ライフサイエンスコーパス: allosteric effect

1 a23Tm decreases these interactions (negative allosteric effect).

2 receptor's affinity for a second substrate (allosteric effect).

3 a to the GAF domains suffices to induce this allosteric effect.

4 3) Carboxylation reduces the allosteric effect.

5 Higher levels of glycerol cause loss of the allosteric effect.

6 e Tf binding site rather than by exerting an allosteric effect.

7 ic site occurred even when MgADP produced no allosteric effect.

8 reased [(3)H]NMS binding to M1 receptors, an allosteric effect.

9 GTP region of beta-tubulin is a long range, allosteric effect.

10 hich inhibits C-type inactivation through an allosteric effect.

11 onding activation appears to involve a major allosteric effect.

12 of inflammasome signaling was mediated by an allosteric effect.

13 there is little sequence specificity to the allosteric effect.

14 membrane-dependent substrate recognition and allosteric effects.

15 ies to probe the biochemical basis for their allosteric effects.

16 fic motifs and regulate protein activity via allosteric effects.

17 hat this residue is a key player in relaying allosteric effects.

18 ns; and those that decrease affinity through allosteric effects.

19 st in designing pharmaceuticals that exploit allosteric effects.

20 e binding is likely achieved by DNA-mediated allosteric effects.

21 tions that substantially alter a modulator's allosteric effects.

22 hatase activity and could promote exon 7 via allosteric effects.

23 odels yield valuable methods for quantifying allosteric effects.

24 ion of the second substrate with no specific allosteric effects.

25 of a biochemical process such as binding and allosteric effects?

26 The propagation of allosteric effects across the domain interface may depen

27 on caused by SH modification of Kir6.2 is an allosteric effect, and is not caused by direct pore bloc

28 dy provides an example of dynamics-dependent allosteric effects, and due to the structural conservati

29 (b) stress the need for quantitation of the allosteric effects; and finally, (c) propose that each s

30 te that metal uptake and this newly observed allosteric effect are buffer dependent.

31 These allosteric effects are focused among a relatively few re

32 These allosteric effects are in agreement with previous foldin

33 These decreases suggest that positive allosteric effects are not mediated by structural change

34 Their allosteric effects are observed only at high concentrati

35 This allosteric effect arises from interactions between N-cap

36 IMP produces only a very small allosteric effect as indicated by a near-zero value for

37 Little is known about the allosteric effects at play in E1A-CBP-pRb interactions,

38 This appears to be caused by an allosteric effect because these residues are not localiz

39 nds reflects the difference between a narrow allosteric effect between two well-defined sites in the

40 roposed to play a major role in transmitting allosteric effects between oxygen binding sites.

41 is hypothesized to modulate BKR activity via allosteric effects between the ER and BKR NADPH sites.

42 ic and stereospecific interactions (positive allosteric effect) between actin and myosin, but Delta23

43 ilibria measurements indicate a differential allosteric effect by inositol hexaphosphate for HbC appr

44 in-1-yl-phenyl)ethyl]amide] displayed biased allosteric effects by blocking cAMP inhibition mediated

45 HSA, and cis/trans-clomiphene gave positive allosteric effects caused by the binding of warfarin to

46 at binding of heparin to thrombin induces an allosteric effect causing destabilization of the thrombi

47 (whereby the magnitude and direction of the allosteric effect change with the nature of the interact

48 s been achieve using light, applied voltage, allosteric effects, chemical reagents, pH, and mechanica

49 etitive inhibition by BFA and the nucleotide allosteric effect combine to stabilize such abortive com

50 AChR and mediate robust positive or negative allosteric effects, depending on the orthosteric ligand

51 reover, RING:Ube2g2 binding induces a second allosteric effect, disrupting Ube2g2:G2BR contacts, decr

52 r with Glu-tRNA(Gln), results either from an allosteric effect due simply to binding of these analogu

53 tate kinetics of hydrolysis and resolves the allosteric effects from apparent modes of interfacial ac

54 Insight into the high-affinity allosteric effect has been hampered by the receptor's co

55 ither an allosteric site nor a compound with allosteric effects has been described.

56 losteric effects; however, the nature of the allosteric effects has been elusive.

