ライフサイエンスコーパス: allosteric inhibition

1 mpervious to glucuronidation and demonstrate allosteric inhibition.

2 ng the Kd for [(3)H]BTXB binding, indicating allosteric inhibition.

3 mall molecule probes that induce sub-maximal allosteric inhibition.

4 the modulatory binding site that mediate the allosteric inhibition.

5 e active site, defining a novel mechanism of allosteric inhibition.

6 ight into the pharmacophore requirements for allosteric inhibition.

7 equirement for an intact PH-KD interface for allosteric inhibition.

8 exible loop mediating the slow-onset step of allosteric inhibition.

9 ithin the L5 pocket is sufficient to restore allosteric inhibition.

10 t these motions are not sufficient to elicit allosteric inhibition.

11 e two compounds were not equivalent in their allosteric inhibition.

12 ions, a salient molecular mechanism enabling allosteric inhibition.

13 determinant of the magnitude of the observed allosteric inhibition.

14 ences to the DegS-PDZ domain, which relieves allosteric inhibition and activates proteolysis.

15 ructure-switching biosensors to enable their allosteric inhibition and activation.

16 e delicate structural discrimination between allosteric inhibition and potentiation of Cys-loop recep

17 steresis in the reaction time course, to ATP allosteric inhibition, and to F6P homotropic cooperativi

18 Cleavage of ATP-bound Pak2 relaxes the allosteric inhibition, as shown by increased solvent acc

19 d 7 (PG14N, PG17N) show potent and selective allosteric inhibition at hMC5R with IC 50 values of 38 +

20 s, with mutual, weak negative cooperativity (allosteric inhibition) between their binding.

21 is a homohexameric enzyme that is subject to allosteric inhibition by 3'-phosphoadenosine 5'-phosphos

22 e efficacy and exhibits a complex pattern of allosteric inhibition by a wide variety of small molecul

23 They support the suggestion that allosteric inhibition by adenine nucleotides is a genera

24 des a PRPP synthetase that is insensitive to allosteric inhibition by adenylate nucleotides.

25 ntral role in the mechanism of catalysis and allosteric inhibition by AMP.

26 compounds targeting mIDH demonstrated common allosteric inhibition by distinct chemotypes.

27 erculosis (MtIPMS) is subject to slow-onset, allosteric inhibition by l-leucine.

28 s not play the central role in producing the allosteric inhibition by PEP as originally envisioned in

29 R72E, T125A, and R171E maintained allosteric inhibition by PEP.

30 rmophilus have led to a structural model for allosteric inhibition by phosphoenolpyruvate (PEP) where

31 The allosteric inhibition exhibited by the unmodified sites

32 ism for inhibition by G418 and suggests that allosteric inhibition from this site is feasible.

33 A model for the mechanism of allosteric inhibition has been derived from conformation

34 A model for the mechanism of allosteric inhibition has been derived from conformation

35 ellular conformational switch which relieves allosteric inhibition imposed on the intracellular domai

36 that this structural transition explains the allosteric inhibition in BsPFK, and this explanation has

37 by phosphorylation in En. casseliflavus and allosteric inhibition in E. coli.

38 ue of Neuron explore the structural basis of allosteric inhibition in ionotropic glutamate receptors,

39 resence of K(+) (but not Na(+)) enhances the allosteric inhibition induced by MgATP.

40 This allosteric inhibition is mediated by direct interaction

41 Notably, this relief from allosteric inhibition is not caused by self-activation t

42 mplification of the complement response, its allosteric inhibition likely represents a fundamental co

43 sis with heat-induced potentiation, and that allosteric inhibition may contribute, in part, to the co

44 The allosteric inhibition mechanism is further elucidated by

45 s eIF4E structure and reveals elements of an allosteric inhibition mechanism leading to the dislocati

46 An allosteric inhibition mechanism of StaDDl by this compou

47 Although the structure is indicative of an allosteric inhibition mechanism, mutational studies and

48 sis revealed a dual active site-directed and allosteric inhibition mode of this compound class.

49 ture of the PRMT3-SGC707 complex confirm the allosteric inhibition mode.

50 ant for the utilization of amino sugars, and allosteric inhibition of Adk activity by HPr-P, but not

51 ce as a pharmacologically tractable site for allosteric inhibition of Bcr-Abl.

52 rate constants for processes which alter the allosteric inhibition of beta-oxidation by acetyl-CoA.

53 an important signaling function through its allosteric inhibition of carnitine palmitoyltransferase

54 entical subunits, which exhibits cooperative allosteric inhibition of catalysis by AMP.

