ライフサイエンスコーパス: allosteric binding site

1 mbrane through binding of Ras.GTP in the SOS allosteric binding site.

2 established a Ki value of 4.4 nM at a known allosteric binding site.

3 art because of the hydrophobic nature of the allosteric binding site.

4 vity with ACh upon interaction with a common allosteric binding site.

5 ituted phenyl rings C that interact with the allosteric binding site.

6 -(phenylethynyl)pyridine] for the antagonist allosteric binding site.

7 gesting that alcohols interact at a discrete allosteric binding site.

8 780 may cause receptor activation through an allosteric binding site.

9 it remains a challenge to identify suitable allosteric binding sites.

10 ation with X-ray crystallography to identify allosteric binding sites.

11 ally the human M2 and M4 muscarinic receptor allosteric binding sites.

12 ide) as a novel probe of the human M2 and M4 allosteric binding sites.

13 d discuss their potential as a new source of allosteric binding sites.

14 ivating (AMP, ADP) and inhibitory (ATP, ADP) allosteric binding sites.

15 nic receptors occurs through orthosteric and allosteric binding sites.

16 of HKI by G6P can occur from both active and allosteric binding sites.

17 s, the results indicate a possible conserved allosteric binding site across the opioid receptor famil

18 h suggests a general lack of selectivity for allosteric binding sites across aminergic G protein-coup

19 residues that interact with IIA(Glc) at the allosteric binding site and 3 residues in the conserved

20 nzyme bound to lysine (2.4 A) identifies the allosteric binding site and clearly shows a conformation

21 tive PRMT3 inhibitor, which occupies a novel allosteric binding site and is noncompetitive with both

22 This site is adjacent to the MgATP allosteric binding site and is only observed in the pres

23 , namely the better fit of the ligand to the allosteric binding site and the addition of fluorine ato

24 To date, the discovery of allosteric binding sites and lead compounds has been mos

25 oms, simulations can enable the discovery of allosteric binding sites and the determination of the me

26 it does define the propagation pathways, the allosteric binding sites, and key on-path residues.

27 s the interrogation of protein active sites, allosteric binding sites, and protein-protein interactio

28 Allosteric binding sites are topographically distinct fr

29 Allosteric binding sites are topographically distinct fr

30 firmed that this inhibitor occupied the same allosteric binding site as our initial lead compound.

31 T-1284), as a tool for characterizing the M1 allosteric binding site, as well as profiling novel M1 P

32 th compact and extended conformations in the allosteric binding sites but conserve extended conformat

33 sis of the N terminus, which is regulated by allosteric binding sites, cofactors, membrane localizati

34 to alanine decreased affinity of NMS for the allosteric binding site confirming results of molecular

35 We have tested the hypothesis that distinct allosteric binding sites control GluR6 receptors via a c

36 a previously identified UDP-glucuronic acid allosteric binding site decreased the binding affinity o

37 We propose that this allosteric binding site defines a pocket that is differe

38 These results suggest that an allosteric binding site exists on the HIV-1 PR and that

39 We describe a completely novel allosteric binding site for class B receptors, providing

40 role of beta(2)AR extracellular region as an allosteric binding site for larger drugs such as salmete

41 ains and show that the DH-PH unit blocks the allosteric binding site for Ras and suppresses the activ

42 n-sensitive rod rhodopsins have at least one allosteric binding site for retinoid, but beta-ionone bi

43 r sAC because they bind to the sAC-specific, allosteric binding site for the physiological activator

44 ed in several CNS disorders and possesses an allosteric binding site for which ligands modulating the

45 (GLIC), are receptors that contain multiple allosteric binding sites for a variety of therapeutics,

46 The existence of such an allosteric binding site had been predicted by biochemica

47 Because allosteric binding sites have been found on many other G

48 rate that E. coli RNA polymerase contains an allosteric binding site in addition to the catalytic sit

49 ng of the ion channel and represents a novel allosteric binding site in Cys-loop receptors.