57 osteric and active sites does not decide the allosteric effect; however, it does define the propagati

58 ipate in chemistry but are thought to confer allosteric effects; however, the nature of the allosteri

59 Allosteric effect implies ligand binding at one site lea

60 Electrostatic interactions may mediate allosteric effects important for C3d-CR2(CCP1-2) associa

61 tion of both the nature and magnitude of the allosteric effect in ATCase.

62 A recent study described an allosteric effect in which the binding of a protein to D

63 he absence of a rate equation to explain the allosteric effects in a tetramer, the data have been com

64 tructural insight into the recently proposed allosteric effects in Abs.

65 itute a mechanism for the recently suggested allosteric effects in Abs.

66 Allosteric effects in hemoglobin arise from the equilibr

67 Allosteric effects in monomers were exclusively negative

68 Allosteric effects in oligomers could be positive or neg

69 in Ras opens opportunities for understanding allosteric effects in Ras function.

70 of an enzyme has been extended to deal with allosteric effects in serine proteases.

71 These results implicate allosteric effects in the regulation of actomyosin funct

72 These results suggest that allosteric effects, including changes in oligomeric stat

73 EBs is improved by DnaC and DnaG, likely via allosteric effects induced by direct protein-protein int

74 We propose that allosteric effects induced upon zinc finger association

75 alpha-N, excluding that their binding caused allosteric effects influencing the interaction; nonethel

76 igands is that the magnitude of the mediated allosteric effect is dependent on the orthosteric probe

77 That is, the allosteric effect is determined by the extent of preferr

78 The inter-domain allosteric effect is likely mediated by the flexibility

79 ee energy, which signifies the nature of the allosteric effect, is opposite that of the enthalpy cont

80 comes less mobile, providing evidence for an allosteric effect linking the HA and heparin-binding sit

81 he thrombin-HCII(L444R) complex and that the allosteric effect may be mediated by the 60-loop.

82 Such allosteric effects may play a prominent role in modulati

83 s in a cryptic state, but after DNA binding, allosteric effects mediate an exposure of the acetylatio

84 nsequence of their inability to override the allosteric effect of 2-oxoglutarate on NifA activity.

85 onformations is reflected in the much weaker allosteric effect of ADP on the ssDNA binding with the a

86 blished conditions for fully quantifying the allosteric effect of AMP on glycogen phosphorylase b.

87 The presence of target miRNA triggered the allosteric effect of CHA amplification, which brought ab

88 ctions of Cl- at three levels: 1) a negative allosteric effect of Cl-, which limits the ability of AT

89 However, the potential allosteric effect of ClpP on the mechanism of ClpA catal

90 n the catalytic subunits of PDE6 rule out an allosteric effect of E4021 by direct binding to these no

91 very from use-dependent block, indicating an allosteric effect of external QX-314 binding on the reco

92 that Mg(2+) potentiates by a factor of 2 the allosteric effect of GDP.

93 Here, we studied for the first time the allosteric effect of geometrical membrane curvature on t

94 ranscriptional regulation by GR, a potential allosteric effect of GR-binding ligands on specific GR-D

95 The allosteric effect of GTP in promoting synapsis by P elem

96 is similarly inhibited, possibly through an allosteric effect of molecular O2 on the enzyme.

97 the DnaC protein eliminates the antagonistic allosteric effect of NTP and NDP on the ssDNA affinity o

98 ast in part, involved in transduction of the allosteric effect of pentobarbital to enhance alpha1beta

99 ed deoxy-RmFixL, exposes the strength of the allosteric effect of RmFixJ on the reaction.

100 , W246A(6.48), and N280A(7.45)) the negative allosteric effect of sodium ions on agonist binding.

101 at least two conformational changes: (i) an allosteric effect of TBP that mediates the activation of

102 change more than one parameter, implying an allosteric effect of the binding to the interface on KS,

103 The allosteric effect of the IgG is altered by deletion of P

104 weak DNA-binding subsite is to modulate the allosteric effect of the strong subsite.

105 bited exaggerated cooperativity, implying an allosteric effect of tropomyosin on actin and allowing t

106 lu-225 are also required to achieve the full allosteric effect of Zn(2+) on agonist binding.

107 43) and N274A(7.45) mutations eliminated the allosteric effects of all three modulators but had littl

108 dylinositol phosphates as second messengers, allosteric effects of ATP binding, changes of actin cyto

109 r as a single allosteric unit to mediate the allosteric effects of ATP binding, without altering the

110 on is an important residue for mediating the allosteric effects of both acidic and alkaline pH change

111 in the rate of modification consistent with allosteric effects of complex formation.