55 several hot spots for either orthosteric or allosteric inhibition of catalytic activity, consistent

56 obe dimer interface leads to an irreversible allosteric inhibition of channel activity upon UV illumi

57 the first time the structural mechanism for allosteric inhibition of DHDPS from the common grapevine

58 -nanosecond motions impact zinc (Zn)-induced allosteric inhibition of DNA binding by the Zn efflux re

59 of the thiophene inhibitors, consistent with allosteric inhibition of DNA gyrase.

60 Demonstrated here is the allosteric inhibition of E. coli FBPase by glucose 6-pho

61 collapse of the mitotic spindle through the allosteric inhibition of Eg5.

62 se Cys residues in Na(+) self-inhibition, an allosteric inhibition of ENaC activity by extracellular

63 for catalytic activity and the mechanism of allosteric inhibition of FBPase by AMP.

64 Both the allosteric inhibition of fibrinogen turnover caused by G

65 Evidently, two pathways of allosteric inhibition of fructose-1,6-bisphosphatase are

66 an colon carcinoma cells, demonstrating that allosteric inhibition of GCC by adenine nucleotides is m

67 We present a model for the allosteric inhibition of GCGR by a monoclonal antibody t

68 erammonemia disorder showed that the loss of allosteric inhibition of GDH by GTP causes excessive sec

69 Additionally, we observed allosteric inhibition of glycosylase activity in the dim

70 discovery efforts have focused primarily on allosteric inhibition of hFPPS and the discovery of non-

71 Our data strengthen the case for allosteric inhibition of HIV RNase H activity, providing

72 te, and aconitate, which was consistent with allosteric inhibition of isocitrate dehydrogenase by P-e

73 se studies therefore offer insights into (i) allosteric inhibition of KGA by BPTES, revealing the dyn

74 sly block two steps in this pathway, through allosteric inhibition of mevalonate kinase (MK) and, for

75 ion of the ADMIDAS residues also reduced the allosteric inhibition of Mn2+-supported ligand binding b

76 combined into a model that accounts for the allosteric inhibition of MtATP-phosphoribosyltransferase

77 the profile of AAS modulation and that this allosteric inhibition of native GnRH neurons should be c

78 This conformational change induces allosteric inhibition of NF-kappaB DNA binding.

79 N2B ATD is essential for ifenprodil-mediated allosteric inhibition of NMDA receptors.

80 We show that direct allosteric inhibition of plasmin could led to new antifi

81 cleotide pool, which results in the enhanced allosteric inhibition of PRPP synthetase and consequentl

82 phosphoenolpyruvate (PEP) contribute to the allosteric inhibition of rabbit muscle pyruvate kinase b

83 ing with TSC-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC.

84 Here we show that allosteric inhibition of RXR results from a rotation of

85 interact with ALX/FPR2 receptors and lead to allosteric inhibition of SAA-initiated epithelial respon

86 ly activated by RAR ligands only, because of allosteric inhibition of the binding of ligands to RXR b

87 l dynamic effects of nucleotide turnover and allosteric inhibition of the kinesin-5 motor.

88 e properties of compounds that would prevent allosteric inhibition of the receptor and how to test fo

89 in a manner consistent with noncompetitive, allosteric inhibition of the receptor-channel complex.

90 odel wherein CK2 phosphorylation triggers an allosteric inhibition of the SNAP190 Myb DNA binding dom

91 e-stimulated insulin secretion that includes allosteric inhibition of tricarboxylic acid cycle enzyme

92 ffect at RG is consistent with either strong allosteric inhibition or competitive inhibition at one o

93 nd binding and not to cause the heterotropic allosteric inhibition per se.

94 de of the protein binding site indicate that allosteric inhibition, rather than direct steric competi

95 tion of phenylethanolamines and ATD-mediated allosteric inhibition remain limited owing to a lack of

96 at an RXXD motif that normally serves as an allosteric inhibition site for active diguanylate cyclas

97 ition against calpain-2 was observed, and an allosteric inhibition site on the enzyme was identified

98 for the distant coupling locus to transplant allosteric inhibition suggest that the coupling locus mo

99 l signaling, wherein ATP is the transmitter, allosteric inhibition the coupling mechanism, and regula

100 In the presence of folate binding and allosteric inhibition, the velocities show a remarkable

101 By illuminating the molecular mechanisms of allosteric inhibition, these studies delineate the intri

102 teric couple mutants still allow binding and allosteric inhibition, they partially relieve the mutual

103 gest the enzyme undergoes a slow relief from allosteric inhibition upon initiation of catalysis on un

104 sis for its regulation, we characterized the allosteric inhibition using gel filtration, steady-state

105 shows a kinetic lag in product formation and allosteric inhibition with unmethylated DNA that is not