of the methyltransferase activity

174 n of MKP3 and ERK2 and specific ERK2-induced allosteric activation of the MKP3 C-terminal phosphatase

175 osttranslational regulation seems to involve allosteric activation of the ML beta-glucan synthase Bgs

176 med that limiting rate constants for heparin allosteric activation of the mutants were altered in con

177 Allosteric activation of the PDZ is achieved by local re

178 ith an armlike structure in DPP9, leading to allosteric activation of the peptidase.

179 he substrate selectivity and Na(+)-dependent allosteric activation of the protease domain of human co

180 ng that this residue may be required for the allosteric activation of the protease.

181 he serpin, antithrombin, to the mechanism of allosteric activation of the protein by heparin was dete

182 rosine 341 (Y341) and are thought to provide allosteric activation of the Raf dimer.

183 bond in the zymogen-like pro-HGF results in allosteric activation of the serine protease-like beta-c

184 factor Xa by antithrombin mainly through an allosteric activation of the serpin inhibitor, but an al

185 parin pentasaccharide, denoted DEFGH, in the allosteric activation of the serpin, antithrombin, we st

186 The allosteric activation of the T127-->L mutant of 3',5'-cy

187 If allosteric activation of type II IPPs by PI(4)P and PS i

188 ur results provide a mechanistic example for allosteric activation of USPs by their regulatory partne

189 wn, however, whether this loop has a role in allosteric activation of VIIa.

190 analyzed the structural determinants of the allosteric activation of yeast pyruvate kinase (YPK) by

191 f the multiligand interactions governing the allosteric activation of YPK.

192 tor protein (CRP) from Escherichia coli, the allosteric activation, or apo-holo transition, involves

193 ough PKC isotypes are characterized by their allosteric activation, phosphorylation also plays a key

194 te binding site of the active subunit blocks allosteric activation regardless of the activity of the

195 t do not affect the cooperativity), and this allosteric activation requires an intact PH domain.

196 Allosteric activation results from an increase in k(cat)

197 s unambiguously show that the conformational allosteric activation signal extends to the EGF1 domain

198 e, we identify a receptor (ephrinB2)-induced allosteric activation site in Nipah virus (NiV) G involv

199 assess the conformational flexibility of the allosteric activation site.

200 cs were observed, suggesting the presence of allosteric activation sites.

201 ations' effects on parameters reflecting the allosteric activation state of the serpin were inconsist

202 he conformational space network, whereas the allosteric activation step covers a much wider region an

203 s Asp residue in nSMase2 disrupts catalysis, allosteric activation, stimulation by phosphatidylserine

204 ector, NADH (0.7-0.9 per site), and exhibits allosteric activation, suggesting that the proteins reta

205 findings implicates the gammaCRD as being an allosteric activation switch in PhK that interacts with

206 hese results indicate that RasGRF1 lacks the allosteric activation switch that is crucial for Sos act

207 omains surrounding the kinase active site in allosteric activation, the nature of that site and the r

208 the enhanced thrombin specificity was due to allosteric activation, the remainder being realized with

209 a, we propose a model in which PLN undergoes allosteric activation upon encountering SERCA.

210 GS is regulated by allosteric activation upon glucose-6-phosphate binding a

211 y towards RhoA, but full activation requires allosteric activation via Galphaq.

212 Allosteric activation was reduced in the double point mu

213 n-activated state and support a new model of allosteric activation we recently proposed in which a ba

214 rms of a two-state model for the interfacial allosteric activation, where the enzyme-substrate comple

215 , ADAMTS13 is regulated by substrate-induced allosteric activation, which may optimize VWF cleavage u

216 nge could be responsible for the interfacial allosteric activation, which thermodynamically relates t

217 n/K-Ras4B interaction, to accomplish K-Ras4B allosteric activation, with a minor contribution from cS