112 dely different ATPase activities reflect the allosteric effects of DNA ligation and demonstrate that

113 onse to ligand is strongly influenced by the allosteric effects of DNA-bound heterodimers.

114 1.50) and D58N(2.50) mutations abolished the allosteric effects of DU124183 and VUF5455, but not HMA,

115 loop residues 123-129 of Eallo underlies the allosteric effects of FAs and allosteric COX-2 inhibitor

116 but studies in which obidoxime reversed the allosteric effects of gallamine and other ligands sugges

117 lysine residues are not associated with the allosteric effects of inorganic anions on the rates of m

118 navirus polymerases is greatly influenced by allosteric effects of ligand binding that are likely to

119 Allosteric effects of mutations, ligand binding, or post

120 The subtype-selective allosteric effects of N-chloromethyl brucine on M2 and M

121 Examination of the allosteric effects of Na(+) on heterologously overexpres

122 otif V, which may be involved in transducing allosteric effects of nucleotide binding and hydrolysis

123 tifs II and VI may function to transduce the allosteric effects of nucleotides on DNA binding.

124 rties of PD 81,723) was found to enhance the allosteric effects of PD 81,723 (15 microM) in brain, bu

125 In the presence of 1 mM GTP, the allosteric effects of PD 81,723 (15 microM) were increas

126 at have previously been shown to enhance the allosteric effects of PD 81,723.

127 contrast, W246A(6.48) increased some of the allosteric effects of sodium ions and amiloride, whereas

128 e have characterized these reactions and the allosteric effects of the alpha subunit.

129 highlight the need to validate the reported allosteric effects of the endogenous ligands lipoxin A4

130 and S247A(6.52) mutations did not influence allosteric effects of the modulators.

131 ms of delta/lambda-chelate conformations and allosteric effects of the substrates.

132 Drugs mimicking the allosteric effects of these mutants may rescue pVHL func

133 h, increases the potency and efficacy of the allosteric effects of this ligand, likely through optimi

134 These results show an absence of allosteric effects of TMR on subdomain 2, while confirmi

135 Thus, ANF has as an allosteric effect on a kinetic branch point.

136 he presence of Tn and Ca2+ exerts a positive allosteric effect on actin to make actomyosin linkage mo

137 ted that extracellular Cl- exerts a negative allosteric effect on ATP-gating of P2X7R channels, we te

138 lts indicate that CpAMs do not have a single allosteric effect on capsid structure.

139 using a novel series of ligands with varying allosteric effect on CRF binding (inhibition to enhancem

140 We next investigated the allosteric effect on CRF-stimulated G-protein coupling.

141 Cl- has a positive allosteric effect on Cu-loading of apoFet3p.

142 e plasma membrane and by exerting a negative allosteric effect on GHS-R1a signaling, respectively.

143 weakly in solution, and hClpX must exert an allosteric effect on hClpP to promote a conformation tha

144 llosteric binding cooperativity and negative allosteric effect on orthosteric ligand maximal signalin

145 nearby N-terminal region, consistent with an allosteric effect on PIPn sensitivity because of altered

146 The allosteric effect on Pit-1, in combination with other DN

147 mic domain of Band 3 protein also produce an allosteric effect on S-nitrosated Hb.

148 studies with tamoxifen, this had a positive allosteric effect on tamoxifen/HSA binding, giving a cou

149 A-FIXa's increased activity is not due to an allosteric effect on the active site, but that the Arg-3

150 direct interaction with toxin, or through an allosteric effect on the alpha subunit.

151 - may also bind to Fet3p and that Cu+ has an allosteric effect on the binding of Cl- to the enzyme.

152 ion of the activation-loop has a significant allosteric effect on the dynamics of the C-lobe.

153 eEF3, strongly suggesting that it exerts an allosteric effect on the hydrolytic activity of eEF3.

154 bits nucleotide exchange on actin implies an allosteric effect on the nucleotide binding cleft.

155 ry near the M4 helix and exerts a long-range allosteric effect on the pore across domain-interfaces.

156 tive indicated that tamoxifen had a negative allosteric effect on warfarin/HSA binding, providing a c

157 These findings uncover a mechanism whereby allosteric effects on an E2 enhance E2-RING finger inter

158 e CB2 receptor PAM, with unforeseen opposite allosteric effects on cannabinoid receptors, suggests it

159 tential mechanisms, including pore block and allosteric effects on channel gating.