50 Together, these data unveil an allosteric binding site in the extracellular ligand-bind

51 expands our understanding of the topology of allosteric binding sites in AChBP and, by extrapolation,

52 resents a structural framework for different allosteric binding sites in the alpha7 nAChR and paves t

53 5 inhibitors were used to translate the CCR5 allosteric binding site into a general pharmacophore, wh

54 Understanding of interactions of NMS at the allosteric binding site is essential for correct analysi

55 th both the orthosteric binding site and the allosteric binding site located between the second and t

56 nt-based screening approach, we uncovered an allosteric binding site located near the beta8-beta9 loo

57 trapeptide (OC252-324) further defines a new allosteric binding site located near the center of fruct

58 i.e., noncompetitive binding sites, negative allosteric binding sites) located on nAChRs.

59 Impaired interaction with the allosteric binding site manifests as low-affinity bindin

60 , reciprocal linkage of functionally opposed allosteric binding sites must have developed independent

61 ate (HPP) tautomerase activity of MIF and an allosteric binding site of AV411 and AV1013 is detected

62 The allosteric binding site of NMS overlaps with the binding

63 inhibitors can be created by exploiting the allosteric binding site of PRMT3.

64 reflects the electrostatic properties in the allosteric binding site of the LDH enzymes.

65 PET) radiotracers for in vivo imaging of the allosteric binding site of the metabotropic glutamate (m

66 with important residues in the catalytic and allosteric binding sites of bacterial PFK and that are c

67 inding affinities of Pi to the catalytic and allosteric binding sites of the enzymes modeled in proto

68 These data suggest that a specific allosteric binding site on b5, which includes residues E

69 Second, removal of Mg(2+) from an allosteric binding site on SecA does not perturb the end

70 ine can bind solely with low affinity to the allosteric binding site on the extracellular domain of N

71 We report the discovery of a novel allosteric binding site on the nuclear receptor RORgamma

72 en identified, it has been proposed to be an allosteric binding site on the PDE-IV enzyme.

73 served results, which includes an additional allosteric binding site on the viral NTPases/helicases t

74 Since the discovery of allosteric binding sites on G protein-coupled receptors,

75 Allosteric binding sites on the adenosine receptor famil

76 when inhibitors are bound at three different allosteric binding sites on the enzyme.

77 These include the presence of allosteric binding sites on the receptor that can be exp

78 The putative allosteric binding site partially overlaps the dimerizat

79 -1 FL CA and characterization of a potential allosteric binding site provides three-dimensional views

80 , Fe2+, Co2+, Ni2+, Zn2+ and Cd2+, but their allosteric binding sites reject other divalent metals su

81 ess route of bicarbonate ion to and from the allosteric binding site, respectively.

82 -loop, and anion-binding exosite 1, the main allosteric binding site, retain mus-ms motions.

83 s of the positive allosteric modulators, the allosteric binding site(s) and structure-activity relati

84 and the inhibitors were found to bind in an allosteric binding site separate from the active site.

85 ations and molecular modelling identified an allosteric binding site that forms at the subunit interf

86 , reveals differences in the orthosteric and allosteric binding sites that contribute to a role in dr

87 le binding sites may provide a new source of allosteric binding sites that could be exploited in the

88 The first structure of a SULT allosteric-binding site (that of SULT1A1) has recently c

89 When the ATP molecules occupy the allosteric binding sites, the allosteric trigger from AT

90 Here, we present the structure of an SULT allosteric binding site-the catechin-binding site of SUL

91 e such protease, gamma secretase, through an allosteric binding site to preferentially increase the c

92 ntify key communication pathways linking the allosteric binding site to the active site of the enzyme

93 o bind to the previously identified ;common' allosteric binding site, Trankle et al. provide evidence

94 ic mechanism, we identified several possible allosteric binding sites using computational searches.

95 nsistent with the structural evidence for an allosteric binding site which is present in the glucose-

96 eptors including the precise location of the allosteric binding site within the transmembrane domain