160 he two enzymes in proximity and by producing allosteric effects on ERAP1, dimerization of ERAP1/2 cre

161 he C-terminal tail but rather exerts its own allosteric effects on Int function in response to the in

162 data of epithelial 15-hLO-2, which probe the allosteric effects on its mechanistic behavior.

163 ges in low-frequency dynamics correlate with allosteric effects on ligand binding without the require

164 Ligands for which the nature of their allosteric effects on mGluRs is experimentally known wer

165 alent cations, such as zinc and copper, have allosteric effects on misfolded aggregates of comparable

166 tances but not others, suggesting additional allosteric effects on orthosteric ligand efficacy.

167 ed receptors can result in novel and nuanced allosteric effects on receptor signaling.

168 the ester substrate MUGB, sTF exerts greater allosteric effects on substrate binding than on the late

169 tion mechanism of PA200 is expressed via its allosteric effects on the 20 S core particle, perhaps fa

170 n be regulated by actin-binding proteins via allosteric effects on the actin.

171 ecular Interface I were most consistent with allosteric effects on the catalytic 3D polymerase molecu

172 stabilized the ligand-binding pocket and had allosteric effects on the dimerization interface.

173 lament regulatory proteins exert significant allosteric effects on the interaction of crossbridges wi

174 g of alpha-site ligands (ASLs) exerts strong allosteric effects on the reaction of substrates at the

175 plies that HAP1-DNA interactions have direct allosteric effects on transcriptional activation.

176 The allosteric effect operates by means of an allosteric cav

177 utants in other cytoplasmic loops, either by allosteric effects or via additional sites of action.

178 es (i.e., the small amino acids have minimal allosteric effects), PEP binding elicits different chang

179 nds to milliseconds, which clearly implicate allosteric effects propagating from the extracellular fa

180 s in the presence of bt10, which point to an allosteric effect rather than destabilization of the dim

181 rom the charge on the analyte, occur through allosteric effects related to the binding process, or re

182 by Zn(2+) binding, which induces cooperative allosteric effects related to those of the pH-dependent

183 that NNI2 inhibitors act through long range allosteric effects, reveal important conformational chan

184 Our results also imply that the allosteric effect should be independent of the base sequ

185 These allosteric effects suggest an ordered, cyclical mechanis

186 The triggering of the allosteric effect takes place by binding of the first an

187 wild-type enzyme, binding of dCTP induces an allosteric effect that affects the subunit interactions

188 e binding of one recognition motif causes an allosteric effect that enhances the subsequent binding o

189 tion of the transition state and an indirect allosteric effect that stabilizes the GDP-bound form.

190 at some of the crystallographically observed allosteric effects that result in the connection of subs

191 loops remains unchanged, but as a result of allosteric effect the structural fluctuations are altere

192 aggregation of target proteins, and through allosteric effects, their activity.

193 eceptors to form dimers and thus demonstrate allosteric effects through binding at the orthosteric si

194 These allosteric effects thus reduce ATP hydrolysis by inactiv

195 s spatially and temporally coordinates these allosteric effects to drive substrate translocation into

196 i.e., mutant E187A) causes MgADP to lose its allosteric effect upon Fru-6-P binding.

197 s towards its exosite and a further negative allosteric effect upon sandwich complexation of the thro

198 f Env antigenicity and immunogenicity and of allosteric effects upon receptor binding.

199 roach for quantitatively characterizing such allosteric effects using protein columns.

200 e GlyR alpha subunit and exerts its positive allosteric effect via an interaction with the Cys loop t

201 rved in the absence of Mg(2+), suggesting an allosteric effect via associated Kir6.2 subunits.

202 In contrast, an allosteric effect was not observed for 2-pyridylcarbinol

203 Although we cannot exclude allosteric effects, we propose that 7E3 binds between C1

204 ydroxyoctadecadienoic acid (13-HODE), and no allosteric effects were seen on diffusion or hydrogen at

205 This sensitivity is the result of allosteric effects where the structure around the buried

206 a general base but rather contributes to an allosteric effect, which includes a major transition sta

207 conformational changes may contribute to the allosteric effects, which regulate metal binding.

208 tion and are beginning to be used to explore allosteric effects within GPCR hetero-dimers.

209 on the binding affinity suggests long-range allosteric effects within IgG.